FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6415, 308 aa 1>>>pF1KB6415 308 - 308 aa - 308 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1627+/-0.00033; mu= 14.1749+/- 0.021 mean_var=129.3694+/-25.983, 0's: 0 Z-trim(120.4): 255 B-trim: 816 in 1/53 Lambda= 0.112761 statistics sampled from 35248 (35560) to 35248 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.752), E-opt: 0.2 (0.417), width: 16 Scan time: 7.780 The best scores are: opt bits E(85289) NP_004156 (OMIM: 179503) GTP-binding protein RAD [ ( 308) 2048 343.7 2.7e-94 NP_001122322 (OMIM: 179503) GTP-binding protein RA ( 308) 2048 343.7 2.7e-94 NP_859053 (OMIM: 600164) GTP-binding protein GEM [ ( 296) 1073 185.1 1.5e-46 NP_005252 (OMIM: 600164) GTP-binding protein GEM [ ( 296) 1073 185.1 1.5e-46 NP_054731 (OMIM: 610388) GTP-binding protein REM 1 ( 298) 878 153.4 5.2e-37 NP_775798 (OMIM: 616955) GTP-binding protein REM 2 ( 340) 814 143.0 7.8e-34 XP_016876548 (OMIM: 616955) PREDICTED: GTP-binding ( 372) 814 143.1 8.3e-34 XP_005267440 (OMIM: 616955) PREDICTED: GTP-binding ( 341) 810 142.4 1.2e-33 XP_016876547 (OMIM: 616955) PREDICTED: GTP-binding ( 373) 810 142.4 1.3e-33 XP_005260461 (OMIM: 610388) PREDICTED: GTP-binding ( 306) 763 134.7 2.3e-31 XP_016883322 (OMIM: 610388) PREDICTED: GTP-binding ( 306) 763 134.7 2.3e-31 XP_011527097 (OMIM: 610388) PREDICTED: GTP-binding ( 304) 762 134.5 2.5e-31 XP_016868804 (OMIM: 600164) PREDICTED: GTP-binding ( 208) 608 109.3 6.8e-24 XP_011534820 (OMIM: 616955) PREDICTED: GTP-binding ( 279) 482 88.9 1.2e-17 NP_001243750 (OMIM: 609591,615355) GTP-binding pro ( 236) 397 75.0 1.6e-13 NP_002921 (OMIM: 609592) GTP-binding protein Rit2 ( 217) 390 73.9 3.3e-13 NP_008843 (OMIM: 609591,615355) GTP-binding protei ( 219) 390 73.9 3.3e-13 NP_005393 (OMIM: 179550) ras-related protein Ral-A ( 206) 374 71.2 1.9e-12 XP_011513768 (OMIM: 179550) PREDICTED: ras-related ( 206) 374 71.2 1.9e-12 XP_006715825 (OMIM: 179550) PREDICTED: ras-related ( 206) 374 71.2 1.9e-12 XP_005263781 (OMIM: 179551) PREDICTED: ras-related ( 228) 353 67.9 2.2e-11 XP_016860110 (OMIM: 179551) PREDICTED: ras-related ( 228) 353 67.9 2.2e-11 XP_011509875 (OMIM: 179551) PREDICTED: ras-related ( 229) 353 67.9 2.2e-11 NP_002872 (OMIM: 179551) ras-related protein Ral-B ( 206) 348 67.0 3.6e-11 XP_005263785 (OMIM: 179551) PREDICTED: ras-related ( 206) 348 67.0 3.6e-11 XP_016860111 (OMIM: 179551) PREDICTED: ras-related ( 206) 348 67.0 3.6e-11 XP_005263784 (OMIM: 179551) PREDICTED: ras-related ( 206) 348 67.0 3.6e-11 XP_005263786 (OMIM: 179551) PREDICTED: ras-related ( 206) 348 67.0 3.6e-11 NP_001243749 (OMIM: 609591,615355) GTP-binding pro ( 183) 335 64.8 1.4e-10 NP_116307 (OMIM: 612664) ras-related and estrogen- ( 199) 329 63.9 3e-10 NP_056461 (OMIM: 179530) ras-related protein Rap-1 ( 184) 316 61.8 1.2e-09 NP_001010942 (OMIM: 179530) ras-related protein Ra ( 184) 316 61.8 1.2e-09 NP_060064 (OMIM: 607863) GTP-binding protein Di-Ra ( 199) 311 61.0 2.3e-09 NP_036382 (OMIM: 600098) ras-related protein R-Ras ( 204) 311 61.0 2.3e-09 XP_016874782 (OMIM: 109800,114480,137215,163200,19 ( 227) 309 60.7 3.2e-09 NP_066361 (OMIM: 179540) ras-related protein Rap-2 ( 183) 306 60.1 3.8e-09 XP_006719132 (OMIM: 109800,114480,137215,163200,19 ( 189) 304 59.8 4.9e-09 NP_203524 (OMIM: 109800,114480,137215,163200,19007 ( 189) 304 59.8 4.9e-09 NP_001177655 (OMIM: 612664) ras-related and estrog ( 180) 303 59.6 5.3e-09 NP_006261 (OMIM: 165090) ras-related protein R-Ras ( 218) 304 59.9 5.4e-09 NP_002877 (OMIM: 179541) ras-related protein Rap-2 ( 183) 302 59.5 6e-09 NP_001278825 (OMIM: 179520) ras-related protein Ra ( 184) 302 59.5 6e-09 NP_001010935 (OMIM: 179520) ras-related protein Ra ( 184) 302 59.5 6e-09 XP_016857453 (OMIM: 179520) PREDICTED: ras-related ( 184) 302 59.5 6e-09 NP_002875 (OMIM: 179520) ras-related protein Rap-1 ( 184) 302 59.5 6e-09 XP_016857451 (OMIM: 179520) PREDICTED: ras-related ( 184) 302 59.5 6e-09 XP_016857452 (OMIM: 179520) PREDICTED: ras-related ( 184) 302 59.5 6e-09 XP_011518955 (OMIM: 109800,114480,137215,163200,19 ( 188) 300 59.2 7.6e-09 NP_004976 (OMIM: 109800,114480,137215,163200,19007 ( 188) 300 59.2 7.6e-09 XP_016875610 (OMIM: 612664) PREDICTED: ras-related ( 196) 300 59.2 7.9e-09 >>NP_004156 (OMIM: 179503) GTP-binding protein RAD [Homo (308 aa) initn: 2048 init1: 2048 opt: 2048 Z-score: 1813.9 bits: 343.7 E(85289): 2.7e-94 Smith-Waterman score: 2048; 100.0% identity (100.0% similar) in 308 aa overlap (1-308:1-308) 10 20 30 40 50 60 pF1KB6 MTLNGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGALTAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MTLNGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGALTAAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AGTGTQGPRLDWPEDSEDSLSSGGSDSDESVYKVLLLGAPGVGKSALARIFGGVEDGPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 AGTGTQGPRLDWPEDSEDSLSSGGSDSDESVYKVLLLGAPGVGKSALARIFGGVEDGPEA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EAAGHTYDRSIVVDGEEASLMVYDIWEQDGGRWLPGHCMAMGDAYVIVYSVTDKGSFEKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 EAAGHTYDRSIVVDGEEASLMVYDIWEQDGGRWLPGHCMAMGDAYVIVYSVTDKGSFEKA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 SELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 SELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 QALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 QALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSK 250 260 270 280 290 300 pF1KB6 SCHDLSVL :::::::: NP_004 SCHDLSVL >>NP_001122322 (OMIM: 179503) GTP-binding protein RAD [H (308 aa) initn: 2048 init1: 2048 opt: 2048 Z-score: 1813.9 bits: 343.7 E(85289): 2.7e-94 Smith-Waterman score: 2048; 100.0% identity (100.0% similar) in 308 aa overlap (1-308:1-308) 10 20 30 40 50 60 pF1KB6 MTLNGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGALTAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTLNGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGALTAAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 AGTGTQGPRLDWPEDSEDSLSSGGSDSDESVYKVLLLGAPGVGKSALARIFGGVEDGPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AGTGTQGPRLDWPEDSEDSLSSGGSDSDESVYKVLLLGAPGVGKSALARIFGGVEDGPEA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EAAGHTYDRSIVVDGEEASLMVYDIWEQDGGRWLPGHCMAMGDAYVIVYSVTDKGSFEKA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EAAGHTYDRSIVVDGEEASLMVYDIWEQDGGRWLPGHCMAMGDAYVIVYSVTDKGSFEKA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 SELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNV 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 QALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSK 250 260 270 280 290 300 pF1KB6 SCHDLSVL :::::::: NP_001 SCHDLSVL >>NP_859053 (OMIM: 600164) GTP-binding protein GEM [Homo (296 aa) initn: 1007 init1: 814 opt: 1073 Z-score: 956.9 bits: 185.1 E(85289): 1.5e-46 Smith-Waterman score: 1073; 57.9% identity (79.8% similar) in 292 aa overlap (23-308:9-296) 10 20 30 40 50 60 pF1KB6 MTLNGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGALTAAA :.:.. : : .: :.:.: : :.. : . NP_859 MTLNNVTMRQGTV--GMQPQQQRWSIPADGRHLMVQKEPHQYSHRN 10 20 30 40 70 80 90 100 110 pF1KB6 AGTGTQGP--RLDWPEDSEDSLSSGGSDSDESVYKVLLLGAPGVGKSALARIFGGVEDGP ..: : .: :: ::. : :.: .. :.:.:.: :::::.:: ::.::.:. NP_859 RHSATPEDHCRRSWSSDSTDSVIS--SESGNTYYRVVLIGEQGVGKSTLANIFAGVHDSM 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB6 EA--EAAGH-TYDRSIVVDGEEASLMVYDIWEQDG-GRWLPGHCMAMGDAYVIVYSVTDK .. :. :. ::.:...:::: :.... :.::. : ..:: ::: .::::.::::.::. NP_859 DSDCEVLGEDTYERTLMVDGESATIILLDMWENKGENEWLHDHCMQVGDAYLIVYSITDR 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB6 GSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSA .:::::::::.::::::::.:.::::::::::::: :::::.:::::::::::::::::: NP_859 ASFEKASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIETSA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB6 ALHHNVQALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGKKAKRFLGRIVARNSRKMA :..:::. ::::.:::.:::::::: : :: : .:.::. .::.:: :.:::.:...:: NP_859 AVQHNVKELFEGIVRQVRLRRDSKEKNERRLAYQKRKESMPRKARRFWGKIVAKNNKNMA 230 240 250 260 270 280 300 pF1KB6 FRAKSKSCHDLSVL :. ::::::::::: NP_859 FKLKSKSCHDLSVL 290 >>NP_005252 (OMIM: 600164) GTP-binding protein GEM [Homo (296 aa) initn: 1007 init1: 814 opt: 1073 Z-score: 956.9 bits: 185.1 E(85289): 1.5e-46 Smith-Waterman score: 1073; 57.9% identity (79.8% similar) in 292 aa overlap (23-308:9-296) 10 20 30 40 50 60 pF1KB6 MTLNGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGALTAAA :.:.. : : .: :.:.: : :.. : . NP_005 MTLNNVTMRQGTV--GMQPQQQRWSIPADGRHLMVQKEPHQYSHRN 10 20 30 40 70 80 90 100 110 pF1KB6 AGTGTQGP--RLDWPEDSEDSLSSGGSDSDESVYKVLLLGAPGVGKSALARIFGGVEDGP ..: : .: :: ::. : :.: .. :.:.:.: :::::.:: ::.::.:. NP_005 RHSATPEDHCRRSWSSDSTDSVIS--SESGNTYYRVVLIGEQGVGKSTLANIFAGVHDSM 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB6 EA--EAAGH-TYDRSIVVDGEEASLMVYDIWEQDG-GRWLPGHCMAMGDAYVIVYSVTDK .. :. :. ::.:...:::: :.... :.::. : ..:: ::: .::::.::::.::. NP_005 DSDCEVLGEDTYERTLMVDGESATIILLDMWENKGENEWLHDHCMQVGDAYLIVYSITDR 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB6 GSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSA .:::::::::.::::::::.:.::::::::::::: :::::.:::::::::::::::::: NP_005 ASFEKASELRIQLRRARQTEDIPIILVGNKSDLVRCREVSVSEGRACAVVFDCKFIETSA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB6 ALHHNVQALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGKKAKRFLGRIVARNSRKMA :..:::. ::::.:::.:::::::: : :: : .:.::. .::.:: :.:::.:...:: NP_005 AVQHNVKELFEGIVRQVRLRRDSKEKNERRLAYQKRKESMPRKARRFWGKIVAKNNKNMA 230 240 250 260 270 280 300 pF1KB6 FRAKSKSCHDLSVL :. ::::::::::: NP_005 FKLKSKSCHDLSVL 290 >>NP_054731 (OMIM: 610388) GTP-binding protein REM 1 [Ho (298 aa) initn: 724 init1: 511 opt: 878 Z-score: 785.4 bits: 153.4 E(85289): 5.2e-37 Smith-Waterman score: 907; 51.4% identity (75.5% similar) in 294 aa overlap (34-308:12-298) 10 20 30 40 50 60 pF1KB6 NGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRS---MPVDERDLQAALTPGALTAAA :::::. .:.. : : :: :... NP_054 MTLNTEQEAKTPLHRRASTPLPLSPRGHQ----PGRLSTVP 10 20 30 70 80 90 100 pF1KB6 AGTGTQGPRLDW----------PEDSEDSLSSGGSDSD---ESVYKVLLLGAPGVGKSAL . : .: ::: : . :. :: .:::. :..:.:.::: :::::..: NP_054 S-TQSQHPRLGQSASLNPPTQKPSPAPDDWSSESSDSEGSWEALYRVVLLGDPGVGKTSL 40 50 60 70 80 90 110 120 130 140 150 160 pF1KB6 ARIFGGVEDGPEAEAAGH-TYDRSIVVDGEEASLMVYDIWEQD--GGRWLPGHCMAMGDA : .:.: .. : :. .:.:...::::...:.: : :: . : :. :.: NP_054 ASLFAGKQERDLHEQLGEDVYERTLTVDGEDTTLVVVDTWEAEKLDKSWSQESCLQGGSA 100 110 120 130 140 150 170 180 190 200 210 220 pF1KB6 YVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRACAVV ::::::..:.::::.:::::.::::..:.: :::::::::.::.: :::::.:::::::: NP_054 YVIVYSIADRGSFESASELRIQLRRTHQADHVPIILVGNKADLARCREVSVEEGRACAVV 160 170 180 190 200 210 230 240 250 260 270 280 pF1KB6 FDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGKKAKRFLGR ::::::::::.:.::: ::::::::.:::: ... :.. . :: ::...:.:::.: NP_054 FDCKFIETSATLQHNVAELFEGVVRQLRLRR--RDSAAKEPPAPRRPASLAQRARRFLAR 220 230 240 250 260 270 290 300 pF1KB6 IVARNSRKMAFRAKSKSCHDLSVL ..::..:. :..:.:::::.:.:: NP_054 LTARSARRRALKARSKSCHNLAVL 280 290 >>NP_775798 (OMIM: 616955) GTP-binding protein REM 2 [Ho (340 aa) initn: 798 init1: 440 opt: 814 Z-score: 728.4 bits: 143.0 E(85289): 7.8e-34 Smith-Waterman score: 822; 49.0% identity (68.6% similar) in 306 aa overlap (21-308:50-340) 10 20 30 40 50 pF1KB6 MTLNGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRSMPVDERDLQAA : :.. : .:. : .: :::: . NP_775 PSGSRRASPPGTPTPEADATLLKKSEKLLAELDRSGLPSAPGAPRRRGSMPVPYKH---- 20 30 40 50 60 70 60 70 80 90 100 pF1KB6 LTPGALTAAAAGTGTQGPRLDWPED-----SEDSLSSG--GSDSDESVYKVLLLGAPGVG : : : .:::: . : :::.:: . . ....::.:.: ::: NP_775 ----QLRRAQAVD-----ELDWPPQASSSGSSDSLGSGEAAPAQKDGIFKVMLVGESGVG 80 90 100 110 120 110 120 130 140 150 160 pF1KB6 KSALARIFGGVE--DGPEAEAAGHTYDRSIVVDGEEASLMVYDIWEQ-DGGRWLPGHCMA ::.:: :::.. .. : : ::.: :.:: ::..:.::::::: :.: :: ::. NP_775 KSTLAGTFGGLQGDSAHEPENPEDTYERRIMVDKEEVTLVVYDIWEQGDAGGWLRDHCLQ 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB6 MGDAYVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRA :::..::.::::. :: :. : ..:: .: :.:.:::::::::.::::::..::: NP_775 TGDAFLIVFSVTDRRSFSKVPETLLRLRAGRPHHDLPVILVGNKSDLARSREVSLEEGRH 190 200 210 220 230 240 230 240 250 260 270 pF1KB6 CAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEANARRQ--------AGTRRRE : ...:: ::::::::::.. ::::.:::::::: ..:...: : ::: NP_775 LAGTLSCKHIETSAALHHNTRELFEGAVRQIRLRRGRNHAGGQRPDPGSPEGPAPPARRE 250 260 270 280 290 300 280 290 300 pF1KB6 SLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL :: :::::::. .: ::.. :. .:.:::::::: NP_775 SLTKKAKRFLANLVPRNAK--FFKQRSRSCHDLSVL 310 320 330 340 >>XP_016876548 (OMIM: 616955) PREDICTED: GTP-binding pro (372 aa) initn: 798 init1: 440 opt: 814 Z-score: 728.0 bits: 143.1 E(85289): 8.3e-34 Smith-Waterman score: 822; 49.0% identity (68.6% similar) in 306 aa overlap (21-308:82-372) 10 20 30 40 50 pF1KB6 MTLNGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRSMPVDERDLQAA : :.. : .:. : .: :::: . XP_016 IPLIASFSLPSHFILEADATLLKKSEKLLAELDRSGLPSAPGAPRRRGSMPVPYKH---- 60 70 80 90 100 60 70 80 90 100 pF1KB6 LTPGALTAAAAGTGTQGPRLDWPED-----SEDSLSSG--GSDSDESVYKVLLLGAPGVG : : : .:::: . : :::.:: . . ....::.:.: ::: XP_016 ----QLRRAQAVD-----ELDWPPQASSSGSSDSLGSGEAAPAQKDGIFKVMLVGESGVG 110 120 130 140 150 110 120 130 140 150 160 pF1KB6 KSALARIFGGVE--DGPEAEAAGHTYDRSIVVDGEEASLMVYDIWEQ-DGGRWLPGHCMA ::.:: :::.. .. : : ::.: :.:: ::..:.::::::: :.: :: ::. XP_016 KSTLAGTFGGLQGDSAHEPENPEDTYERRIMVDKEEVTLVVYDIWEQGDAGGWLRDHCLQ 160 170 180 190 200 210 170 180 190 200 210 220 pF1KB6 MGDAYVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEGRA :::..::.::::. :: :. : ..:: .: :.:.:::::::::.::::::..::: XP_016 TGDAFLIVFSVTDRRSFSKVPETLLRLRAGRPHHDLPVILVGNKSDLARSREVSLEEGRH 220 230 240 250 260 270 230 240 250 260 270 pF1KB6 CAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEANARRQ--------AGTRRRE : ...:: ::::::::::.. ::::.:::::::: ..:...: : ::: XP_016 LAGTLSCKHIETSAALHHNTRELFEGAVRQIRLRRGRNHAGGQRPDPGSPEGPAPPARRE 280 290 300 310 320 330 280 290 300 pF1KB6 SLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL :: :::::::. .: ::.. :. .:.:::::::: XP_016 SLTKKAKRFLANLVPRNAK--FFKQRSRSCHDLSVL 340 350 360 370 >>XP_005267440 (OMIM: 616955) PREDICTED: GTP-binding pro (341 aa) initn: 807 init1: 440 opt: 810 Z-score: 724.9 bits: 142.4 E(85289): 1.2e-33 Smith-Waterman score: 818; 49.0% identity (67.9% similar) in 308 aa overlap (21-308:50-341) 10 20 30 40 50 pF1KB6 MTLNGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRSMPVDERDLQAA : :.. : .:. : .: :::: . XP_005 PSGSRRASPPGTPTPEADATLLKKSEKLLAELDRSGLPSAPGAPRRRGSMPVPYKH---- 20 30 40 50 60 70 60 70 80 90 100 pF1KB6 LTPGALTAAAAGTGTQGPRLDWPED-----SEDSLSSG--GSDSDESVYKVLLLGAPGVG : : : .:::: . : :::.:: . . ....::.:.: ::: XP_005 ----QLRRAQAVD-----ELDWPPQASSSGSSDSLGSGEAAPAQKDGIFKVMLVGESGVG 80 90 100 110 120 110 120 130 140 150 pF1KB6 KSALARIFGGVEDG----PEAEAAGHTYDRSIVVDGEEASLMVYDIWEQ-DGGRWLPGHC ::.:: :::.. :: : ::.: :.:: ::..:.::::::: :.: :: :: XP_005 KSTLAGTFGGLQGDSAHEPENPAED-TYERRIMVDKEEVTLVVYDIWEQGDAGGWLRDHC 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB6 MAMGDAYVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEG . :::..::.::::. :: :. : ..:: .: :.:.:::::::::.::::::..:: XP_005 LQTGDAFLIVFSVTDRRSFSKVPETLLRLRAGRPHHDLPVILVGNKSDLARSREVSLEEG 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB6 RACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEANARRQ--------AGTRR : : ...:: ::::::::::.. ::::.:::::::: ..:...: : : XP_005 RHLAGTLSCKHIETSAALHHNTRELFEGAVRQIRLRRGRNHAGGQRPDPGSPEGPAPPAR 250 260 270 280 290 300 280 290 300 pF1KB6 RESLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL :::: :::::::. .: ::.. :. .:.:::::::: XP_005 RESLTKKAKRFLANLVPRNAK--FFKQRSRSCHDLSVL 310 320 330 340 >>XP_016876547 (OMIM: 616955) PREDICTED: GTP-binding pro (373 aa) initn: 807 init1: 440 opt: 810 Z-score: 724.4 bits: 142.4 E(85289): 1.3e-33 Smith-Waterman score: 818; 49.0% identity (67.9% similar) in 308 aa overlap (21-308:82-373) 10 20 30 40 50 pF1KB6 MTLNGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRSMPVDERDLQAA : :.. : .:. : .: :::: . XP_016 IPLIASFSLPSHFILEADATLLKKSEKLLAELDRSGLPSAPGAPRRRGSMPVPYKH---- 60 70 80 90 100 60 70 80 90 100 pF1KB6 LTPGALTAAAAGTGTQGPRLDWPED-----SEDSLSSG--GSDSDESVYKVLLLGAPGVG : : : .:::: . : :::.:: . . ....::.:.: ::: XP_016 ----QLRRAQAVD-----ELDWPPQASSSGSSDSLGSGEAAPAQKDGIFKVMLVGESGVG 110 120 130 140 150 110 120 130 140 150 pF1KB6 KSALARIFGGVEDG----PEAEAAGHTYDRSIVVDGEEASLMVYDIWEQ-DGGRWLPGHC ::.:: :::.. :: : ::.: :.:: ::..:.::::::: :.: :: :: XP_016 KSTLAGTFGGLQGDSAHEPENPAED-TYERRIMVDKEEVTLVVYDIWEQGDAGGWLRDHC 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB6 MAMGDAYVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVDEG . :::..::.::::. :: :. : ..:: .: :.:.:::::::::.::::::..:: XP_016 LQTGDAFLIVFSVTDRRSFSKVPETLLRLRAGRPHHDLPVILVGNKSDLARSREVSLEEG 220 230 240 250 260 270 220 230 240 250 260 270 pF1KB6 RACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEANARRQ--------AGTRR : : ...:: ::::::::::.. ::::.:::::::: ..:...: : : XP_016 RHLAGTLSCKHIETSAALHHNTRELFEGAVRQIRLRRGRNHAGGQRPDPGSPEGPAPPAR 280 290 300 310 320 330 280 290 300 pF1KB6 RESLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL :::: :::::::. .: ::.. :. .:.:::::::: XP_016 RESLTKKAKRFLANLVPRNAK--FFKQRSRSCHDLSVL 340 350 360 370 >>XP_005260461 (OMIM: 610388) PREDICTED: GTP-binding pro (306 aa) initn: 750 init1: 511 opt: 763 Z-score: 684.2 bits: 134.7 E(85289): 2.3e-31 Smith-Waterman score: 890; 50.0% identity (73.2% similar) in 302 aa overlap (34-308:12-306) 10 20 30 40 50 60 pF1KB6 NGGGSGAGGSRGGGQERERRRGSTPWGPAPPLHRRS---MPVDERDLQAALTPGALTAAA :::::. .:.. : : :: :... XP_005 MTLNTEQEAKTPLHRRASTPLPLSPRGHQ----PGRLSTVP 10 20 30 70 80 90 100 pF1KB6 AGTGTQGPRLDW----------PEDSEDSLSSGGSDSD---ESVYKVLLLGAPGVGKSAL . : .: ::: : . :. :: .:::. :..:.:.::: :::::..: XP_005 S-TQSQHPRLGQSASLNPPTQKPSPAPDDWSSESSDSEGSWEALYRVVLLGDPGVGKTSL 40 50 60 70 80 90 110 120 130 140 150 pF1KB6 ARIFGGVEDGPEAEAAGH---------TYDRSIVVDGEEASLMVYDIWEQD--GGRWLPG : .:.: .. : : .:.:...::::...:.: : :: . : XP_005 ASLFAGKQERDLHEQLGDPALPSVAEDVYERTLTVDGEDTTLVVVDTWEAEKLDKSWSQE 100 110 120 130 140 150 160 170 180 190 200 210 pF1KB6 HCMAMGDAYVIVYSVTDKGSFEKASELRVQLRRARQTDDVPIILVGNKSDLVRSREVSVD :. :.:::::::..:.::::.:::::.::::..:.: :::::::::.::.: :::::. XP_005 SCLQGGSAYVIVYSIADRGSFESASELRIQLRRTHQADHVPIILVGNKADLARCREVSVE 160 170 180 190 200 210 220 230 240 250 260 270 pF1KB6 EGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEANARRQAGTRRRESLGK ::::::::::::::::::.:.::: ::::::::.:::: ... :.. . :: ::.. XP_005 EGRACAVVFDCKFIETSATLQHNVAELFEGVVRQLRLRR--RDSAAKEPPAPRRPASLAQ 220 230 240 250 260 270 280 290 300 pF1KB6 KAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL .:.:::.:..::..:. :..:.:::::.:.:: XP_005 RARRFLARLTARSARRRALKARSKSCHNLAVL 280 290 300 308 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 20:52:22 2016 done: Fri Nov 4 20:52:23 2016 Total Scan time: 7.780 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]