FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6463, 322 aa 1>>>pF1KB6463 322 - 322 aa - 322 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.8707+/-0.000324; mu= 10.5518+/- 0.020 mean_var=149.4150+/-30.058, 0's: 0 Z-trim(120.8): 6 B-trim: 1309 in 2/54 Lambda= 0.104925 statistics sampled from 36541 (36558) to 36541 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.766), E-opt: 0.2 (0.429), width: 16 Scan time: 8.280 The best scores are: opt bits E(85289) NP_057651 (OMIM: 611883) BRCA2 and CDKN1A-interact ( 322) 2108 330.2 3.5e-90 NP_510869 (OMIM: 611883) BRCA2 and CDKN1A-interact ( 292) 1883 296.1 5.8e-80 NP_510868 (OMIM: 611883) BRCA2 and CDKN1A-interact ( 314) 1695 267.7 2.3e-71 >>NP_057651 (OMIM: 611883) BRCA2 and CDKN1A-interacting (322 aa) initn: 2108 init1: 2108 opt: 2108 Z-score: 1740.1 bits: 330.2 E(85289): 3.5e-90 Smith-Waterman score: 2108; 100.0% identity (100.0% similar) in 322 aa overlap (1-322:1-322) 10 20 30 40 50 60 pF1KB6 MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDKEKDEEDEVIDEEVNIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDKEKDEEDEVIDEEVNIE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 FEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSNDDMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 FEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSNDDMD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKSMVEQLDKFLNDTTKPVGLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 EDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKSMVEQLDKFLNDTTKPVGLLL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 SERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYFYLLISKTFVEAGKNNSKKKPSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 SERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYFYLLISKTFVEAGKNNSKKKPSN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 KKKAALMFANAEEEFFYEEQGKPEVLGGPDTRRGLEPVPIQHNGGSRGQVTALVSLKAGL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 KKKAALMFANAEEEFFYEEQGKPEVLGGPDTRRGLEPVPIQHNGGSRGQVTALVSLKAGL 250 260 270 280 290 300 310 320 pF1KB6 IQSRSTLSDFQGTFMTVGIALS :::::::::::::::::::::: NP_057 IQSRSTLSDFQGTFMTVGIALS 310 320 >>NP_510869 (OMIM: 611883) BRCA2 and CDKN1A-interacting (292 aa) initn: 2183 init1: 1883 opt: 1883 Z-score: 1556.5 bits: 296.1 E(85289): 5.8e-80 Smith-Waterman score: 1883; 99.7% identity (99.7% similar) in 286 aa overlap (1-286:1-286) 10 20 30 40 50 60 pF1KB6 MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDKEKDEEDEVIDEEVNIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_510 MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDKEKDEEDEVIDEEVNIE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 FEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSNDDMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_510 FEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSNDDMD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKSMVEQLDKFLNDTTKPVGLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_510 EDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKSMVEQLDKFLNDTTKPVGLLL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 SERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYFYLLISKTFVEAGKNNSKKKPSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_510 SERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYFYLLISKTFVEAGKNNSKKKPSN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 KKKAALMFANAEEEFFYEEQGKPEVLGGPDTRRGLEPVPIQHNGGSRGQVTALVSLKAGL :::::::::::::::::::::::::::::::::::::::::::: : NP_510 KKKAALMFANAEEEFFYEEQGKPEVLGGPDTRRGLEPVPIQHNGWSVPPVLE 250 260 270 280 290 310 320 pF1KB6 IQSRSTLSDFQGTFMTVGIALS >>NP_510868 (OMIM: 611883) BRCA2 and CDKN1A-interacting (314 aa) initn: 1995 init1: 1695 opt: 1695 Z-score: 1402.3 bits: 267.7 E(85289): 2.3e-71 Smith-Waterman score: 1695; 99.6% identity (100.0% similar) in 259 aa overlap (1-259:1-259) 10 20 30 40 50 60 pF1KB6 MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDKEKDEEDEVIDEEVNIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_510 MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDKEKDEEDEVIDEEVNIE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 FEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSNDDMD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_510 FEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSNDDMD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKSMVEQLDKFLNDTTKPVGLLL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_510 EDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKSMVEQLDKFLNDTTKPVGLLL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 SERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYFYLLISKTFVEAGKNNSKKKPSN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_510 SERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYFYLLISKTFVEAGKNNSKKKPSN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 KKKAALMFANAEEEFFYEEQGKPEVLGGPDTRRGLEPVPIQHNGGSRGQVTALVSLKAGL ::::::::::::::::::. NP_510 KKKAALMFANAEEEFFYEKAILKFNYSVQEESDTCLGGKWSFDDVPMTPLRTVMLIPGDK 250 260 270 280 290 300 322 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 23:04:42 2016 done: Fri Nov 4 23:04:44 2016 Total Scan time: 8.280 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]