Result of FASTA (omim) for
pF1KB6493
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6493, 331 aa
1>>>pF1KB6493 331 - 331 aa - 331 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1992+/-0.000375; mu= 15.6596+/- 0.023
mean_var=55.7893+/-11.114, 0's: 0 Z-trim(112.5): 13 B-trim: 0 in 0/50
Lambda= 0.171711
statistics sampled from 21437 (21446) to 21437 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.251), width: 16
Scan time: 7.580
The best scores are: opt bits E(85289)
NP_004573 (OMIM: 179080) geranylgeranyl transferas ( 331) 2284 574.0 1.5e-163
NP_005014 (OMIM: 602031) geranylgeranyl transferas ( 377) 452 120.2 6.9e-27
XP_005272077 (OMIM: 602031) PREDICTED: geranylgera ( 381) 452 120.2 7e-27
XP_011541792 (OMIM: 602031) PREDICTED: geranylgera ( 408) 452 120.2 7.4e-27
XP_011541794 (OMIM: 602031) PREDICTED: geranylgera ( 285) 446 118.7 1.5e-26
NP_002019 (OMIM: 134636) protein farnesyltransfera ( 437) 421 112.5 1.6e-24
>>NP_004573 (OMIM: 179080) geranylgeranyl transferase ty (331 aa)
initn: 2284 init1: 2284 opt: 2284 Z-score: 3057.3 bits: 574.0 E(85289): 1.5e-163
Smith-Waterman score: 2284; 100.0% identity (100.0% similar) in 331 aa overlap (1-331:1-331)
10 20 30 40 50 60
pF1KB6 MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLM
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDVNKVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDVNKVV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 EYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 FGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 YSWWVLASLKIIGRLHWIDREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YSWWVLASLKIIGRLHWIDREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSL
250 260 270 280 290 300
310 320 330
pF1KB6 LGEEQIKPVNPVFCMPEEVLQRVNVQPELVS
:::::::::::::::::::::::::::::::
NP_004 LGEEQIKPVNPVFCMPEEVLQRVNVQPELVS
310 320 330
>>NP_005014 (OMIM: 602031) geranylgeranyl transferase ty (377 aa)
initn: 463 init1: 252 opt: 452 Z-score: 603.7 bits: 120.2 E(85289): 6.9e-27
Smith-Waterman score: 477; 30.3% identity (60.6% similar) in 317 aa overlap (39-323:40-354)
10 20 30 40 50 60
pF1KB6 IIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNR
: : :.. ...:. .:.. .: .:.
NP_005 AGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNK
10 20 30 40 50 60
70 80 90 100
pF1KB6 EEILAFIKSCQ----------HECG-------GISASIGHDP---------HLLYTLSAV
..:. .: : : ..:: :: . .. : :. .: ...
NP_005 DDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGL
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB6 QILT-LYDSINVIDVNKVVEYVKGLQKEDGSFAGDIWG-EIDTRFSFCAVATLALLGKLD
. :. : :... .. . . ...:: ::::: . : : : :: .:: .:.. .
NP_005 SCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWS
130 140 150 160 170 180
170 180 190 200 210
pF1KB6 AINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDL----LG
.....::: .. :..:.:.. : :::.:. .: . : . ..:..: :. .
NP_005 GMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIK
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB6 WWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRNFILACQDEETG
: :: ..: .:::.: :.:::.:: :.::.. ... . :: ::.::. ::. .:
NP_005 RWCIMRQ--QNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVG
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB6 GFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVNPVFCMPEEVLQRVNVQPELVS
::: : . : .:. ::: ::::. : : :.:.. . .. .:.
NP_005 GFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSK
310 320 330 340 350 360
NP_005 QCSENVHIST
370
>>XP_005272077 (OMIM: 602031) PREDICTED: geranylgeranyl (381 aa)
initn: 463 init1: 252 opt: 452 Z-score: 603.6 bits: 120.2 E(85289): 7e-27
Smith-Waterman score: 477; 30.3% identity (60.6% similar) in 317 aa overlap (39-323:40-354)
10 20 30 40 50 60
pF1KB6 IIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNR
: : :.. ...:. .:.. .: .:.
XP_005 AGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNK
10 20 30 40 50 60
70 80 90 100
pF1KB6 EEILAFIKSCQ----------HECG-------GISASIGHDP---------HLLYTLSAV
..:. .: : : ..:: :: . .. : :. .: ...
XP_005 DDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGL
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB6 QILT-LYDSINVIDVNKVVEYVKGLQKEDGSFAGDIWG-EIDTRFSFCAVATLALLGKLD
. :. : :... .. . . ...:: ::::: . : : : :: .:: .:.. .
XP_005 SCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWS
130 140 150 160 170 180
170 180 190 200 210
pF1KB6 AINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDL----LG
.....::: .. :..:.:.. : :::.:. .: . : . ..:..: :. .
XP_005 GMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIK
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB6 WWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRNFILACQDEETG
: :: ..: .:::.: :.:::.:: :.::.. ... . :: ::.::. ::. .:
XP_005 RWCIMRQ--QNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVG
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB6 GFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVNPVFCMPEEVLQRVNVQPELVS
::: : . : .:. ::: ::::. : : :.:.. . .. .:.
XP_005 GFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSK
310 320 330 340 350 360
XP_005 QCSENVESYNQISC
370 380
>>XP_011541792 (OMIM: 602031) PREDICTED: geranylgeranyl (408 aa)
initn: 463 init1: 252 opt: 452 Z-score: 603.1 bits: 120.2 E(85289): 7.4e-27
Smith-Waterman score: 477; 30.3% identity (60.6% similar) in 317 aa overlap (39-323:40-354)
10 20 30 40 50 60
pF1KB6 IIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYWGLTVMDLMGQLHRMNR
: : :.. ...:. .:.. .: .:.
XP_011 AGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNK
10 20 30 40 50 60
70 80 90 100
pF1KB6 EEILAFIKSCQ----------HECG-------GISASIGHDP---------HLLYTLSAV
..:. .: : : ..:: :: . .. : :. .: ...
XP_011 DDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGL
70 80 90 100 110 120
110 120 130 140 150 160
pF1KB6 QILT-LYDSINVIDVNKVVEYVKGLQKEDGSFAGDIWG-EIDTRFSFCAVATLALLGKLD
. :. : :... .. . . ...:: ::::: . : : : :: .:: .:.. .
XP_011 SCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWS
130 140 150 160 170 180
170 180 190 200 210
pF1KB6 AINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDL----LG
.....::: .. :..:.:.. : :::.:. .: . : . ..:..: :. .
XP_011 GMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIK
190 200 210 220 230 240
220 230 240 250 260 270
pF1KB6 WWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRNFILACQDEETG
: :: ..: .:::.: :.:::.:: :.::.. ... . :: ::.::. ::. .:
XP_011 RWCIMRQ--QNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVG
250 260 270 280 290 300
280 290 300 310 320 330
pF1KB6 GFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVNPVFCMPEEVLQRVNVQPELVS
::: : . : .:. ::: ::::. : : :.:.. . .. .:.
XP_011 GFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSK
310 320 330 340 350 360
XP_011 QCSENKEFPGLKDLCFKNIGSYCQELPSRNSVAIHKLNNKV
370 380 390 400
>>XP_011541794 (OMIM: 602031) PREDICTED: geranylgeranyl (285 aa)
initn: 463 init1: 252 opt: 446 Z-score: 597.6 bits: 118.7 E(85289): 1.5e-26
Smith-Waterman score: 446; 34.2% identity (65.3% similar) in 225 aa overlap (104-323:9-231)
80 90 100 110 120 130
pF1KB6 FIKSCQHECGGISASIGHDPHLLYTLSAVQILTLYDSINVIDVNKVVEYVKGLQKEDGSF
.. : :... .. . . ...:: :::::
XP_011 MTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSF
10 20 30
140 150 160 170 180 190
pF1KB6 AGDIWG-EIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAG
. : : : :: .:: .:.. ......::: .. :..:.:.. : :::.:
XP_011 CAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGG
40 50 60 70 80 90
200 210 220 230 240
pF1KB6 QIYCCTGFLAITSQLHQVNSDL----LGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLAS
. .: . : . ..:..: :. . : :: ..: .:::.: :.:::.:: :.
XP_011 STFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQ--QNGYHGRPNKPVDTCYSFWVGAT
100 110 120 130 140 150
250 260 270 280 290 300
pF1KB6 LKIIGRLHWIDREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKP
::.. ... . :: ::.::. ::. .:::: : . : .:. ::: ::::. : :
XP_011 LKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICK
160 170 180 190 200 210
310 320 330
pF1KB6 VNPVFCMPEEVLQRVNVQPELVS
:.:.. . .. .:.
XP_011 VHPALNVSTRTSERLLDLHQSWKTKDSKQCSENKEFPGLKDLCFKNIGSYCQELPSRNSV
220 230 240 250 260 270
>>NP_002019 (OMIM: 134636) protein farnesyltransferase s (437 aa)
initn: 490 init1: 209 opt: 421 Z-score: 561.1 bits: 112.5 E(85289): 1.6e-24
Smith-Waterman score: 521; 29.9% identity (59.5% similar) in 338 aa overlap (21-321:76-410)
10 20 30 40
pF1KB6 MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKK--DDYEYCMSEYLRMS
::: :. . : .. : :: :. . :
NP_002 IEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYL-KRGLRQLTDAYE-CL-DASRPW
50 60 70 80 90 100
50 60 70 80 90 100
pF1KB6 GIYWGLTVMDLMGQ-LHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTL
:: : ..:. . . .. .. :.. :: ::.... :. ::: : .::. : .
NP_002 LCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCI
110 120 130 140 150 160
110 120 130 140 150 160
pF1KB6 Y---DSINVIDVNKVVEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINV
.. ..:. .:...:. .:.. :::: . ::.:.: ..::... .: . .
NP_002 IGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLF
170 180 190 200 210 220
170 180 190 200 210 220
pF1KB6 EKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQL
: . :.. :.:..::.: :: :.:.: .: . :.: .. ...: : :. ::.
NP_002 EGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQM
230 240 250 260 270 280
230 240 250 260 270
pF1KB6 P-SGGLNGRPEKLPDVCYSWWVLASLKIIGRL------------HWI-DREKLRNFILAC
::..:: .:: : :::.: . : .. : ::. .. :...:: :
NP_002 RFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMC
290 300 310 320 330 340
280 290 300 310
pF1KB6 QDEETGGFADRPGDMVDPFHTLFGIAGLSL--------------LG--EEQIKPVNPVFC
. .::. :.:: : .:: . ..:::. :: :. ..:..::.
NP_002 CQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYN
350 360 370 380 390 400
320 330
pF1KB6 M-PEEVLQRVNVQPELVS
. :..:.:
NP_002 IGPDKVIQATTYFLQKPVPGFEELKDETSAEPATD
410 420 430
331 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 21:02:14 2016 done: Fri Nov 4 21:02:15 2016
Total Scan time: 7.580 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]