FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KB6469, 324 aa
  1>>>pF1KB6469 324 - 324 aa - 324 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 7.6025+/-0.000428; mu= 5.4031+/- 0.027
 mean_var=137.0900+/-26.883, 0's: 0 Z-trim(115.0): 11  B-trim: 283 in 1/50
 Lambda= 0.109540
 statistics sampled from 25148 (25159) to 25148 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.638), E-opt: 0.2 (0.295), width:  16
 Scan time:  7.640

The best scores are:                                      opt bits E(85289)
NP_002802 (OMIM: 157970) 26S proteasome non-ATPase ( 324) 2098 343.0 4.9e-94
NP_003745 (OMIM: 603914) eukaryotic translation in ( 357)  404 75.3 2.1e-13
NP_006824 (OMIM: 614729) COP9 signalosome complex  ( 327)  366 69.3 1.2e-11


>>NP_002802 (OMIM: 157970) 26S proteasome non-ATPase reg  (324 aa)
 initn: 2098 init1: 2098 opt: 2098  Z-score: 1809.2  bits: 343.0 E(85289): 4.9e-94
Smith-Waterman score: 2098; 100.0% identity (100.0% similar) in 324 aa overlap (1-324:1-324)

               10        20        30        40        50        60
pF1KB6 MPELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MPELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KB6 DDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSV
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KB6 LVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIK
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHVTSEIGAEEAEEVGVEHLLRDIK
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KB6 DTTVGTLSQRITNQVHGLKGLNSKLLDIRSYLEKVATGKLPINHQIIYQLQDVFNLLPDV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DTTVGTLSQRITNQVHGLKGLNSKLLDIRSYLEKVATGKLPINHQIIYQLQDVFNLLPDV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KB6 SLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKDR
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEESKKDR
              250       260       270       280       290       300

              310       320    
pF1KB6 KEDKEKDKDKEKSDVKKEEKKEKK
       ::::::::::::::::::::::::
NP_002 KEDKEKDKDKEKSDVKKEEKKEKK
              310       320    

>>NP_003745 (OMIM: 603914) eukaryotic translation initia  (357 aa)
 initn: 371 init1: 187 opt: 404  Z-score: 361.8  bits: 75.3 E(85289): 2.1e-13
Smith-Waterman score: 404; 29.0% identity (64.7% similar) in 272 aa overlap (9-277:92-356)

                                     10        20        30        
pF1KB6                       MPELAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGV
                                     : .::..: :.:: ..: ..  .  ::.:.
NP_003 TPASAQAPAQTPAPALPGPALPGPFPGGRVVRLHPVILASIVDSYERRNE--GAARVIGT
              70        80        90       100       110           

       40        50        60        70        80        90        
pF1KB6 LLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTG
       :::. .:. ..:.: :.:: .:.. . .:   : .. .::: . :::.  : :.::: ::
NP_003 LLGTVDKHSVEVTNCFSVPHNESEDEVAV---DMEFAKNMYELHKKVSPNELILGWYATG
     120       130       140          150       160       170      

      100       110       120       130       140       150        
pF1KB6 PKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEHV
         . .... :.: ..:  :: . . .:.. ..  .  .::.:.  .   :   .  :  .
NP_003 HDITEHSVLIHEYYSREAPNPIHLTVDTSLQNGRMSIKAYVSTL-MGVPGRTMGVMFTPL
        180       190       200       210       220        230     

      160       170        180       190       200        210      
pF1KB6 TSEIGAEEAEEVGVEHLLRD-IKDTTVGTLSQRITNQVHGLKG-LNSKLLDIRSYLEKVA
       : . .  ..:..::. ...  .. . :  ::. . .:: : .. ... :  . .: : : 
NP_003 TVKYAYYDTERIGVDLIMKTCFSPNRVIGLSSDL-QQVGGASARIQDALSTVLQYAEDVL
         240       250       260        270       280       290    

        220       230       240       250       260       270      
pF1KB6 TGKLPINHQIIYQLQDVFNLLPDVSLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHN-L
       .::.  .. .   :... : .: .  ..:   .  . :: ..:.:::.: .: .::.. :
NP_003 SGKVSADNTVGRFLMSLVNQVPKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEKL
          300       310       320       330       340       350    

         280       290       300       310       320    
pF1KB6 INNKIANRDAEKKEGQEKEESKKDRKEDKEKDKDKEKSDVKKEEKKEKK
       .:                                               
NP_003 VNL                                              
                                                        

>>NP_006824 (OMIM: 614729) COP9 signalosome complex subu  (327 aa)
 initn: 277 init1: 182 opt: 366  Z-score: 329.9  bits: 69.3 E(85289): 1.2e-11
Smith-Waterman score: 366; 26.4% identity (63.7% similar) in 273 aa overlap (9-277:41-307)

                                     10        20         30       
pF1KB6                       MPELAVQKVVVHPLVLLSVVDHFNRI-GKVGNQKRVVG
                                     :..::::.:.. ::. :. .. :   .:.:
NP_006 TNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALHPLVILNISDHWIRMRSQEGRPVQVIG
               20        30        40        50        60        70

        40        50        60        70        80        90       
pF1KB6 VLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHT
       .:.:. . . ..: ::: . ...  ..  .  .:..:  .   .::.:  . ...::: :
NP_006 ALIGKQEGRNIEVMNSFEL-LSHTVEEKII--IDKEYYYTKEEQFKQVFKELEFLGWYTT
               80         90         100       110       120       

       100       110       120       130       140       150       
pF1KB6 GPKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEH
       :     .:: ... . .   . ... ..   :   ::. .. :: .. . :  :   : .
NP_006 GGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIIN-GEATM-LFAE
       130       140       150       160       170        180      

       160       170       180          190       200       210    
pF1KB6 VTSEIGAEEAEEVGVEHLLRDIKDTTVG---TLSQRITNQVHGLKGLNSKLLDIRSYLEK
       .:  ...::::..::.:. : .  :  :   :.....  :  ..: :.:..  :  :.. 
NP_006 LTYTLATEEAERIGVDHVAR-MTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKA
         190       200        210       220       230       240    

          220       230       240       250       260       270    
pF1KB6 VATGKLPINHQIIYQLQDVFNLLPDVSLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHN
         .:..:.::.:. .   . . :: .: ..:   :: . ::  ...::... ..  ....
NP_006 SEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQ
          250       260       270       280       290       300    

          280       290       300       310       320    
pF1KB6 LINNKIANRDAEKKEGQEKEESKKDRKEDKEKDKDKEKSDVKKEEKKEKK
       ..:                                               
NP_006 FVNKFNVLYDRQGIGRRMRGLFF                           
          310       320                                  




324 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Fri Nov  4 16:34:03 2016 done: Fri Nov  4 16:34:04 2016
 Total Scan time:  7.640 Total Display time: -0.010

Function used was FASTA [36.3.4 Apr, 2011]