FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6501, 358 aa 1>>>pF1KB6501 358 - 358 aa - 358 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 9.5506+/-0.000522; mu= -3.9874+/- 0.031 mean_var=554.7778+/-126.427, 0's: 0 Z-trim(118.2): 1764 B-trim: 33 in 1/54 Lambda= 0.054452 statistics sampled from 28358 (30858) to 28358 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.715), E-opt: 0.2 (0.362), width: 16 Scan time: 8.480 The best scores are: opt bits E(85289) NP_005035 (OMIM: 300083) cAMP-dependent protein ki ( 358) 2455 208.0 2.6e-53 XP_005271076 (OMIM: 176892) PREDICTED: cAMP-depend ( 338) 1238 112.4 1.5e-24 NP_001229787 (OMIM: 176892) cAMP-dependent protein ( 339) 1238 112.4 1.5e-24 XP_005271075 (OMIM: 176892) PREDICTED: cAMP-depend ( 346) 1238 112.4 1.5e-24 XP_005271074 (OMIM: 176892) PREDICTED: cAMP-depend ( 347) 1238 112.4 1.5e-24 XP_005271073 (OMIM: 176892) PREDICTED: cAMP-depend ( 349) 1238 112.4 1.5e-24 XP_005271072 (OMIM: 176892) PREDICTED: cAMP-depend ( 350) 1238 112.4 1.6e-24 NP_002722 (OMIM: 176892) cAMP-dependent protein ki ( 351) 1238 112.4 1.6e-24 XP_006710821 (OMIM: 176892) PREDICTED: cAMP-depend ( 354) 1238 112.4 1.6e-24 NP_001229788 (OMIM: 176892) cAMP-dependent protein ( 355) 1238 112.4 1.6e-24 NP_001229789 (OMIM: 176892) cAMP-dependent protein ( 357) 1238 112.4 1.6e-24 NP_001229786 (OMIM: 176892) cAMP-dependent protein ( 358) 1238 112.4 1.6e-24 NP_891993 (OMIM: 176892) cAMP-dependent protein ki ( 398) 1238 112.5 1.7e-24 NP_002721 (OMIM: 601639,615830) cAMP-dependent pro ( 351) 1235 112.2 1.8e-24 NP_001229791 (OMIM: 176892) cAMP-dependent protein ( 338) 1234 112.1 1.9e-24 NP_997401 (OMIM: 601639,615830) cAMP-dependent pro ( 343) 1229 111.7 2.5e-24 NP_001291278 (OMIM: 601639,615830) cAMP-dependent ( 427) 1229 111.8 2.8e-24 NP_002723 (OMIM: 176893,616176) cAMP-dependent pro ( 351) 1149 105.4 2e-22 NP_001229790 (OMIM: 176892) cAMP-dependent protein ( 321) 1008 94.3 4.1e-19 XP_016871902 (OMIM: 176894,615436) PREDICTED: cGMP ( 585) 1000 94.1 8.6e-19 XP_016871901 (OMIM: 176894,615436) PREDICTED: cGMP ( 591) 1000 94.1 8.7e-19 NP_001091982 (OMIM: 176894,615436) cGMP-dependent ( 671) 1000 94.2 9.3e-19 NP_006249 (OMIM: 176894,615436) cGMP-dependent pro ( 686) 1000 94.2 9.4e-19 NP_001269409 (OMIM: 601591) cGMP-dependent protein ( 342) 957 90.3 6.8e-18 NP_001269410 (OMIM: 601591) cGMP-dependent protein ( 342) 957 90.3 6.8e-18 XP_005263183 (OMIM: 601591) PREDICTED: cGMP-depend ( 762) 957 90.9 1e-17 NP_006250 (OMIM: 601591) cGMP-dependent protein ki ( 762) 957 90.9 1e-17 XP_016857208 (OMIM: 176892) PREDICTED: cAMP-depend ( 245) 924 87.5 3.4e-17 XP_016857207 (OMIM: 176892) PREDICTED: cAMP-depend ( 246) 924 87.5 3.4e-17 XP_016857203 (OMIM: 176892) PREDICTED: cAMP-depend ( 256) 924 87.5 3.5e-17 XP_016857202 (OMIM: 176892) PREDICTED: cAMP-depend ( 258) 924 87.5 3.5e-17 XP_016857199 (OMIM: 176892) PREDICTED: cAMP-depend ( 261) 924 87.5 3.5e-17 XP_016857198 (OMIM: 176892) PREDICTED: cAMP-depend ( 262) 924 87.5 3.6e-17 NP_001287844 (OMIM: 176892) cAMP-dependent protein ( 264) 924 87.5 3.6e-17 XP_016857195 (OMIM: 176892) PREDICTED: cAMP-depend ( 265) 924 87.5 3.6e-17 XP_016882437 (OMIM: 601639,615830) PREDICTED: cAMP ( 296) 924 87.6 3.8e-17 XP_005271077 (OMIM: 176892) PREDICTED: cAMP-depend ( 305) 924 87.6 3.8e-17 XP_016857209 (OMIM: 176892) PREDICTED: cAMP-depend ( 244) 917 86.9 5e-17 NP_001287846 (OMIM: 176892) cAMP-dependent protein ( 245) 917 86.9 5e-17 XP_016857206 (OMIM: 176892) PREDICTED: cAMP-depend ( 252) 917 87.0 5.1e-17 XP_016857205 (OMIM: 176892) PREDICTED: cAMP-depend ( 253) 917 87.0 5.1e-17 XP_016857204 (OMIM: 176892) PREDICTED: cAMP-depend ( 255) 917 87.0 5.1e-17 NP_997461 (OMIM: 176892) cAMP-dependent protein ki ( 257) 917 87.0 5.2e-17 XP_016857201 (OMIM: 176892) PREDICTED: cAMP-depend ( 260) 917 87.0 5.2e-17 XP_016857200 (OMIM: 176892) PREDICTED: cAMP-depend ( 261) 917 87.0 5.2e-17 XP_016857197 (OMIM: 176892) PREDICTED: cAMP-depend ( 263) 917 87.0 5.2e-17 XP_016857196 (OMIM: 176892) PREDICTED: cAMP-depend ( 264) 917 87.0 5.2e-17 NP_001287845 (OMIM: 176892) cAMP-dependent protein ( 304) 917 87.1 5.6e-17 XP_016863905 (OMIM: 601591) PREDICTED: cGMP-depend ( 774) 922 88.1 7e-17 XP_016863904 (OMIM: 601591) PREDICTED: cGMP-depend ( 774) 922 88.1 7e-17 >>NP_005035 (OMIM: 300083) cAMP-dependent protein kinase (358 aa) initn: 2455 init1: 2455 opt: 2455 Z-score: 1078.1 bits: 208.0 E(85289): 2.6e-53 Smith-Waterman score: 2455; 99.7% identity (100.0% similar) in 358 aa overlap (1-358:1-358) 10 20 30 40 50 60 pF1KB6 MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPAYSLQDFDTLATVGTGTF ::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::: NP_005 MEAPGLAQAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPVYSLQDFDTLATVGTGTF 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDER :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 GRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDER 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 FLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSG 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 FPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 FPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHH 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 RWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 RWFRSVDWEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF 310 320 330 340 350 >>XP_005271076 (OMIM: 176892) PREDICTED: cAMP-dependent (338 aa) initn: 1267 init1: 1227 opt: 1238 Z-score: 561.6 bits: 112.4 E(85289): 1.5e-24 Smith-Waterman score: 1238; 54.8% identity (84.2% similar) in 303 aa overlap (38-340:20-322) 10 20 30 40 50 60 pF1KB6 QAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPAYSLQDFDTLATVGTGTFGRVHLVK .: .:.::. :.:::.:::: ::: XP_005 MSVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVK 10 20 30 40 70 80 90 100 110 120 pF1KB6 EKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLME .:......:.:... :..::: .:. ::: .:. :. :::.:: ....:. :::.:: XP_005 HKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVME 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB6 YVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIK ::::::.::.:: :::: . ::.:.:. ..::::: ...::::::::.:.:..:.:. XP_005 YVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQ 110 120 130 140 150 160 190 200 210 220 230 240 pF1KB6 LTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDD .:::::::.. :::::::::::::::.: :::...::::::::.::.:: .:.:::: : XP_005 VTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 170 180 190 200 210 220 250 260 270 280 290 300 pF1KB6 NPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVD .:. ::.::..::. :: :.. .:::...:: :: :.:.::.:::..:.: :.:: ..: XP_005 QPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTD 230 240 250 260 270 280 310 320 330 340 350 pF1KB6 WEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF : :. :::.. :..::. :.::::::. : :.: XP_005 WIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 290 300 310 320 330 >>NP_001229787 (OMIM: 176892) cAMP-dependent protein kin (339 aa) initn: 1267 init1: 1227 opt: 1238 Z-score: 561.6 bits: 112.4 E(85289): 1.5e-24 Smith-Waterman score: 1238; 54.8% identity (84.2% similar) in 303 aa overlap (38-340:21-323) 10 20 30 40 50 60 pF1KB6 QAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPAYSLQDFDTLATVGTGTFGRVHLVK .: .:.::. :.:::.:::: ::: NP_001 MGLLKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVK 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 EKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLME .:......:.:... :..::: .:. ::: .:. :. :::.:: ....:. :::.:: NP_001 HKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVME 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 YVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIK ::::::.::.:: :::: . ::.:.:. ..::::: ...::::::::.:.:..:.:. NP_001 YVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQ 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 LTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDD .:::::::.. :::::::::::::::.: :::...::::::::.::.:: .:.:::: : NP_001 VTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 NPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVD .:. ::.::..::. :: :.. .:::...:: :: :.:.::.:::..:.: :.:: ..: NP_001 QPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTD 240 250 260 270 280 290 310 320 330 340 350 pF1KB6 WEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF : :. :::.. :..::. :.::::::. : :.: NP_001 WIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 300 310 320 330 >>XP_005271075 (OMIM: 176892) PREDICTED: cAMP-dependent (346 aa) initn: 1267 init1: 1227 opt: 1238 Z-score: 561.5 bits: 112.4 E(85289): 1.5e-24 Smith-Waterman score: 1238; 54.8% identity (84.2% similar) in 303 aa overlap (38-340:28-330) 10 20 30 40 50 60 pF1KB6 QAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPAYSLQDFDTLATVGTGTFGRVHLVK .: .:.::. :.:::.:::: ::: XP_005 MSACSSSEISVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVK 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 EKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLME .:......:.:... :..::: .:. ::: .:. :. :::.:: ....:. :::.:: XP_005 HKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVME 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 YVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIK ::::::.::.:: :::: . ::.:.:. ..::::: ...::::::::.:.:..:.:. XP_005 YVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQ 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 LTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDD .:::::::.. :::::::::::::::.: :::...::::::::.::.:: .:.:::: : XP_005 VTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 NPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVD .:. ::.::..::. :: :.. .:::...:: :: :.:.::.:::..:.: :.:: ..: XP_005 QPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTD 240 250 260 270 280 290 310 320 330 340 350 pF1KB6 WEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF : :. :::.. :..::. :.::::::. : :.: XP_005 WIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 300 310 320 330 340 >>XP_005271074 (OMIM: 176892) PREDICTED: cAMP-dependent (347 aa) initn: 1267 init1: 1227 opt: 1238 Z-score: 561.5 bits: 112.4 E(85289): 1.5e-24 Smith-Waterman score: 1238; 54.8% identity (84.2% similar) in 303 aa overlap (38-340:29-331) 10 20 30 40 50 60 pF1KB6 QAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPAYSLQDFDTLATVGTGTFGRVHLVK .: .:.::. :.:::.:::: ::: XP_005 MGLSCSSSEISVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVK 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 EKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLME .:......:.:... :..::: .:. ::: .:. :. :::.:: ....:. :::.:: XP_005 HKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVME 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 YVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIK ::::::.::.:: :::: . ::.:.:. ..::::: ...::::::::.:.:..:.:. XP_005 YVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQ 120 130 140 150 160 170 190 200 210 220 230 240 pF1KB6 LTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDD .:::::::.. :::::::::::::::.: :::...::::::::.::.:: .:.:::: : XP_005 VTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 180 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 NPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVD .:. ::.::..::. :: :.. .:::...:: :: :.:.::.:::..:.: :.:: ..: XP_005 QPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTD 240 250 260 270 280 290 310 320 330 340 350 pF1KB6 WEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF : :. :::.. :..::. :.::::::. : :.: XP_005 WIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 300 310 320 330 340 >>XP_005271073 (OMIM: 176892) PREDICTED: cAMP-dependent (349 aa) initn: 1267 init1: 1227 opt: 1238 Z-score: 561.5 bits: 112.4 E(85289): 1.5e-24 Smith-Waterman score: 1238; 54.8% identity (84.2% similar) in 303 aa overlap (38-340:31-333) 10 20 30 40 50 60 pF1KB6 QAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPAYSLQDFDTLATVGTGTFGRVHLVK .: .:.::. :.:::.:::: ::: XP_005 MSACSSSEISDSFVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 EKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLME .:......:.:... :..::: .:. ::: .:. :. :::.:: ....:. :::.:: XP_005 HKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVME 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 YVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIK ::::::.::.:: :::: . ::.:.:. ..::::: ...::::::::.:.:..:.:. XP_005 YVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDD .:::::::.. :::::::::::::::.: :::...::::::::.::.:: .:.:::: : XP_005 VTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 NPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVD .:. ::.::..::. :: :.. .:::...:: :: :.:.::.:::..:.: :.:: ..: XP_005 QPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTD 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 WEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF : :. :::.. :..::. :.::::::. : :.: XP_005 WIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 310 320 330 340 >>XP_005271072 (OMIM: 176892) PREDICTED: cAMP-dependent (350 aa) initn: 1267 init1: 1227 opt: 1238 Z-score: 561.5 bits: 112.4 E(85289): 1.6e-24 Smith-Waterman score: 1238; 54.8% identity (84.2% similar) in 303 aa overlap (38-340:32-334) 10 20 30 40 50 60 pF1KB6 QAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPAYSLQDFDTLATVGTGTFGRVHLVK .: .:.::. :.:::.:::: ::: XP_005 GLSCSSSEISDSFVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 EKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLME .:......:.:... :..::: .:. ::: .:. :. :::.:: ....:. :::.:: XP_005 HKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVME 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 YVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIK ::::::.::.:: :::: . ::.:.:. ..::::: ...::::::::.:.:..:.:. XP_005 YVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDD .:::::::.. :::::::::::::::.: :::...::::::::.::.:: .:.:::: : XP_005 VTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 NPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVD .:. ::.::..::. :: :.. .:::...:: :: :.:.::.:::..:.: :.:: ..: XP_005 QPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTD 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 WEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF : :. :::.. :..::. :.::::::. : :.: XP_005 WIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 310 320 330 340 350 >>NP_002722 (OMIM: 176892) cAMP-dependent protein kinase (351 aa) initn: 1267 init1: 1227 opt: 1238 Z-score: 561.5 bits: 112.4 E(85289): 1.6e-24 Smith-Waterman score: 1238; 54.8% identity (84.2% similar) in 303 aa overlap (38-340:33-335) 10 20 30 40 50 60 pF1KB6 QAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPAYSLQDFDTLATVGTGTFGRVHLVK .: .:.::. :.:::.:::: ::: NP_002 NAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 EKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLME .:......:.:... :..::: .:. ::: .:. :. :::.:: ....:. :::.:: NP_002 HKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVME 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 YVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIK ::::::.::.:: :::: . ::.:.:. ..::::: ...::::::::.:.:..:.:. NP_002 YVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDD .:::::::.. :::::::::::::::.: :::...::::::::.::.:: .:.:::: : NP_002 VTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 NPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVD .:. ::.::..::. :: :.. .:::...:: :: :.:.::.:::..:.: :.:: ..: NP_002 QPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTD 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 WEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF : :. :::.. :..::. :.::::::. : :.: NP_002 WIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 310 320 330 340 350 >>XP_006710821 (OMIM: 176892) PREDICTED: cAMP-dependent (354 aa) initn: 1267 init1: 1227 opt: 1238 Z-score: 561.4 bits: 112.4 E(85289): 1.6e-24 Smith-Waterman score: 1238; 54.8% identity (84.2% similar) in 303 aa overlap (38-340:36-338) 10 20 30 40 50 60 pF1KB6 QAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPAYSLQDFDTLATVGTGTFGRVHLVK .: .:.::. :.:::.:::: ::: XP_006 SSDASACSSSEISVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 EKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLME .:......:.:... :..::: .:. ::: .:. :. :::.:: ....:. :::.:: XP_006 HKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVME 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 YVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIK ::::::.::.:: :::: . ::.:.:. ..::::: ...::::::::.:.:..:.:. XP_006 YVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDD .:::::::.. :::::::::::::::.: :::...::::::::.::.:: .:.:::: : XP_006 VTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 NPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVD .:. ::.::..::. :: :.. .:::...:: :: :.:.::.:::..:.: :.:: ..: XP_006 QPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTD 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 WEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF : :. :::.. :..::. :.::::::. : :.: XP_006 WIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 310 320 330 340 350 >>NP_001229788 (OMIM: 176892) cAMP-dependent protein kin (355 aa) initn: 1267 init1: 1227 opt: 1238 Z-score: 561.4 bits: 112.4 E(85289): 1.6e-24 Smith-Waterman score: 1238; 54.8% identity (84.2% similar) in 303 aa overlap (38-340:37-339) 10 20 30 40 50 60 pF1KB6 QAAAAESDSRKVAEETPDGAPALCPSPEALSPEPPAYSLQDFDTLATVGTGTFGRVHLVK .: .:.::. :.:::.:::: ::: NP_001 SSDASACSSSEISVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 EKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPFLIRLFWTWHDERFLYMLME .:......:.:... :..::: .:. ::: .:. :. :::.:: ....:. :::.:: NP_001 HKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVME 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 YVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEIVYRDLKPENILLDRDGHIK ::::::.::.:: :::: . ::.:.:. ..::::: ...::::::::.:.:..:.:. NP_001 YVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDD .:::::::.. :::::::::::::::.: :::...::::::::.::.:: .:.:::: : NP_001 VTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFAD 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 NPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLGNMKNGANDVKHHRWFRSVD .:. ::.::..::. :: :.. .:::...:: :: :.:.::.:::..:.: :.:: ..: NP_001 QPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTD 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 WEAVPQRKLKPPIVPKIAGDGDTSNFETYPENDWDTAAPVPQKDLEIFKNF : :. :::.. :..::. :.::::::. : :.: NP_001 WIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF 310 320 330 340 350 358 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 12:53:07 2016 done: Sun Nov 6 12:53:08 2016 Total Scan time: 8.480 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]