FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6404, 334 aa 1>>>pF1KB6404 334 - 334 aa - 334 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0647+/-0.000425; mu= 13.1878+/- 0.026 mean_var=166.9052+/-34.273, 0's: 0 Z-trim(114.5): 572 B-trim: 66 in 2/50 Lambda= 0.099275 statistics sampled from 23682 (24434) to 23682 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.286), width: 16 Scan time: 7.980 The best scores are: opt bits E(85289) XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-c ( 334) 2251 334.9 1.5e-91 NP_438172 (OMIM: 609012) WD repeat-containing prot ( 334) 2251 334.9 1.5e-91 NP_060058 (OMIM: 609012) WD repeat-containing prot ( 334) 2251 334.9 1.5e-91 NP_115708 (OMIM: 616850) WD repeat domain-containi ( 315) 544 90.3 5.7e-18 NP_001093207 (OMIM: 616850) WD repeat domain-conta ( 315) 544 90.3 5.7e-18 XP_016861593 (OMIM: 614783,614813) PREDICTED: POC1 ( 321) 537 89.4 1.2e-17 NP_001155052 (OMIM: 614783,614813) POC1 centriolar ( 359) 537 89.4 1.2e-17 NP_001155053 (OMIM: 614783,614813) POC1 centriolar ( 369) 537 89.4 1.3e-17 NP_056241 (OMIM: 614783,614813) POC1 centriolar pr ( 407) 537 89.5 1.3e-17 XP_011531863 (OMIM: 614783,614813) PREDICTED: POC1 ( 326) 522 87.2 5.2e-17 XP_011531864 (OMIM: 614783,614813) PREDICTED: POC1 ( 300) 519 86.7 6.6e-17 XP_011531862 (OMIM: 614783,614813) PREDICTED: POC1 ( 374) 515 86.3 1.1e-16 NP_001188493 (OMIM: 605961) pleiotropic regulator ( 505) 501 84.5 5.4e-16 NP_002660 (OMIM: 605961) pleiotropic regulator 1 i ( 514) 501 84.5 5.5e-16 XP_016860391 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 498 83.8 5.6e-16 XP_016860389 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 498 83.8 5.6e-16 XP_011510137 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 498 83.8 5.6e-16 XP_016860390 (OMIM: 612173) PREDICTED: sperm-assoc ( 323) 498 83.8 5.6e-16 XP_016860387 (OMIM: 612173) PREDICTED: sperm-assoc ( 390) 498 83.9 6.2e-16 XP_016860385 (OMIM: 612173) PREDICTED: sperm-assoc ( 512) 498 84.0 7.3e-16 XP_016860386 (OMIM: 612173) PREDICTED: sperm-assoc ( 512) 498 84.0 7.3e-16 XP_011510124 (OMIM: 612173) PREDICTED: sperm-assoc ( 528) 498 84.1 7.5e-16 XP_011510125 (OMIM: 612173) PREDICTED: sperm-assoc ( 528) 498 84.1 7.5e-16 XP_011510123 (OMIM: 612173) PREDICTED: sperm-assoc ( 537) 498 84.1 7.6e-16 XP_011510121 (OMIM: 612173) PREDICTED: sperm-assoc ( 577) 498 84.1 7.9e-16 XP_011510116 (OMIM: 612173) PREDICTED: sperm-assoc ( 600) 498 84.1 8.1e-16 NP_078808 (OMIM: 612173) sperm-associated antigen ( 631) 498 84.2 8.3e-16 XP_016880191 (OMIM: 601545,607432) PREDICTED: plat ( 345) 475 80.5 5.7e-15 NP_000421 (OMIM: 601545,607432) platelet-activatin ( 410) 475 80.6 6.3e-15 XP_016880190 (OMIM: 601545,607432) PREDICTED: plat ( 410) 475 80.6 6.3e-15 XP_016880189 (OMIM: 601545,607432) PREDICTED: plat ( 410) 475 80.6 6.3e-15 XP_016880188 (OMIM: 601545,607432) PREDICTED: plat ( 410) 475 80.6 6.3e-15 XP_011522203 (OMIM: 601545,607432) PREDICTED: plat ( 428) 475 80.6 6.5e-15 XP_011522205 (OMIM: 601545,607432) PREDICTED: plat ( 428) 475 80.6 6.5e-15 XP_011522204 (OMIM: 601545,607432) PREDICTED: plat ( 428) 475 80.6 6.5e-15 NP_056975 (OMIM: 605585) pre-mRNA-processing facto ( 579) 463 79.1 2.6e-14 NP_001186706 (OMIM: 614784,615973) POC1 centriolar ( 436) 452 77.4 6.4e-14 NP_758440 (OMIM: 614784,615973) POC1 centriolar pr ( 478) 452 77.4 6.8e-14 XP_011510120 (OMIM: 612173) PREDICTED: sperm-assoc ( 577) 452 77.5 7.6e-14 XP_011510119 (OMIM: 612173) PREDICTED: sperm-assoc ( 582) 452 77.5 7.6e-14 XP_011510118 (OMIM: 612173) PREDICTED: sperm-assoc ( 592) 452 77.5 7.7e-14 XP_011510117 (OMIM: 612173) PREDICTED: sperm-assoc ( 592) 452 77.5 7.7e-14 NP_001309196 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 441 75.5 1.5e-13 NP_001309195 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 441 75.5 1.5e-13 NP_001231855 (OMIM: 607795,615922) U4/U6 small nuc ( 521) 441 75.9 2.1e-13 NP_004688 (OMIM: 607795,615922) U4/U6 small nuclea ( 522) 441 75.9 2.1e-13 XP_011530390 (OMIM: 606278) PREDICTED: F-box/WD re ( 540) 432 74.6 5.3e-13 NP_001013433 (OMIM: 606278) F-box/WD repeat-contai ( 589) 432 74.7 5.6e-13 NP_060785 (OMIM: 606278) F-box/WD repeat-containin ( 627) 432 74.7 5.8e-13 XP_011530388 (OMIM: 606278) PREDICTED: F-box/WD re ( 679) 432 74.7 6.1e-13 >>XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-conta (334 aa) initn: 2251 init1: 2251 opt: 2251 Z-score: 1764.6 bits: 334.9 E(85289): 1.5e-91 Smith-Waterman score: 2251; 100.0% identity (100.0% similar) in 334 aa overlap (1-334:1-334) 10 20 30 40 50 60 pF1KB6 MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 250 260 270 280 290 300 310 320 330 pF1KB6 TDVVISTACHPTENIIASAALENDKTIKLWKSDC :::::::::::::::::::::::::::::::::: XP_005 TDVVISTACHPTENIIASAALENDKTIKLWKSDC 310 320 330 >>NP_438172 (OMIM: 609012) WD repeat-containing protein (334 aa) initn: 2251 init1: 2251 opt: 2251 Z-score: 1764.6 bits: 334.9 E(85289): 1.5e-91 Smith-Waterman score: 2251; 100.0% identity (100.0% similar) in 334 aa overlap (1-334:1-334) 10 20 30 40 50 60 pF1KB6 MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_438 MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_438 ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_438 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_438 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_438 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 250 260 270 280 290 300 310 320 330 pF1KB6 TDVVISTACHPTENIIASAALENDKTIKLWKSDC :::::::::::::::::::::::::::::::::: NP_438 TDVVISTACHPTENIIASAALENDKTIKLWKSDC 310 320 330 >>NP_060058 (OMIM: 609012) WD repeat-containing protein (334 aa) initn: 2251 init1: 2251 opt: 2251 Z-score: 1764.6 bits: 334.9 E(85289): 1.5e-91 Smith-Waterman score: 2251; 100.0% identity (100.0% similar) in 334 aa overlap (1-334:1-334) 10 20 30 40 50 60 pF1KB6 MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 ASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 CLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 RDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 WDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH 250 260 270 280 290 300 310 320 330 pF1KB6 TDVVISTACHPTENIIASAALENDKTIKLWKSDC :::::::::::::::::::::::::::::::::: NP_060 TDVVISTACHPTENIIASAALENDKTIKLWKSDC 310 320 330 >>NP_115708 (OMIM: 616850) WD repeat domain-containing p (315 aa) initn: 746 init1: 311 opt: 544 Z-score: 443.6 bits: 90.3 E(85289): 5.7e-18 Smith-Waterman score: 544; 32.7% identity (61.5% similar) in 312 aa overlap (25-333:5-306) 10 20 30 40 50 pF1KB6 MATEEKKPETEAARAQPTPSSSATQSKPTPVK-PNYALKFTLAGHTKAVSSVKFSPNGEW . :: : . :. :: :: :: .:.:. .:.. NP_115 MAFPEPKPRPPELPQKRLK-TLDCGQGAVRAVRFNVDGNY 10 20 30 60 70 80 90 100 110 pF1KB6 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG . ..:: .:.:. : . .: ::: . :.: : :.. : :.. ::.. .:::.:: NP_115 CLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASG 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB6 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAV . .. ..::.. : .:: ....:.:::.: :.: :: .. . ..:: : ::.: NP_115 QVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSV 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB6 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT . . :...: :: : .: :: .. . . :.. . :: .:. :...::.: NP_115 KVS--DHEILAGSVDGRVRRYDLRMGQLFSDYVGS---PITCTCFSRDGQCTLVSSLDST 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB6 LKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL :.: : . :. : : ::::..: . .: . .:: :::. :..:.: .. : NP_115 LRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTH-VVSCSEDGKVFFWDLVEGALALAL 220 230 240 250 260 270 300 310 320 330 pF1KB6 QGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC . :: : : :::: . .: ... :. . NP_115 PVGSGVVQSLAYHPTEPCLLTAM---GGSVQCWREEAYEAEDGAG 280 290 300 310 >>NP_001093207 (OMIM: 616850) WD repeat domain-containin (315 aa) initn: 746 init1: 311 opt: 544 Z-score: 443.6 bits: 90.3 E(85289): 5.7e-18 Smith-Waterman score: 544; 32.7% identity (61.5% similar) in 312 aa overlap (25-333:5-306) 10 20 30 40 50 pF1KB6 MATEEKKPETEAARAQPTPSSSATQSKPTPVK-PNYALKFTLAGHTKAVSSVKFSPNGEW . :: : . :. :: :: :: .:.:. .:.. NP_001 MAFPEPKPRPPELPQKRLK-TLDCGQGAVRAVRFNVDGNY 10 20 30 60 70 80 90 100 110 pF1KB6 LASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSG . ..:: .:.:. : . .: ::: . :.: : :.. : :.. ::.. .:::.:: NP_001 CLTCGSDKTLKLWNPLRGTLLRTYSGHGYEVLDAAGSFDNSSLCSGGGDKAVVLWDVASG 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB6 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAV . .. ..::.. : .:: ....:.:::.: :.: :: .. . ..:: : ::.: NP_001 QVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSIRCWDCRSRRPEPVQTLDEARDGVSSV 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB6 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNT . . :...: :: : .: :: .. . . :.. . :: .:. :...::.: NP_001 KVS--DHEILAGSVDGRVRRYDLRMGQLFSDYVGS---PITCTCFSRDGQCTLVSSLDST 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB6 LKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKL :.: : . :. : : ::::..: . .: . .:: :::. :..:.: .. : NP_001 LRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDTH-VVSCSEDGKVFFWDLVEGALALAL 220 230 240 250 260 270 300 310 320 330 pF1KB6 QGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC . :: : : :::: . .: ... :. . NP_001 PVGSGVVQSLAYHPTEPCLLTAM---GGSVQCWREEAYEAEDGAG 280 290 300 310 >>XP_016861593 (OMIM: 614783,614813) PREDICTED: POC1 cen (321 aa) initn: 389 init1: 389 opt: 537 Z-score: 438.1 bits: 89.4 E(85289): 1.2e-17 Smith-Waterman score: 537; 35.7% identity (69.0% similar) in 258 aa overlap (31-286:10-260) 10 20 30 40 50 pF1KB6 MATEEKKPETEAARAQPTPSSSATQSKPTPVKP-NYALKFTLAGHTKAVSSVKFSPNGEW .:: . : .:: :: ::. :.:::.:. XP_016 MDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSGHL 10 20 30 60 70 80 90 100 110 pF1KB6 LASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS :::.: :: ..:: . . : :.:. .: . .: . ::.. .:.::::::.:.: . XP_016 LASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB6 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH : : .:. : :.: : .:.:.. ::::.: :..:..:: .. .:... :. :. : XP_016 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB6 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL :. .:. :.....:. ..::. . . :. . . :. ..: :.:.:...:. :.:: XP_016 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY-QLHSAAVNGLSFHPSGNYLITASSDSTL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB6 KLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ :. : .:. : : ::.. . :: :: ....::. :. :..: XP_016 KILDLMEGRLLYTLHGHQGPATTV--AFSRTG-EYFASGGSDEQVMVWKSNFDIVDHGEV 220 230 240 250 260 270 300 310 320 330 pF1KB6 GHTDVVISTACHPTENIIASAALENDKTIKLWKSDC XP_016 TKVPRPPATLASSMGNLTVSILEQRLTLTEDKLKQCLENQQLIMQRATP 280 290 300 310 320 >>NP_001155052 (OMIM: 614783,614813) POC1 centriolar pro (359 aa) initn: 389 init1: 389 opt: 537 Z-score: 437.6 bits: 89.4 E(85289): 1.2e-17 Smith-Waterman score: 537; 35.7% identity (69.0% similar) in 258 aa overlap (31-286:48-298) 10 20 30 40 50 pF1KB6 MATEEKKPETEAARAQPTPSSSATQSKPTPVKP-NYALKFTLAGHTKAVSSVKFSPNGEW .:: . : .:: :: ::. :.:::.:. NP_001 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSGHL 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB6 LASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS :::.: :: ..:: . . : :.:. .: . .: . ::.. .:.::::::.:.: . NP_001 LASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 80 90 100 110 120 130 120 130 140 150 160 170 pF1KB6 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH : : .:. : :.: : .:.:.. ::::.: :..:..:: .. .:... :. :. : NP_001 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 140 150 160 170 180 190 180 190 200 210 220 230 pF1KB6 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL :. .:. :.....:. ..::. . . :. . . :. ..: :.:.:...:. :.:: NP_001 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY-QLHSAAVNGLSFHPSGNYLITASSDSTL 200 210 220 230 240 250 240 250 260 270 280 290 pF1KB6 KLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ :. : .:. : : ::.. . :: :: ....::. :. :..: NP_001 KILDLMEGRLLYTLHGHQGPATTV--AFSRTG-EYFASGGSDEQVMVWKSNFDIVDHGEV 260 270 280 290 300 310 300 310 320 330 pF1KB6 GHTDVVISTACHPTENIIASAALENDKTIKLWKSDC NP_001 TKVPRPPATLASSMGNLTVSILEQRLTLTEDKLKQCLENQQLIMQRATP 320 330 340 350 >>NP_001155053 (OMIM: 614783,614813) POC1 centriolar pro (369 aa) initn: 389 init1: 389 opt: 537 Z-score: 437.5 bits: 89.4 E(85289): 1.3e-17 Smith-Waterman score: 537; 35.7% identity (69.0% similar) in 258 aa overlap (31-286:10-260) 10 20 30 40 50 pF1KB6 MATEEKKPETEAARAQPTPSSSATQSKPTPVKP-NYALKFTLAGHTKAVSSVKFSPNGEW .:: . : .:: :: ::. :.:::.:. NP_001 MDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSGHL 10 20 30 60 70 80 90 100 110 pF1KB6 LASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS :::.: :: ..:: . . : :.:. .: . .: . ::.. .:.::::::.:.: . NP_001 LASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 40 50 60 70 80 90 120 130 140 150 160 170 pF1KB6 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH : : .:. : :.: : .:.:.. ::::.: :..:..:: .. .:... :. :. : NP_001 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 100 110 120 130 140 150 180 190 200 210 220 230 pF1KB6 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL :. .:. :.....:. ..::. . . :. . . :. ..: :.:.:...:. :.:: NP_001 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY-QLHSAAVNGLSFHPSGNYLITASSDSTL 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB6 KLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ :. : .:. : : ::.. . :: :: ....::. :. :..: NP_001 KILDLMEGRLLYTLHGHQGPATTV--AFSRTG-EYFASGGSDEQVMVWKSNFDIVDHGEV 220 230 240 250 260 270 300 310 320 330 pF1KB6 GHTDVVISTACHPTENIIASAALENDKTIKLWKSDC NP_001 TKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQPQEPVSVPQTLTSTLEHIVGQL 280 290 300 310 320 330 >>NP_056241 (OMIM: 614783,614813) POC1 centriolar protei (407 aa) initn: 389 init1: 389 opt: 537 Z-score: 437.0 bits: 89.5 E(85289): 1.3e-17 Smith-Waterman score: 537; 35.7% identity (69.0% similar) in 258 aa overlap (31-286:48-298) 10 20 30 40 50 pF1KB6 MATEEKKPETEAARAQPTPSSSATQSKPTPVKP-NYALKFTLAGHTKAVSSVKFSPNGEW .:: . : .:: :: ::. :.:::.:. NP_056 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSGHL 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB6 LASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS :::.: :: ..:: . . : :.:. .: . .: . ::.. .:.::::::.:.: . NP_056 LASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 80 90 100 110 120 130 120 130 140 150 160 170 pF1KB6 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH : : .:. : :.: : .:.:.. ::::.: :..:..:: .. .:... :. :. : NP_056 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 140 150 160 170 180 190 180 190 200 210 220 230 pF1KB6 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL :. .:. :.....:. ..::. . . :. . . :. ..: :.:.:...:. :.:: NP_056 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY-QLHSAAVNGLSFHPSGNYLITASSDSTL 200 210 220 230 240 250 240 250 260 270 280 290 pF1KB6 KLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ :. : .:. : : ::.. . :: :: ....::. :. :..: NP_056 KILDLMEGRLLYTLHGHQGPATTV--AFSRTG-EYFASGGSDEQVMVWKSNFDIVDHGEV 260 270 280 290 300 310 300 310 320 330 pF1KB6 GHTDVVISTACHPTENIIASAALENDKTIKLWKSDC NP_056 TKVPRPPATLASSMGNLPEVDFPVPPGRGRSVESVQSQPQEPVSVPQTLTSTLEHIVGQL 320 330 340 350 360 370 >>XP_011531863 (OMIM: 614783,614813) PREDICTED: POC1 cen (326 aa) initn: 389 init1: 389 opt: 522 Z-score: 426.4 bits: 87.2 E(85289): 5.2e-17 Smith-Waterman score: 522; 34.4% identity (66.7% similar) in 270 aa overlap (31-298:48-311) 10 20 30 40 50 pF1KB6 MATEEKKPETEAARAQPTPSSSATQSKPTPVKP-NYALKFTLAGHTKAVSSVKFSPNGEW .:: . : .:: :: ::. :.:::.:. XP_011 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSGHL 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB6 LASSSADKLIKIWGAYDGKFEKTI-SGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSS :::.: :: ..:: . . : :.:. .: . .: . ::.. .:.::::::.:.: . XP_011 LASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 80 90 100 110 120 130 120 130 140 150 160 170 pF1KB6 GKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH : : .:. : :.: : .:.:.. ::::.: :..:..:: .. .:... :. :. : XP_011 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 140 150 160 170 180 190 180 190 200 210 220 230 pF1KB6 FNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTL :. .:. :.....:. ..::. . . :. . . :. ..: :.:.:...:. :.:: XP_011 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHY-QLHSAAVNGLSFHPSGNYLITASSDSTL 200 210 220 230 240 250 240 250 260 270 280 290 pF1KB6 KLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ :. : .:. : : ::.. . :: :: . .::... : : . . .::. XP_011 KILDLMEGRLLYTLHGHQGPATTV--AFSRTGEYFASGGSDEQTVSILEQRLTLTEDKLK 260 270 280 290 300 310 300 310 320 330 pF1KB6 GHTDVVISTACHPTENIIASAALENDKTIKLWKSDC XP_011 QCLENQQLIMQRATP 320 334 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 22:52:46 2016 done: Fri Nov 4 22:52:47 2016 Total Scan time: 7.980 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]