Result of FASTA (ccds) for
pF1KB6557
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6557, 372 aa
1>>>pF1KB6557 372 - 372 aa - 372 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.6498+/-0.0007; mu= 10.5550+/- 0.042
mean_var=101.8287+/-20.548, 0's: 0 Z-trim(111.7): 62 B-trim: 0 in 0/53
Lambda= 0.127098
statistics sampled from 12550 (12614) to 12550 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.747), E-opt: 0.2 (0.387), width: 16
Scan time: 2.550
The best scores are: opt bits E(32554)
CCDS6558.1 CNTFR gene_id:1271|Hs108|chr9 ( 372) 2570 481.4 5.6e-136
CCDS72927.1 IL6R gene_id:3570|Hs108|chr1 ( 352) 386 80.9 1.9e-15
CCDS1067.1 IL6R gene_id:3570|Hs108|chr1 ( 468) 372 78.4 1.4e-14
CCDS12123.1 EBI3 gene_id:10148|Hs108|chr19 ( 229) 366 77.1 1.7e-14
CCDS6567.1 IL11RA gene_id:3590|Hs108|chr9 ( 422) 370 78.0 1.7e-14
CCDS1068.1 IL6R gene_id:3570|Hs108|chr1 ( 365) 369 77.8 1.7e-14
>>CCDS6558.1 CNTFR gene_id:1271|Hs108|chr9 (372 aa)
initn: 2570 init1: 2570 opt: 2570 Z-score: 2554.7 bits: 481.4 E(32554): 5.6e-136
Smith-Waterman score: 2570; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:1-372)
10 20 30 40 50 60
pF1KB6 MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS65 PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL
310 320 330 340 350 360
370
pF1KB6 AAAAATASSLLI
::::::::::::
CCDS65 AAAAATASSLLI
370
>>CCDS72927.1 IL6R gene_id:3570|Hs108|chr1 (352 aa)
initn: 309 init1: 145 opt: 386 Z-score: 390.8 bits: 80.9 E(32554): 1.9e-15
Smith-Waterman score: 431; 30.8% identity (56.5% similar) in 354 aa overlap (10-333:6-352)
10 20 30 40 50
pF1KB6 MAAPVPWACCAVLAA---AAAVVYAQRHSP-QEAPHVQYERL-GSDVTLPC-GTANWD-A
::.::: : ... : :. : ::. . : :..::: : :. : :
CCDS72 MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNA
10 20 30 40 50
60 70 80 90 100
pF1KB6 AVTW--RVNGTDLAPDLLNG--SQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPP
.: : : .. :. : .:.:....: :: :.:.. . . : : : .::
CCDS72 TVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYR--AGRPAGTVHLLVDVPP
60 70 80 90 100 110
110 120 130 140 150
pF1KB6 REPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMV---------CE-KDPA
.:: ::: .. .. : : : :. . .:: :.. :. .. .
CCDS72 EEPQLSCFRKSPLSNVVCEWG---PRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQES
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB6 LKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAI-TFDEFTIVKPDPPENVVARPVPSN
: :.. . :.. : ::. :....: . . ::. :..:::: :... : :
CCDS72 QKFSCQLAVPEGDSSF-YIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARN
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB6 PRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAH-TITDAYAGKEYI
:: : :::: : .: . . :.: :::: . ..: : .: ::..: ...
CCDS72 PRWLSVTWQDPHSW-NSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHV
240 250 260 270 280
280 290 300 310 320 330
pF1KB6 IQVAAKDNE-IGTWSDWSVAAHATPWTEE--PR----HLTTEAQAAETTTSTTSSLAPPP
.:. :... : ::.:: : .::::.. :: ....: . :..: .... ::
CCDS72 VQLRAQEEFGQGEWSEWSPEAMGTPWTDRLSPRCPGWSTAVQSQLTATSASWVQAILPPQ
290 300 310 320 330 340
340 350 360 370
pF1KB6 TTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI
:
CCDS72 PPK
350
>>CCDS1067.1 IL6R gene_id:3570|Hs108|chr1 (468 aa)
initn: 272 init1: 145 opt: 372 Z-score: 375.1 bits: 78.4 E(32554): 1.4e-14
Smith-Waterman score: 420; 29.9% identity (54.9% similar) in 388 aa overlap (10-358:6-386)
10 20 30 40 50
pF1KB6 MAAPVPWACCAVLAA---AAAVVYAQRHSP-QEAPHVQYERL-GSDVTLPC-GTANWD-A
::.::: : ... : :. : ::. . : :..::: : :. : :
CCDS10 MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNA
10 20 30 40 50
60 70 80 90 100
pF1KB6 AVTW--RVNGTDLAPDLLNG--SQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPP
.: : : .. :. : .:.:....: :: :.:.. . . : : : .::
CCDS10 TVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYR--AGRPAGTVHLLVDVPP
60 70 80 90 100 110
110 120 130 140 150
pF1KB6 REPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMV---------CE-KDPA
.:: ::: .. .. : : : :. . .:: :.. :. .. .
CCDS10 EEPQLSCFRKSPLSNVVCEWG---PRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQES
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB6 LKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAI-TFDEFTIVKPDPPENVVARPVPSN
: :.. . :.. : ::. :....: . . ::. :..:::: :... : :
CCDS10 QKFSCQLAVPEGDSSF-YIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARN
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB6 PRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAH-TITDAYAGKEYI
:: : :::: : .: . . :.: :::: . ..: : .: ::..: ...
CCDS10 PRWLSVTWQDPHSW-NSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHV
240 250 260 270 280
280 290 300 310 320
pF1KB6 IQVAAKDNE-IGTWSDWSVAAHATPWTEE--P---RHLTTEAQAAETT----------TS
.:. :... : ::.:: : .::::: : ...: :: :. ..
CCDS10 VQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSA
290 300 310 320 330 340
330 340 350 360 370
pF1KB6 TTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI
...:: .... : : .::. . :. . :.:
CCDS10 NATSLPVQDSSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMHPPYS
350 360 370 380 390 400
CCDS10 LGQLVPERPRPTPVLVPLISPPVSPSSLGSDNTSSHNRPDARDPRSPYDISNTDYFFPR
410 420 430 440 450 460
>>CCDS12123.1 EBI3 gene_id:10148|Hs108|chr19 (229 aa)
initn: 296 init1: 103 opt: 366 Z-score: 373.8 bits: 77.1 E(32554): 1.7e-14
Smith-Waterman score: 366; 32.5% identity (58.6% similar) in 203 aa overlap (108-300:24-224)
80 90 100 110 120 130
pF1KB6 GLELGHSGLYACFHRDSWHLRHQVLLHVGLPPRE---PVLSCRSNTYPKGFYCSWHLP-T
:: : ..::.. :: . ::: :: .
CCDS12 MTPQLLLALVLWASCPPCSGRKGPPAALTLPRVQCRASRYPIAVDCSWTLPPA
10 20 30 40 50
140 150 160 170 180
pF1KB6 PTYI-PNTFNVTVLHG----SKIMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALG
:. : .: .: : .. : .. .. : : ..::: : ..... . :
CCDS12 PNSTSPVSFIATYRLGMAARGHSWPCLQQTPTSTSCTITDVQLFSMAPYVLNVTAVHPWG
60 70 80 90 100 110
190 200 210 220 230 240
pF1KB6 HNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRP
... . : :.::::::.: : : :.:.: :. :..:: :: : ::...::.
CCDS12 SSSSFVPFITEHIIKPDPPEGV--RLSPLAERQLQVQWEPPGSWPFPEIFSLKYWIRYKR
120 130 140 150 160 170
250 260 270 280 290 300
pF1KB6 LILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKD-NEIGTWSDWSVAAHATPWTEEPR
....: ..:. . . .: .::::.: .. : ::::. : ::
CCDS12 QGAARFHRVGPIEATSFILRAVRPRARYYVQVAAQDLTDYGELSDWSLPATATMSLGK
180 190 200 210 220
310 320 330 340 350 360
pF1KB6 HLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATA
>>CCDS6567.1 IL11RA gene_id:3590|Hs108|chr9 (422 aa)
initn: 368 init1: 229 opt: 370 Z-score: 373.8 bits: 78.0 E(32554): 1.7e-14
Smith-Waterman score: 535; 32.4% identity (56.4% similar) in 346 aa overlap (12-333:12-351)
10 20 30 40 50
pF1KB6 MAAPVPWACCAVLAAAAAVVYAQRHSPQE--APHVQYERLGSDVTLPCGTANWDAAVTWR
..:.:.:.: :. :: : ::: . : .: : : .. :.:
CCDS65 MSSSCSGLSRVLVAVATALVSASSPCPQAWGPPGVQYGQPGRSVKLCCPGVTAGDPVSWF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 VNGTD---LAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLS
.: .:: : .::: . : : : :. : : :..: :: .::.:
CCDS65 RDGEPKLLQGPDSGLGHELVLAQADSTDEGTYICQTLDG-ALGGTVTLQLGYPPARPVVS
70 80 90 100 110
120 130 140 150 160
pF1KB6 CRSNTYPKGFYCSWH------LPTPTYIPNTFNVTVLHGSKI--------MVCEKDPALK
:.. : ..: :.: ::: :. . . ::: ... : .::
CCDS65 CQAADY-ENFSCTWSPSQISGLPT-RYLTSYRKKTVLGADSQRRSPSTGPWPCPQDPLGA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KB6 NRCHIRYMHLFSTIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRR
:: .. ...: .:..... : :: .. . . .:..::::... .. ::. :::
CCDS65 ARCVVHGAEFWS--QYRINVTEVNPLGASTRLLDVSLQSILRPDPPQGLRVESVPGYPRR
180 190 200 210 220 230
230 240 250 260 270 280
pF1KB6 LEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVA
:...: :..:: : ::: :.::: :. :: : ..:::: :: . ..:.
CCDS65 LRASWTYPASWPCQPHFLLKFRLQYRPAQHPAWSTVE-PAGLEEVITDAVAGLPHAVRVS
240 250 260 270 280 290
290 300 310 320 330
pF1KB6 AKDN-EIGTWSDWSVAAHATPWTEE-PRHLTTEAQ--AAETTTSTTSSLAPP-PTTKICD
:.: . :::: :: : .:: : :... . .: . . ..: ::: :. .
CCDS65 ARDFLDAGTWSTWSPEAWGTPSTGTIPKEIPAWGQLHTQPEVEPQVDSPAPPRPSLQPHP
300 310 320 330 340 350
340 350 360 370
pF1KB6 PGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI
CCDS65 RLLDHRDSVEQVAVLASLGILSFLGLVAGALALGLWLRLRRGGKDGSPKPGFLASVIPVD
360 370 380 390 400 410
>>CCDS1068.1 IL6R gene_id:3570|Hs108|chr1 (365 aa)
initn: 320 init1: 145 opt: 369 Z-score: 373.7 bits: 77.8 E(32554): 1.7e-14
Smith-Waterman score: 414; 30.9% identity (54.6% similar) in 366 aa overlap (10-344:6-364)
10 20 30 40 50
pF1KB6 MAAPVPWACCAVLAA---AAAVVYAQRHSP-QEAPHVQYERL-GSDVTLPC-GTANWD-A
::.::: : ... : :. : ::. . : :..::: : :. : :
CCDS10 MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNA
10 20 30 40 50
60 70 80 90 100
pF1KB6 AVTW--RVNGTDLAPDLLNG--SQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPP
.: : : .. :. : .:.:....: :: :.:.. . . : : : .::
CCDS10 TVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYR--AGRPAGTVHLLVDVPP
60 70 80 90 100 110
110 120 130 140 150
pF1KB6 REPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMV---------CE-KDPA
.:: ::: .. .. : : : :. . .:: :.. :. .. .
CCDS10 EEPQLSCFRKSPLSNVVCEWG---PRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQES
120 130 140 150 160 170
160 170 180 190 200 210
pF1KB6 LKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAI-TFDEFTIVKPDPPENVVARPVPSN
: :.. . :.. : ::. :....: . . ::. :..:::: :... : :
CCDS10 QKFSCQLAVPEGDSSF-YIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARN
180 190 200 210 220 230
220 230 240 250 260 270
pF1KB6 PRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAH-TITDAYAGKEYI
:: : :::: : .: . . :.: :::: . ..: : .: ::..: ...
CCDS10 PRWLSVTWQDPHSW-NSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHV
240 250 260 270 280
280 290 300 310 320 330
pF1KB6 IQVAAKDNE-IGTWSDWSVAAHATPWTEE--P---RHLTTEAQAAETTTSTTSSLAPPPT
.:. :... : ::.:: : .::::: : ...: :: :. . . : .
CCDS10 VQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSA
290 300 310 320 330 340
340 350 360 370
pF1KB6 TKICDPG--ELGSGGGPSAPFLVSVPITLALAAAAATASSLLI
. :: . :: :
CCDS10 NATSLPGSRRRGSCGL
350 360
372 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 15:56:25 2016 done: Fri Nov 4 15:56:25 2016
Total Scan time: 2.550 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]