FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6462, 352 aa 1>>>pF1KB6462 352 - 352 aa - 352 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.2678+/-0.00109; mu= 3.2378+/- 0.064 mean_var=191.8993+/-40.718, 0's: 0 Z-trim(109.4): 141 B-trim: 33 in 1/51 Lambda= 0.092584 statistics sampled from 10719 (10870) to 10719 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.701), E-opt: 0.2 (0.334), width: 16 Scan time: 2.430 The best scores are: opt bits E(32554) CCDS6483.1 SH3GL2 gene_id:6456|Hs108|chr9 ( 352) 2330 323.6 1.5e-88 CCDS10325.2 SH3GL3 gene_id:6457|Hs108|chr15 ( 347) 1617 228.4 7e-60 CCDS73772.1 SH3GL3 gene_id:6457|Hs108|chr15 ( 355) 1532 217.1 1.9e-56 CCDS32874.1 SH3GL1 gene_id:6455|Hs108|chr19 ( 368) 1390 198.1 9.8e-51 CCDS56076.1 SH3GL1 gene_id:6455|Hs108|chr19 ( 320) 830 123.3 2.9e-28 CCDS59335.1 SH3GL1 gene_id:6455|Hs108|chr19 ( 304) 666 101.3 1.1e-21 >>CCDS6483.1 SH3GL2 gene_id:6456|Hs108|chr9 (352 aa) initn: 2330 init1: 2330 opt: 2330 Z-score: 1703.2 bits: 323.6 E(32554): 1.5e-88 Smith-Waterman score: 2330; 100.0% identity (100.0% similar) in 352 aa overlap (1-352:1-352) 10 20 30 40 50 60 pF1KB6 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS64 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS64 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS64 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS64 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS64 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYD 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 FEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH :::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS64 FEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH 310 320 330 340 350 >>CCDS10325.2 SH3GL3 gene_id:6457|Hs108|chr15 (347 aa) initn: 1642 init1: 1212 opt: 1617 Z-score: 1188.6 bits: 228.4 E(32554): 7e-60 Smith-Waterman score: 1617; 68.1% identity (87.6% similar) in 354 aa overlap (1-352:1-347) 10 20 30 40 50 60 pF1KB6 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP :::::::::::::.: :::..:::::::::.: .::::.:::...: ::..:: ::::: CCDS10 MSVAGLKKQFHKASQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILSKTTEYLQP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA ::: ::::.:.::.:::::: : ::::.:.::.. :::.:.:::.: .:: :: ::::. CCDS10 NPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGNALIEVGES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD :. ..::::::::.:::.:::::: :.::::.:: ::::::::::::.:::::: ::::: CCDS10 MKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKKKRVGKIPD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL ::.:::.:::.::::.:: ::::.:: :.::::::.....: :.::.:...:::.. .: CCDS10 EEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEILQELQSKL 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSG--VQMDQPCCRAL . :: ::: :::::.:.: . :.. .:.: :.. : .: . :::::::.: CCDS10 QMRISAASSVPRREYKPRP-------VKRSSSELNGVSTTSVVKTTGSNIPMDQPCCRGL 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 YDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH :::::::.:::::::::::::::::::::::::.::.::::::::::..: ::. CCDS10 YDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPLPQ 300 310 320 330 340 >>CCDS73772.1 SH3GL3 gene_id:6457|Hs108|chr15 (355 aa) initn: 1554 init1: 1124 opt: 1532 Z-score: 1127.1 bits: 217.1 E(32554): 1.9e-56 Smith-Waterman score: 1532; 67.1% identity (87.1% similar) in 340 aa overlap (15-352:23-355) 10 20 30 40 50 pF1KB6 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMT : :::..:::::::::.: .::::.:::...: ::.. CCDS73 MDGIFAGIICNQANRCLTWTSQQLFSEKISGAEGTKLDDEFLDMERKIDVTNKVVAEILS 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 KTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGP :: :::::::: ::::.:.::.:::::: : ::::.:.::.. :::.:.:::.: .:: CCDS73 KTTEYLQPNPAYRAKLGMLNTVSKIRGQVKTTGYPQTEGLLGDCMLKYGKELGEDSTFGN 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 ALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKK :: ::::.:. ..::::::::.:::.:::::: :.::::.:: ::::::::::::.:::: CCDS73 ALIEVGESMKLMAEVKDSLDINVKQTFIDPLQLLQDKDLKEIGHHLKKLEGRRLDYDYKK 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB6 KRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQI :: :::::::.:::.:::.::::.:: ::::.:: :.::::::.....: :.::.:...: CCDS73 KRVGKIPDEEVRQAVEKFEESKELAERSMFNFLENDVEQVSQLAVFIEAALDYHRQSTEI 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB6 LQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSG--VQM ::.. .:. :: ::: :::::.:.: . :.. .:.: :.. : .: . : CCDS73 LQELQSKLQMRISAASSVPRREYKPRP-------VKRSSSELNGVSTTSVVKTTGSNIPM 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 DQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVAL ::::::.::::::::.:::::::::::::::::::::::::.::.::::::::::..: : CCDS73 DQPCCRGLYDFEPENQGELGFKEGDIITLTNQIDENWYEGMIHGESGFFPINYVEVIVPL 300 310 320 330 340 350 pF1KB6 PH :. CCDS73 PQ >>CCDS32874.1 SH3GL1 gene_id:6455|Hs108|chr19 (368 aa) initn: 1721 init1: 1349 opt: 1390 Z-score: 1024.4 bits: 198.1 E(32554): 9.8e-51 Smith-Waterman score: 1720; 71.1% identity (87.0% similar) in 370 aa overlap (1-352:1-368) 10 20 30 40 50 60 pF1KB6 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP ::::::::::.::.: :::::::::::::::::::::.::::::.:: :....::::::: CCDS32 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA ::::::::.:.::.:::::: :.:::::.:.::.: :.. :.::: . ::: :: ..::. CCDS32 NPASRAKLTMLNTVSKIRGQVKNPGYPQSEGLLGECMIRHGKELGGESNFGDALLDAGES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD :..:.::::::::::::::::::::: .:::.:::::::::::::::::::::::::::: CCDS32 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL ::::::::::.::::.::.:: :::: ::::::::::::.:::.::.::::::.... .: CCDS32 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL 190 200 210 220 230 240 250 260 270 280 pF1KB6 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPK---------------- ..:.:.:::.:.:::.:::: : :. : :::. : .:: CCDS32 KRRMREASSRPKREYKPKPREP--FDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRT 250 260 270 280 290 290 300 310 320 330 340 pF1KB6 PSGVQ--MDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPIN :: . .::: :.:::::::::.:::::.:::.:::::::::::::::: :.:::::.. CCDS32 PSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLS 300 310 320 330 340 350 350 pF1KB6 YVEILVALPH :::.:: ::. CCDS32 YVEVLVPLPQ 360 >>CCDS56076.1 SH3GL1 gene_id:6455|Hs108|chr19 (320 aa) initn: 1161 init1: 789 opt: 830 Z-score: 620.9 bits: 123.3 E(32554): 2.9e-28 Smith-Waterman score: 1395; 62.4% identity (75.4% similar) in 370 aa overlap (1-352:1-320) 10 20 30 40 50 60 pF1KB6 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP ::::::::::.::.: :::::::::::::::::::::.::::::.:: :....::::::: CCDS56 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA :: : :: ..::. CCDS56 NP------------------------------------------------GDALLDAGES 70 130 140 150 160 170 180 pF1KB6 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD :..:.::::::::::::::::::::: .:::.:::::::::::::::::::::::::::: CCDS56 MKRLAEVKDSLDIEVKQNFIDPLQNLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD 80 90 100 110 120 130 190 200 210 220 230 240 pF1KB6 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL ::::::::::.::::.::.:: :::: ::::::::::::.:::.::.::::::.... .: CCDS56 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL 140 150 160 170 180 190 250 260 270 280 pF1KB6 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPK---------------- ..:.:.:::.:.:::.:::: : :. : :::. : .:: CCDS56 KRRMREASSRPKREYKPKPREP--FDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRT 200 210 220 230 240 250 290 300 310 320 330 340 pF1KB6 PSGVQ--MDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPIN :: . .::: :.:::::::::.:::::.:::.:::::::::::::::: :.:::::.. CCDS56 PSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLS 260 270 280 290 300 310 350 pF1KB6 YVEILVALPH :::.:: ::. CCDS56 YVEVLVPLPQ 320 >>CCDS59335.1 SH3GL1 gene_id:6455|Hs108|chr19 (304 aa) initn: 997 init1: 625 opt: 666 Z-score: 502.9 bits: 101.3 E(32554): 1.1e-21 Smith-Waterman score: 1290; 59.5% identity (71.6% similar) in 370 aa overlap (1-352:1-304) 10 20 30 40 50 60 pF1KB6 MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP ::::::::::.::.: :::::::::::::::::::::.::::::.:: :....::::::: CCDS59 MSVAGLKKQFYKASQLVSEKVGGAEGTKLDDDFKEMEKKVDVTSKAVTEVLARTIEYLQP 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA ::::::::.:.::.:::::: CCDS59 NPASRAKLTMLNTVSKIRGQ---------------------------------------- 70 80 130 140 150 160 170 180 pF1KB6 MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD :: .:::.:::::::::::::::::::::::::::: CCDS59 ------------------------NLCEKDLKEIQHHLKKLEGRRLDFDYKKKRQGKIPD 90 100 110 190 200 210 220 230 240 pF1KB6 EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL ::::::::::.::::.::.:: :::: ::::::::::::.:::.::.::::::.... .: CCDS59 EELRQALEKFEESKEVAETSMHNLLETDIEQVSQLSALVDAQLDYHRQAVQILDELAEKL 120 130 140 150 160 170 250 260 270 280 pF1KB6 EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPK---------------- ..:.:.:::.:.:::.:::: : :. : :::. : .:: CCDS59 KRRMREASSRPKREYKPKPREP--FDLGEPEQSNGGFPCTTAPKIAASSSFRSSDKPIRT 180 190 200 210 220 230 290 300 310 320 330 340 pF1KB6 PSGVQ--MDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPIN :: . .::: :.:::::::::.:::::.:::.:::::::::::::::: :.:::::.. CCDS59 PSRSMPPLDQPSCKALYDFEPENDGELGFHEGDVITLTNQIDENWYEGMLDGQSGFFPLS 240 250 260 270 280 290 350 pF1KB6 YVEILVALPH :::.:: ::. CCDS59 YVEVLVPLPQ 300 352 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 20:56:01 2016 done: Fri Nov 4 20:56:01 2016 Total Scan time: 2.430 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]