FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6430, 343 aa 1>>>pF1KB6430 343 - 343 aa - 343 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1697+/-0.000371; mu= 17.4336+/- 0.023 mean_var=78.3649+/-16.184, 0's: 0 Z-trim(114.6): 147 B-trim: 1114 in 2/50 Lambda= 0.144882 statistics sampled from 24356 (24526) to 24356 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.288), width: 16 Scan time: 8.010 The best scores are: opt bits E(85289) XP_016866305 (OMIM: 142871,600807) PREDICTED: HLA ( 343) 2355 501.8 9e-142 NP_002118 (OMIM: 142871,600807) HLA class I histoc ( 338) 2320 494.4 1.4e-139 NP_002107 (OMIM: 142800,608579) HLA class I histoc ( 365) 1968 420.9 2.1e-117 NP_001229687 (OMIM: 142800,608579) HLA class I his ( 365) 1941 415.3 1.1e-115 XP_016885777 (OMIM: 142800,608579) PREDICTED: HLA ( 362) 1897 406.1 6.2e-113 XP_005275388 (OMIM: 142800,608579) PREDICTED: HLA ( 391) 1897 406.1 6.5e-113 NP_005505 (OMIM: 106300,142830,608579) major histo ( 362) 1891 404.8 1.5e-112 NP_001229971 (OMIM: 142840,177900,609423) HLA clas ( 366) 1865 399.4 6.4e-111 NP_002108 (OMIM: 142840,177900,609423) HLA class I ( 366) 1856 397.5 2.4e-110 NP_061823 (OMIM: 143110) HLA class I histocompatib ( 346) 1841 394.3 2e-109 XP_016866302 (OMIM: 143110) PREDICTED: HLA class I ( 388) 1841 394.4 2.2e-109 XP_016866301 (OMIM: 143110) PREDICTED: HLA class I ( 420) 1841 394.4 2.3e-109 XP_016866299 (OMIM: 143110) PREDICTED: HLA class I ( 435) 1841 394.4 2.4e-109 NP_001091949 (OMIM: 143110) HLA class I histocompa ( 442) 1841 394.4 2.4e-109 XP_011512866 (OMIM: 143110) PREDICTED: HLA class I ( 343) 1833 392.7 6.3e-109 XP_016866300 (OMIM: 143110) PREDICTED: HLA class I ( 431) 1833 392.7 7.5e-109 NP_005507 (OMIM: 143010) HLA class I histocompatib ( 358) 1812 388.3 1.4e-107 XP_016866298 (OMIM: 143010) PREDICTED: HLA class I ( 359) 1812 388.3 1.4e-107 XP_011512859 (OMIM: 106300,142830,608579) PREDICTE ( 323) 1742 373.6 3.2e-103 XP_016866296 (OMIM: 143010) PREDICTED: HLA class I ( 399) 1734 372.0 1.2e-102 XP_016866297 (OMIM: 143010) PREDICTED: HLA class I ( 399) 1734 372.0 1.2e-102 XP_016866304 (OMIM: 143110) PREDICTED: HLA class I ( 228) 1235 267.5 2e-71 XP_016866303 (OMIM: 143110) PREDICTED: HLA class I ( 324) 1235 267.6 2.6e-71 NP_001091948 (OMIM: 143110) HLA class I histocompa ( 254) 1033 225.3 1.1e-58 XP_016866307 (OMIM: 142871,600807) PREDICTED: HLA ( 246) 910 199.6 5.9e-51 XP_016866306 (OMIM: 142871,600807) PREDICTED: HLA ( 246) 910 199.6 5.9e-51 NP_001522 (OMIM: 600764) major histocompatibility ( 341) 796 175.9 1.1e-43 NP_001287678 (OMIM: 104300,176100,176200,235200,61 ( 337) 718 159.6 8.9e-39 NP_000401 (OMIM: 104300,176100,176200,235200,61263 ( 348) 718 159.6 9.2e-39 XP_011512845 (OMIM: 104300,176100,176200,235200,61 ( 348) 718 159.6 9.2e-39 NP_620578 (OMIM: 104300,176100,176200,235200,61263 ( 325) 677 151.0 3.3e-36 NP_001176 (OMIM: 194460) zinc-alpha-2-glycoprotein ( 298) 658 147.0 4.9e-35 XP_011507765 (OMIM: 600764) PREDICTED: major histo ( 254) 593 133.4 5.3e-31 NP_620576 (OMIM: 104300,176100,176200,235200,61263 ( 260) 558 126.1 8.6e-29 NP_001170990 (OMIM: 600169) MHC class I polypeptid ( 332) 508 115.7 1.4e-25 NP_000238 (OMIM: 600169) MHC class I polypeptide-r ( 383) 491 112.2 1.9e-24 NP_001181929 (OMIM: 600764) major histocompatibili ( 249) 486 111.0 2.8e-24 NP_001181964 (OMIM: 600764) major histocompatibili ( 214) 485 110.7 2.9e-24 NP_005922 (OMIM: 602436) MHC class I polypeptide-r ( 383) 464 106.5 9.4e-23 NP_001181928 (OMIM: 600764) major histocompatibili ( 296) 436 100.6 4.5e-21 NP_001276089 (OMIM: 602436) MHC class I polypeptid ( 351) 433 100.0 7.9e-21 NP_004098 (OMIM: 601437) IgG receptor FcRn large s ( 365) 415 96.3 1.1e-19 NP_001129491 (OMIM: 601437) IgG receptor FcRn larg ( 365) 415 96.3 1.1e-19 NP_001276082 (OMIM: 600169) MHC class I polypeptid ( 235) 363 85.3 1.5e-16 NP_001276081 (OMIM: 600169) MHC class I polypeptid ( 235) 363 85.3 1.5e-16 NP_620573 (OMIM: 104300,176100,176200,235200,61263 ( 256) 360 84.7 2.4e-16 NP_620579 (OMIM: 104300,176100,176200,235200,61263 ( 168) 352 82.8 5.7e-16 NP_001297142 (OMIM: 600764) major histocompatibili ( 178) 334 79.1 8e-15 NP_001307581 (OMIM: 188370) T-cell surface glycopr ( 316) 332 78.9 1.7e-14 NP_001754 (OMIM: 188370) T-cell surface glycoprote ( 327) 332 78.9 1.7e-14 >>XP_016866305 (OMIM: 142871,600807) PREDICTED: HLA clas (343 aa) initn: 2355 init1: 2355 opt: 2355 Z-score: 2666.2 bits: 501.8 E(85289): 9e-142 Smith-Waterman score: 2355; 100.0% identity (100.0% similar) in 343 aa overlap (1-343:1-343) 10 20 30 40 50 60 pF1KB6 MKTPRMVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MKTPRMVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEAS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 SHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAAN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 VAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 EIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLM 250 260 270 280 290 300 310 320 330 340 pF1KB6 LRWKQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD ::::::::::::::::::::::::::::::::::::::::::: XP_016 LRWKQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD 310 320 330 340 >>NP_002118 (OMIM: 142871,600807) HLA class I histocompa (338 aa) initn: 2320 init1: 2320 opt: 2320 Z-score: 2626.8 bits: 494.4 E(85289): 1.4e-139 Smith-Waterman score: 2320; 100.0% identity (100.0% similar) in 338 aa overlap (6-343:1-338) 10 20 30 40 50 60 pF1KB6 MKTPRMVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDT ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDT 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 QFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 QFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEAS 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 SHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAAN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 SHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAAN 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 VAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 VAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 EIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLM 240 250 260 270 280 290 310 320 330 340 pF1KB6 LRWKQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD ::::::::::::::::::::::::::::::::::::::::::: NP_002 LRWKQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD 300 310 320 330 >>NP_002107 (OMIM: 142800,608579) HLA class I histocompa (365 aa) initn: 1968 init1: 1968 opt: 1968 Z-score: 2228.7 bits: 420.9 E(85289): 2.1e-117 Smith-Waterman score: 1968; 82.8% identity (95.0% similar) in 338 aa overlap (6-343:1-338) 10 20 30 40 50 60 pF1KB6 MKTPRMVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDT :.:::::::.:::::::.::.::::::::::: ..:::::::::::::.:::::: NP_002 MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDT 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 QFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEAS ::::::::.: ::::::::.::::::::..::::.::..::::..: :::::::::::. NP_002 QFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 SHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAAN :::.: : :::.:::::.::::.: :::::::.::::::::::::: ::::.::: :::. NP_002 SHTIQIMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAH 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 VAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPA ::: ::::.:::::::.:::::::: :::.::::::.::::. :.:::::::::::::: NP_002 EAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 EIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLM :: :::::::::::::.:::::::::::::::::::::::::::::::::::::::.:: NP_002 EITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLT 240 250 260 270 280 290 310 320 330 340 pF1KB6 LRWKQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD :::. :: :::::.::.::::.:.::.:::.::::.::.:::: NP_002 LRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQG 300 310 320 330 340 350 NP_002 SDVSLTACKV 360 >>NP_001229687 (OMIM: 142800,608579) HLA class I histoco (365 aa) initn: 1941 init1: 1941 opt: 1941 Z-score: 2198.2 bits: 415.3 E(85289): 1.1e-115 Smith-Waterman score: 1941; 81.7% identity (93.8% similar) in 338 aa overlap (6-343:1-338) 10 20 30 40 50 60 pF1KB6 MKTPRMVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDT :.:::::::.:::::::.::.::::::::::: ..:::::::::::::.:::::: NP_001 MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDT 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 QFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEAS ::::::::.: .:::::::.::::::::..:::: :::.:::: :: :::::::::: . NP_001 QFVRFDSDAASQKMEPRAPWIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 SHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAAN :::.: : :::.: :::.::::.: :::::::.::::::::::::: ::::.::: ::.. NP_001 SHTIQIMYGCDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAVH 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 VAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPA .:::::.:::: ::. :.:::::::: :::.::::::.::::. :.:::::::::::::: NP_001 AAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 EIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLM :: :::::::::::::.:::::::::::::::::::::::::::::::::::::::.:: NP_001 EITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLT 240 250 260 270 280 290 310 320 330 340 pF1KB6 LRWKQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD :::. :: :::::.::.::::.:.::.:::.::::.::.:::: NP_001 LRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQG 300 310 320 330 340 350 NP_001 SDVSLTACKV 360 >>XP_016885777 (OMIM: 142800,608579) PREDICTED: HLA clas (362 aa) initn: 1897 init1: 1897 opt: 1897 Z-score: 2148.5 bits: 406.1 E(85289): 6.2e-113 Smith-Waterman score: 1897; 81.2% identity (93.4% similar) in 335 aa overlap (9-343:1-335) 10 20 30 40 50 60 pF1KB6 MKTPRMVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDT :::::: :::::::.::.::::::::::: ..:::::::::::::.:::::: XP_016 MAPRTLVLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDT 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 QFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEAS ::::::::.: ::::::::.::::::::. :::..:::.:: :..: :::::::::::. XP_016 QFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 SHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAAN :::.: : :::.::: :.::::.:::::::::.::.:::::::::: ::: .:.: :::. XP_016 SHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAAH 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 VAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPA :::: ::::::::::::.:::::::: :::.: ::::.::: : :.:::::::::.:::: XP_016 VAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 EIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLM :: :::::::::::::.::::::::::::::::::::::::.::::::::::::::.:: XP_016 EITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLT 240 250 260 270 280 290 310 320 330 340 pF1KB6 LRWKQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD :::. :: :::::.::.::::...::.:::.::::.::.:::: XP_016 LRWEPSSQPTIPIVGIIAGLVLFGAVITGAVVAAVMWRRKSSDRKGGSYSQAASSDSAQG 300 310 320 330 340 350 XP_016 SDVSLTACKV 360 >>XP_005275388 (OMIM: 142800,608579) PREDICTED: HLA clas (391 aa) initn: 1897 init1: 1897 opt: 1897 Z-score: 2148.1 bits: 406.1 E(85289): 6.5e-113 Smith-Waterman score: 1897; 81.2% identity (93.4% similar) in 335 aa overlap (9-343:1-335) 10 20 30 40 50 60 pF1KB6 MKTPRMVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDT :::::: :::::::.::.::::::::::: ..:::::::::::::.:::::: XP_005 MAPRTLVLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDT 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 QFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEAS ::::::::.: ::::::::.::::::::. :::..:::.:: :..: :::::::::::. XP_005 QFVRFDSDAASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 SHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAAN :::.: : :::.::: :.::::.:::::::::.::.:::::::::: ::: .:.: :::. XP_005 SHTVQRMYGCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAAH 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 VAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPA :::: ::::::::::::.:::::::: :::.: ::::.::: : :.:::::::::.:::: XP_005 VAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 EIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLM :: :::::::::::::.::::::::::::::::::::::::.::::::::::::::.:: XP_005 EITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHVQHEGLPKPLT 240 250 260 270 280 290 310 320 330 340 pF1KB6 LRWKQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD :::. :: :::::.::.::::...::.:::.::::.::.:::: XP_005 LRWEPSSQPTIPIVGIIAGLVLFGAVITGAVVAAVMWRRKSSDRKGGSYSQAASSDSAQG 300 310 320 330 340 350 XP_005 SDVSLTACKGESLEGLMCVGCWAEQWTQLCYGVSFHWMY 360 370 380 390 >>NP_005505 (OMIM: 106300,142830,608579) major histocomp (362 aa) initn: 1891 init1: 1891 opt: 1891 Z-score: 2141.8 bits: 404.8 E(85289): 1.5e-112 Smith-Waterman score: 1891; 81.0% identity (93.2% similar) in 337 aa overlap (6-342:1-337) 10 20 30 40 50 60 pF1KB6 MKTPRMVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDT :.::::::..::::.::.:::::::::::::: ..::::::::::::..:::::: NP_005 MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDT 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 QFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEAS ::::::::.: :: ::::::.::::::::...:. ::.::::: .:..::::::::::. NP_005 QFVRFDSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 SHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAAN ::::: : :::.: :::::::..:::::::::.::::::::::::::::::..:: ::: NP_005 SHTLQSMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAR 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 VAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPA :::::::::: :::::.:::::::. :.:::::::::::::. :.:::::::::::::: NP_005 EAEQRRAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 EIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLM :: :::::::::::::.:::::::::: ::::::::::::::::::::::::::::.:: NP_005 EITLTWQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLT 240 250 260 270 280 290 310 320 330 340 pF1KB6 LRWKQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD :::. :: :.::.::::::.:::.:: ::.::::. :.::: NP_005 LRWEPSSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQG 300 310 320 330 340 350 NP_005 SDVSLTA 360 >>NP_001229971 (OMIM: 142840,177900,609423) HLA class I (366 aa) initn: 1907 init1: 1830 opt: 1865 Z-score: 2112.3 bits: 399.4 E(85289): 6.4e-111 Smith-Waterman score: 1865; 80.5% identity (92.6% similar) in 338 aa overlap (6-342:1-338) 10 20 30 40 50 60 pF1KB6 MKTPRMVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDT : :::::.:.:::::.:.:::::: :::::::..:::::::::::::..:::::: NP_001 MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDT 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 QFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEAS ::::::::.: :: :::::::::::::::..::.: : .::.::..:..::::::::: . NP_001 QFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQNYKRQAQADRVSLRNLRGYYNQSEDG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 SHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAAN ::::: : ::::: ::::::::.: :::::::.::::::::::::::::::..:: ::: NP_001 SHTLQRMYGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAAR 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 VAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPA .::: ::::::::::::.:::::::: ::::.::::::::::. :.:::::::::::::: NP_001 AAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 EIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLM :: :::::::::::::.::::::::::::::::::::::::.:::::::.::::: ::: NP_001 EITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLT 240 250 260 270 280 290 310 320 330 340 pF1KB6 LRWKQSSLPTIPIMGIVAGLVVLAAV-VTGAAVAAVLWRKKSSD : :. :: ::::::::::::.::... : ::.:.:.. :.::: NP_001 LSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQ 300 310 320 330 340 350 NP_001 GSDESLITCKA 360 >>NP_002108 (OMIM: 142840,177900,609423) HLA class I his (366 aa) initn: 1898 init1: 1821 opt: 1856 Z-score: 2102.2 bits: 397.5 E(85289): 2.4e-110 Smith-Waterman score: 1856; 80.2% identity (92.6% similar) in 338 aa overlap (6-342:1-338) 10 20 30 40 50 60 pF1KB6 MKTPRMVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDT : :::::.:.:::::.:.:::::: :::::::..:::::::::::::..:::::: NP_002 MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDT 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 QFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEAS ::::::::.: :: :::::::::::::::..::.. : .::.::..:..::::::::: . NP_002 QFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 SHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAAN ::::: : ::::: ::::::::.: :::::::.::::::::::::::::::..:: ::: NP_002 SHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAAR 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 VAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPA .::: ::::::::::::.:::::::: ::::.::::::::::. :.:::::::::::::: NP_002 AAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 EIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLM :: :::::::::::::.::::::::::::::::::::::::.:::::::.::::: ::: NP_002 EITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLT 240 250 260 270 280 290 310 320 330 340 pF1KB6 LRWKQSSLPTIPIMGIVAGLVVLAAV-VTGAAVAAVLWRKKSSD : :. :: ::::::::::::.::... : ::.:.:.. :.::: NP_002 LSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQ 300 310 320 330 340 350 NP_002 GSDESLITCKA 360 >>NP_061823 (OMIM: 143110) HLA class I histocompatibilit (346 aa) initn: 1841 init1: 1841 opt: 1841 Z-score: 2085.5 bits: 394.3 E(85289): 2e-109 Smith-Waterman score: 1841; 79.1% identity (91.9% similar) in 335 aa overlap (9-343:1-335) 10 20 30 40 50 60 pF1KB6 MKTPRMVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDT ::::.:.:::::::.::.:::::::.::::.:::::::::::.::. ::::: NP_061 MAPRSLLLLLSGALALTDTWAGSHSLRYFSTAVSRPGRGEPRYIAVEYVDDT 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 QFVRFDSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEAS ::.:::::.: :::::: ::::::::.::: : .::.:::::. :..: ::::::. NP_061 QFLRFDSDAAIPRMEPREPWVEQEGPQYWEWTTGYAKANAQTDRVALRNLLRRYNQSEAG 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 SHTLQWMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAAN ::::: : :::.: ::::::::.:.:::::::..:::::::::::::.:::..: :: . NP_061 SHTLQGMNGCDMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTAADTVAQITQRFYEAEE 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 VAEQRRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPA ::. :.:::: :.: :.:::::::: ::::::::.::.:::. :.:::::::::::::: NP_061 YAEEFRTYLEGECLELLRRYLENGKETLQRADPPKAHVAHHPISDHEATLRCWALGFYPA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 EIILTWQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLM :: ::::::::.::::.:::::::::::::::::::::: ::::::::::::::::.::. NP_061 EITLTWQRDGEEQTQDTELVETRPAGDGTFQKWAAVVVPPGEEQRYTCHVQHEGLPQPLI 240 250 260 270 280 290 310 320 330 340 pF1KB6 LRWKQSSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD :::.:: :::::.:::::::::.::::::.::::.::::::: NP_061 LRWEQSPQPTIPIVGIVAGLVVLGAVVTGAVVAAVMWRKKSSDRNRGSYSQAAV 300 310 320 330 340 343 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 16:45:26 2016 done: Fri Nov 4 16:45:28 2016 Total Scan time: 8.010 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]