FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6557, 372 aa 1>>>pF1KB6557 372 - 372 aa - 372 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3207+/-0.000302; mu= 12.4233+/- 0.019 mean_var=104.8427+/-21.718, 0's: 0 Z-trim(119.3): 113 B-trim: 628 in 1/60 Lambda= 0.125258 statistics sampled from 33111 (33256) to 33111 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.745), E-opt: 0.2 (0.39), width: 16 Scan time: 9.290 The best scores are: opt bits E(85289) XP_016869752 (OMIM: 118946) PREDICTED: ciliary neu ( 372) 2570 474.7 1.5e-133 NP_001833 (OMIM: 118946) ciliary neurotrophic fact ( 372) 2570 474.7 1.5e-133 XP_016869754 (OMIM: 118946) PREDICTED: ciliary neu ( 372) 2570 474.7 1.5e-133 XP_016869753 (OMIM: 118946) PREDICTED: ciliary neu ( 372) 2570 474.7 1.5e-133 NP_671693 (OMIM: 118946) ciliary neurotrophic fact ( 372) 2570 474.7 1.5e-133 NP_001193940 (OMIM: 118946) ciliary neurotrophic f ( 372) 2570 474.7 1.5e-133 XP_016869751 (OMIM: 118946) PREDICTED: ciliary neu ( 439) 2570 474.7 1.7e-133 XP_016869749 (OMIM: 118946) PREDICTED: ciliary neu ( 439) 2570 474.7 1.7e-133 XP_016869750 (OMIM: 118946) PREDICTED: ciliary neu ( 439) 2570 474.7 1.7e-133 NP_001193795 (OMIM: 147880,614689,614752) interleu ( 352) 386 80.0 9.2e-15 NP_000556 (OMIM: 147880,614689,614752) interleukin ( 468) 372 77.6 6.7e-14 NP_001136256 (OMIM: 600939,614188) interleukin-11 ( 422) 370 77.2 7.9e-14 NP_852004 (OMIM: 147880,614689,614752) interleukin ( 365) 369 76.9 8e-14 NP_005746 (OMIM: 605816) interleukin-27 subunit be ( 229) 366 76.3 8e-14 XP_011525921 (OMIM: 605816) PREDICTED: interleukin ( 229) 366 76.3 8e-14 XP_016856689 (OMIM: 147880,614689,614752) PREDICTE ( 501) 368 76.9 1.2e-13 XP_006711362 (OMIM: 147880,614689,614752) PREDICTE ( 381) 363 75.9 1.8e-13 XP_006711361 (OMIM: 147880,614689,614752) PREDICTE ( 484) 363 75.9 2.1e-13 XP_016856688 (OMIM: 147880,614689,614752) PREDICTE ( 517) 363 76.0 2.2e-13 XP_011526726 (OMIM: 272430,604237) PREDICTED: cyto ( 404) 268 58.7 2.7e-08 XP_011526725 (OMIM: 272430,604237) PREDICTED: cyto ( 419) 268 58.7 2.8e-08 NP_004741 (OMIM: 272430,604237) cytokine receptor- ( 422) 268 58.7 2.8e-08 XP_011526724 (OMIM: 272430,604237) PREDICTED: cyto ( 423) 268 58.7 2.8e-08 XP_005245197 (OMIM: 147880,614689,614752) PREDICTE ( 338) 266 58.3 3e-08 XP_005245196 (OMIM: 147880,614689,614752) PREDICTE ( 360) 266 58.3 3.2e-08 XP_016856690 (OMIM: 147880,614689,614752) PREDICTE ( 371) 266 58.3 3.2e-08 NP_001191247 (OMIM: 176761,615554,615555) prolacti ( 268) 253 55.9 1.3e-07 NP_001191246 (OMIM: 176761,615554,615555) prolacti ( 288) 251 55.5 1.7e-07 XP_016865135 (OMIM: 176761,615554,615555) PREDICTE ( 309) 251 55.6 1.8e-07 NP_001191244 (OMIM: 176761,615554,615555) prolacti ( 349) 251 55.6 2e-07 NP_001191245 (OMIM: 176761,615554,615555) prolacti ( 376) 251 55.6 2.1e-07 NP_001177910 (OMIM: 600694) interleukin-6 receptor ( 857) 254 56.4 2.8e-07 NP_002175 (OMIM: 600694) interleukin-6 receptor su ( 918) 254 56.4 3e-07 NP_000940 (OMIM: 176761,615554,615555) prolactin r ( 622) 251 55.8 3.2e-07 XP_011512370 (OMIM: 176761,615554,615555) PREDICTE ( 622) 251 55.8 3.2e-07 XP_006714547 (OMIM: 176761,615554,615555) PREDICTE ( 622) 251 55.8 3.2e-07 XP_011512371 (OMIM: 176761,615554,615555) PREDICTE ( 622) 251 55.8 3.2e-07 NP_786943 (OMIM: 600694) interleukin-6 receptor su ( 329) 244 54.3 4.6e-07 XP_016856693 (OMIM: 601642) PREDICTED: interleukin ( 498) 210 48.3 4.6e-05 NP_001245145 (OMIM: 601642) interleukin-12 recepto ( 635) 210 48.4 5.5e-05 XP_016856692 (OMIM: 601642) PREDICTED: interleukin ( 659) 210 48.4 5.7e-05 NP_001306162 (OMIM: 601642) interleukin-12 recepto ( 659) 210 48.4 5.7e-05 NP_001245143 (OMIM: 601642) interleukin-12 recepto ( 659) 210 48.4 5.7e-05 XP_016856691 (OMIM: 601642) PREDICTED: interleukin ( 700) 210 48.4 6e-05 NP_001245144 (OMIM: 601642) interleukin-12 recepto ( 776) 210 48.4 6.5e-05 XP_006710680 (OMIM: 601642) PREDICTED: interleukin ( 776) 210 48.4 6.5e-05 XP_011539686 (OMIM: 601642) PREDICTED: interleukin ( 809) 210 48.4 6.7e-05 XP_005270882 (OMIM: 601642) PREDICTED: interleukin ( 862) 210 48.5 7e-05 XP_005270885 (OMIM: 601642) PREDICTED: interleukin ( 862) 210 48.5 7e-05 NP_001550 (OMIM: 601642) interleukin-12 receptor s ( 862) 210 48.5 7e-05 >>XP_016869752 (OMIM: 118946) PREDICTED: ciliary neurotr (372 aa) initn: 2570 init1: 2570 opt: 2570 Z-score: 2518.6 bits: 474.7 E(85289): 1.5e-133 Smith-Waterman score: 2570; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:1-372) 10 20 30 40 50 60 pF1KB6 MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL 310 320 330 340 350 360 370 pF1KB6 AAAAATASSLLI :::::::::::: XP_016 AAAAATASSLLI 370 >>NP_001833 (OMIM: 118946) ciliary neurotrophic factor r (372 aa) initn: 2570 init1: 2570 opt: 2570 Z-score: 2518.6 bits: 474.7 E(85289): 1.5e-133 Smith-Waterman score: 2570; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:1-372) 10 20 30 40 50 60 pF1KB6 MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL 310 320 330 340 350 360 370 pF1KB6 AAAAATASSLLI :::::::::::: NP_001 AAAAATASSLLI 370 >>XP_016869754 (OMIM: 118946) PREDICTED: ciliary neurotr (372 aa) initn: 2570 init1: 2570 opt: 2570 Z-score: 2518.6 bits: 474.7 E(85289): 1.5e-133 Smith-Waterman score: 2570; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:1-372) 10 20 30 40 50 60 pF1KB6 MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL 310 320 330 340 350 360 370 pF1KB6 AAAAATASSLLI :::::::::::: XP_016 AAAAATASSLLI 370 >>XP_016869753 (OMIM: 118946) PREDICTED: ciliary neurotr (372 aa) initn: 2570 init1: 2570 opt: 2570 Z-score: 2518.6 bits: 474.7 E(85289): 1.5e-133 Smith-Waterman score: 2570; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:1-372) 10 20 30 40 50 60 pF1KB6 MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL 310 320 330 340 350 360 370 pF1KB6 AAAAATASSLLI :::::::::::: XP_016 AAAAATASSLLI 370 >>NP_671693 (OMIM: 118946) ciliary neurotrophic factor r (372 aa) initn: 2570 init1: 2570 opt: 2570 Z-score: 2518.6 bits: 474.7 E(85289): 1.5e-133 Smith-Waterman score: 2570; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:1-372) 10 20 30 40 50 60 pF1KB6 MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_671 PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL 310 320 330 340 350 360 370 pF1KB6 AAAAATASSLLI :::::::::::: NP_671 AAAAATASSLLI 370 >>NP_001193940 (OMIM: 118946) ciliary neurotrophic facto (372 aa) initn: 2570 init1: 2570 opt: 2570 Z-score: 2518.6 bits: 474.7 E(85289): 1.5e-133 Smith-Waterman score: 2570; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:1-372) 10 20 30 40 50 60 pF1KB6 MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVS 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHAT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLAL 310 320 330 340 350 360 370 pF1KB6 AAAAATASSLLI :::::::::::: NP_001 AAAAATASSLLI 370 >>XP_016869751 (OMIM: 118946) PREDICTED: ciliary neurotr (439 aa) initn: 2570 init1: 2570 opt: 2570 Z-score: 2517.6 bits: 474.7 E(85289): 1.7e-133 Smith-Waterman score: 2570; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:68-439) 10 20 30 pF1KB6 MAAPVPWACCAVLAAAAAVVYAQRHSPQEA :::::::::::::::::::::::::::::: XP_016 LTGQRLRVYSSSDGGGAAGSKDTLGLSSSVMAAPVPWACCAVLAAAAAVVYAQRHSPQEA 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB6 PHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDLAPDLLNGSQLVLHGLELGHSGLYACF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDLAPDLLNGSQLVLHGLELGHSGLYACF 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB6 HRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSK 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB6 IMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENV 220 230 240 250 260 270 220 230 240 250 260 270 pF1KB6 VARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDA 280 290 300 310 320 330 280 290 300 310 320 330 pF1KB6 YAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAAETTTSTTSSLAPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAAETTTSTTSSLAPPP 340 350 360 370 380 390 340 350 360 370 pF1KB6 TTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI :::::::::::::::::::::::::::::::::::::::::: XP_016 TTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI 400 410 420 430 >>XP_016869749 (OMIM: 118946) PREDICTED: ciliary neurotr (439 aa) initn: 2570 init1: 2570 opt: 2570 Z-score: 2517.6 bits: 474.7 E(85289): 1.7e-133 Smith-Waterman score: 2570; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:68-439) 10 20 30 pF1KB6 MAAPVPWACCAVLAAAAAVVYAQRHSPQEA :::::::::::::::::::::::::::::: XP_016 LTGQRLRVYSSSDGGGAAGSKDTLGLSSSVMAAPVPWACCAVLAAAAAVVYAQRHSPQEA 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB6 PHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDLAPDLLNGSQLVLHGLELGHSGLYACF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDLAPDLLNGSQLVLHGLELGHSGLYACF 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB6 HRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSK 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB6 IMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENV 220 230 240 250 260 270 220 230 240 250 260 270 pF1KB6 VARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDA 280 290 300 310 320 330 280 290 300 310 320 330 pF1KB6 YAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAAETTTSTTSSLAPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAAETTTSTTSSLAPPP 340 350 360 370 380 390 340 350 360 370 pF1KB6 TTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI :::::::::::::::::::::::::::::::::::::::::: XP_016 TTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI 400 410 420 430 >>XP_016869750 (OMIM: 118946) PREDICTED: ciliary neurotr (439 aa) initn: 2570 init1: 2570 opt: 2570 Z-score: 2517.6 bits: 474.7 E(85289): 1.7e-133 Smith-Waterman score: 2570; 100.0% identity (100.0% similar) in 372 aa overlap (1-372:68-439) 10 20 30 pF1KB6 MAAPVPWACCAVLAAAAAVVYAQRHSPQEA :::::::::::::::::::::::::::::: XP_016 LTGQRLRVYSSSDGGGAAGSKDTLGLSSSVMAAPVPWACCAVLAAAAAVVYAQRHSPQEA 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB6 PHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDLAPDLLNGSQLVLHGLELGHSGLYACF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDLAPDLLNGSQLVLHGLELGHSGLYACF 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB6 HRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSK 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB6 IMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENV 220 230 240 250 260 270 220 230 240 250 260 270 pF1KB6 VARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDA 280 290 300 310 320 330 280 290 300 310 320 330 pF1KB6 YAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAAETTTSTTSSLAPPP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAAETTTSTTSSLAPPP 340 350 360 370 380 390 340 350 360 370 pF1KB6 TTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI :::::::::::::::::::::::::::::::::::::::::: XP_016 TTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI 400 410 420 430 >>NP_001193795 (OMIM: 147880,614689,614752) interleukin- (352 aa) initn: 309 init1: 145 opt: 386 Z-score: 386.0 bits: 80.0 E(85289): 9.2e-15 Smith-Waterman score: 431; 30.8% identity (56.5% similar) in 354 aa overlap (10-333:6-352) 10 20 30 40 50 pF1KB6 MAAPVPWACCAVLAA---AAAVVYAQRHSP-QEAPHVQYERL-GSDVTLPC-GTANWD-A ::.::: : ... : :. : ::. . : :..::: : :. : : NP_001 MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNA 10 20 30 40 50 60 70 80 90 100 pF1KB6 AVTW--RVNGTDLAPDLLNG--SQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPP .: : : .. :. : .:.:....: :: :.:.. . . : : : .:: NP_001 TVHWVLRKPAAGSHPSRWAGMGRRLLLRSVQLHDSGNYSCYR--AGRPAGTVHLLVDVPP 60 70 80 90 100 110 110 120 130 140 150 pF1KB6 REPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMV---------CE-KDPA .:: ::: .. .. : : : :. . .:: :.. :. .. . NP_001 EEPQLSCFRKSPLSNVVCEWG---PRSTPSLTTKAVLLVRKFQNSPAEDFQEPCQYSQES 120 130 140 150 160 170 160 170 180 190 200 210 pF1KB6 LKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAI-TFDEFTIVKPDPPENVVARPVPSN : :.. . :.. : ::. :....: . . ::. :..:::: :... : : NP_001 QKFSCQLAVPEGDSSF-YIVSMCVASSVGSKFSKTQTFQGCGILQPDPPANITVTAVARN 180 190 200 210 220 230 220 230 240 250 260 270 pF1KB6 PRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAH-TITDAYAGKEYI :: : :::: : .: . . :.: :::: . ..: : .: ::..: ... NP_001 PRWLSVTWQDPHSW-NSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIHDAWSGLRHV 240 250 260 270 280 280 290 300 310 320 330 pF1KB6 IQVAAKDNE-IGTWSDWSVAAHATPWTEE--PR----HLTTEAQAAETTTSTTSSLAPPP .:. :... : ::.:: : .::::.. :: ....: . :..: .... :: NP_001 VQLRAQEEFGQGEWSEWSPEAMGTPWTDRLSPRCPGWSTAVQSQLTATSASWVQAILPPQ 290 300 310 320 330 340 340 350 360 370 pF1KB6 TTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI : NP_001 PPK 350 372 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 15:56:25 2016 done: Fri Nov 4 15:56:27 2016 Total Scan time: 9.290 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]