FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6485, 328 aa 1>>>pF1KB6485 328 - 328 aa - 328 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5574+/-0.000879; mu= 14.3521+/- 0.053 mean_var=68.3590+/-14.055, 0's: 0 Z-trim(106.4): 23 B-trim: 361 in 1/50 Lambda= 0.155123 statistics sampled from 8972 (8989) to 8972 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.276), width: 16 Scan time: 2.790 The best scores are: opt bits E(32554) CCDS11287.1 RAD51D gene_id:5892|Hs108|chr17 ( 328) 2075 473.4 1.1e-133 CCDS45646.1 RAD51D gene_id:5892|Hs108|chr17 ( 348) 1531 351.6 5.2e-97 CCDS11288.1 RAD51D gene_id:5892|Hs108|chr17 ( 216) 1069 248.1 4.6e-66 CCDS9790.1 RAD51B gene_id:5890|Hs108|chr14 ( 350) 311 78.6 8.2e-15 CCDS9789.1 RAD51B gene_id:5890|Hs108|chr14 ( 384) 311 78.6 8.8e-15 CCDS81815.1 RAD51B gene_id:5890|Hs108|chr14 ( 425) 311 78.6 9.6e-15 >>CCDS11287.1 RAD51D gene_id:5892|Hs108|chr17 (328 aa) initn: 2075 init1: 2075 opt: 2075 Z-score: 2513.4 bits: 473.4 E(32554): 1.1e-133 Smith-Waterman score: 2075; 100.0% identity (100.0% similar) in 328 aa overlap (1-328:1-328) 10 20 30 40 50 60 pF1KB6 MGVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKALVALRRVLLAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MGVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKALVALRRVLLAQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 FSAFPVNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGEVTEIVGGPGSGKTQVCLCM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 FSAFPVNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGEVTEIVGGPGSGKTQVCLCM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 AANVAHGLQQNVLYVDSNGGLTASRLLQLLQAKTQDEEEQAEALRRIQVVHAFDIFQMLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 AANVAHGLQQNVLYVDSNGGLTASRLLQLLQAKTQDEEEQAEALRRIQVVHAFDIFQMLD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 VLQELRGTVAQQVTGSSGTVKVVVVDSVTAVVSPLLGGQQREGLALMMQLARELKTLARD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 VLQELRGTVAQQVTGSSGTVKVVVVDSVTAVVSPLLGGQQREGLALMMQLARELKTLARD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 LGMAVVVTNHITRDRDSGRLKPALGRSWSFVPSTRILLDTIEGAGASGGRRMACLAKSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LGMAVVVTNHITRDRDSGRLKPALGRSWSFVPSTRILLDTIEGAGASGGRRMACLAKSSR 250 260 270 280 290 300 310 320 pF1KB6 QPTGFQEMVDIGTWGTSEQSATLQGDQT :::::::::::::::::::::::::::: CCDS11 QPTGFQEMVDIGTWGTSEQSATLQGDQT 310 320 >>CCDS45646.1 RAD51D gene_id:5892|Hs108|chr17 (348 aa) initn: 1824 init1: 1530 opt: 1531 Z-score: 1855.1 bits: 351.6 E(32554): 5.2e-97 Smith-Waterman score: 1783; 85.6% identity (89.4% similar) in 348 aa overlap (1-328:1-348) 10 20 30 40 50 pF1KB6 MGVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKALVALRRVLLA- ::::::::::::::::::::::::::::::::::::::::::::::::. : :. CCDS45 MGVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKTWRAHSSGNLGG 10 20 30 40 50 60 60 70 80 90 100 pF1KB6 -QFSAFPV--NGADLYEELKTS------TAILS--------TGIGS--LDKLLDAGLYTG :. :. . . . . :: . : :: :.... :::::::::::: CCDS45 LQLPQVPAGRSWSGVRNALKKAGLGHGGTDGLSLNAFDERGTAVSTSRLDKLLDAGLYTG 70 80 90 100 110 120 110 120 130 140 150 160 pF1KB6 EVTEIVGGPGSGKTQVCLCMAANVAHGLQQNVLYVDSNGGLTASRLLQLLQAKTQDEEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 EVTEIVGGPGSGKTQVCLCMAANVAHGLQQNVLYVDSNGGLTASRLLQLLQAKTQDEEEQ 130 140 150 160 170 180 170 180 190 200 210 220 pF1KB6 AEALRRIQVVHAFDIFQMLDVLQELRGTVAQQVTGSSGTVKVVVVDSVTAVVSPLLGGQQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 AEALRRIQVVHAFDIFQMLDVLQELRGTVAQQVTGSSGTVKVVVVDSVTAVVSPLLGGQQ 190 200 210 220 230 240 230 240 250 260 270 280 pF1KB6 REGLALMMQLARELKTLARDLGMAVVVTNHITRDRDSGRLKPALGRSWSFVPSTRILLDT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 REGLALMMQLARELKTLARDLGMAVVVTNHITRDRDSGRLKPALGRSWSFVPSTRILLDT 250 260 270 280 290 300 290 300 310 320 pF1KB6 IEGAGASGGRRMACLAKSSRQPTGFQEMVDIGTWGTSEQSATLQGDQT :::::::::::::::::::::::::::::::::::::::::::::::: CCDS45 IEGAGASGGRRMACLAKSSRQPTGFQEMVDIGTWGTSEQSATLQGDQT 310 320 330 340 >>CCDS11288.1 RAD51D gene_id:5892|Hs108|chr17 (216 aa) initn: 1069 init1: 1069 opt: 1069 Z-score: 1299.5 bits: 248.1 E(32554): 4.6e-66 Smith-Waterman score: 1141; 65.9% identity (65.9% similar) in 328 aa overlap (1-328:1-216) 10 20 30 40 50 60 pF1KB6 MGVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKALVALRRVLLAQ ::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 MGVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKA----------- 10 20 30 40 70 80 90 100 110 120 pF1KB6 FSAFPVNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGEVTEIVGGPGSGKTQVCLCM CCDS11 ------------------------------------------------------------ 130 140 150 160 170 180 pF1KB6 AANVAHGLQQNVLYVDSNGGLTASRLLQLLQAKTQDEEEQAEALRRIQVVHAFDIFQMLD ::::::::::::::::::: CCDS11 -----------------------------------------EALRRIQVVHAFDIFQMLD 50 60 190 200 210 220 230 240 pF1KB6 VLQELRGTVAQQVTGSSGTVKVVVVDSVTAVVSPLLGGQQREGLALMMQLARELKTLARD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 VLQELRGTVAQQVTGSSGTVKVVVVDSVTAVVSPLLGGQQREGLALMMQLARELKTLARD 70 80 90 100 110 120 250 260 270 280 290 300 pF1KB6 LGMAVVVTNHITRDRDSGRLKPALGRSWSFVPSTRILLDTIEGAGASGGRRMACLAKSSR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS11 LGMAVVVTNHITRDRDSGRLKPALGRSWSFVPSTRILLDTIEGAGASGGRRMACLAKSSR 130 140 150 160 170 180 310 320 pF1KB6 QPTGFQEMVDIGTWGTSEQSATLQGDQT :::::::::::::::::::::::::::: CCDS11 QPTGFQEMVDIGTWGTSEQSATLQGDQT 190 200 210 >>CCDS9790.1 RAD51B gene_id:5890|Hs108|chr14 (350 aa) initn: 257 init1: 131 opt: 311 Z-score: 379.5 bits: 78.6 E(32554): 8.2e-15 Smith-Waterman score: 326; 28.1% identity (57.6% similar) in 356 aa overlap (11-327:10-348) 10 20 30 40 50 60 pF1KB6 MGVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKALVALRRVLLAQ ::..:. . : :.: : :.. . :. . ::::... : .... CCDS97 MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHELL-CMVSR 10 20 30 40 50 70 80 90 100 110 pF1KB6 FSAFPVNGADLYEELKT---STAILSTGIGSLDKLLDAGLYTGEVTEIVGGPGSGKTQVC : .. : . .. : :.::: ...::. : .:. : .:::.: :: :::: : CCDS97 ACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFC 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 LCMA------ANVAHGLQQNVLYVDSNGGLTASRLLQLLQAKTQDEEEQAEALRRIQV-V . :. .:.. ::. :.:.:......: ::... ... . : : . : CCDS97 IMMSILATLPTNMG-GLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSKV 120 130 140 150 160 170 180 190 200 210 220 pF1KB6 HAFDIFQMLDVLQELRGTVAQQVTGSSGTVKVVVVDSVTAVV----SPLLGGQQREGLAL : . . .:::... .. ... :.: .:.:..:::..:: . : :. .: . CCDS97 HLYRELTCDEVLQRIE-SLEEEII-SKG-IKLVILDSVASVVRKEFDAQLQGNLKERNKF 180 190 200 210 220 230 230 240 250 260 pF1KB6 MMQLARELKTLARDLGMAVVVTNHITRDRDSGRL-------KPA---------------- . . : :: ::..... :..::.:: . :: : .:: CCDS97 LAREASSLKYLAEEFSIPVILTNQITT-HLSGALASQADLVSPADDLSLSEGTSGSSCVI 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB6 --LGRSWSFVPSTRILLDTIEGAGASGGRRMACLAKSSRQPTGFQEMVDIGTWGTSEQSA :: .:: .::..:. ... ::. .::: : : .: . .:.. CCDS97 AALGNTWSHSVNTRLILQYLDSE-----RRQILIAKSPLAP--FTSFV----YTIKEEGL 300 310 320 330 340 pF1KB6 TLQGDQT .:::.. CCDS97 VLQGQEKP 350 >>CCDS9789.1 RAD51B gene_id:5890|Hs108|chr14 (384 aa) initn: 257 init1: 131 opt: 311 Z-score: 378.8 bits: 78.6 E(32554): 8.8e-15 Smith-Waterman score: 321; 28.6% identity (56.8% similar) in 336 aa overlap (11-305:10-333) 10 20 30 40 50 60 pF1KB6 MGVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKALVALRRVLLAQ ::..:. . : :.: : :.. . :. . ::::... : . ... CCDS97 MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHEL--LCMVS 10 20 30 40 50 70 80 90 100 110 pF1KB6 FSAFP----VNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGEVTEIVGGPGSGKTQV . : . : . : :.::: ...::. : .:. : .:::.: :: :::: CCDS97 RACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQF 60 70 80 90 100 110 120 130 140 150 160 pF1KB6 CLCMA------ANVAHGLQQNVLYVDSNGGLTASRLLQLLQAKTQDEEEQAEALRRIQV- :. :. .:.. ::. :.:.:......: ::... ... . : : . CCDS97 CIMMSILATLPTNMG-GLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB6 VHAFDIFQMLDVLQELRGTVAQQVTGSSGTVKVVVVDSVTAVV----SPLLGGQQREGLA :: . . .:::... .. ... :.: .:.:..:::..:: . : :. .: CCDS97 VHLYRELTCDEVLQRIE-SLEEEII-SKG-IKLVILDSVASVVRKEFDAQLQGNLKERNK 180 190 200 210 220 230 230 240 250 260 pF1KB6 LMMQLARELKTLARDLGMAVVVTNHITRDRDSGRL-------KPA--------------- .. . : :: ::..... :..::.:: :: : .:: CCDS97 FLAREASSLKYLAEEFSIPVILTNQITTHL-SGALASQADLVSPADDLSLSEGTSGSSCV 240 250 260 270 280 290 270 280 290 300 310 pF1KB6 ---LGRSWSFVPSTRILLDTIEGAGASGGRRMACLAKSSRQP-TGFQEMVDIGTWGTSEQ :: .:: .::..:. ... ::. .::: : :.: CCDS97 IAALGNTWSHSVNTRLILQYLDSE-----RRQILIAKSPLAPFTSFVYTIKEEGLVLQET 300 310 320 330 340 320 pF1KB6 SATLQGDQT CCDS97 TFCSVTQAELNWAPEILPPQPPEQLGLQMCHHTQLIF 350 360 370 380 >>CCDS81815.1 RAD51B gene_id:5890|Hs108|chr14 (425 aa) initn: 257 init1: 131 opt: 311 Z-score: 378.1 bits: 78.6 E(32554): 9.6e-15 Smith-Waterman score: 321; 28.6% identity (56.8% similar) in 336 aa overlap (11-305:10-333) 10 20 30 40 50 60 pF1KB6 MGVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKALVALRRVLLAQ ::..:. . : :.: : :.. . :. . ::::... : . ... CCDS81 MGSKKLKRVGLSQELCDRLSRHQILTCQDFLCLSPLELMKVTGLSYRGVHEL--LCMVS 10 20 30 40 50 70 80 90 100 110 pF1KB6 FSAFP----VNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGEVTEIVGGPGSGKTQV . : . : . : :.::: ...::. : .:. : .:::.: :: :::: CCDS81 RACAPKMQTAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQF 60 70 80 90 100 110 120 130 140 150 160 pF1KB6 CLCMA------ANVAHGLQQNVLYVDSNGGLTASRLLQLLQAKTQDEEEQAEALRRIQV- :. :. .:.. ::. :.:.:......: ::... ... . : : . CCDS81 CIMMSILATLPTNMG-GLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSK 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB6 VHAFDIFQMLDVLQELRGTVAQQVTGSSGTVKVVVVDSVTAVV----SPLLGGQQREGLA :: . . .:::... .. ... :.: .:.:..:::..:: . : :. .: CCDS81 VHLYRELTCDEVLQRIE-SLEEEII-SKG-IKLVILDSVASVVRKEFDAQLQGNLKERNK 180 190 200 210 220 230 230 240 250 260 pF1KB6 LMMQLARELKTLARDLGMAVVVTNHITRDRDSGRL-------KPA--------------- .. . : :: ::..... :..::.:: :: : .:: CCDS81 FLAREASSLKYLAEEFSIPVILTNQITTHL-SGALASQADLVSPADDLSLSEGTSGSSCV 240 250 260 270 280 290 270 280 290 300 310 pF1KB6 ---LGRSWSFVPSTRILLDTIEGAGASGGRRMACLAKSSRQP-TGFQEMVDIGTWGTSEQ :: .:: .::..:. ... ::. .::: : :.: CCDS81 IAALGNTWSHSVNTRLILQYLDSE-----RRQILIAKSPLAPFTSFVYTIKEEGLVLQVV 300 310 320 330 340 320 pF1KB6 SATLQGDQT CCDS81 RTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLLPSVSMCPPQMHSTVLSSALP 350 360 370 380 390 400 328 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 21:00:24 2016 done: Fri Nov 4 21:00:25 2016 Total Scan time: 2.790 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]