FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6542, 391 aa 1>>>pF1KB6542 391 - 391 aa - 391 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8218+/-0.000939; mu= 13.6294+/- 0.056 mean_var=67.1551+/-13.604, 0's: 0 Z-trim(105.1): 27 B-trim: 327 in 1/50 Lambda= 0.156507 statistics sampled from 8232 (8245) to 8232 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.628), E-opt: 0.2 (0.253), width: 16 Scan time: 2.800 The best scores are: opt bits E(32554) CCDS1991.1 RMND5A gene_id:64795|Hs108|chr2 ( 391) 2642 605.7 2.4e-173 CCDS4431.1 RMND5B gene_id:64777|Hs108|chr5 ( 393) 1908 439.9 1.9e-123 CCDS75382.1 RMND5B gene_id:64777|Hs108|chr5 ( 380) 1733 400.4 1.4e-111 CCDS77888.1 MAEA gene_id:10296|Hs108|chr4 ( 348) 280 72.3 7.5e-13 CCDS75090.1 MAEA gene_id:10296|Hs108|chr4 ( 395) 280 72.3 8.4e-13 CCDS33936.1 MAEA gene_id:10296|Hs108|chr4 ( 396) 280 72.3 8.5e-13 >>CCDS1991.1 RMND5A gene_id:64795|Hs108|chr2 (391 aa) initn: 2642 init1: 2642 opt: 2642 Z-score: 3225.7 bits: 605.7 E(32554): 2.4e-173 Smith-Waterman score: 2642; 100.0% identity (100.0% similar) in 391 aa overlap (1-391:1-391) 10 20 30 40 50 60 pF1KB6 MDQCVTVERELEKVLHKFSGYGQLCERGLEELIDYTGGLKHEILQSHGQDAELSGTLSLV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS19 MDQCVTVERELEKVLHKFSGYGQLCERGLEELIDYTGGLKHEILQSHGQDAELSGTLSLV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LTQCCKRIKDTVQKLASDHKDIHSSVSRVGKAIDKNFDSDISSVGIDGCWQADSQRLLNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS19 LTQCCKRIKDTVQKLASDHKDIHSSVSRVGKAIDKNFDSDISSVGIDGCWQADSQRLLNE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 VMVEHFFRQGMLDVAEELCQESGLSVDPSQKEPFVELNRILEALKVRVLRPALEWAVSNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS19 VMVEHFFRQGMLDVAEELCQESGLSVDPSQKEPFVELNRILEALKVRVLRPALEWAVSNR 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EMLIAQNSSLEFKLHRLYFISLLMGGTTNQREALQYAKNFQPFALNHQKDIQVLMGSLVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS19 EMLIAQNSSLEFKLHRLYFISLLMGGTTNQREALQYAKNFQPFALNHQKDIQVLMGSLVY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 LRQGIENSPYVHLLDANQWADICDIFTRDACALLGLSVESPLSVSFSAGCVALPALINIK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS19 LRQGIENSPYVHLLDANQWADICDIFTRDACALLGLSVESPLSVSFSAGCVALPALINIK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 AVIEQRQCTGVWNQKDELPIEVDLGKKCWYHSIFACPILRQQTTDNNPPMKLVCGHIISR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS19 AVIEQRQCTGVWNQKDELPIEVDLGKKCWYHSIFACPILRQQTTDNNPPMKLVCGHIISR 310 320 330 340 350 360 370 380 390 pF1KB6 DALNKMFNGSKLKCPYCPMEQSPGDAKQIFF ::::::::::::::::::::::::::::::: CCDS19 DALNKMFNGSKLKCPYCPMEQSPGDAKQIFF 370 380 390 >>CCDS4431.1 RMND5B gene_id:64777|Hs108|chr5 (393 aa) initn: 1911 init1: 1418 opt: 1908 Z-score: 2329.9 bits: 439.9 E(32554): 1.9e-123 Smith-Waterman score: 1908; 70.0% identity (90.3% similar) in 393 aa overlap (1-391:1-393) 10 20 30 40 50 60 pF1KB6 MDQCVTVERELEKVLHKFSGYGQLCERGLEELIDYTGGLKHEILQSHGQDAELSGTLSLV :.::. :::::.:::.:: ::: :::.::::. :.: :. :. .. : . ::.::::: CCDS44 MEQCACVERELDKVLQKFLTYGQHCERSLEELLHYVGQLRAELASAALQGTPLSATLSLV 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 LTQCCKRIKDTVQKLASDHKDIHSSVSRVGKAIDKNFDSDISSVGIDGCWQA--DSQRLL ..:::..:::::::::::::::::::::::::::.::::.: .: :. :.: ..:..: CCDS44 MSQCCRKIKDTVQKLASDHKDIHSSVSRVGKAIDRNFDSEICGVVSDAVWDAREQQQQIL 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 NEVMVEHFFRQGMLDVAEELCQESGLSVDPSQKEPFVELNRILEALKVRVLRPALEWAVS . ..:::...::::.::::::::: :.:: . :.::.:::::::::. . : :::::::: CCDS44 QMAIVEHLYQQGMLSVAEELCQESTLNVDLDFKQPFLELNRILEALHEQDLGPALEWAVS 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB6 NREMLIAQNSSLEFKLHRLYFISLLMGGTTNQREALQYAKNFQPFALNHQKDIQVLMGSL .:. :. :::::::::::.:: :: :: ..: :::.::..::::: ::..:::.:::: CCDS44 HRQRLLELNSSLEFKLHRLHFIRLLAGGPAKQLEALSYARHFQPFARLHQREIQVMMGSL 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB6 VYLRQGIENSPYVHLLDANQWADICDIFTRDACALLGLSVESPLSVSFSAGCVALPALIN :::: :.:.::: ::::...::.::. ::::::.::::::::::::::..::::::.:.: CCDS44 VYLRLGLEKSPYCHLLDSSHWAEICETFTRDACSLLGLSVESPLSVSFASGCVALPVLMN 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB6 IKAVIEQRQCTGVWNQKDELPIEVDLGKKCWYHSIFACPILRQQTTDNNPPMKLVCGHII :::::::::::::::.:::::::..:: ::::::.::::::::::.:.:::.::.:::.: CCDS44 IKAVIEQRQCTGVWNHKDELPIEIELGMKCWYHSVFACPILRQQTSDSNPPIKLICGHVI 310 320 330 340 350 360 360 370 380 390 pF1KB6 SRDALNKMFNGSKLKCPYCPMEQSPGDAKQIFF :::::::..::.:::::::::::.:.:.:.:.: CCDS44 SRDALNKLINGGKLKCPYCPMEQNPADGKRIIF 370 380 390 >>CCDS75382.1 RMND5B gene_id:64777|Hs108|chr5 (380 aa) initn: 1714 init1: 1418 opt: 1733 Z-score: 2116.6 bits: 400.4 E(32554): 1.4e-111 Smith-Waterman score: 1733; 71.9% identity (91.9% similar) in 345 aa overlap (49-391:36-380) 20 30 40 50 60 70 pF1KB6 SGYGQLCERGLEELIDYTGGLKHEILQSHGQDAELSGTLSLVLTQCCKRIKDTVQKLASD : . ::.:::::..:::..::::::::::: CCDS75 LDLPGSSSPPSHLSLLRSWDHRRVPPCPALQGTPLSATLSLVMSQCCRKIKDTVQKLASD 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB6 HKDIHSSVSRVGKAIDKNFDSDISSVGIDGCWQA--DSQRLLNEVMVEHFFRQGMLDVAE ::::::::::::::::.::::.: .: :. :.: ..:..:. ..:::...::::.::: CCDS75 HKDIHSSVSRVGKAIDRNFDSEICGVVSDAVWDAREQQQQILQMAIVEHLYQQGMLSVAE 70 80 90 100 110 120 140 150 160 170 180 190 pF1KB6 ELCQESGLSVDPSQKEPFVELNRILEALKVRVLRPALEWAVSNREMLIAQNSSLEFKLHR :::::: :.:: . :.::.:::::::::. . : ::::::::.:. :. :::::::::: CCDS75 ELCQESTLNVDLDFKQPFLELNRILEALHEQDLGPALEWAVSHRQRLLELNSSLEFKLHR 130 140 150 160 170 180 200 210 220 230 240 250 pF1KB6 LYFISLLMGGTTNQREALQYAKNFQPFALNHQKDIQVLMGSLVYLRQGIENSPYVHLLDA :.:: :: :: ..: :::.::..::::: ::..:::.:::::::: :.:.::: ::::. CCDS75 LHFIRLLAGGPAKQLEALSYARHFQPFARLHQREIQVMMGSLVYLRLGLEKSPYCHLLDS 190 200 210 220 230 240 260 270 280 290 300 310 pF1KB6 NQWADICDIFTRDACALLGLSVESPLSVSFSAGCVALPALINIKAVIEQRQCTGVWNQKD ..::.::. ::::::.::::::::::::::..::::::.:.::::::::::::::::.:: CCDS75 SHWAEICETFTRDACSLLGLSVESPLSVSFASGCVALPVLMNIKAVIEQRQCTGVWNHKD 250 260 270 280 290 300 320 330 340 350 360 370 pF1KB6 ELPIEVDLGKKCWYHSIFACPILRQQTTDNNPPMKLVCGHIISRDALNKMFNGSKLKCPY :::::..:: ::::::.::::::::::.:.:::.::.:::.::::::::..::.:::::: CCDS75 ELPIEIELGMKCWYHSVFACPILRQQTSDSNPPIKLICGHVISRDALNKLINGGKLKCPY 310 320 330 340 350 360 380 390 pF1KB6 CPMEQSPGDAKQIFF :::::.:.:.:.:.: CCDS75 CPMEQNPADGKRIIF 370 380 >>CCDS77888.1 MAEA gene_id:10296|Hs108|chr4 (348 aa) initn: 219 init1: 123 opt: 280 Z-score: 344.2 bits: 72.3 E(32554): 7.5e-13 Smith-Waterman score: 280; 26.3% identity (57.8% similar) in 270 aa overlap (110-375:72-331) 80 90 100 110 120 130 pF1KB6 KDIHSSVSRVGKAIDKNFDSDISSVGIDGCWQADSQRLLNEVMVEHFFRQGMLDVAEELC :. .. ....::::..: :. ..: .: CCDS77 QAEDESAKLCKRRIEHLKEHSSDQPAAASVWK---RKRMDRMMVEHLLRCGYYNTAVKLA 50 60 70 80 90 140 150 160 170 180 190 pF1KB6 QESGLSVDPSQKEPFVELNRILEALKVRVLRPALEWAVSNREMLIAQNSSLEFKLHRLYF ..::. : . : :. ... :.:. : : : .:. : ..: :::.:. : CCDS77 RQSGIE-DLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKSCLEFSLRIQEF 100 110 120 130 140 150 200 210 220 230 240 250 pF1KB6 ISLLMGGTTNQR-EALQYA-KNFQPFALNHQKDIQVLMGSLVYLRQGIENSPYVHLLDAN : :. :.: .:...: :.:. .. ... :: :.. . ::: ::: CCDS77 IELI---RQNKRLDAVRHARKHFSQAEGSQLDEVRQAMGMLAF-PPDTHISPYKDLLDPA 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB6 QWADICDIFTRDACALLGLSVESPLSVSFSAGCVAL--PALINIKAVIEQRQCTGVWNQK .: . . : : : :. .: ......:: :. : . . .. .: . CCDS77 RWRMLIQQFRYDNYRLHQLGNNSVFTLTLQAGLSAIKTPQCYKEDGSSKSPDCPVCSRSL 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB6 DELPIEVDLGKKCWYHSIFACPILRQQTTDNNPPMKLVCGHIISRDALNKMFNGSKLKCP ..: . ... : .: ..: : . ..::::: : :.. . ..: .. . .:. :: CCDS77 NKLAQPLPMAH-C-ANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDDKVVCP 280 290 300 310 320 330 380 390 pF1KB6 YCPMEQSPGDAKQIFF CCDS77 RTKEVFHFSQAEKVYIM 340 >>CCDS75090.1 MAEA gene_id:10296|Hs108|chr4 (395 aa) initn: 219 init1: 123 opt: 280 Z-score: 343.3 bits: 72.3 E(32554): 8.4e-13 Smith-Waterman score: 280; 26.3% identity (57.8% similar) in 270 aa overlap (110-375:119-378) 80 90 100 110 120 130 pF1KB6 KDIHSSVSRVGKAIDKNFDSDISSVGIDGCWQADSQRLLNEVMVEHFFRQGMLDVAEELC :. .. ....::::..: :. ..: .: CCDS75 QAEDESAKLCKRRIEHLKEHSSDQPAAASVWK---RKRMDRMMVEHLLRCGYYNTAVKLA 90 100 110 120 130 140 140 150 160 170 180 190 pF1KB6 QESGLSVDPSQKEPFVELNRILEALKVRVLRPALEWAVSNREMLIAQNSSLEFKLHRLYF ..::. : . : :. ... :.:. : : : .:. : ..: :::.:. : CCDS75 RQSGIE-DLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKSCLEFSLRIQEF 150 160 170 180 190 200 200 210 220 230 240 250 pF1KB6 ISLLMGGTTNQR-EALQYA-KNFQPFALNHQKDIQVLMGSLVYLRQGIENSPYVHLLDAN : :. :.: .:...: :.:. .. ... :: :.. . ::: ::: CCDS75 IELI---RQNKRLDAVRHARKHFSQAEGSQLDEVRQAMGMLAF-PPDTHISPYKDLLDPA 210 220 230 240 250 260 260 270 280 290 300 310 pF1KB6 QWADICDIFTRDACALLGLSVESPLSVSFSAGCVAL--PALINIKAVIEQRQCTGVWNQK .: . . : : : :. .: ......:: :. : . . .. .: . CCDS75 RWRMLIQQFRYDNYRLHQLGNNSVFTLTLQAGLSAIKTPQCYKEDGSSKSPDCPVCSRSL 270 280 290 300 310 320 320 330 340 350 360 370 pF1KB6 DELPIEVDLGKKCWYHSIFACPILRQQTTDNNPPMKLVCGHIISRDALNKMFNGSKLKCP ..: . ... : .: ..: : . ..::::: : :.. . ..: .. . .:. :: CCDS75 NKLAQPLPMAH-C-ANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDDKVVCP 330 340 350 360 370 380 390 pF1KB6 YCPMEQSPGDAKQIFF CCDS75 RTKEVFHFSQAEKVYIM 380 390 >>CCDS33936.1 MAEA gene_id:10296|Hs108|chr4 (396 aa) initn: 219 init1: 123 opt: 280 Z-score: 343.3 bits: 72.3 E(32554): 8.5e-13 Smith-Waterman score: 280; 26.3% identity (57.8% similar) in 270 aa overlap (110-375:120-379) 80 90 100 110 120 130 pF1KB6 KDIHSSVSRVGKAIDKNFDSDISSVGIDGCWQADSQRLLNEVMVEHFFRQGMLDVAEELC :. .. ....::::..: :. ..: .: CCDS33 QAEDESAKLCKRRIEHLKEHSSDQPAAASVWK---RKRMDRMMVEHLLRCGYYNTAVKLA 90 100 110 120 130 140 140 150 160 170 180 190 pF1KB6 QESGLSVDPSQKEPFVELNRILEALKVRVLRPALEWAVSNREMLIAQNSSLEFKLHRLYF ..::. : . : :. ... :.:. : : : .:. : ..: :::.:. : CCDS33 RQSGIE-DLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKSCLEFSLRIQEF 150 160 170 180 190 200 200 210 220 230 240 250 pF1KB6 ISLLMGGTTNQR-EALQYA-KNFQPFALNHQKDIQVLMGSLVYLRQGIENSPYVHLLDAN : :. :.: .:...: :.:. .. ... :: :.. . ::: ::: CCDS33 IELI---RQNKRLDAVRHARKHFSQAEGSQLDEVRQAMGMLAF-PPDTHISPYKDLLDPA 210 220 230 240 250 260 260 270 280 290 300 310 pF1KB6 QWADICDIFTRDACALLGLSVESPLSVSFSAGCVAL--PALINIKAVIEQRQCTGVWNQK .: . . : : : :. .: ......:: :. : . . .. .: . CCDS33 RWRMLIQQFRYDNYRLHQLGNNSVFTLTLQAGLSAIKTPQCYKEDGSSKSPDCPVCSRSL 270 280 290 300 310 320 320 330 340 350 360 370 pF1KB6 DELPIEVDLGKKCWYHSIFACPILRQQTTDNNPPMKLVCGHIISRDALNKMFNGSKLKCP ..: . ... : .: ..: : . ..::::: : :.. . ..: .. . .:. :: CCDS33 NKLAQPLPMAH-C-ANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDDKVVCP 330 340 350 360 370 380 390 pF1KB6 YCPMEQSPGDAKQIFF CCDS33 RTKEVFHFSQAEKVYIM 380 390 391 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:02:47 2016 done: Sat Nov 5 04:02:47 2016 Total Scan time: 2.800 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]