FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6449, 317 aa 1>>>pF1KB6449 317 - 317 aa - 317 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4351+/-0.000914; mu= 10.8753+/- 0.054 mean_var=124.7155+/-25.087, 0's: 0 Z-trim(109.9): 174 B-trim: 10 in 1/50 Lambda= 0.114846 statistics sampled from 10993 (11188) to 10993 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.714), E-opt: 0.2 (0.344), width: 16 Scan time: 2.770 The best scores are: opt bits E(32554) CCDS9656.1 NFKBIA gene_id:4792|Hs108|chr14 ( 317) 2141 365.8 2.5e-101 CCDS34463.1 NFKBIE gene_id:4794|Hs108|chr6 ( 500) 483 91.2 1.8e-18 CCDS54783.1 NFKB1 gene_id:4790|Hs108|chr4 ( 968) 458 87.4 5.1e-17 CCDS3657.1 NFKB1 gene_id:4790|Hs108|chr4 ( 969) 458 87.4 5.1e-17 CCDS41565.1 NFKB2 gene_id:4791|Hs108|chr10 ( 899) 396 77.1 5.9e-14 CCDS41564.1 NFKB2 gene_id:4791|Hs108|chr10 ( 900) 396 77.1 5.9e-14 CCDS12642.2 BCL3 gene_id:602|Hs108|chr19 ( 454) 363 71.3 1.6e-12 >>CCDS9656.1 NFKBIA gene_id:4792|Hs108|chr14 (317 aa) initn: 2141 init1: 2141 opt: 2141 Z-score: 1932.6 bits: 365.8 E(32554): 2.5e-101 Smith-Waterman score: 2141; 100.0% identity (100.0% similar) in 317 aa overlap (1-317:1-317) 10 20 30 40 50 60 pF1KB6 MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS96 MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 RGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS96 RGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 TNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS96 TNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATN 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 YNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS96 YNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 ADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS96 ADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTE 250 260 270 280 290 300 310 pF1KB6 DELPYDDCVFGGQRLTL ::::::::::::::::: CCDS96 DELPYDDCVFGGQRLTL 310 >>CCDS34463.1 NFKBIE gene_id:4794|Hs108|chr6 (500 aa) initn: 457 init1: 237 opt: 483 Z-score: 445.3 bits: 91.2 E(32554): 1.8e-18 Smith-Waterman score: 483; 37.6% identity (65.6% similar) in 250 aa overlap (70-315:255-496) 40 50 60 70 80 90 pF1KB6 EEYEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKG ..::::...:::.::: :. . . . CCDS34 GGPEAEDPAPRLPLPHVGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQ 230 240 250 260 270 280 100 110 120 130 140 150 pF1KB6 DLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLAS .. :..:::: :: ::::: .:: ..::. : . :.: .:.: ::.::.. :: CCDS34 EV--LDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLAC 290 300 310 320 330 340 160 170 180 190 200 210 pF1KB6 VGVLTQSCTTPHL---HSI-LKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPC . : .. : ::. :. :..: .:::.:... ..:::. :::...:: CCDS34 ARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGT 350 360 370 380 390 400 220 230 240 250 260 270 pF1KB6 NGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLE .:.:::::::. :. ::..::. ::.:. .: .: .:. :: :.. : . . CCDS34 SGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGAD 410 420 430 440 450 460 280 290 300 310 pF1KB6 NLQMLPESEDEESYDTESEFTEFTEDELPYDDCVFGGQRLTL .: : . ::: : ...:: . ::.:: ..:. : CCDS34 SL--LRNVEDE----TPQDLTEESLVLLPFDDLKISGKLLLCTD 470 480 490 500 >>CCDS54783.1 NFKB1 gene_id:4790|Hs108|chr4 (968 aa) initn: 434 init1: 164 opt: 458 Z-score: 419.1 bits: 87.4 E(32554): 5.1e-17 Smith-Waterman score: 458; 40.9% identity (65.1% similar) in 235 aa overlap (72-302:541-767) 50 60 70 80 90 100 pF1KB6 YEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDL :.::: ::::::: .. :. .... ..: . CCDS54 RHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLI 520 530 540 550 560 570 110 120 130 140 150 pF1KB6 A--FLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLAS . ..:..:.: ::::::::::.: ...: :: :: : : : ::. :::: ..: CCDS54 SDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKV 580 590 600 610 620 630 160 170 180 190 200 210 pF1KB6 VGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRT ...: . . : : : .: . .::: . . : . :::. :::::::: .::: CCDS54 LSILLKHKKAALL---LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRT 640 650 660 670 680 220 230 240 250 260 270 pF1KB6 ALHLAVDLQNPDLVS-LLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQ ::::::. .: .:.. :::. : :. .::.: .: ... :: :::. : . CCDS54 ALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGAD--- 690 700 710 720 730 740 280 290 300 310 pF1KB6 MLPESEDEES-YDTESEFTEFTEDELPYDDCVFGGQRLTL : :. : :: .. . . ::: CCDS54 --PLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATSWQVFDILNGKPYEPEFTSDDL 750 760 770 780 790 800 >>CCDS3657.1 NFKB1 gene_id:4790|Hs108|chr4 (969 aa) initn: 434 init1: 164 opt: 458 Z-score: 419.1 bits: 87.4 E(32554): 5.1e-17 Smith-Waterman score: 458; 40.9% identity (65.1% similar) in 235 aa overlap (72-302:542-768) 50 60 70 80 90 100 pF1KB6 YEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDL :.::: ::::::: .. :. .... ..: . CCDS36 RHANALFDYAVTGDVKMLLAVQRHLTAVQDENGDSVLHLAIIHLHSQLVRDLLEVTSGLI 520 530 540 550 560 570 110 120 130 140 150 pF1KB6 A--FLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLAS . ..:..:.: ::::::::::.: ...: :: :: : : : ::. :::: ..: CCDS36 SDDIINMRNDLYQTPLHLAVITKQEDVVEDLLRAGADLSLLDRLGNSVLHLAAKEGHDKV 580 590 600 610 620 630 160 170 180 190 200 210 pF1KB6 VGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRT ...: . . : : : .: . .::: . . : . :::. :::::::: .::: CCDS36 LSILLKHKKAALL---LDHPNGDGLNAIHLAMMSNSLPCLLLLVAAGADVNAQEQKSGRT 640 650 660 670 680 220 230 240 250 260 270 pF1KB6 ALHLAVDLQNPDLVS-LLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQ ::::::. .: .:.. :::. : :. .::.: .: ... :: :::. : . CCDS36 ALHLAVEHDNISLAGCLLLEGDAHVDSTTYDGTTPLHIAAGRGSTRLAALLKAAGAD--- 690 700 710 720 730 740 280 290 300 310 pF1KB6 MLPESEDEES-YDTESEFTEFTEDELPYDDCVFGGQRLTL : :. : :: .. . . ::: CCDS36 --PLVENFEPLYDLDDSWENAGEDEGVVPGTTPLDMATSWQVFDILNGKPYEPEFTSDDL 750 760 770 780 790 800 >>CCDS41565.1 NFKB2 gene_id:4791|Hs108|chr10 (899 aa) initn: 385 init1: 178 opt: 396 Z-score: 364.0 bits: 77.1 E(32554): 5.9e-14 Smith-Waterman score: 399; 37.8% identity (63.4% similar) in 238 aa overlap (72-297:486-721) 50 60 70 80 90 pF1KB6 YEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKG-- :.::. ::::::: . .. ... .. CCDS41 RSARALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQ 460 470 480 490 500 510 100 110 120 130 140 150 pF1KB6 DLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLAS ::. .:. :.:.::::::::::.: .. :: .: :: : : .:.. .::: . : : CCDS41 DLGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAP 520 530 540 550 560 570 160 170 180 190 200 210 pF1KB6 --VGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNG . .: :: .: . ..:. ...: .::: ..:::. ::.:.: : .: CCDS41 ELLRALLQS-GAPAVPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGG 580 590 600 610 620 630 220 230 240 250 260 270 pF1KB6 RTALHLAVDLQNPDLVS-LLLKCGADVNRVTYQGYSPYQLT--WGRPS-TRIQQQLG-QL :::::::..... ::. :. : :.:: :. : .: .:. : :. ::. . : .. CCDS41 RTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADI 640 650 660 670 680 690 280 290 300 310 pF1KB6 TLEN---LQMLPESEDEESYDTESEFTEFTEDELPYDDCVFGGQRLTL :: : :: .: :..:: : CCDS41 HAENEEPLCPLPSPPTSDS-DSDSEGPEKDTRSSFRGHTPLDLTCSTKVKTLLLNAAQNT 700 710 720 730 740 750 >>CCDS41564.1 NFKB2 gene_id:4791|Hs108|chr10 (900 aa) initn: 385 init1: 178 opt: 396 Z-score: 364.0 bits: 77.1 E(32554): 5.9e-14 Smith-Waterman score: 399; 37.8% identity (63.4% similar) in 238 aa overlap (72-297:486-721) 50 60 70 80 90 pF1KB6 YEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKG-- :.::. ::::::: . .. ... .. CCDS41 RSARALLDYGVTADARALLAGQRHLLTAQDENGDTPLHLAIIHGQTSVIEQIVYVIHHAQ 460 470 480 490 500 510 100 110 120 130 140 150 pF1KB6 DLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLAS ::. .:. :.:.::::::::::.: .. :: .: :: : : .:.. .::: . : : CCDS41 DLGVVNLTNHLHQTPLHLAVITGQTSVVSFLLRVGADPALLDRHGDSAMHLALRAGAGAP 520 530 540 550 560 570 160 170 180 190 200 210 pF1KB6 --VGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNG . .: :: .: . ..:. ...: .::: ..:::. ::.:.: : .: CCDS41 ELLRALLQS-GAPAVPQLLHMPDFEGLYPVHLAVRARSPECLDLLVDSGAEVEATERQGG 580 590 600 610 620 630 220 230 240 250 260 270 pF1KB6 RTALHLAVDLQNPDLVS-LLLKCGADVNRVTYQGYSPYQLT--WGRPS-TRIQQQLG-QL :::::::..... ::. :. : :.:: :. : .: .:. : :. ::. . : .. CCDS41 RTALHLATEMEELGLVTHLVTKLRANVNARTFAGNTPLHLAAGLGYPTLTRLLLKAGADI 640 650 660 670 680 690 280 290 300 310 pF1KB6 TLEN---LQMLPESEDEESYDTESEFTEFTEDELPYDDCVFGGQRLTL :: : :: .: :..:: : CCDS41 HAENEEPLCPLPSPPTSDS-DSDSEGPEKDTRSSFRGHTPLDLTCSTKVKTLLLNAAQNT 700 710 720 730 740 750 >>CCDS12642.2 BCL3 gene_id:602|Hs108|chr19 (454 aa) initn: 363 init1: 211 opt: 363 Z-score: 338.4 bits: 71.3 E(32554): 1.6e-12 Smith-Waterman score: 363; 35.9% identity (62.1% similar) in 206 aa overlap (56-260:116-319) 30 40 50 60 70 80 pF1KB6 LDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGSE-PWKQQLTEDGDSFLHLAIIH :.: : ... . ::::. ::.:... CCDS12 GALLPLYPTRAMGSPFPLVNLPTPLYPMMCPMEHPLSADIAMATRADEDGDTPLHIAVVQ 90 100 110 120 130 140 90 100 110 120 130 140 pF1KB6 EEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRG . . ... . :.. :::.::::::::::. : ... :. :: .: : .: CCDS12 GNLPAVHRLVNLFQQGGRELDIYNNLRQTPLHLAVITTLPSVVRLLVTAGASPMALDRHG 150 160 170 180 190 200 150 160 170 180 190 200 pF1KB6 NTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVS .: :::::. . . .: .: . : :.: ::.: : ::.: :.::. CCDS12 QTAAHLACEHRSPTCLRALLDSAAPGTLD--LEARNYDGLTALHVAVNTECQETVQLLLE 210 220 230 240 250 260 210 220 230 240 250 260 pF1KB6 LGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTR :::..: . .::. : ::. .. ..:.:::. ::.:: :.: : . . :: CCDS12 RGADIDAVDIKSGRSPLIHAVENNSLSMVQLLLQHGANVNAQMYSGSSALHSASGRGLLP 270 280 290 300 310 320 270 280 290 300 310 pF1KB6 IQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTEDELPYDDCVFGGQRLTL CCDS12 LVRTLVRSGADSSLKNCHNDTPLMVARSRRVIDILRGKATRPASTSQPDPSPDRSANTSP 330 340 350 360 370 380 317 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 17:31:52 2016 done: Fri Nov 4 17:31:52 2016 Total Scan time: 2.770 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]