FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6446, 347 aa 1>>>pF1KB6446 347 - 347 aa - 347 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.5951+/-0.000351; mu= 0.0462+/- 0.022 mean_var=355.9533+/-71.640, 0's: 0 Z-trim(125.3): 30 B-trim: 0 in 0/61 Lambda= 0.067979 statistics sampled from 48619 (48649) to 48619 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.836), E-opt: 0.2 (0.57), width: 16 Scan time: 10.040 The best scores are: opt bits E(85289) XP_011536324 (OMIM: 613142) PREDICTED: probable E3 ( 347) 2428 251.1 2.6e-66 XP_005268760 (OMIM: 613142) PREDICTED: probable E3 ( 347) 2428 251.1 2.6e-66 NP_001273175 (OMIM: 613142) probable E3 ubiquitin- ( 347) 2428 251.1 2.6e-66 NP_848597 (OMIM: 613142) probable E3 ubiquitin-pro ( 347) 2428 251.1 2.6e-66 NP_001273174 (OMIM: 613142) probable E3 ubiquitin- ( 350) 2394 247.8 2.6e-65 XP_005268754 (OMIM: 613142) PREDICTED: probable E3 ( 350) 2394 247.8 2.6e-65 XP_005268757 (OMIM: 613142) PREDICTED: probable E3 ( 350) 2394 247.8 2.6e-65 XP_005268755 (OMIM: 613142) PREDICTED: probable E3 ( 350) 2394 247.8 2.6e-65 NP_612144 (OMIM: 613143) E3 ubiquitin-protein liga ( 740) 751 87.0 1.4e-16 XP_016867216 (OMIM: 613141) PREDICTED: probable E3 ( 575) 487 61.0 7.2e-09 XP_016867215 (OMIM: 613141) PREDICTED: probable E3 ( 575) 487 61.0 7.2e-09 NP_001096066 (OMIM: 613141) probable E3 ubiquitin- ( 575) 487 61.0 7.2e-09 XP_016867214 (OMIM: 613141) PREDICTED: probable E3 ( 622) 487 61.1 7.6e-09 XP_011514075 (OMIM: 613141) PREDICTED: probable E3 ( 622) 487 61.1 7.6e-09 NP_001096064 (OMIM: 613141) probable E3 ubiquitin- ( 622) 487 61.1 7.6e-09 XP_011514076 (OMIM: 613141) PREDICTED: probable E3 ( 622) 487 61.1 7.6e-09 XP_005250188 (OMIM: 613141) PREDICTED: probable E3 ( 622) 487 61.1 7.6e-09 XP_005250189 (OMIM: 613141) PREDICTED: probable E3 ( 622) 487 61.1 7.6e-09 XP_011514077 (OMIM: 613141) PREDICTED: probable E3 ( 622) 487 61.1 7.6e-09 XP_016867212 (OMIM: 613141) PREDICTED: probable E3 ( 622) 487 61.1 7.6e-09 NP_001096065 (OMIM: 613141) probable E3 ubiquitin- ( 622) 487 61.1 7.6e-09 XP_011514074 (OMIM: 613141) PREDICTED: probable E3 ( 622) 487 61.1 7.6e-09 XP_016867213 (OMIM: 613141) PREDICTED: probable E3 ( 622) 487 61.1 7.6e-09 NP_065943 (OMIM: 613141) probable E3 ubiquitin-pro ( 622) 487 61.1 7.6e-09 NP_001287656 (OMIM: 616110) E3 ubiquitin-protein l ( 513) 424 54.8 4.9e-07 XP_006718546 (OMIM: 616110) PREDICTED: E3 ubiquiti ( 513) 424 54.8 4.9e-07 NP_055992 (OMIM: 616110) E3 ubiquitin-protein liga ( 619) 424 54.9 5.5e-07 NP_004407 (OMIM: 602582) E3 ubiquitin-protein liga ( 620) 409 53.4 1.5e-06 XP_011536311 (OMIM: 602582) PREDICTED: E3 ubiquiti ( 620) 409 53.4 1.5e-06 XP_016867217 (OMIM: 613141) PREDICTED: probable E3 ( 568) 336 46.2 0.00021 >>XP_011536324 (OMIM: 613142) PREDICTED: probable E3 ubi (347 aa) initn: 2428 init1: 2428 opt: 2428 Z-score: 1311.5 bits: 251.1 E(85289): 2.6e-66 Smith-Waterman score: 2428; 100.0% identity (100.0% similar) in 347 aa overlap (1-347:1-347) 10 20 30 40 50 60 pF1KB6 MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 QYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 QYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTT 250 260 270 280 290 300 310 320 330 340 pF1KB6 GRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD ::::::::::::::::::::::::::::::::::::::::::::::: XP_011 GRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD 310 320 330 340 >>XP_005268760 (OMIM: 613142) PREDICTED: probable E3 ubi (347 aa) initn: 2428 init1: 2428 opt: 2428 Z-score: 1311.5 bits: 251.1 E(85289): 2.6e-66 Smith-Waterman score: 2428; 100.0% identity (100.0% similar) in 347 aa overlap (1-347:1-347) 10 20 30 40 50 60 pF1KB6 MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 QYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTT 250 260 270 280 290 300 310 320 330 340 pF1KB6 GRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD ::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD 310 320 330 340 >>NP_001273175 (OMIM: 613142) probable E3 ubiquitin-prot (347 aa) initn: 2428 init1: 2428 opt: 2428 Z-score: 1311.5 bits: 251.1 E(85289): 2.6e-66 Smith-Waterman score: 2428; 100.0% identity (100.0% similar) in 347 aa overlap (1-347:1-347) 10 20 30 40 50 60 pF1KB6 MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 QYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTT 250 260 270 280 290 300 310 320 330 340 pF1KB6 GRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD ::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD 310 320 330 340 >>NP_848597 (OMIM: 613142) probable E3 ubiquitin-protein (347 aa) initn: 2428 init1: 2428 opt: 2428 Z-score: 1311.5 bits: 251.1 E(85289): 2.6e-66 Smith-Waterman score: 2428; 100.0% identity (100.0% similar) in 347 aa overlap (1-347:1-347) 10 20 30 40 50 60 pF1KB6 MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 QLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 GPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 RHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVI 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 QYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_848 QYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTT 250 260 270 280 290 300 310 320 330 340 pF1KB6 GRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD ::::::::::::::::::::::::::::::::::::::::::::::: NP_848 GRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD 310 320 330 340 >>NP_001273174 (OMIM: 613142) probable E3 ubiquitin-prot (350 aa) initn: 2394 init1: 2394 opt: 2394 Z-score: 1293.5 bits: 247.8 E(85289): 2.6e-65 Smith-Waterman score: 2394; 99.7% identity (100.0% similar) in 342 aa overlap (6-347:9-350) 10 20 30 40 50 pF1KB6 MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDI :.:::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPILSSSGSKMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 YVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEM 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 HRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB6 EKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB6 IVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTS 250 260 270 280 290 300 300 310 320 330 340 pF1KB6 MTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD 310 320 330 340 350 >>XP_005268754 (OMIM: 613142) PREDICTED: probable E3 ubi (350 aa) initn: 2394 init1: 2394 opt: 2394 Z-score: 1293.5 bits: 247.8 E(85289): 2.6e-65 Smith-Waterman score: 2394; 99.7% identity (100.0% similar) in 342 aa overlap (6-347:9-350) 10 20 30 40 50 pF1KB6 MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDI :.:::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPILSSSGSKMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 YVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEM 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 HRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB6 EKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB6 IVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTS 250 260 270 280 290 300 300 310 320 330 340 pF1KB6 MTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD :::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD 310 320 330 340 350 >>XP_005268757 (OMIM: 613142) PREDICTED: probable E3 ubi (350 aa) initn: 2394 init1: 2394 opt: 2394 Z-score: 1293.5 bits: 247.8 E(85289): 2.6e-65 Smith-Waterman score: 2394; 99.7% identity (100.0% similar) in 342 aa overlap (6-347:9-350) 10 20 30 40 50 pF1KB6 MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDI :.:::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPILSSSGSKMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 YVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEM 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 HRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB6 EKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB6 IVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTS 250 260 270 280 290 300 300 310 320 330 340 pF1KB6 MTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD :::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD 310 320 330 340 350 >>XP_005268755 (OMIM: 613142) PREDICTED: probable E3 ubi (350 aa) initn: 2394 init1: 2394 opt: 2394 Z-score: 1293.5 bits: 247.8 E(85289): 2.6e-65 Smith-Waterman score: 2394; 99.7% identity (100.0% similar) in 342 aa overlap (6-347:9-350) 10 20 30 40 50 pF1KB6 MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDI :.:::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MPILSSSGSKMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDI 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 YVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEM 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 HRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTL 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB6 EKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGT 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB6 IVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTS 250 260 270 280 290 300 300 310 320 330 340 pF1KB6 MTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD :::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD 310 320 330 340 350 >>NP_612144 (OMIM: 613143) E3 ubiquitin-protein ligase D (740 aa) initn: 742 init1: 532 opt: 751 Z-score: 418.8 bits: 87.0 E(85289): 1.4e-16 Smith-Waterman score: 751; 53.4% identity (71.6% similar) in 204 aa overlap (143-344:540-739) 120 130 140 150 160 170 pF1KB6 EHPEMHRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQ ::: . . : ..... : ::. :. NP_612 GGMSSLAGKKLKEGHETPMDIDSDDSKAASPPLKGSVSSEASELDKKEKGICVICMDTIS 510 520 530 540 550 560 180 190 200 210 220 230 pF1KB6 NAKTLEKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRML--VSKDATLLLP : :.: ::.: :: ::..:.. : :: : :: ::::. : :. ::.:. :: NP_612 NKKVLPKCKHEFCAPCINKAMSYKPICPTCQTSYGIQKGNQPE-GSMVFTVSRDS---LP 570 580 590 600 610 620 240 250 260 270 280 290 pF1KB6 SYEKYGTIVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRL .::..::::: : . :.: :::::: :::: :.::::: :: ::: :. .::::.: NP_612 GYESFGTIVITYSMKAGIQTEEHPNPGKRYPGIQRTAYLPDNKEGRKVLKLLYRAFDQKL 630 640 650 660 670 680 300 310 320 330 340 pF1KB6 TFTIGTSMTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD ::.: : . : .:::::::::::: :::...:::::.:: ::.:::.:::: NP_612 IFTVGYSRVLGVSDVITWNDIHHKTSRFGGPEMYGYPDPSYLKRVKEELKAKGIE 690 700 710 720 730 740 >>XP_016867216 (OMIM: 613141) PREDICTED: probable E3 ubi (575 aa) initn: 476 init1: 319 opt: 487 Z-score: 280.2 bits: 61.0 E(85289): 7.2e-09 Smith-Waterman score: 512; 38.0% identity (55.3% similar) in 255 aa overlap (122-347:326-570) 100 110 120 130 140 150 pF1KB6 ELKKAQRQGELMGCLALGGGGEHPEMHRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLPP : : :. : : : : : : . XP_016 SSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALA----GATPKPEPEPEQVIK 300 310 320 330 340 350 160 170 180 pF1KB6 RLREEAE-EQESTCPICL---------GEIQNAKT--------LEKCRHSF--------- :: . . : ::. ... ..:. : :: :.: XP_016 NYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCLLAMY 360 370 380 390 400 410 190 200 210 220 230 240 pF1KB6 CEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVIQYVF :.: .:: :: : .::. .:.::: :.: : . . ::..: :::.: : . XP_016 CNGNKDGSLQ----CPSCKTIYGEKTGTQPQ-GKMEVLR-FQMSLPGHEDCGTILIVYSI 420 430 440 450 460 250 260 270 280 290 300 pF1KB6 PPGVQGAEHPNPGVRYP--GTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTTGR : :.:: :::::: . : : :::: .: ::: :.. :. .:: ::.::: :::. XP_016 PHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTGE 470 480 490 500 510 520 310 320 330 340 pF1KB6 PNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD ....::.::::: . :::::.:: : :: :.:.:.: XP_016 TDTVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ 530 540 550 560 570 347 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 22:39:00 2016 done: Fri Nov 4 22:39:01 2016 Total Scan time: 10.040 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]