FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6470, 354 aa 1>>>pF1KB6470 354 - 354 aa - 354 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0469+/-0.000869; mu= 12.2956+/- 0.052 mean_var=74.1299+/-14.772, 0's: 0 Z-trim(106.5): 35 B-trim: 54 in 1/50 Lambda= 0.148963 statistics sampled from 9017 (9045) to 9017 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.278), width: 16 Scan time: 2.670 The best scores are: opt bits E(32554) CCDS5568.1 RFC2 gene_id:5982|Hs108|chr7 ( 354) 2320 507.9 5.1e-144 CCDS75618.1 RFC2 gene_id:5982|Hs108|chr7 ( 251) 1594 351.9 3.5e-97 CCDS5567.1 RFC2 gene_id:5982|Hs108|chr7 ( 320) 1383 306.5 1.9e-83 CCDS9185.1 RFC5 gene_id:5985|Hs108|chr12 ( 340) 740 168.4 8.1e-42 CCDS41843.2 RFC5 gene_id:5985|Hs108|chr12 ( 319) 706 161.1 1.2e-39 CCDS3283.1 RFC4 gene_id:5984|Hs108|chr3 ( 363) 673 154.0 1.9e-37 >>CCDS5568.1 RFC2 gene_id:5982|Hs108|chr7 (354 aa) initn: 2320 init1: 2320 opt: 2320 Z-score: 2699.1 bits: 507.9 E(32554): 5.1e-144 Smith-Waterman score: 2320; 100.0% identity (100.0% similar) in 354 aa overlap (1-354:1-354) 10 20 30 40 50 60 pF1KB6 MEVEAVCGGAGEVEAQDSDPAPAFSKAPGSAGHYELPWVEKYRPVKLNEIVGNEDTVSRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MEVEAVCGGAGEVEAQDSDPAPAFSKAPGSAGHYELPWVEKYRPVKLNEIVGNEDTVSRL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 EVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAMLELNASNDRGIDVVRNKI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 EVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAMLELNASNDRGIDVVRNKI 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 KMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 KMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEP 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 IQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 IQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 SGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIF 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 RVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKTMAPVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 RVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKTMAPVAS 310 320 330 340 350 >>CCDS75618.1 RFC2 gene_id:5982|Hs108|chr7 (251 aa) initn: 1594 init1: 1594 opt: 1594 Z-score: 1858.3 bits: 351.9 E(32554): 3.5e-97 Smith-Waterman score: 1594; 99.2% identity (99.6% similar) in 247 aa overlap (108-354:5-251) 80 90 100 110 120 130 pF1KB6 PGTGKTTSILCLARALLGPALKDAMLELNASNDRGIDVVRNKIKMFAQQKVTLPKGRHKI :. ::::::::::::::::::::::::::: CCDS75 MCPTSSLRGIDVVRNKIKMFAQQKVTLPKGRHKI 10 20 30 140 150 160 170 180 190 pF1KB6 IILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 IILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQ 40 50 60 70 80 90 200 210 220 230 240 250 pF1KB6 ILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 ILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFINSENVFKVCDE 100 110 120 130 140 150 260 270 280 290 300 310 pF1KB6 PHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS75 PHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFI 160 170 180 190 200 210 320 330 340 350 pF1KB6 KEIGYTHMKIAEGVNSLLQMAGLLARLCQKTMAPVAS ::::::::::::::::::::::::::::::::::::: CCDS75 KEIGYTHMKIAEGVNSLLQMAGLLARLCQKTMAPVAS 220 230 240 250 >>CCDS5567.1 RFC2 gene_id:5982|Hs108|chr7 (320 aa) initn: 1382 init1: 1382 opt: 1383 Z-score: 1611.5 bits: 306.5 E(32554): 1.9e-83 Smith-Waterman score: 2024; 90.4% identity (90.4% similar) in 354 aa overlap (1-354:1-320) 10 20 30 40 50 60 pF1KB6 MEVEAVCGGAGEVEAQDSDPAPAFSKAPGSAGHYELPWVEKYRPVKLNEIVGNEDTVSRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 MEVEAVCGGAGEVEAQDSDPAPAFSKAPGSAGHYELPWVEKYRPVKLNEIVGNEDTVSRL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 EVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAMLELNASNDRGIDVVRNKI :::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 EVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAMLELNASND---------- 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 KMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEP :::::::::::::::::::::::::::::::::::: CCDS55 ------------------------SMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEP 120 130 140 190 200 210 220 230 240 pF1KB6 IQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 IQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTF 150 160 170 180 190 200 250 260 270 280 290 300 pF1KB6 SGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 SGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIF 210 220 230 240 250 260 310 320 330 340 350 pF1KB6 RVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKTMAPVAS :::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS55 RVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKTMAPVAS 270 280 290 300 310 320 >>CCDS9185.1 RFC5 gene_id:5985|Hs108|chr12 (340 aa) initn: 678 init1: 573 opt: 740 Z-score: 864.2 bits: 168.4 E(32554): 8.1e-42 Smith-Waterman score: 740; 37.2% identity (70.7% similar) in 317 aa overlap (28-342:12-327) 10 20 30 40 50 60 pF1KB6 MEVEAVCGGAGEVEAQDSDPAPAFSKAPGSAGHYELPWVEKYRPVKLNEIVGNEDTVSRL :... .::::::::: ::......: .: . CCDS91 METSALKQQEQPAATKIRNLPWVEKYRPQTLNDLISHQDILSTI 10 20 30 40 70 80 90 100 110 pF1KB6 EVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAM-LELNASNDRGIDVVRNK . : : .:.... ::::::::..:: :. : .: ::::::.:::::..:. CCDS91 QKFINEDRLPHLLLYGPPGTGKTSTILACAKQLYKDKEFGSMVLELNASDDRGIDIIRGP 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB6 IKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIE : ::. .. . :: :..::::::.::. ::.::::..: ....::: : :: .::: CCDS91 ILSFASTRTIFKKG-FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIP 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB6 PIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQST .::::. .:. :: .. :: .:.:.:.: ..::..:.. ..::::.::: :::: CCDS91 ALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQST 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB6 FSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHL-GYSPEDIIGN .:: .. :.:. .: . .... .: .. ::. ...: : : . .::. . CCDS91 NMAFGKVTEETVYTCTGHPLKSDIANILDWMLNQDFTTAYRNITELKTLKGLALHDILTE 230 240 250 260 270 280 300 310 320 330 340 350 pF1KB6 IFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKTMAPVAS : . .. ...... ... ..... :.: .:...:.: CCDS91 IHLFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQLSSLIAAFQVTRDLIVAEA 290 300 310 320 330 340 >>CCDS41843.2 RFC5 gene_id:5985|Hs108|chr12 (319 aa) initn: 648 init1: 543 opt: 706 Z-score: 825.2 bits: 161.1 E(32554): 1.2e-39 Smith-Waterman score: 706; 37.3% identity (70.6% similar) in 306 aa overlap (39-342:2-306) 10 20 30 40 50 60 pF1KB6 GAGEVEAQDSDPAPAFSKAPGSAGHYELPWVEKYRPVKLNEIVGNEDTVSRLEVFAREGN :::::: ::......: .: .. : : CCDS41 MVEKYRPQTLNDLISHQDILSTIQKFINEDR 10 20 30 70 80 90 100 110 120 pF1KB6 VPNIIIAGPPGTGKTTSILCLARALLGPALKDAM-LELNASNDRGIDVVRNKIKMFAQQK .:.... ::::::::..:: :. : .: ::::::.:::::..:. : ::. . CCDS41 LPHLLLYGPPGTGKTSTILACAKQLYKDKEFGSMVLELNASDDRGIDIIRGPILSFASTR 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 VTLPKGRHKIIILDEADSMTDGAQQALRRTMEIYSKTTRFALACNASDKIIEPIQSRCAV . . :: :..::::::.::. ::.::::..: ....::: : :: .::: .::::. CCDS41 TIFKKG-FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTR 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB6 LRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFSGFGFIN .:. :: .. :: .:.:.:.: ..::..:.. ..::::.::: :::: .:: .. CCDS41 FRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVT 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB6 SENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHL-GYSPEDIIGNIFRVCKTF :.:. .: . .... .: .. ::. ...: : : . .::. .: . CCDS41 EETVYTCTGHPLKSDIANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIHLFVHRV 220 230 240 250 260 270 310 320 330 340 350 pF1KB6 QMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLCQKTMAPVAS .. ...... ... ..... :.: .:...:.: CCDS41 DFPSSVRIHLLTKMADIEYRLSVGTNEKIQLSSLIAAFQVTRDLIVAEA 280 290 300 310 >>CCDS3283.1 RFC4 gene_id:5984|Hs108|chr3 (363 aa) initn: 639 init1: 347 opt: 673 Z-score: 786.0 bits: 154.0 E(32554): 1.9e-37 Smith-Waterman score: 676; 37.1% identity (67.1% similar) in 334 aa overlap (29-347:27-358) 10 20 30 40 50 pF1KB6 MEVEAVCGGAGEVEAQDSDPAPAFSKAPGSAGHYE----LPWVEKYRPVKLNEIVGNEDT ::.:. . .:::::::: ..:.. .:.. CCDS32 MQAFLKGTSISTKPPLTKDRGVAASAGSSGENKKAKPVPWVEKYRPKCVDEVAFQEEV 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 VSRLEVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPAL-KDAMLELNASNDRGIDV :. :. . ...::... ::::::::..:: :: :.:: : . .::::::..:::.: CCDS32 VAVLKKSLEGADLPNLLFYGPPGTGKTSTILAAARELFGPELFRLRVLELNASDERGIQV 60 70 80 90 100 110 120 130 140 150 160 pF1KB6 VRNKIKMFAQQKVTLPK--GR----HKIIILDEADSMTDGAQQALRRTMEIYSKTTRFAL ::.:.: ::: :. . :. ::.:::::::::..:: ::::::: :::::: : CCDS32 VREKVKNFAQLTVSGSRSDGKPCPPFKIVILDEADSMTSAAQAALRRTMEKESKTTRFCL 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB6 ACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDM :: ..::::. :::. .:. :.: ::... .:: : .:.:. .. ...::. CCDS32 ICNYVSRIIEPLTSRCSKFRFKPLSDKIQQQRLLDIAKKENVKISDEGIAYLVKVSEGDL 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB6 RQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQH----CVNANIDEAYKILAHL :.:.. :::. : ..: . :: . .. : :. : ....:. .. : CCDS32 RKAITFLQSATRLTG--GKEITEKVITDIAGVIPAEKIDGVFAACQSGSFDKLEAVVKDL 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB6 WHLGYSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTHMKIAEGVNSLLQMAGLLARLC :.. ...... : .... : . .... . .:.:.. ::. .: : . CCDS32 IDEGHAATQLVNQLHDVVVENNLSDKQKSIITEKLAEVDKCLADGADEHLQLISLCATVM 300 310 320 330 340 350 350 pF1KB6 QKTMAPVAS :. CCDS32 QQLSQNC 360 354 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 20:57:13 2016 done: Fri Nov 4 20:57:13 2016 Total Scan time: 2.670 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]