FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6474, 355 aa 1>>>pF1KB6474 355 - 355 aa - 355 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.7509+/-0.000978; mu= 13.3340+/- 0.059 mean_var=60.4250+/-11.994, 0's: 0 Z-trim(103.7): 24 B-trim: 0 in 0/48 Lambda= 0.164993 statistics sampled from 7521 (7531) to 7521 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.606), E-opt: 0.2 (0.231), width: 16 Scan time: 2.670 The best scores are: opt bits E(32554) CCDS5638.1 PON1 gene_id:5444|Hs108|chr7 ( 355) 2353 568.8 2.5e-162 CCDS5640.1 PON2 gene_id:5445|Hs108|chr7 ( 354) 1634 397.6 8.2e-111 CCDS5639.1 PON3 gene_id:5446|Hs108|chr7 ( 354) 1497 365.0 5.4e-101 CCDS47644.1 PON2 gene_id:5445|Hs108|chr7 ( 342) 1101 270.7 1.2e-72 >>CCDS5638.1 PON1 gene_id:5444|Hs108|chr7 (355 aa) initn: 2353 init1: 2353 opt: 2353 Z-score: 3027.8 bits: 568.8 E(32554): 2.5e-162 Smith-Waterman score: 2353; 100.0% identity (100.0% similar) in 355 aa overlap (1-355:1-355) 10 20 30 40 50 60 pF1KB6 MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL ::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS56 ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL 310 320 330 340 350 >>CCDS5640.1 PON2 gene_id:5445|Hs108|chr7 (354 aa) initn: 1642 init1: 1258 opt: 1634 Z-score: 2102.9 bits: 397.6 E(32554): 8.2e-111 Smith-Waterman score: 1634; 65.9% identity (89.0% similar) in 355 aa overlap (1-355:1-354) 10 20 30 40 50 60 pF1KB6 MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN :..:.:. :::..:::. .. . ..::.: :::. :.::.:.:.::::.::::..:::: CCDS56 MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF ::::.: :::.::..:: :..:: ::.:::.:: : . :: :. ::..:::::::::: CCDS56 GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRIS-RGFDLASFNPHGISTF 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG :.:...::.:::::. :.:::.:::.: :.:::::::..:.:::..:::.:::: :::. CCDS56 IDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYA 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL :::::: ::.:. : ::.: :. ::::::.::.::::::: ::::::::: ::.:.:.. CCDS56 TNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADI 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP :::.::: :::.: .:: :: :...:::::.:.:: .::.::::::::.:.: :: .::: CCDS56 LAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPP 240 250 260 270 280 290 310 320 330 340 350 pF1KB6 ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL .::::::::::.:.: :: :::.::.:::::.::::: :::::::..:.:::::: CCDS56 SSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL 300 310 320 330 340 350 >>CCDS5639.1 PON3 gene_id:5446|Hs108|chr7 (354 aa) initn: 1488 init1: 1102 opt: 1497 Z-score: 1926.6 bits: 365.0 E(32554): 5.4e-101 Smith-Waterman score: 1497; 60.8% identity (85.6% similar) in 355 aa overlap (1-355:1-354) 10 20 30 40 50 60 pF1KB6 MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN :.::.::.:::.::.: . ... :.:: :::.::: ::.:.. .:.::::..:::. CCDS56 MGKLVALVLLGVGLSLVGEMFLAFRERVNASREVEPVEPENCHLIEELESGSEDIDILPS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF :::::::::::::. .: :. ::::.::::::..: . : :.:. :: ::::::: : CCDS56 GLAFISSGLKYPGMPNFAPDEPGKIFLMDLNEQNPRAQALEISGG-FDKELFNPHGISIF 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG :.::..:: ::::: :::::.:::.:...::..::::.:.:: ..::::..:::.::. CCDS56 IDKDNTVYLYVVNHPHMKSTVEIFKFEEQQRSLVYLKTIKHELLKSVNDIVVLGPEQFYA 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL : :::: . :. .:: : : :.::..::: ::.:::.:: ::::..: : ::::.:.. CCDS56 TRDHYFTNSLLSFFEMILDLRWTYVLFYSPREVKVVAKGFCSANGITVSADQKYVYVADV 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP :..::..::: :: :: :: ....:::::..::: :::. .::::: ::.. :. :.:: CCDS56 AAKNIHIMEKHDNWDLTQLKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLNYNPEDPP 240 250 260 270 280 290 310 320 330 340 350 pF1KB6 ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL .::::::::.:.:.:.:. :::.::.::::..:::::.::.::::::::.::::: CCDS56 GSEVLRIQNVLSEKPRVSTVYANNGSVLQGTSVASVYHGKILIGTVFHKTLYCEL 300 310 320 330 340 350 >>CCDS47644.1 PON2 gene_id:5445|Hs108|chr7 (342 aa) initn: 1569 init1: 1101 opt: 1101 Z-score: 1417.5 bits: 270.7 E(32554): 1.2e-72 Smith-Waterman score: 1538; 63.7% identity (85.6% similar) in 355 aa overlap (1-355:1-342) 10 20 30 40 50 60 pF1KB6 MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN :..:.:. :::..:::. .. . ..::.: :::. :.::.:.:.::::.::::..:::: CCDS47 MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF ::::.: :::.::..:: :..:: ::.:::.:: : . :: :. ::..:::::::::: CCDS47 GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRIS-RGFDLASFNPHGISTF 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG :.. :.:::.:::.: :.:::::::..:.:::..:::.:::: :::. CCDS47 IDNE------------FKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYA 120 130 140 150 160 190 200 210 220 230 240 pF1KB6 TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL :::::: ::.:. : ::.: :. ::::::.::.::::::: ::::::::: ::.:.:.. CCDS47 TNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADI 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB6 LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP :::.::: :::.: .:: :: :...:::::.:.:: .::.::::::::.:.: :: .::: CCDS47 LAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPP 230 240 250 260 270 280 310 320 330 340 350 pF1KB6 ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL .::::::::::.:.: :: :::.::.:::::.::::: :::::::..:.:::::: CCDS47 SSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL 290 300 310 320 330 340 355 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 16:31:46 2016 done: Fri Nov 4 16:31:46 2016 Total Scan time: 2.670 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]