FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6533, 367 aa 1>>>pF1KB6533 367 - 367 aa - 367 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0581+/-0.000418; mu= 12.7612+/- 0.026 mean_var=93.5033+/-19.060, 0's: 0 Z-trim(113.3): 156 B-trim: 1543 in 2/54 Lambda= 0.132636 statistics sampled from 22421 (22616) to 22421 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.631), E-opt: 0.2 (0.265), width: 16 Scan time: 6.450 The best scores are: opt bits E(85289) NP_004408 (OMIM: 600714) dual specificity protein ( 367) 2422 474.0 2.4e-133 NP_001385 (OMIM: 602747) dual specificity protein ( 394) 1521 301.6 2e-81 NP_476499 (OMIM: 602747) dual specificity protein ( 303) 1198 239.7 6.7e-63 XP_011542730 (OMIM: 602747) PREDICTED: dual specif ( 303) 1198 239.7 6.7e-63 NP_004409 (OMIM: 603068) dual specificity protein ( 314) 1041 209.7 7.6e-54 NP_004410 (OMIM: 603069) dual specificity protein ( 384) 952 192.7 1.2e-48 XP_016859035 (OMIM: 603068) PREDICTED: dual specif ( 342) 845 172.2 1.6e-42 NP_009138 (OMIM: 608867) dual specificity protein ( 482) 532 112.4 2.2e-24 NP_001938 (OMIM: 602749) dual specificity protein ( 419) 478 102.0 2.6e-21 NP_001937 (OMIM: 602748,615269) dual specificity p ( 381) 470 100.4 6.9e-21 NP_001305432 (OMIM: 300134) dual specificity prote ( 384) 460 98.5 2.6e-20 NP_001386 (OMIM: 300134) dual specificity protein ( 384) 460 98.5 2.6e-20 XP_011529426 (OMIM: 300134) PREDICTED: dual specif ( 384) 460 98.5 2.6e-20 XP_011529425 (OMIM: 300134) PREDICTED: dual specif ( 415) 460 98.6 2.8e-20 XP_006719218 (OMIM: 607175) PREDICTED: dual specif ( 665) 433 93.5 1.5e-18 NP_085143 (OMIM: 607175) dual specificity protein ( 665) 433 93.5 1.5e-18 XP_011519158 (OMIM: 607175) PREDICTED: dual specif ( 665) 433 93.5 1.5e-18 XP_011519159 (OMIM: 607175) PREDICTED: dual specif ( 665) 433 93.5 1.5e-18 NP_004411 (OMIM: 602038) dual specificity protein ( 625) 420 91.0 7.8e-18 XP_011518234 (OMIM: 602038) PREDICTED: dual specif ( 625) 420 91.0 7.8e-18 XP_011518235 (OMIM: 602038) PREDICTED: dual specif ( 625) 420 91.0 7.8e-18 XP_011522536 (OMIM: 606618) PREDICTED: dual specif ( 198) 379 82.8 7.1e-16 NP_008957 (OMIM: 606618) dual specificity protein ( 198) 379 82.8 7.1e-16 XP_005257034 (OMIM: 606618) PREDICTED: dual specif ( 198) 379 82.8 7.1e-16 XP_005253545 (OMIM: 607175) PREDICTED: dual specif ( 517) 367 80.8 7.6e-15 XP_016875477 (OMIM: 607175) PREDICTED: dual specif ( 517) 367 80.8 7.6e-15 XP_016880743 (OMIM: 606779) PREDICTED: protein pho ( 480) 350 77.5 6.8e-14 XP_016880742 (OMIM: 606779) PREDICTED: protein pho ( 529) 350 77.6 7.3e-14 XP_016880741 (OMIM: 606779) PREDICTED: protein pho (1328) 350 77.8 1.5e-13 XP_011523708 (OMIM: 606779) PREDICTED: protein pho (1347) 350 77.8 1.6e-13 XP_011523709 (OMIM: 606779) PREDICTED: protein pho (1347) 350 77.8 1.6e-13 NP_001291723 (OMIM: 611446) dual specificity prote ( 188) 338 75.0 1.6e-13 XP_011528223 (OMIM: 611446) PREDICTED: dual specif ( 188) 338 75.0 1.6e-13 NP_001291724 (OMIM: 611446) dual specificity prote ( 188) 338 75.0 1.6e-13 NP_689724 (OMIM: 611446) dual specificity protein ( 188) 338 75.0 1.6e-13 XP_016884117 (OMIM: 611446) PREDICTED: dual specif ( 188) 338 75.0 1.6e-13 XP_006724211 (OMIM: 611446) PREDICTED: dual specif ( 188) 338 75.0 1.6e-13 XP_011528222 (OMIM: 611446) PREDICTED: dual specif ( 188) 338 75.0 1.6e-13 XP_005261425 (OMIM: 611446) PREDICTED: dual specif ( 188) 338 75.0 1.6e-13 XP_016884116 (OMIM: 611446) PREDICTED: dual specif ( 188) 338 75.0 1.6e-13 XP_011523707 (OMIM: 606779) PREDICTED: protein pho (1394) 350 77.9 1.6e-13 XP_006722212 (OMIM: 606779) PREDICTED: protein pho (1401) 350 77.9 1.6e-13 XP_011523706 (OMIM: 606779) PREDICTED: protein pho (1405) 350 77.9 1.6e-13 NP_203747 (OMIM: 606779) protein phosphatase Sling (1423) 350 77.9 1.6e-13 XP_011523704 (OMIM: 606779) PREDICTED: protein pho (1430) 350 77.9 1.6e-13 XP_005258116 (OMIM: 606779) PREDICTED: protein pho (1430) 350 77.9 1.6e-13 XP_016880740 (OMIM: 606779) PREDICTED: protein pho (1449) 350 77.9 1.7e-13 NP_001269058 (OMIM: 606779) protein phosphatase Sl (1450) 350 77.9 1.7e-13 XP_005258115 (OMIM: 606779) PREDICTED: protein pho (1450) 350 77.9 1.7e-13 NP_001154802 (OMIM: 606778) protein phosphatase Sl ( 692) 333 74.4 8.7e-13 >>NP_004408 (OMIM: 600714) dual specificity protein phos (367 aa) initn: 2422 init1: 2422 opt: 2422 Z-score: 2514.9 bits: 474.0 E(85289): 2.4e-133 Smith-Waterman score: 2422; 100.0% identity (100.0% similar) in 367 aa overlap (1-367:1-367) 10 20 30 40 50 60 pF1KB6 MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 GLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 LKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 LYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 IDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 IDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFS 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 FMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_004 FMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSP 310 320 330 340 350 360 pF1KB6 ITTSPSC ::::::: NP_004 ITTSPSC >>NP_001385 (OMIM: 602747) dual specificity protein phos (394 aa) initn: 1387 init1: 1189 opt: 1521 Z-score: 1582.7 bits: 301.6 E(85289): 2e-81 Smith-Waterman score: 1521; 63.1% identity (83.5% similar) in 369 aa overlap (6-367:26-394) 10 20 30 pF1KB6 MVMEVGTLDAGGLRALLG-ERAAQCLLLDCRSFFAFNAGH : ..: .. :: ...::::::: :.: .::. NP_001 MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGY 10 20 30 40 50 60 40 50 60 70 80 90 pF1KB6 IAGSVNVRFSTIVRRRAKGAMGLEHIVP-NAELRGRLLAGAYHAVVLLDERSAALDGAKR : :::::: .:::::::::...::.:.: . :.:.:: .: : ::.. :::: .. .. NP_001 ILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLRE 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 DGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAE :.:..:.. :: :.:. ... .:::::: ::. ::.::: .. .. :. :. . . NP_001 DSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLD 130 140 150 160 170 180 160 170 180 190 200 210 pF1KB6 SGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHY :::::.:::.::::::::::::::::::::.:.:::::::::::.:::..::::::::: NP_001 LGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHY 190 200 210 220 230 240 220 230 240 250 260 270 pF1KB6 QYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNR ::: ::::::::::::::: :::..::..:. :::.::::::::::::::::::: .: NP_001 QYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKR 250 260 270 280 290 300 280 290 300 310 320 330 pF1KB6 VKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTT- :.:.:::::::::::::::::::::::::::::::: :.:::.::. . .:: . .: NP_001 VRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATP 310 320 330 340 350 360 340 350 360 pF1KB6 ----VFNFPVSIPVHSTNSALSYLQSPITTSPSC ::.::::. :::. :.: ::.::::::::: NP_001 TSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC 370 380 390 >>NP_476499 (OMIM: 602747) dual specificity protein phos (303 aa) initn: 1068 init1: 1068 opt: 1198 Z-score: 1250.3 bits: 239.7 E(85289): 6.7e-63 Smith-Waterman score: 1198; 66.2% identity (82.9% similar) in 275 aa overlap (98-367:30-303) 70 80 90 100 110 120 pF1KB6 NAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEA : ..::... : ..: .:::: NP_476 MGRKVHSNGSQFAEHSRSPRRTGRDCKPVRAPSMALGVSQLAGRSRCL-CSESQGGYER 10 20 30 40 50 130 140 150 160 170 180 pF1KB6 FSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAY ::. ::.::: .. .. :. :. . . :::::.:::.:::::::::::::::::: NP_476 FSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAY 60 70 80 90 100 110 190 200 210 220 230 240 pF1KB6 HASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSI ::.:.:::::::::::.:::..:::::::::::: ::::::::::::::: :::..::.. NP_476 HAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAV 120 130 140 150 160 170 250 260 270 280 290 300 pF1KB6 KNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQ :. :::.::::::::::::::::::: .::.:.::::::::::::::::::::::::: NP_476 KDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQ 180 190 200 210 220 230 310 320 330 340 350 360 pF1KB6 FESQVLAPHCSAEAGSPAMAVLDRGTSTTT-----VFNFPVSIPVHSTNSALSYLQSPIT ::::::: :.:::.::. . .:: . .: ::.::::. :::. :.: ::.:::: NP_476 FESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPIT 240 250 260 270 280 290 pF1KB6 TSPSC ::::: NP_476 TSPSC 300 >>XP_011542730 (OMIM: 602747) PREDICTED: dual specificit (303 aa) initn: 1068 init1: 1068 opt: 1198 Z-score: 1250.3 bits: 239.7 E(85289): 6.7e-63 Smith-Waterman score: 1198; 66.2% identity (82.9% similar) in 275 aa overlap (98-367:30-303) 70 80 90 100 110 120 pF1KB6 NAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEA : ..::... : ..: .:::: XP_011 MGRKVHSNGSQFAEHSRSPRRTGRDCKPVRAPSMALGVSQLAGRSRCL-CSESQGGYER 10 20 30 40 50 130 140 150 160 170 180 pF1KB6 FSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAY ::. ::.::: .. .. :. :. . . :::::.:::.:::::::::::::::::: XP_011 FSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAY 60 70 80 90 100 110 190 200 210 220 230 240 pF1KB6 HASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSI ::.:.:::::::::::.:::..:::::::::::: ::::::::::::::: :::..::.. XP_011 HAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAV 120 130 140 150 160 170 250 260 270 280 290 300 pF1KB6 KNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQ :. :::.::::::::::::::::::: .::.:.::::::::::::::::::::::::: XP_011 KDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQ 180 190 200 210 220 230 310 320 330 340 350 360 pF1KB6 FESQVLAPHCSAEAGSPAMAVLDRGTSTTT-----VFNFPVSIPVHSTNSALSYLQSPIT ::::::: :.:::.::. . .:: . .: ::.::::. :::. :.: ::.:::: XP_011 FESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPIT 240 250 260 270 280 290 pF1KB6 TSPSC ::::: XP_011 TSPSC 300 >>NP_004409 (OMIM: 603068) dual specificity protein phos (314 aa) initn: 944 init1: 774 opt: 1041 Z-score: 1087.7 bits: 209.7 E(85289): 7.6e-54 Smith-Waterman score: 1041; 53.5% identity (77.6% similar) in 312 aa overlap (8-313:9-312) 10 20 30 40 50 pF1KB6 MVMEVGTLDAGGLRALLGE--RAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAK :. ..: .:: . .: . :::::: :.:: :. .. : .....::::. NP_004 MGLEAARELECAALGTLLRDPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALLRRRAR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 G--AMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARA : : : ..:. :: ::. : .:.::: ::.. . :. . .:: .:.:: NP_004 GPPAAVLACLLPDRALRTRLVRGELARAVVLDEGSASVAELRPDSPAHVLLAALLHETRA 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 AQ--VFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGG . :.::.::...:.. ::.:::. .: .:: : . ... :. .:.::::: NP_004 GPTAVYFLRGGFDGFQGCCPDLCSEAPAP---ALP-----PTGDKTSRSDSRAPVYDQGG 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 PVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADI ::::::.:.::: :.: . :.: ::::..::::.::::::: ..:::::::::. ..: NP_004 PVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEI 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 SSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRS :.::.::: ::: .::.::::.:::::::::::::::::::.. ::.:::::.::::::. NP_004 SAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRG 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 IISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSA .:::::::::::::::.::: NP_004 VISPNFSFMGQLLQFETQVLCH 300 310 >>NP_004410 (OMIM: 603069) dual specificity protein phos (384 aa) initn: 899 init1: 658 opt: 952 Z-score: 994.4 bits: 192.7 E(85289): 1.2e-48 Smith-Waterman score: 1006; 45.4% identity (69.5% similar) in 394 aa overlap (3-367:1-384) 10 20 30 40 50 pF1KB6 MVMEVGTLDAGGLRALL-GERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKG- :.: .::. :: .: : ::.:..:::: ..:: :... ::.:: ....: :::.: NP_004 MKVTSLDGRQLRKMLRKEAAARCVVLDCRPYLAFAASNVRGSLNVNLNSVVLRRARGG 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 AMGLEHIVPNAELRGRLL---AGAYHAVVLLDERSAALDGAKRDGTLALAAGAL--CREA :.. ....:. :.::: .:. :::.::. : . ..... .. .: : : NP_004 AVSARYVLPDEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARVVLTSLLACLPA 60 70 80 90 100 110 120 130 140 150 160 pF1KB6 RAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPL----- . .:.:::::::.: . :: : . :.: .: .. :.:. :. NP_004 -GPRVYFLKGGYETFYSEYPECCVDVK-------PISQEKIESERALISQCGKPVVNVSY 120 130 140 150 160 170 170 180 190 200 210 220 pF1KB6 ---YDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPV ::::::::::::::::::::::. ..: : ::::.::: . : .:: ::: NP_004 RPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACATHLHYKWIPV 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB6 EDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAF ::.: ::::: :.::::::: ... ::.:.:::.:::::: :::.::::.:.. .: ::: NP_004 EDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMKTKQFRLKEAF 240 250 260 270 280 290 290 300 310 320 330 pF1KB6 EFVKQRRSIISPNFSFMGQLLQFESQVLA-------PHCSAEA-GSPAMAVLDRGTSTT- ...:::::..::::.:::::::.::..: : :..:: :: .. :. . NP_004 DYIKQRRSMVSPNFGFMGQLLQYESEILPSTPNPQPPSCQGEAAGSSLIGHLQTLSPDMQ 300 310 320 330 340 350 340 350 360 pF1KB6 -TVFNFPVSI----PVHSTNSALSYLQSPITTSPSC . .::.:. :.::: : :: .::..:. :: NP_004 GAYCTFPASVLAPVPTHSTVSELS--RSPVATATSC 360 370 380 >>XP_016859035 (OMIM: 603068) PREDICTED: dual specificit (342 aa) initn: 944 init1: 774 opt: 845 Z-score: 884.5 bits: 172.2 E(85289): 1.6e-42 Smith-Waterman score: 975; 49.1% identity (71.2% similar) in 340 aa overlap (8-313:9-340) 10 20 30 40 50 pF1KB6 MVMEVGTLDAGGLRALLGE--RAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAK :. ..: .:: . .: . :::::: :.:: :. .. : .....::::. XP_016 MGLEAARELECAALGTLLRDPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALLRRRAR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 G--AMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARA : : : ..:. :: ::. : .:.::: ::.. . :. . .:: .:.:: XP_016 GPPAAVLACLLPDRALRTRLVRGELARAVVLDEGSASVAELRPDSPAHVLLAALLHETRA 70 80 90 100 110 120 120 130 140 pF1KB6 AQ--VFFLKG----------------------------GYEAFSASCPELCSKQSTPMGL . :.::.: :...:.. ::.:::. .: XP_016 GPTAVYFLRGEQAGRPWPAPPDSSPAFPADRALPLLAGGFDGFQGCCPDLCSEAPAP--- 130 140 150 160 170 150 160 170 180 190 200 pF1KB6 SLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALIN .:: : . ... :. .:.:::::::::::.:.::: :.: . :.: ::::..: XP_016 ALP-----PTGDKTSRSDSRAPVYDQGGPVEILPYLFLGSCSHSSDLQGLQACGITAVLN 180 190 200 210 220 230 210 220 230 240 250 260 pF1KB6 VSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRS :::.::::::: ..:::::::::. ..::.::.::: ::: .::.::::.:::::::::: XP_016 VSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRS 240 250 260 270 280 290 270 280 290 300 310 320 pF1KB6 ATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPA :::::::::.. ::.:::::.::::::..:::::::::::::::.::: XP_016 ATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVLCH 300 310 320 330 340 330 340 350 360 pF1KB6 MAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC >>NP_009138 (OMIM: 608867) dual specificity protein phos (482 aa) initn: 445 init1: 339 opt: 532 Z-score: 558.6 bits: 112.4 E(85289): 2.2e-24 Smith-Waterman score: 532; 33.0% identity (63.6% similar) in 294 aa overlap (25-309:173-459) 10 20 30 40 50 pF1KB6 MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRR ...::: :. .: .:: :.:.. . . : NP_009 QLASIKIIYPNDLAKKMTKCSKSHLPSQGPVIIDCRPFMEYNKSHIQGAVHINCADKISR 150 160 170 180 190 200 60 70 80 90 100 110 pF1KB6 R--AKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCRE : .: . . .. : . . . ... :: . . . . : .. .: :: NP_009 RRLQQGKITVLDLISCREGKDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHIVLESLKRE 210 220 230 240 250 260 120 130 140 150 160 pF1KB6 ARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSC-----STP .. : :::: .:. . .::... :.: : .: .. : .:: NP_009 GKEPLV--LKGGLSSFKQNHENLCDNS-----LQLQECREVGGGASAASSLLPQPIPTTP 270 280 290 300 310 170 180 190 200 210 220 pF1KB6 LYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCP-NHFE-GHYQYKSIPV ... . :::::.::. :. : .. :.: .:::... : :.: : ..:: .:. NP_009 DIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPA 320 330 340 350 360 370 230 240 250 260 270 280 pF1KB6 EDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAF :..: .. ..:.::..::. .. : ...:::::.:::::: .::::. .:. . .:. NP_009 TDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAY 380 390 400 410 420 430 290 300 310 320 330 340 pF1KB6 EFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSI .::: .: :::::..::::::.:: NP_009 KFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVETVV 440 450 460 470 480 >>NP_001938 (OMIM: 602749) dual specificity protein phos (419 aa) initn: 619 init1: 331 opt: 478 Z-score: 503.7 bits: 102.0 E(85289): 2.6e-21 Smith-Waterman score: 620; 36.1% identity (62.8% similar) in 352 aa overlap (22-344:70-414) 10 20 30 40 50 pF1KB6 MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRF-ST :. :::::: :...:: ..:. . . NP_001 GTGAGAATGAGAMPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGL 40 50 60 70 80 90 60 70 80 90 100 pF1KB6 IVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLL-DERSAALDGAKRDGTLALAAGAL ..:: :: . .. :.:: . :. . :.::: :: .: . . :. : . : : NP_001 MLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATA--EWQPEPGAPASVLGLL 100 110 120 130 140 150 110 120 130 140 150 pF1KB6 CREAR--AAQVFFLKGGYEAFSASCPELC--------SKQSTP----MGLS-LPLSTSVP .. : . :...:.::.. :.. : : : .:.: .::. : .:.. NP_001 LQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCS 160 170 180 190 200 210 160 170 180 190 200 pF1KB6 D--------SAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINV : :. . .. .: . . ::.:::.:::: : .. :.: :: ..:: NP_001 DGESDRELPSSATESDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNV 220 230 240 250 260 270 210 220 230 240 250 260 pF1KB6 SANCPNHFE--GHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISR . : :: :: :.. ::.::. :. . ..:..: :::.::: .. :.::: ::::: NP_001 TPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISR 280 290 300 310 320 330 270 280 290 300 310 320 pF1KB6 SATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQV-LAPHCSAEAGS :.:. .::::. ..:..:..:::...: :::::.::::::.:: . :. :. .:.: NP_001 SVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGLSSPCDNHASS 340 350 360 370 380 390 330 340 350 360 pF1KB6 PAMAVLDRGTSTTTVFN-FPVSIPVHSTNSALSYLQSPITTSPSC . :: : : ::.. NP_001 EQLYF-----STPTNHNLFPLNTLEST 400 410 >>NP_001937 (OMIM: 602748,615269) dual specificity prote (381 aa) initn: 553 init1: 322 opt: 470 Z-score: 496.0 bits: 100.4 E(85289): 6.9e-21 Smith-Waterman score: 582; 35.5% identity (64.0% similar) in 344 aa overlap (25-339:35-373) 10 20 30 40 50 pF1KB6 MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRR ::.::: ....:: ...:: . :. : NP_001 LRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLR 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 R-AKGAMGLEHIVPNAELRGRLLAG-AYHAVVLLDERSAALDGAKRDGTLALAAGALCRE : :: . .. . .: : :. . .::: :: :. : . : .. : : .. NP_001 RLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSS--DWNENTGGESVL-GLLLKK 70 80 90 100 110 120 120 130 140 150 pF1KB6 AR--AAQVFFLKGGYEAFSAS----CPE----LCSKQSTPM---GLS-LPLSTSVPDSAE . . ..:.:.::. :.: : ::..: :. ::. : .:.. .. : NP_001 LKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIE 130 140 150 160 170 180 160 170 180 190 200 pF1KB6 S--------GCSSCSTPLYDQGG--PVEILPFLYLGSAYHASRKDMLDALGITALINVSA : . .: ..:: .. ::::::::::: : .. :.:. .:: ..::. NP_001 SDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTP 190 200 210 220 230 240 210 220 230 240 250 260 pF1KB6 NCPNHFE--GHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSA : :: :: :...::.::. :. . ..:..: :::.::: .. . :.::: ::::::. NP_001 NLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSV 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB6 TICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQV-LAPHCSAEAGSPA :. .::::. .....:...::...: :::::.::::::.:: . :. :. .. :: NP_001 TVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRV--PA 310 320 330 340 350 330 340 350 360 pF1KB6 MAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC . . :. .:. NP_001 QQLYFTTPSNQNVYQVDSLQST 360 370 380 367 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 21:07:38 2016 done: Fri Nov 4 21:07:39 2016 Total Scan time: 6.450 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]