FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6453, 318 aa 1>>>pF1KB6453 318 - 318 aa - 318 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5218+/-0.000302; mu= 15.5990+/- 0.019 mean_var=78.4168+/-15.335, 0's: 0 Z-trim(118.4): 7 B-trim: 209 in 1/51 Lambda= 0.144834 statistics sampled from 31306 (31312) to 31306 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.742), E-opt: 0.2 (0.367), width: 16 Scan time: 7.740 The best scores are: opt bits E(85289) NP_542380 (OMIM: 107748) DNA-(apurinic or apyrimid ( 318) 2175 463.5 2.6e-130 NP_542379 (OMIM: 107748) DNA-(apurinic or apyrimid ( 318) 2175 463.5 2.6e-130 NP_001632 (OMIM: 107748) DNA-(apurinic or apyrimid ( 318) 2175 463.5 2.6e-130 NP_001231178 (OMIM: 107748) DNA-(apurinic or apyri ( 318) 2175 463.5 2.6e-130 NP_001258677 (OMIM: 300773) DNA-(apurinic or apyri ( 347) 185 47.7 4.2e-05 NP_055296 (OMIM: 300773) DNA-(apurinic or apyrimid ( 518) 187 48.2 4.3e-05 >>NP_542380 (OMIM: 107748) DNA-(apurinic or apyrimidinic (318 aa) initn: 2175 init1: 2175 opt: 2175 Z-score: 2460.4 bits: 463.5 E(85289): 2.6e-130 Smith-Waterman score: 2175; 99.7% identity (100.0% similar) in 318 aa overlap (1-318:1-318) 10 20 30 40 50 60 pF1KB6 MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 APSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: NP_542 APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI 250 260 270 280 290 300 310 pF1KB6 RSKALGSDHCPITLYLAL :::::::::::::::::: NP_542 RSKALGSDHCPITLYLAL 310 >>NP_542379 (OMIM: 107748) DNA-(apurinic or apyrimidinic (318 aa) initn: 2175 init1: 2175 opt: 2175 Z-score: 2460.4 bits: 463.5 E(85289): 2.6e-130 Smith-Waterman score: 2175; 99.7% identity (100.0% similar) in 318 aa overlap (1-318:1-318) 10 20 30 40 50 60 pF1KB6 MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 APSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: NP_542 APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_542 GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI 250 260 270 280 290 300 310 pF1KB6 RSKALGSDHCPITLYLAL :::::::::::::::::: NP_542 RSKALGSDHCPITLYLAL 310 >>NP_001632 (OMIM: 107748) DNA-(apurinic or apyrimidinic (318 aa) initn: 2175 init1: 2175 opt: 2175 Z-score: 2460.4 bits: 463.5 E(85289): 2.6e-130 Smith-Waterman score: 2175; 99.7% identity (100.0% similar) in 318 aa overlap (1-318:1-318) 10 20 30 40 50 60 pF1KB6 MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 APSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: NP_001 APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI 250 260 270 280 290 300 310 pF1KB6 RSKALGSDHCPITLYLAL :::::::::::::::::: NP_001 RSKALGSDHCPITLYLAL 310 >>NP_001231178 (OMIM: 107748) DNA-(apurinic or apyrimidi (318 aa) initn: 2175 init1: 2175 opt: 2175 Z-score: 2460.4 bits: 463.5 E(85289): 2.6e-130 Smith-Waterman score: 2175; 99.7% identity (100.0% similar) in 318 aa overlap (1-318:1-318) 10 20 30 40 50 60 pF1KB6 MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 APSDKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV :::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::: NP_001 APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI 250 260 270 280 290 300 310 pF1KB6 RSKALGSDHCPITLYLAL :::::::::::::::::: NP_001 RSKALGSDHCPITLYLAL 310 >>NP_001258677 (OMIM: 300773) DNA-(apurinic or apyrimidi (347 aa) initn: 203 init1: 107 opt: 185 Z-score: 212.6 bits: 47.7 E(85289): 4.2e-05 Smith-Waterman score: 185; 31.5% identity (57.7% similar) in 130 aa overlap (199-318:15-142) 170 180 190 200 210 220 pF1KB6 TAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKK ::. . ... ::::.::. :: . : . NP_001 MRFYRLLQIRAEALLAAGSHVIILGDLNTAHRPIDHWDAV-NLE 10 20 30 40 230 240 250 260 270 pF1KB6 NAGFTPQERQGFGELLQAV---------PLADSFRHLYPNTPYAYTFWTYMMNARSKNVG : :. . ::. . :. ::.: . :. :.: :. . .:: : : NP_001 CFEEDPG-RKWMDSLLSNLGCQSASHVGPFIDSYRCFQPKQEGAFTCWSAVTGARHLNYG 50 60 70 80 90 100 280 290 300 310 pF1KB6 WRLDYFLLSHSL-LPALCDSKIRSKALGSDHCPITLYLAL :::: : ...: . .. : . ...::::::. :.. NP_001 SRLDYVLGDRTLVIDTFQASFLLPEVMGSDHCPVGAVLSVSSVPAKQCPPLCTRFLPEFA 110 120 130 140 150 160 NP_001 GTQLKILRFLVPLEQSPVLEQSTLQHNNQTRVQTCQNKAQVRSTRPQPSQVGSSRGQKNL 170 180 190 200 210 220 >>NP_055296 (OMIM: 300773) DNA-(apurinic or apyrimidinic (518 aa) initn: 276 init1: 107 opt: 187 Z-score: 212.4 bits: 48.2 E(85289): 4.3e-05 Smith-Waterman score: 280; 27.2% identity (51.9% similar) in 320 aa overlap (62-318:2-313) 40 50 60 70 80 pF1KB6 KNDKEAAGEGPALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAP-- :.. :::..:.: . :. : .. : NP_055 MLRVVSWNINGIR-----RPLQGVANQEPSN 10 20 90 100 110 120 130 pF1KB6 ---------------DILCLQETKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGV--- ::.:::::: ... : : . : . .:.: .. ::::: NP_055 CAAVAVGRILDELDADIVCLQETKVTRDALTEPLAIVEGYN-SYFSFSRNRSGYSGVATF 30 40 50 60 70 80 140 150 160 pF1KB6 ---------------GLLSRQCPLKVSYG----IGEEEH---DQEGRVIVAEFD------ ::.. : :: . .:: :.:::..... NP_055 CKDNATPVAAEEGLSGLFATQNGDVGCYGNMDEFTQEELRALDSEGRALLTQHKIRTWEG 90 100 110 120 130 140 170 180 190 200 210 pF1KB6 ---SFVLVTAYVPNAGRGLV-RLEYRQRWDEAFRKFLKGL-ASRKPLVLCGDLNVAHEEI ...:...: :.: : :: ...:. . .. ..: :. . ... ::::.::. : NP_055 KEKTLTLINVYCPHADPGRPERLVFKMRFYRLLQIRAEALLAAGSHVIILGDLNTAHRPI 150 160 170 180 190 200 220 230 240 250 260 pF1KB6 DLRNPKGNKKNAGFTPQERQGFGELLQAV---------PLADSFRHLYPNTPYAYTFWTY : . : . : :. . ::. . :. ::.: . :. :.: :. NP_055 DHWDAV-NLECFEEDPG-RKWMDSLLSNLGCQSASHVGPFIDSYRCFQPKQEGAFTCWSA 210 220 230 240 250 260 270 280 290 300 310 pF1KB6 MMNARSKNVGWRLDYFLLSHSL-LPALCDSKIRSKALGSDHCPITLYLAL . .:: : : :::: : ...: . .. : . ...::::::. :.. NP_055 VTGARHLNYGSRLDYVLGDRTLVIDTFQASFLLPEVMGSDHCPVGAVLSVSSVPAKQCPP 270 280 290 300 310 320 NP_055 LCTRFLPEFAGTQLKILRFLVPLEQSPVLEQSTLQHNNQTRVQTCQNKAQVRSTRPQPSQ 330 340 350 360 370 380 318 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 23:00:06 2016 done: Fri Nov 4 23:00:07 2016 Total Scan time: 7.740 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]