FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6553, 371 aa 1>>>pF1KB6553 371 - 371 aa - 371 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.8611+/-0.000288; mu= 20.3117+/- 0.018 mean_var=103.0535+/-25.263, 0's: 0 Z-trim(118.6): 386 B-trim: 3125 in 2/50 Lambda= 0.126341 statistics sampled from 31173 (31779) to 31173 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.723), E-opt: 0.2 (0.373), width: 16 Scan time: 8.690 The best scores are: opt bits E(85289) NP_000045 (OMIM: 300538,300539,304800) vasopressin ( 371) 2516 469.0 7.8e-132 XP_006724891 (OMIM: 300538,300539,304800) PREDICTE ( 371) 2516 469.0 7.8e-132 NP_001139623 (OMIM: 300538,300539,304800) vasopres ( 309) 2076 388.7 9.7e-108 NP_000907 (OMIM: 167055) oxytocin receptor [Homo s ( 389) 915 177.2 5.6e-44 XP_011532064 (OMIM: 167055) PREDICTED: oxytocin re ( 389) 915 177.2 5.6e-44 NP_000697 (OMIM: 600821) vasopressin V1a receptor ( 418) 784 153.4 9.1e-37 NP_000698 (OMIM: 600264) vasopressin V1b receptor ( 424) 668 132.2 2.1e-30 NP_001287864 (OMIM: 608584,608595) neuropeptide S ( 390) 511 103.6 8.3e-22 NP_997056 (OMIM: 608584,608595) neuropeptide S rec ( 377) 507 102.8 1.3e-21 NP_997055 (OMIM: 608584,608595) neuropeptide S rec ( 371) 505 102.4 1.7e-21 NP_001287862 (OMIM: 608584,608595) neuropeptide S ( 366) 443 91.1 4.3e-18 NP_000397 (OMIM: 138850,146110) gonadotropin-relea ( 328) 376 78.8 1.9e-14 NP_000947 (OMIM: 176804,208550) prostaglandin E2 r ( 358) 291 63.4 9.3e-10 NP_001287863 (OMIM: 608584,608595) neuropeptide S ( 305) 284 62.0 2e-09 NP_005152 (OMIM: 600052) apelin receptor [Homo sap ( 380) 272 60.0 1.1e-08 NP_937822 (OMIM: 606925) pyroglutamylated RFamide ( 431) 272 60.0 1.1e-08 NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 270 59.6 1.3e-08 NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 270 59.6 1.4e-08 NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 270 59.6 1.4e-08 NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 270 59.6 1.4e-08 NP_002502 (OMIM: 162341) neuromedin-B receptor iso ( 390) 270 59.6 1.4e-08 NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 270 59.7 1.4e-08 NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 270 59.7 1.5e-08 XP_011508789 (OMIM: 604153) PREDICTED: neuromedin- ( 403) 269 59.5 1.6e-08 NP_006047 (OMIM: 604153) neuromedin-U receptor 1 [ ( 426) 269 59.5 1.7e-08 NP_001044 (OMIM: 182455) somatostatin receptor typ ( 364) 268 59.2 1.7e-08 NP_001166031 (OMIM: 182455) somatostatin receptor ( 364) 268 59.2 1.7e-08 XP_005253267 (OMIM: 118445) PREDICTED: gastrin/cho ( 516) 267 59.2 2.4e-08 NP_795344 (OMIM: 118445) gastrin/cholecystokinin t ( 447) 266 59.0 2.5e-08 NP_115940 (OMIM: 176400,604161,614837) kiSS-1 rece ( 398) 265 58.7 2.6e-08 NP_150598 (OMIM: 606665) melanopsin isoform 1 [Hom ( 478) 251 56.3 1.7e-07 XP_016872445 (OMIM: 606665) PREDICTED: melanopsin ( 528) 251 56.3 1.8e-07 XP_016883343 (OMIM: 602548) PREDICTED: nociceptin ( 370) 242 54.5 4.6e-07 NP_872588 (OMIM: 602548) nociceptin receptor isofo ( 370) 242 54.5 4.6e-07 NP_001186948 (OMIM: 602548) nociceptin receptor is ( 370) 242 54.5 4.6e-07 NP_000904 (OMIM: 602548) nociceptin receptor isofo ( 370) 242 54.5 4.6e-07 XP_016883342 (OMIM: 602548) PREDICTED: nociceptin ( 388) 242 54.5 4.8e-07 XP_011527130 (OMIM: 602548) PREDICTED: nociceptin ( 388) 242 54.5 4.8e-07 XP_016883341 (OMIM: 602548) PREDICTED: nociceptin ( 388) 242 54.5 4.8e-07 NP_001305782 (OMIM: 602548) nociceptin receptor is ( 399) 242 54.5 4.8e-07 NP_002522 (OMIM: 162651) neurotensin receptor type ( 418) 239 54.0 7.3e-07 NP_000902 (OMIM: 165195) delta-type opioid recepto ( 372) 238 53.8 7.7e-07 XP_011527129 (OMIM: 162651) PREDICTED: neurotensin ( 336) 237 53.5 8.2e-07 XP_016874005 (OMIM: 118445) PREDICTED: gastrin/cho ( 381) 237 53.6 8.9e-07 NP_858043 (OMIM: 601531) leukotriene B4 receptor 1 ( 352) 233 52.8 1.4e-06 NP_001137391 (OMIM: 601531) leukotriene B4 recepto ( 352) 233 52.8 1.4e-06 XP_016881180 (OMIM: 600377) PREDICTED: galanin rec ( 269) 230 52.1 1.7e-06 NP_001305784 (OMIM: 602548) nociceptin receptor is ( 341) 231 52.4 1.8e-06 NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 231 52.5 1.8e-06 XP_016872446 (OMIM: 606665) PREDICTED: melanopsin ( 405) 228 52.0 2.9e-06 >>NP_000045 (OMIM: 300538,300539,304800) vasopressin V2 (371 aa) initn: 2516 init1: 2516 opt: 2516 Z-score: 2487.8 bits: 469.0 E(85289): 7.8e-132 Smith-Waterman score: 2516; 100.0% identity (100.0% similar) in 371 aa overlap (1-371:1-371) 10 20 30 40 50 60 pF1KB6 MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT 310 320 330 340 350 360 370 pF1KB6 ASSSLAKDTSS ::::::::::: NP_000 ASSSLAKDTSS 370 >>XP_006724891 (OMIM: 300538,300539,304800) PREDICTED: v (371 aa) initn: 2516 init1: 2516 opt: 2516 Z-score: 2487.8 bits: 469.0 E(85289): 7.8e-132 Smith-Waterman score: 2516; 100.0% identity (100.0% similar) in 371 aa overlap (1-371:1-371) 10 20 30 40 50 60 pF1KB6 MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT 310 320 330 340 350 360 370 pF1KB6 ASSSLAKDTSS ::::::::::: XP_006 ASSSLAKDTSS 370 >>NP_001139623 (OMIM: 300538,300539,304800) vasopressin (309 aa) initn: 2076 init1: 2076 opt: 2076 Z-score: 2055.2 bits: 388.7 E(85289): 9.7e-108 Smith-Waterman score: 2076; 100.0% identity (100.0% similar) in 304 aa overlap (1-304:1-304) 10 20 30 40 50 60 pF1KB6 MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVAWAFSLLLSLPQLFIFAQ 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASLVPGP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SERPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWDPEA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT :::: NP_001 PLEGGCSRG >>NP_000907 (OMIM: 167055) oxytocin receptor [Homo sapie (389 aa) initn: 807 init1: 331 opt: 915 Z-score: 910.5 bits: 177.2 E(85289): 5.6e-44 Smith-Waterman score: 923; 42.3% identity (67.0% similar) in 388 aa overlap (4-371:13-379) 10 20 30 40 50 pF1KB6 MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAV :...::.: :. .: . : :. :::.:.:.: .... . NP_000 MEGALAANWSAEAANASAAP-----PGAEGNRTAGPP--RRNEALARVEVAVLCLILLLA 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 ALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDAL .:. :: :: : :. : . . :. :: .:::.::.::::::: : : :: ::: : NP_000 LSGNACVLLAL-RTTRQKH-SRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 CRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNR-PVLVAWAFSLLL :: :::::.:::.::.:..: :.::: :::.:. . :. . .: ::..: :. NP_000 CRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRT----DRLAVLATWLGCLVA 120 130 140 150 160 180 190 200 210 220 230 pF1KB6 SLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFR : ::. ::. :.: ..:: :::: : .::: ..:.:::.: :...:.. .::: :: NP_000 SAPQVHIFSLREV--ADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISF 170 180 190 200 210 220 240 250 260 270 pF1KB6 EIHASL-----VPGPSERP-------GGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVV .: .: . . .: : ::: :..: .: : .::.::..::. NP_000 KIWQNLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSV---KLISKAKIRTVKMTFIIVL 230 240 250 260 270 280 280 290 300 310 320 330 pF1KB6 VYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSEL-R ....::.:::.::.:..:: .:: :.. :...::::::::: ::::: :.. . :: . NP_000 AFIVCWTPFFFVQMWSVWDANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQ 290 300 310 320 330 340 340 350 360 370 pF1KB6 SLLCCA----RGRTPPSLGPQDESCTTASSS--LAKDTSS .:::. .:: :: . : . ::: :.. .:: NP_000 RFLCCSASYLKGRR---LGETSASKKSNSSSFVLSHRSSSQRSCSQPSTA 350 360 370 380 >>XP_011532064 (OMIM: 167055) PREDICTED: oxytocin recept (389 aa) initn: 807 init1: 331 opt: 915 Z-score: 910.5 bits: 177.2 E(85289): 5.6e-44 Smith-Waterman score: 923; 42.3% identity (67.0% similar) in 388 aa overlap (4-371:13-379) 10 20 30 40 50 pF1KB6 MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAV :...::.: :. .: . : :. :::.:.:.: .... . XP_011 MEGALAANWSAEAANASAAP-----PGAEGNRTAGPP--RRNEALARVEVAVLCLILLLA 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 ALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDAL .:. :: :: : :. : . . :. :: .:::.::.::::::: : : :: ::: : XP_011 LSGNACVLLAL-RTTRQKH-SRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLL 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 CRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNR-PVLVAWAFSLLL :: :::::.:::.::.:..: :.::: :::.:. . :. . .: ::..: :. XP_011 CRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRT----DRLAVLATWLGCLVA 120 130 140 150 160 180 190 200 210 220 230 pF1KB6 SLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFR : ::. ::. :.: ..:: :::: : .::: ..:.:::.: :...:.. .::: :: XP_011 SAPQVHIFSLREV--ADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAACYGLISF 170 180 190 200 210 220 240 250 260 270 pF1KB6 EIHASL-----VPGPSERP-------GGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVV .: .: . . .: : ::: :..: .: : .::.::..::. XP_011 KIWQNLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSV---KLISKAKIRTVKMTFIIVL 230 240 250 260 270 280 280 290 300 310 320 330 pF1KB6 VYVLCWAPFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSEL-R ....::.:::.::.:..:: .:: :.. :...::::::::: ::::: :.. . :: . XP_011 AFIVCWTPFFFVQMWSVWDANAPKEASAFIIVMLLASLNSCCNPWIYMLFTGHLFHELVQ 290 300 310 320 330 340 340 350 360 370 pF1KB6 SLLCCA----RGRTPPSLGPQDESCTTASSS--LAKDTSS .:::. .:: :: . : . ::: :.. .:: XP_011 RFLCCSASYLKGRR---LGETSASKKSNSSSFVLSHRSSSQRSCSQPSTA 350 360 370 380 >>NP_000697 (OMIM: 600821) vasopressin V1a receptor [Hom (418 aa) initn: 820 init1: 336 opt: 784 Z-score: 781.1 bits: 153.4 E(85289): 9.1e-37 Smith-Waterman score: 882; 42.2% identity (72.6% similar) in 329 aa overlap (28-342:42-366) 10 20 30 40 50 pF1KB6 MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGL : :.:. ::. :.:.:...:....:.:. NP_000 SGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSS 20 30 40 50 60 70 60 70 80 90 100 110 pF1KB6 VLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKY :: :: : :. . .:.:: :: :::::::.::::::. : : :::::: :::.::. NP_000 VLLALHRTPRKT--SRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKH 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 LQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVA-WAFSLLLSLPQLF ::. ::.::.::...:: ::. :.:.:. . .. :. .: ...: :..:..:: :: : NP_000 LQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQP--ARRSRLMIAAAWVLSFVLSTPQYF 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB6 IFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASL .:.. .:.. . . :::: : .::: :.::::.. .::::.. ...: .: .: .. NP_000 VFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNV 190 200 210 220 230 240 240 250 260 270 280 pF1KB6 VPGPSERP--GGRRRGR--RTG---SPGEGA--HVSAAVAKTVRMTLVIVVVYVLCWAPF . : :... : . : .: .. .: : .::.::.:::..:..::::: NP_000 RGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPF 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB6 FLVQLWAAWDPEA---PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSE-LRSLLCCA :..:.:..::: . :. ... ::.::::: ::::: ::. . .. ..:. :: NP_000 FIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQ 310 320 330 340 350 360 350 360 370 pF1KB6 RGRTPPSLGPQDESCTTASSSLAKDTSS NP_000 NMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST 370 380 390 400 410 >>NP_000698 (OMIM: 600264) vasopressin V1b receptor [Hom (424 aa) initn: 931 init1: 352 opt: 668 Z-score: 666.7 bits: 132.2 E(85289): 2.1e-30 Smith-Waterman score: 933; 44.4% identity (67.9% similar) in 358 aa overlap (13-348:10-361) 10 20 30 40 50 60 pF1KB6 MLMASTTSAVPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLA .:. . : . : :: ::..:...:. :.: .. .: :: NP_000 MDSGPLWDANPTPRGTLSAPNATTPWLGRDEELAKVEIGVLATVLVLATGGNLAVLL 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 ALARRGRRGHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQM .:.. ::. . .:.:. :: :.::::::::::::: : : ::.::: :::::::::. NP_000 TLGQLGRKR--SRMHLFVLHLALTDLAVALFQVLPQLLWDITYRFQGPDLLCRAVKYLQV 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 VGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRPVLVA--WAFSLLLSLPQLFIF ..:.::.::.:::::::. :.:.:. . .. . . . .:.: : .. ..::::.::: NP_000 LSMFASTYMLLAMTLDRYLAVCHPLRSLQQPGQSTY---LLIAAPWLLAAIFSLPQVFIF 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 AQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHASL-V . :.: :::: :::: :. ::: :.:.:: .: .:: :. ..:: :: .:: .: : NP_000 SLREVIQGSGVLDCWADFGFPWGPRAYLTWTTLAIFVLPVTMLTACYSLICHEICKNLKV 180 190 200 210 220 230 240 250 260 270 280 pF1KB6 PGPSERPGG---RRRGRRT---------GSPGEGAHV---SAAVAKTVRMTLVIVVVYVL . : :: : : . : :.. . . : : .::.::.:::..:. NP_000 KTQAWRVGGGGWRTWDRPSPSTLAATTRGLPSRVSSINTISRAKIRTVKMTFVIVLAYIA 240 250 260 270 280 290 290 300 310 320 330 pF1KB6 CWAPFFLVQLWAAWDPEAPLEGAP---FVLLMLLASLNSCTNPWIYASFSSSV-SSELRS :::::: ::.:..:: .:: : . :.. :::..:::: ::::: .:.: . :: NP_000 CWAPFFSVQMWSVWDKNAPDEDSTNVAFTISMLLGNLNSCCNPWIYMGFNSHLLPRPLRH 300 310 320 330 340 350 340 350 360 370 pF1KB6 LLCCARGRTPPSLGPQDESCTTASSSLAKDTSS : ::. : : NP_000 LACCG-GPQPRMRRRLSDGSLSSRHTTLLTRSSCPATLSLSLSLTLSGRPRPEESPRDLE 360 370 380 390 400 410 >>NP_001287864 (OMIM: 608584,608595) neuropeptide S rece (390 aa) initn: 341 init1: 189 opt: 511 Z-score: 512.5 bits: 103.6 E(85289): 8.3e-22 Smith-Waterman score: 511; 28.7% identity (61.7% similar) in 345 aa overlap (40-369:52-380) 10 20 30 40 50 60 pF1KB6 VPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRG .: : ..:: . ..:..:: . :: ... NP_001 SPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKS 30 40 50 60 70 80 70 80 90 100 110 120 pF1KB6 HWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYM . . :. .: ..: ..: ..: .. :. : : .:: .::.:.:::.: .:::.:. NP_001 R---MTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYV 90 100 110 120 130 130 140 150 160 170 180 pF1KB6 ILAMTLDRHRAICRPMLAYRHGSGAHWNRP-VLVAWAFSLLLSLPQLFIFAQRNVEGGSG ......::..:: :: . .: . : ...::..:.:.:.: :.::..:.. ..: NP_001 LVSLSIDRYHAIVYPM---KFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTL--SNG 140 150 160 170 180 190 190 200 210 220 230 240 pF1KB6 VTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREI------HASLVPGPSE ..::: . . :.: .:..:. : :. ...: : . ... . :. NP_001 EVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSD 200 210 220 230 240 250 250 260 270 280 290 300 pF1KB6 RPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWD--PEA :. .: ..: .: : :.......:..... ::.:.:: .. .. :.. NP_001 -------GKLCSSYNRGL-ISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDT 260 270 280 290 300 310 320 330 340 350 pF1KB6 PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRS-----LLCCARGRTPP-SLGPQ . :... : .::: :: :: ::::.: :. :: : . : . NP_001 QERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCRANSSVYLLACDVSVLWALVLTSE 310 320 330 340 350 360 360 370 pF1KB6 DESCTTASSSLAKDTSS ::: . . :: : NP_001 KESCESWRRKGAKITGFQNDVPGEN 370 380 390 >>NP_997056 (OMIM: 608584,608595) neuropeptide S recepto (377 aa) initn: 352 init1: 189 opt: 507 Z-score: 508.7 bits: 102.8 E(85289): 1.3e-21 Smith-Waterman score: 507; 28.4% identity (63.0% similar) in 327 aa overlap (40-357:52-362) 10 20 30 40 50 60 pF1KB6 VPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRG .: : ..:: . ..:..:: . :: ... NP_997 SPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKS 30 40 50 60 70 80 70 80 90 100 110 120 pF1KB6 HWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYM . . :. .: ..: ..: ..: .. :. : : .:: .::.:.:::.: .:::.:. NP_997 R---MTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYV 90 100 110 120 130 130 140 150 160 170 180 pF1KB6 ILAMTLDRHRAICRPMLAYRHGSGAHWNRP-VLVAWAFSLLLSLPQLFIFAQRNVEGGSG ......::..:: :: . .: . : ...::..:.:.:.: :.::..:.. ..: NP_997 LVSLSIDRYHAIVYPM---KFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTL--SNG 140 150 160 170 180 190 190 200 210 220 230 240 pF1KB6 VTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREI------HASLVPGPSE ..::: . . :.: .:..:. : :. ...: : . ... . :. NP_997 EVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSD 200 210 220 230 240 250 250 260 270 280 290 300 pF1KB6 RPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWD--PEA :. .: ..: .: : :.......:..... ::.:.:: .. .. :.. NP_997 -------GKLCSSYNRGL-ISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDT 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT . :... : .::: :: :: ::::.: : . .. : :: :. NP_997 QERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCRVIRLRQLQEAALMLCPQRENWKG 310 320 330 340 350 360 370 pF1KB6 ASSSLAKDTSS NP_997 TWPGVPSWALPR 370 >>NP_997055 (OMIM: 608584,608595) neuropeptide S recepto (371 aa) initn: 341 init1: 189 opt: 505 Z-score: 506.8 bits: 102.4 E(85289): 1.7e-21 Smith-Waterman score: 505; 29.0% identity (64.5% similar) in 307 aa overlap (40-337:52-342) 10 20 30 40 50 60 pF1KB6 VPGHPSLPSLPSNSSQERPLDTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRG .: : ..:: . ..:..:: . :: ... NP_997 SPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKS 30 40 50 60 70 80 70 80 90 100 110 120 pF1KB6 HWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYM . . :. .: ..: ..: ..: .. :. : : .:: .::.:.:::.: .:::.:. NP_997 R---MTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYV 90 100 110 120 130 130 140 150 160 170 180 pF1KB6 ILAMTLDRHRAICRPMLAYRHGSGAHWNRP-VLVAWAFSLLLSLPQLFIFAQRNVEGGSG ......::..:: :: . .: . : ...::..:.:.:.: :.::..:.. ..: NP_997 LVSLSIDRYHAIVYPM---KFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTL--SNG 140 150 160 170 180 190 190 200 210 220 230 240 pF1KB6 VTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREI------HASLVPGPSE ..::: . . :.: .:..:. : :. ...: : . ... . :. NP_997 EVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSD 200 210 220 230 240 250 250 260 270 280 290 300 pF1KB6 RPGGRRRGRRTGSPGEGAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWD--PEA :. .: ..: .: : :.......:..... ::.:.:: .. .. :.. NP_997 -------GKLCSSYNRGL-ISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDT 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 PLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCARGRTPPSLGPQDESCTT . :... : .::: :: :: ::::.: : NP_997 QERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQIL 310 320 330 340 350 360 370 pF1KB6 ASSSLAKDTSS NP_997 SKPEFI 370 371 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 11:27:13 2016 done: Sat Nov 5 11:27:14 2016 Total Scan time: 8.690 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]