FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6552, 394 aa 1>>>pF1KB6552 394 - 394 aa - 394 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.2945+/-0.000275; mu= 13.3943+/- 0.018 mean_var=97.0816+/-19.611, 0's: 0 Z-trim(120.7): 139 B-trim: 1992 in 1/56 Lambda= 0.130168 statistics sampled from 36154 (36309) to 36154 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.757), E-opt: 0.2 (0.426), width: 16 Scan time: 9.210 The best scores are: opt bits E(85289) NP_001385 (OMIM: 602747) dual specificity protein ( 394) 2644 506.3 5.3e-143 NP_476499 (OMIM: 602747) dual specificity protein ( 303) 1717 332.1 1.1e-90 XP_011542730 (OMIM: 602747) PREDICTED: dual specif ( 303) 1717 332.1 1.1e-90 NP_004408 (OMIM: 600714) dual specificity protein ( 367) 1521 295.3 1.5e-79 NP_004410 (OMIM: 603069) dual specificity protein ( 384) 963 190.6 5.5e-48 NP_004409 (OMIM: 603068) dual specificity protein ( 314) 947 187.5 3.8e-47 XP_016859035 (OMIM: 603068) PREDICTED: dual specif ( 342) 786 157.3 5.1e-38 NP_009138 (OMIM: 608867) dual specificity protein ( 482) 582 119.1 2.3e-26 NP_001938 (OMIM: 602749) dual specificity protein ( 419) 477 99.3 1.8e-20 NP_001937 (OMIM: 602748,615269) dual specificity p ( 381) 472 98.4 3.2e-20 XP_011529426 (OMIM: 300134) PREDICTED: dual specif ( 384) 454 95.0 3.3e-19 NP_001305432 (OMIM: 300134) dual specificity prote ( 384) 454 95.0 3.3e-19 NP_001386 (OMIM: 300134) dual specificity protein ( 384) 454 95.0 3.3e-19 XP_011529425 (OMIM: 300134) PREDICTED: dual specif ( 415) 454 95.0 3.5e-19 NP_004411 (OMIM: 602038) dual specificity protein ( 625) 415 87.8 7.9e-17 XP_011518235 (OMIM: 602038) PREDICTED: dual specif ( 625) 415 87.8 7.9e-17 XP_011518234 (OMIM: 602038) PREDICTED: dual specif ( 625) 415 87.8 7.9e-17 NP_085143 (OMIM: 607175) dual specificity protein ( 665) 402 85.4 4.5e-16 XP_006719218 (OMIM: 607175) PREDICTED: dual specif ( 665) 402 85.4 4.5e-16 XP_011519159 (OMIM: 607175) PREDICTED: dual specif ( 665) 402 85.4 4.5e-16 XP_011519158 (OMIM: 607175) PREDICTED: dual specif ( 665) 402 85.4 4.5e-16 XP_011522536 (OMIM: 606618) PREDICTED: dual specif ( 198) 367 78.5 1.6e-14 XP_005257034 (OMIM: 606618) PREDICTED: dual specif ( 198) 367 78.5 1.6e-14 NP_008957 (OMIM: 606618) dual specificity protein ( 198) 367 78.5 1.6e-14 XP_016875477 (OMIM: 607175) PREDICTED: dual specif ( 517) 347 75.0 4.7e-13 XP_005253545 (OMIM: 607175) PREDICTED: dual specif ( 517) 347 75.0 4.7e-13 NP_001154802 (OMIM: 606778) protein phosphatase Sl ( 692) 326 71.1 9.2e-12 NP_001154803 (OMIM: 606778) protein phosphatase Sl ( 703) 326 71.1 9.3e-12 XP_016880742 (OMIM: 606779) PREDICTED: protein pho ( 529) 324 70.7 9.6e-12 XP_016874981 (OMIM: 606778) PREDICTED: protein pho ( 923) 326 71.2 1.2e-11 XP_011536803 (OMIM: 606778) PREDICTED: protein pho ( 969) 326 71.2 1.2e-11 XP_005269042 (OMIM: 606778) PREDICTED: protein pho ( 969) 326 71.2 1.2e-11 XP_011536802 (OMIM: 606778) PREDICTED: protein pho ( 969) 326 71.2 1.2e-11 XP_016874980 (OMIM: 606778) PREDICTED: protein pho (1033) 326 71.2 1.3e-11 NP_061857 (OMIM: 606778) protein phosphatase Sling (1049) 326 71.2 1.3e-11 XP_005269041 (OMIM: 606778) PREDICTED: protein pho (1049) 326 71.2 1.3e-11 XP_011536799 (OMIM: 606778) PREDICTED: protein pho (1060) 326 71.2 1.3e-11 XP_011528222 (OMIM: 611446) PREDICTED: dual specif ( 188) 315 68.7 1.3e-11 XP_005261425 (OMIM: 611446) PREDICTED: dual specif ( 188) 315 68.7 1.3e-11 NP_689724 (OMIM: 611446) dual specificity protein ( 188) 315 68.7 1.3e-11 XP_006724211 (OMIM: 611446) PREDICTED: dual specif ( 188) 315 68.7 1.3e-11 XP_016884117 (OMIM: 611446) PREDICTED: dual specif ( 188) 315 68.7 1.3e-11 NP_001291724 (OMIM: 611446) dual specificity prote ( 188) 315 68.7 1.3e-11 XP_016884116 (OMIM: 611446) PREDICTED: dual specif ( 188) 315 68.7 1.3e-11 NP_001291723 (OMIM: 611446) dual specificity prote ( 188) 315 68.7 1.3e-11 XP_011528223 (OMIM: 611446) PREDICTED: dual specif ( 188) 315 68.7 1.3e-11 XP_016880743 (OMIM: 606779) PREDICTED: protein pho ( 480) 320 69.9 1.5e-11 XP_016880741 (OMIM: 606779) PREDICTED: protein pho (1328) 322 70.5 2.6e-11 XP_011523708 (OMIM: 606779) PREDICTED: protein pho (1347) 322 70.5 2.7e-11 XP_011523709 (OMIM: 606779) PREDICTED: protein pho (1347) 322 70.5 2.7e-11 >>NP_001385 (OMIM: 602747) dual specificity protein phos (394 aa) initn: 2644 init1: 2644 opt: 2644 Z-score: 2688.3 bits: 506.3 E(85289): 5.3e-143 Smith-Waterman score: 2644; 100.0% identity (100.0% similar) in 394 aa overlap (1-394:1-394) 10 20 30 40 50 60 pF1KB6 MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGY 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLRE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLRE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 LGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHY 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 QYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKR 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 VRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATP 310 320 330 340 350 360 370 380 390 pF1KB6 TSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC :::::::::::::::::::::::::::::::::: NP_001 TSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC 370 380 390 >>NP_476499 (OMIM: 602747) dual specificity protein phos (303 aa) initn: 1712 init1: 1712 opt: 1717 Z-score: 1749.2 bits: 332.1 E(85289): 1.1e-90 Smith-Waterman score: 1717; 90.7% identity (93.4% similar) in 289 aa overlap (111-394:17-303) 90 100 110 120 130 pF1KB6 VSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQAL--RRNAERT :::: .. :. . : .:: . : :. NP_476 MGRKVHSNGSQFAEHSRSPR-RTGRDCKPVRAPSMALGVSQLAGRS 10 20 30 40 140 150 160 170 180 190 pF1KB6 DICLL---KGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGG :: .::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 R-CLCSESQGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGG 50 60 70 80 90 100 200 210 220 230 240 250 pF1KB6 PVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 PVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADI 110 120 130 140 150 160 260 270 280 290 300 310 pF1KB6 SSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 SSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRS 170 180 190 200 210 220 320 330 340 350 360 370 pF1KB6 IISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_476 IISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVH 230 240 250 260 270 280 380 390 pF1KB6 SAPSSLPYLHSPITTSPSC ::::::::::::::::::: NP_476 SAPSSLPYLHSPITTSPSC 290 300 >>XP_011542730 (OMIM: 602747) PREDICTED: dual specificit (303 aa) initn: 1712 init1: 1712 opt: 1717 Z-score: 1749.2 bits: 332.1 E(85289): 1.1e-90 Smith-Waterman score: 1717; 90.7% identity (93.4% similar) in 289 aa overlap (111-394:17-303) 90 100 110 120 130 pF1KB6 VSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQAL--RRNAERT :::: .. :. . : .:: . : :. XP_011 MGRKVHSNGSQFAEHSRSPR-RTGRDCKPVRAPSMALGVSQLAGRS 10 20 30 40 140 150 160 170 180 190 pF1KB6 DICLL---KGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGG :: .::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 R-CLCSESQGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGG 50 60 70 80 90 100 200 210 220 230 240 250 pF1KB6 PVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADI 110 120 130 140 150 160 260 270 280 290 300 310 pF1KB6 SSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 SSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRS 170 180 190 200 210 220 320 330 340 350 360 370 pF1KB6 IISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVH 230 240 250 260 270 280 380 390 pF1KB6 SAPSSLPYLHSPITTSPSC ::::::::::::::::::: XP_011 SAPSSLPYLHSPITTSPSC 290 300 >>NP_004408 (OMIM: 600714) dual specificity protein phos (367 aa) initn: 1387 init1: 1189 opt: 1521 Z-score: 1549.0 bits: 295.3 E(85289): 1.5e-79 Smith-Waterman score: 1521; 63.1% identity (83.5% similar) in 369 aa overlap (26-394:6-367) 10 20 30 40 50 60 pF1KB6 MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGY : ..: .. :: ...::::::: :.: .::. NP_004 MVMEVGTLDAGGLRALLG-ERAAQCLLLDCRSFFAFNAGH 10 20 30 70 80 90 100 110 120 pF1KB6 ILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLRE : :::::: .:::::::::...::.:.: . :.:.:: .: : ::.. :::: .. .. NP_004 IAGSVNVRFSTIVRRRAKGAMGLEHIVP-NAELRGRLLAGAYHAVVLLDERSAALDGAKR 40 50 60 70 80 90 130 140 150 160 170 180 pF1KB6 DSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLD :.:..:.. :: :.:. ... .:::::: ::. ::.::: .. .. :. :. . . NP_004 DGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAE 100 110 120 130 140 150 190 200 210 220 230 240 pF1KB6 LGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHY :::::.:::.::::::::::::::::::::.:.:::::::::::.:::..::::::::: NP_004 SGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHY 160 170 180 190 200 210 250 260 270 280 290 300 pF1KB6 QYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKR ::: ::::::::::::::: :::..::..:. :::.::::::::::::::::::: .: NP_004 QYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNR 220 230 240 250 260 270 310 320 330 340 350 360 pF1KB6 VRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATP :.:.:::::::::::::::::::::::::::::::: :.:::.::. . .:: . .: NP_004 VKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTT- 280 290 300 310 320 330 370 380 390 pF1KB6 TSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC ::.::::. :::. :.: ::.::::::::: NP_004 ----VFNFPVSIPVHSTNSALSYLQSPITTSPSC 340 350 360 >>NP_004410 (OMIM: 603069) dual specificity protein phos (384 aa) initn: 952 init1: 635 opt: 963 Z-score: 982.4 bits: 190.6 E(85289): 5.5e-48 Smith-Waterman score: 971; 46.7% identity (67.7% similar) in 381 aa overlap (41-394:19-384) 20 30 40 50 60 70 pF1KB6 DCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGYILGSVNVRCN ....:..:::::.:: .:. . ::.:: : NP_004 MKVTSLDGRQLRKMLRKEAAARCVVLDCRPYLAFAASNVRGSLNVNLN 10 20 30 40 80 90 100 110 120 pF1KB6 TIVRRRAKG-SVSLEQILPAEEEVRARLRS---GLYSAVIVYDERSPRAESLREDSTVSL ..: :::.: .:: . .:: .: .:::: . : .::.: :. : . ..:::.:.. . NP_004 SVVLRRARGGAVSARYVLP-DEAARARLLQEGGGGVAAVVVLDQGSRHWQKLREESAARV 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB6 VVQALRRNAERTD-ICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSS :. .: . .:::::: : ::::: : .: :. : :. NP_004 VLTSLLACLPAGPRVYFLKGGYETFYSEYPECCVDVK-------PISQEKIESERALISQ 110 120 130 140 150 160 190 200 210 220 230 pF1KB6 CGTPL--------HDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFE :: :. .::::::::::::::::::::.. ..: : :::::::: . NP_004 CGKPVVNVSYRPAYDQGGPVEILPFLYLGSAYHASKCEFLANLHITALLNVSRRTSEACA 170 180 190 200 210 220 240 250 260 270 280 290 pF1KB6 GHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMM : .:: :::::.: ::::: :.:::..:: :.. :.:::::.:::::: :::.:::: NP_004 THLHYKWIPVEDSHTADISSHFQEAIDFIDCVREKGGKVLVHCEAGISRSPTICMAYLMK 230 240 250 260 270 280 300 310 320 330 340 pF1KB6 KKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAT-------SCAAEAASPS--G :. ::.:::...:::::..::::.:::::::.::..: . :: .:::. : : NP_004 TKQFRLKEAFDYIKQRRSMVSPNFGFMGQLLQYESEILPSTPNPQPPSCQGEAAGSSLIG 290 300 310 320 330 340 350 360 370 380 390 pF1KB6 PLRERGKTPATPTSQFVF-SFPVSV----GVHSAPSSLPYLHSPITTSPSC :. .: : .. .::.:: .::. : : .::..:. :: NP_004 HLQT-----LSPDMQGAYCTFPASVLAPVPTHSTVSELS--RSPVATATSC 350 360 370 380 >>NP_004409 (OMIM: 603068) dual specificity protein phos (314 aa) initn: 866 init1: 729 opt: 947 Z-score: 967.5 bits: 187.5 E(85289): 3.8e-47 Smith-Waterman score: 950; 48.2% identity (71.4% similar) in 336 aa overlap (4-335:3-312) 10 20 30 40 50 60 pF1KB6 MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGY .: ::..:..: :. :: . . :::::::::: . NP_004 MGLEAARELECAALGTLL-RDPR----------------EAERTLLLDCRPFLAFCRRH 10 20 30 40 70 80 90 100 110 pF1KB6 ILGSVNVRCNTIVRRRAKG--SVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESL . .. : :...::::.: .. : .:: .. .:.:: : . ..: :: : . : NP_004 VRAARPVPWNALLRRRARGPPAAVLACLLP-DRALRTRLVRGELARAVVLDEGSASVAEL 50 60 70 80 90 100 120 130 140 150 160 170 pF1KB6 REDSTVSLVVQAL--RRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSAT : :: . ... :: . : : . .:.::.. :.. :..::.. : : .::.. NP_004 RPDSPAHVLLAALLHETRAGPTAVYFLRGGFDGFQGCCPDLCSEAPA-----PALPPTGD 110 120 130 140 150 180 190 200 210 220 230 pF1KB6 EPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHF . . :. .:..::::::::::.:.::: :.. . :.: ::::.::::..::::: NP_004 KT---SRSDSRAPVYDQGGPVEILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHF 160 170 180 190 200 210 240 250 260 270 280 290 pF1KB6 EGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLM :: ..:: ::::::. ..::.::.::: .:: ::. ::::::::::::::::::::::: NP_004 EGLFRYKSIPVEDNQMVEISAWFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLM 220 230 240 250 260 270 300 310 320 330 340 350 pF1KB6 MKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKT ...::::.:::.::::::..:::::::::::::::.::: NP_004 QSRRVRLDEAFDFVKQRRGVISPNFSFMGQLLQFETQVLCH 280 290 300 310 360 370 380 390 pF1KB6 PATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC >>XP_016859035 (OMIM: 603068) PREDICTED: dual specificit (342 aa) initn: 875 init1: 729 opt: 786 Z-score: 803.5 bits: 157.3 E(85289): 5.1e-38 Smith-Waterman score: 888; 44.7% identity (66.3% similar) in 365 aa overlap (4-335:3-340) 10 20 30 40 50 60 pF1KB6 MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGY .: ::..:..: :. :: . . :::::::::: . XP_016 MGLEAARELECAALGTLL-RDPR----------------EAERTLLLDCRPFLAFCRRH 10 20 30 40 70 80 90 100 110 pF1KB6 ILGSVNVRCNTIVRRRAKG--SVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESL . .. : :...::::.: .. : .:: .. .:.:: : . ..: :: : . : XP_016 VRAARPVPWNALLRRRARGPPAAVLACLLP-DRALRTRLVRGELARAVVLDEGSASVAEL 50 60 70 80 90 100 120 130 140 pF1KB6 REDSTVSLVVQALRRN-------------------------------AERTDICLLKGGY : :: . ... :: .. :.:. . :: ::. XP_016 RPDSPAHVLLAALLHETRAGPTAVYFLRGEQAGRPWPAPPDSSPAFPADRA-LPLLAGGF 110 120 130 140 150 160 150 160 170 180 190 200 pF1KB6 ERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGS . :.. :..::.. : : .::.. . . :. .:..::::::::::.:.::: XP_016 DGFQGCCPDLCSEAPA-----PALPPTGDKT---SRSDSRAPVYDQGGPVEILPYLFLGS 170 180 190 200 210 210 220 230 240 250 260 pF1KB6 AYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYID :.. . :.: ::::.::::..::::::: ..:: ::::::. ..::.::.::: .:: XP_016 CSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAIGFID 220 230 240 250 260 270 270 280 290 300 310 320 pF1KB6 AVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQL ::. :::::::::::::::::::::::...::::.:::.::::::..::::::::::: XP_016 WVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSFMGQL 280 290 300 310 320 330 330 340 350 360 370 380 pF1KB6 LQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSP ::::.::: XP_016 LQFETQVLCH 340 >>NP_009138 (OMIM: 608867) dual specificity protein phos (482 aa) initn: 544 init1: 338 opt: 582 Z-score: 594.3 bits: 119.1 E(85289): 2.3e-26 Smith-Waterman score: 582; 34.0% identity (66.3% similar) in 297 aa overlap (39-331:167-459) 10 20 30 40 50 60 pF1KB6 EMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGYILGSVNVR ::: : ...:::::. .. ..: :.:.. NP_009 VSGTPKQLASIKIIYPNDLAKKMTKCSKSHLPSQGP-VIIDCRPFMEYNKSHIQGAVHIN 140 150 160 170 180 190 70 80 90 100 110 120 pF1KB6 C-NTIVRRR-AKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSL : . : ::: .:.... ... .: . .. . . .::::: . . . .. . . NP_009 CADKISRRRLQQGKITVLDLISCREG-KDSFKRIFSKEIIVYDENTNEPSRVMPSQPLHI 200 210 220 230 240 250 130 140 150 160 170 180 pF1KB6 VVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSC :...:.: : . .:::: :.... ..:... : ... : NP_009 VLESLKR--EGKEPLVLKGGLSSFKQNHENLCDNSLQLQECREVGGGASAASSLLPQPIP 260 270 280 290 300 310 190 200 210 220 230 240 pF1KB6 GTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCP-NHFE-GHYQYKC :: ... . :::::.::. : : .. :.: ..::.. : :.: : ..:: NP_009 TTPDIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKR 320 330 340 350 360 370 250 260 270 280 290 300 pF1KB6 IPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLE .:. :..: .. ..: ::.:.:. ...: .:.:::::.:::::: .:::: . :. . NP_009 LPATDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMT 380 390 400 410 420 430 310 320 330 340 350 360 pF1KB6 EAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQF .:..::: .: :::::..::::::.:: NP_009 DAYKFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPRILTPKLMGVETVV 440 450 460 470 480 >>NP_001938 (OMIM: 602749) dual specificity protein phos (419 aa) initn: 553 init1: 333 opt: 477 Z-score: 488.6 bits: 99.3 E(85289): 1.8e-20 Smith-Waterman score: 624; 34.4% identity (62.8% similar) in 366 aa overlap (24-345:37-397) 10 20 30 40 pF1KB6 MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLP------------- .:.:.:.... :. ..: NP_001 GPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWLQEELEA 10 20 30 40 50 60 50 60 70 80 90 pF1KB6 -SGGKCLLLDCRPFLAHSAGYILGSVNVRC-NTIVRRRAKGSVSLEQILPAEEEVRARLR .:.. ::::::: ...: ..:. . ..:: ::.. ...:.: . . . :. NP_001 RGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHAD-KERFA 70 80 90 100 110 120 100 110 120 130 140 150 pF1KB6 SGLYSA-VIVYDERSP--RAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYP . .: :..::: . . : :...:..: :: .. .. :.::...:..:: NP_001 TRCKAATVLLYDEATAEWQPEPGAPASVLGLLLQKLRDDGCQAYY--LQGGFNKFQTEYS 130 140 150 160 170 180 160 170 180 190 pF1KB6 EFCSKTKALAAIPPPVPPSATEPLDLG-------CS--------------SCGTPLHDQG : : . .. : ::... : :: :: : :.:. .. NP_001 EHCETNVDSSSSPSSSPPTSV--LGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQ 190 200 210 220 230 240 200 210 220 230 240 250 pF1KB6 G--PVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFE--GHYQYKCIPVEDN ::.:::.:::: : .. :.: :: .:::. . :: :: :.. :: ::. :. NP_001 PAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDH 250 260 270 280 290 300 260 270 280 290 300 310 pF1KB6 HKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFV . ..:..: ::: .:: ... . ::::: ::::::.:. .::::.: . :..:..:: NP_001 WSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFV 310 320 330 340 350 360 320 330 340 350 360 pF1KB6 KQRRSIISPNFSFMGQLLQFESQV-LATSCAAEAASPSGPLRERGKTPATPTSQFVFSFP :...: :::::.::::::.:: . :.. : .:.: NP_001 KRKKSNISPNFNFMGQLLDFERTLGLSSPCDNHASSEQLYFSTPTNHNLFPLNTLEST 370 380 390 400 410 370 380 390 pF1KB6 VSVGVHSAPSSLPYLHSPITTSPSC >>NP_001937 (OMIM: 602748,615269) dual specificity prote (381 aa) initn: 570 init1: 318 opt: 472 Z-score: 484.1 bits: 98.4 E(85289): 3.2e-20 Smith-Waterman score: 589; 34.9% identity (62.9% similar) in 350 aa overlap (44-366:33-373) 20 30 40 50 60 70 pF1KB6 VLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGYILGSVNVRCNTIV . ::.:::: . ...: ...:: :. NP_001 DTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIM 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB6 RRR-AKGSVSLEQILP-AEEEVRARLRSGLYSAVIVYDERSPR-AESLREDSTVSLVVQA :: ::.. .. .. .:.. : : : ..:..::: : :. .:...:... NP_001 LRRLQKGNLPVRALFTRGEDRDRFTRRCGT-DTVVLYDESSSDWNENTGGESVLGLLLKK 70 80 90 100 110 120 140 150 160 170 pF1KB6 LRRNAERTDICLLKGGYERFSSEYPEFCSKT--KALAAIPPPVP------------PSAT :. .. :. :.::. .:..:. : . . .. ::.: :. NP_001 LKDEGCRA--FYLEGGFSKFQAEFSLHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSD 130 140 150 160 170 180 190 200 210 220 pF1KB6 EPLDL------GCSSCGTPLHDQGG--PVEILPFLYLGSAYHAARRDMLDALGITALLNV :: . .: :.:: .. ::::::::::: : .. :.:. .:: .::: NP_001 IESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNV 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB6 SSDCPNHFE--GHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISR . . :: :: :...:: ::. :. . ..:..: ::: .:: .. ::::: ::::: NP_001 TPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISR 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB6 SATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASP :.:. .::::.: . ...:...::...: :::::.::::::.:: ..:. : . : NP_001 SVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFE-RTLGLSSPCDNRVP 300 310 320 330 340 350 350 360 370 380 390 pF1KB6 SGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC . : .::..: :. NP_001 AQQLYF-----TTPSNQNVYQVDSLQST 360 370 380 394 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 23:17:10 2016 done: Fri Nov 4 23:17:11 2016 Total Scan time: 9.210 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]