Result of FASTA (omim) for
pF1KB6474
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6474, 355 aa
1>>>pF1KB6474 355 - 355 aa - 355 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3409+/-0.000459; mu= 16.1204+/- 0.029
mean_var=65.3787+/-13.465, 0's: 0 Z-trim(110.8): 21 B-trim: 506 in 1/47
Lambda= 0.158619
statistics sampled from 19238 (19255) to 19238 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.594), E-opt: 0.2 (0.226), width: 16
Scan time: 6.710
The best scores are: opt bits E(85289)
NP_000437 (OMIM: 168820,612633) serum paraoxonase/ ( 355) 2353 547.5 1.6e-155
NP_000296 (OMIM: 602447) serum paraoxonase/arylest ( 354) 1634 383.0 5.5e-106
NP_000931 (OMIM: 602720) serum paraoxonase/lactona ( 354) 1497 351.6 1.5e-96
XP_016867846 (OMIM: 602447) PREDICTED: serum parao ( 284) 1343 316.3 5.1e-86
XP_005250510 (OMIM: 602447) PREDICTED: serum parao ( 286) 1343 316.3 5.1e-86
XP_016867847 (OMIM: 602447) PREDICTED: serum parao ( 268) 1298 306.0 6.1e-83
NP_001018171 (OMIM: 602447) serum paraoxonase/aryl ( 342) 1101 261.0 2.8e-69
>>NP_000437 (OMIM: 168820,612633) serum paraoxonase/aryl (355 aa)
initn: 2353 init1: 2353 opt: 2353 Z-score: 2913.0 bits: 547.5 E(85289): 1.6e-155
Smith-Waterman score: 2353; 100.0% identity (100.0% similar) in 355 aa overlap (1-355:1-355)
10 20 30 40 50 60
pF1KB6 MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP
250 260 270 280 290 300
310 320 330 340 350
pF1KB6 ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
310 320 330 340 350
>>NP_000296 (OMIM: 602447) serum paraoxonase/arylesteras (354 aa)
initn: 1642 init1: 1258 opt: 1634 Z-score: 2023.7 bits: 383.0 E(85289): 5.5e-106
Smith-Waterman score: 1634; 65.9% identity (89.0% similar) in 355 aa overlap (1-355:1-354)
10 20 30 40 50 60
pF1KB6 MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN
:..:.:. :::..:::. .. . ..::.: :::. :.::.:.:.::::.::::..::::
NP_000 MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF
::::.: :::.::..:: :..:: ::.:::.:: : . :: :. ::..::::::::::
NP_000 GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRIS-RGFDLASFNPHGISTF
70 80 90 100 110
130 140 150 160 170 180
pF1KB6 TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG
:.:...::.:::::. :.:::.:::.: :.:::::::..:.:::..:::.:::: :::.
NP_000 IDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYA
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB6 TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL
:::::: ::.:. : ::.: :. ::::::.::.::::::: ::::::::: ::.:.:..
NP_000 TNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADI
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB6 LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP
:::.::: :::.: .:: :: :...:::::.:.:: .::.::::::::.:.: :: .:::
NP_000 LAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPP
240 250 260 270 280 290
310 320 330 340 350
pF1KB6 ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
.::::::::::.:.: :: :::.::.:::::.::::: :::::::..:.::::::
NP_000 SSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL
300 310 320 330 340 350
>>NP_000931 (OMIM: 602720) serum paraoxonase/lactonase 3 (354 aa)
initn: 1488 init1: 1102 opt: 1497 Z-score: 1854.3 bits: 351.6 E(85289): 1.5e-96
Smith-Waterman score: 1497; 60.8% identity (85.6% similar) in 355 aa overlap (1-355:1-354)
10 20 30 40 50 60
pF1KB6 MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN
:.::.::.:::.::.: . ... :.:: :::.::: ::.:.. .:.::::..:::.
NP_000 MGKLVALVLLGVGLSLVGEMFLAFRERVNASREVEPVEPENCHLIEELESGSEDIDILPS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF
:::::::::::::. .: :. ::::.::::::..: . : :.:. :: ::::::: :
NP_000 GLAFISSGLKYPGMPNFAPDEPGKIFLMDLNEQNPRAQALEISGG-FDKELFNPHGISIF
70 80 90 100 110
130 140 150 160 170 180
pF1KB6 TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG
:.::..:: ::::: :::::.:::.:...::..::::.:.:: ..::::..:::.::.
NP_000 IDKDNTVYLYVVNHPHMKSTVEIFKFEEQQRSLVYLKTIKHELLKSVNDIVVLGPEQFYA
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB6 TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL
: :::: . :. .:: : : :.::..::: ::.:::.:: ::::..: : ::::.:..
NP_000 TRDHYFTNSLLSFFEMILDLRWTYVLFYSPREVKVVAKGFCSANGITVSADQKYVYVADV
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB6 LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP
:..::..::: :: :: :: ....:::::..::: :::. .::::: ::.. :. :.::
NP_000 AAKNIHIMEKHDNWDLTQLKVIQLGTLVDNLTVDPATGDILAGCHPNPMKLLNYNPEDPP
240 250 260 270 280 290
310 320 330 340 350
pF1KB6 ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
.::::::::.:.:.:.:. :::.::.::::..:::::.::.::::::::.:::::
NP_000 GSEVLRIQNVLSEKPRVSTVYANNGSVLQGTSVASVYHGKILIGTVFHKTLYCEL
300 310 320 330 340 350
>>XP_016867846 (OMIM: 602447) PREDICTED: serum paraoxona (284 aa)
initn: 1325 init1: 1258 opt: 1343 Z-score: 1665.3 bits: 316.3 E(85289): 5.1e-86
Smith-Waterman score: 1343; 68.5% identity (89.2% similar) in 279 aa overlap (77-355:7-284)
50 60 70 80 90 100
pF1KB6 GIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSK
: :..:: ::.:::.:: : . :: :. .
XP_016 MRAAEHFAPDKPGGILMMDLKEEKPRARELRISRG-
10 20 30
110 120 130 140 150 160
pF1KB6 FDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPN
::..:::::::::: :.:...::.:::::. :.:::.:::.: :.:::::::..:.:::.
XP_016 FDLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPS
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB6 LNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGI
.:::.:::: :::.:::::: ::.:. : ::.: :. ::::::.::.::::::: ::::
XP_016 VNDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGI
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB6 NISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHP
::::: ::.:.:..:::.::: :::.: .:: :: :...:::::.:.:: .::.::::::
XP_016 NISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHP
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB6 NGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTV
::.:.: :: .:::.::::::::::.:.: :: :::.::.:::::.::::: :::::::.
XP_016 NGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTL
220 230 240 250 260 270
350
pF1KB6 FHKALYCEL
.:.::::::
XP_016 YHRALYCEL
280
>>XP_005250510 (OMIM: 602447) PREDICTED: serum paraoxona (286 aa)
initn: 1325 init1: 1258 opt: 1343 Z-score: 1665.3 bits: 316.3 E(85289): 5.1e-86
Smith-Waterman score: 1343; 68.5% identity (89.2% similar) in 279 aa overlap (77-355:9-286)
50 60 70 80 90 100
pF1KB6 GIETGSEDLEILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSK
: :..:: ::.:::.:: : . :: :. .
XP_005 MVWLFLVCFAPDKPGGILMMDLKEEKPRARELRISRG-
10 20 30
110 120 130 140 150 160
pF1KB6 FDVSSFNPHGISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPN
::..:::::::::: :.:...::.:::::. :.:::.:::.: :.:::::::..:.:::.
XP_005 FDLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPS
40 50 60 70 80 90
170 180 190 200 210 220
pF1KB6 LNDIVAVGPEHFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGI
.:::.:::: :::.:::::: ::.:. : ::.: :. ::::::.::.::::::: ::::
XP_005 VNDITAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGI
100 110 120 130 140 150
230 240 250 260 270 280
pF1KB6 NISPDGKYVYIAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHP
::::: ::.:.:..:::.::: :::.: .:: :: :...:::::.:.:: .::.::::::
XP_005 NISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHP
160 170 180 190 200 210
290 300 310 320 330 340
pF1KB6 NGMKIFFYDSENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTV
::.:.: :: .:::.::::::::::.:.: :: :::.::.:::::.::::: :::::::.
XP_005 NGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTL
220 230 240 250 260 270
350
pF1KB6 FHKALYCEL
.:.::::::
XP_005 YHRALYCEL
280
>>XP_016867847 (OMIM: 602447) PREDICTED: serum paraoxona (268 aa)
initn: 1296 init1: 1258 opt: 1298 Z-score: 1610.0 bits: 306.0 E(85289): 6.1e-83
Smith-Waterman score: 1298; 68.8% identity (89.2% similar) in 269 aa overlap (87-355:1-268)
60 70 80 90 100 110
pF1KB6 ILPNGLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHG
.:::.:: : . :: :. ::..::::::
XP_016 MMDLKEEKPRARELRIS-RGFDLASFNPHG
10 20
120 130 140 150 160 170
pF1KB6 ISTFTDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPE
:::: :.:...::.:::::. :.:::.:::.: :.:::::::..:.:::..:::.::::
XP_016 ISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPA
30 40 50 60 70 80
180 190 200 210 220 230
pF1KB6 HFYGTNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVY
:::.:::::: ::.:. : ::.: :. ::::::.::.::::::: ::::::::: ::.:
XP_016 HFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIY
90 100 110 120 130 140
240 250 260 270 280 290
pF1KB6 IAELLAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDS
.:..:::.::: :::.: .:: :: :...:::::.:.:: .::.::::::::.:.: ::
XP_016 VADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDP
150 160 170 180 190 200
300 310 320 330 340 350
pF1KB6 ENPPASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
.:::.::::::::::.:.: :: :::.::.:::::.::::: :::::::..:.::::::
XP_016 NNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL
210 220 230 240 250 260
>>NP_001018171 (OMIM: 602447) serum paraoxonase/aryleste (342 aa)
initn: 1569 init1: 1101 opt: 1101 Z-score: 1364.8 bits: 261.0 E(85289): 2.8e-69
Smith-Waterman score: 1538; 63.7% identity (85.6% similar) in 355 aa overlap (1-355:1-342)
10 20 30 40 50 60
pF1KB6 MAKLIALTLLGMGLALFRNHQSSYQTRLNALREVQPVELPNCNLVKGIETGSEDLEILPN
:..:.:. :::..:::. .. . ..::.: :::. :.::.:.:.::::.::::..::::
NP_001 MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GLAFISSGLKYPGIKSFNPNSPGKILLMDLNEEDPTVLELGITGSKFDVSSFNPHGISTF
::::.: :::.::..:: :..:: ::.:::.:: : . :: :. ::..::::::::::
NP_001 GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRIS-RGFDLASFNPHGISTF
70 80 90 100 110
130 140 150 160 170 180
pF1KB6 TDEDNAMYLLVVNHPDAKSTVELFKFQEEEKSLLHLKTIRHKLLPNLNDIVAVGPEHFYG
:.. :.:::.:::.: :.:::::::..:.:::..:::.:::: :::.
NP_001 IDNE------------FKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYA
120 130 140 150 160
190 200 210 220 230 240
pF1KB6 TNDHYFLDPYLQSWEMYLGLAWSYVVYYSPSEVRVVAEGFDFANGINISPDGKYVYIAEL
:::::: ::.:. : ::.: :. ::::::.::.::::::: ::::::::: ::.:.:..
NP_001 TNDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADI
170 180 190 200 210 220
250 260 270 280 290 300
pF1KB6 LAHKIHVYEKHANWTLTPLKSLDFNTLVDNISVDPETGDLWVGCHPNGMKIFFYDSENPP
:::.::: :::.: .:: :: :...:::::.:.:: .::.::::::::.:.: :: .:::
NP_001 LAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPP
230 240 250 260 270 280
310 320 330 340 350
pF1KB6 ASEVLRIQNILTEEPKVTQVYAENGTVLQGSTVASVYKGKLLIGTVFHKALYCEL
.::::::::::.:.: :: :::.::.:::::.::::: :::::::..:.::::::
NP_001 SSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL
290 300 310 320 330 340
355 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 16:31:46 2016 done: Fri Nov 4 16:31:47 2016
Total Scan time: 6.710 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]