FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6561, 374 aa 1>>>pF1KB6561 374 - 374 aa - 374 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3303+/-0.000354; mu= 11.9804+/- 0.022 mean_var=104.4696+/-21.617, 0's: 0 Z-trim(115.5): 183 B-trim: 443 in 1/54 Lambda= 0.125481 statistics sampled from 25779 (26013) to 25779 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.305), width: 16 Scan time: 7.850 The best scores are: opt bits E(85289) NP_000557 (OMIM: 146760) high affinity immunoglobu ( 374) 2507 464.5 1.7e-130 XP_005245014 (OMIM: 146760) PREDICTED: high affini ( 375) 2495 462.4 7.8e-130 XP_005245015 (OMIM: 146760) PREDICTED: high affini ( 282) 1815 339.2 7.1e-93 NP_001231839 (OMIM: 601502) high affinity immunogl ( 224) 1482 278.8 8.3e-75 NP_001017986 (OMIM: 601502) high affinity immunogl ( 280) 1264 239.4 7.6e-63 XP_016856150 (OMIM: 601502) PREDICTED: high affini ( 281) 1251 237.1 3.9e-62 NP_001002901 (OMIM: 609251) Fc receptor-like B iso ( 426) 654 129.1 1.8e-29 NP_001307170 (OMIM: 609251) Fc receptor-like B iso ( 426) 654 129.1 1.8e-29 NP_001004340 (OMIM: 601502) high affinity immunogl ( 188) 640 126.3 5.6e-29 XP_016856151 (OMIM: 601502) PREDICTED: high affini ( 195) 640 126.3 5.7e-29 NP_001257964 (OMIM: 610665) low affinity immunoglo ( 268) 598 118.8 1.4e-26 NP_001121068 (OMIM: 146740,615707) low affinity im ( 253) 590 117.4 3.7e-26 NP_001121064 (OMIM: 146740,615707) low affinity im ( 358) 590 117.5 4.9e-26 NP_000561 (OMIM: 610665) low affinity immunoglobul ( 233) 586 116.6 5.8e-26 NP_001231682 (OMIM: 610665) low affinity immunoglo ( 269) 586 116.7 6.5e-26 XP_016856157 (OMIM: 146790,152700,611162) PREDICTE ( 275) 584 116.3 8.5e-26 NP_001121065 (OMIM: 146740,615707) low affinity im ( 254) 578 115.2 1.7e-25 NP_001316049 (OMIM: 146740,615707) low affinity im ( 254) 578 115.2 1.7e-25 NP_001121067 (OMIM: 146740,615707) low affinity im ( 254) 578 115.2 1.7e-25 NP_000560 (OMIM: 146740,615707) low affinity immun ( 359) 578 115.3 2.2e-25 NP_067674 (OMIM: 146790,152700,611162) low affinit ( 316) 575 114.7 2.9e-25 NP_001257965 (OMIM: 610665) low affinity immunoglo ( 216) 572 114.1 3.2e-25 NP_001002275 (OMIM: 152700,604590,611162) low affi ( 309) 574 114.5 3.3e-25 XP_016856152 (OMIM: 146790,152700,611162) PREDICTE ( 368) 575 114.8 3.3e-25 XP_016856159 (OMIM: 152700,604590,611162) PREDICTE ( 323) 574 114.6 3.4e-25 XP_016856156 (OMIM: 146790,152700,611162) PREDICTE ( 276) 573 114.3 3.4e-25 XP_016856155 (OMIM: 146790,152700,611162) PREDICTE ( 328) 573 114.4 3.9e-25 XP_011508335 (OMIM: 605877) PREDICTED: Fc receptor ( 844) 575 115.0 6.4e-25 NP_001002273 (OMIM: 152700,604590,611162) low affi ( 290) 568 113.4 6.6e-25 XP_011508334 (OMIM: 605877) PREDICTED: Fc receptor ( 884) 575 115.0 6.6e-25 XP_011508333 (OMIM: 605877) PREDICTED: Fc receptor ( 884) 575 115.0 6.6e-25 NP_112571 (OMIM: 605877) Fc receptor-like protein ( 977) 575 115.1 7.2e-25 NP_001182317 (OMIM: 605877) Fc receptor-like prote ( 998) 575 115.1 7.3e-25 NP_001177757 (OMIM: 152700,604590,611162) low affi ( 303) 565 112.9 1e-24 XP_011507593 (OMIM: 146790,152700,611162) PREDICTE ( 261) 564 112.7 1e-24 NP_003992 (OMIM: 152700,604590,611162) low affinit ( 310) 565 112.9 1e-24 XP_016856160 (OMIM: 152700,604590,611162) PREDICTE ( 310) 565 112.9 1e-24 XP_016856158 (OMIM: 152700,604590,611162) PREDICTE ( 324) 565 112.9 1.1e-24 NP_001129691 (OMIM: 146790,152700,611162) low affi ( 317) 564 112.7 1.2e-24 XP_011507592 (OMIM: 146790,152700,611162) PREDICTE ( 317) 564 112.7 1.2e-24 XP_016856154 (OMIM: 146790,152700,611162) PREDICTE ( 353) 564 112.8 1.3e-24 XP_016856153 (OMIM: 146790,152700,611162) PREDICTE ( 353) 564 112.8 1.3e-24 XP_011507589 (OMIM: 146790,152700,611162) PREDICTE ( 369) 564 112.8 1.3e-24 XP_011508336 (OMIM: 605876) PREDICTED: Fc receptor ( 514) 563 112.7 1.9e-24 XP_016856161 (OMIM: 152700,604590,611162) PREDICTE ( 291) 559 111.8 2e-24 NP_001002274 (OMIM: 152700,604590,611162) low affi ( 291) 559 111.8 2e-24 XP_011507594 (OMIM: 152700,604590,611162) PREDICTE ( 234) 552 110.5 4.1e-24 NP_112572 (OMIM: 605876) Fc receptor-like protein ( 515) 553 110.9 6.8e-24 NP_963857 (OMIM: 188030,612169) low affinity immun ( 323) 548 109.8 8.8e-24 XP_011508366 (OMIM: 606891) PREDICTED: Fc receptor ( 364) 515 103.9 6.1e-22 >>NP_000557 (OMIM: 146760) high affinity immunoglobulin (374 aa) initn: 2507 init1: 2507 opt: 2507 Z-score: 2463.6 bits: 464.5 E(85289): 1.7e-130 Smith-Waterman score: 2507; 100.0% identity (100.0% similar) in 374 aa overlap (1-374:1-374) 10 20 30 40 50 60 pF1KB6 MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 ALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 ISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRN 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 TSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 TSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVG 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 IMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_000 IMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQ 310 320 330 340 350 360 370 pF1KB6 LQEGVHRKEPQGAT :::::::::::::: NP_000 LQEGVHRKEPQGAT 370 >>XP_005245014 (OMIM: 146760) PREDICTED: high affinity i (375 aa) initn: 2389 init1: 2389 opt: 2495 Z-score: 2451.9 bits: 462.4 E(85289): 7.8e-130 Smith-Waterman score: 2495; 99.7% identity (99.7% similar) in 375 aa overlap (1-374:1-375) 10 20 30 40 50 pF1KB6 MWFLTTLLLWVPVDGQV-DTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLN ::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::: XP_005 MWFLTTLLLWVPVDGQVVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 GTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 LALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 LALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB6 GISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGR 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB6 NTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAV 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB6 GIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEE 310 320 330 340 350 360 360 370 pF1KB6 QLQEGVHRKEPQGAT ::::::::::::::: XP_005 QLQEGVHRKEPQGAT 370 >>XP_005245015 (OMIM: 146760) PREDICTED: high affinity i (282 aa) initn: 1876 init1: 1815 opt: 1815 Z-score: 1788.3 bits: 339.2 E(85289): 7.1e-93 Smith-Waterman score: 1815; 100.0% identity (100.0% similar) in 272 aa overlap (103-374:11-282) 80 90 100 110 120 130 pF1KB6 TSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLV :::::::::::::::::::::::::::::: XP_005 MWFLTTLLLWGWLLLQVSSRVFTEGEPLALRCHAWKDKLV 10 20 30 40 140 150 160 170 180 190 pF1KB6 YNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAP 50 60 70 80 90 100 200 210 220 230 240 250 pF1KB6 VLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 VLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARR 110 120 130 140 150 160 260 270 280 290 300 310 pF1KB6 EDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 EDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVT 170 180 190 200 210 220 320 330 340 350 360 370 pF1KB6 IRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 IRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQG 230 240 250 260 270 280 pF1KB6 AT :: XP_005 AT >>NP_001231839 (OMIM: 601502) high affinity immunoglobul (224 aa) initn: 1481 init1: 1245 opt: 1482 Z-score: 1464.0 bits: 278.8 E(85289): 8.3e-75 Smith-Waterman score: 1482; 98.7% identity (98.7% similar) in 224 aa overlap (1-223:1-224) 10 20 30 40 50 60 pF1KB6 MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: NP_001 TATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFMEGEPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 ALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAG 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 IS-VTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGR :: :::::::::::::::::::::::::::::::::::::::: NP_001 ISQYTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGL 190 200 210 220 240 250 260 270 280 290 pF1KB6 NTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAV >>NP_001017986 (OMIM: 601502) high affinity immunoglobul (280 aa) initn: 1849 init1: 1245 opt: 1264 Z-score: 1249.3 bits: 239.4 E(85289): 7.6e-63 Smith-Waterman score: 1665; 73.3% identity (73.8% similar) in 374 aa overlap (1-374:1-280) 10 20 30 40 50 60 pF1KB6 MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPL :::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: NP_001 TATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFMEGEPL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 ALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRN :: NP_001 IS---------------------------------------------------------- 250 260 270 280 290 300 pF1KB6 TSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVG . : ::::::::::::::::::: NP_001 ------------------------------------QYTVKGLQLPTPVWFHVLFYLAVG 190 200 310 320 330 340 350 360 pF1KB6 IMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQ :::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::: NP_001 IMFLVNTVLWVTIRKELKRKKKWNLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQ 210 220 230 240 250 260 370 pF1KB6 LQEGVHRKEPQGAT :::::::::::::: NP_001 LQEGVHRKEPQGAT 270 280 >>XP_016856150 (OMIM: 601502) PREDICTED: high affinity i (281 aa) initn: 1730 init1: 1126 opt: 1251 Z-score: 1236.6 bits: 237.1 E(85289): 3.9e-62 Smith-Waterman score: 1652; 72.8% identity (73.6% similar) in 375 aa overlap (1-374:1-281) 10 20 30 40 50 pF1KB6 MWFLTTLLLWVPVDGQV-DTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLN ::::::::::::::::: :::::::::::::::::::::.:::::::::::::::::::: XP_016 MWFLTTLLLWVPVDGQVVDTTKAVITLQPPWVSVFQEETITLHCEVLHLPGSSSTQWFLN 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 GTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEP ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::: XP_016 GTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFMEGEP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 LALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSA 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB6 GISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGR ::: XP_016 GIS--------------------------------------------------------- 240 250 260 270 280 290 pF1KB6 NTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAV . : :::::::::::::::::: XP_016 -------------------------------------QYTVKGLQLPTPVWFHVLFYLAV 190 200 300 310 320 330 340 350 pF1KB6 GIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEE ::::::::::::::::::::::::.::::::::::::::::::::::::::::::::::: XP_016 GIMFLVNTVLWVTIRKELKRKKKWNLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEE 210 220 230 240 250 260 360 370 pF1KB6 QLQEGVHRKEPQGAT ::::::::::::::: XP_016 QLQEGVHRKEPQGAT 270 280 >>NP_001002901 (OMIM: 609251) Fc receptor-like B isoform (426 aa) initn: 490 init1: 327 opt: 654 Z-score: 649.9 bits: 129.1 E(85289): 1.8e-29 Smith-Waterman score: 654; 40.5% identity (62.5% similar) in 291 aa overlap (1-278:1-285) 10 20 30 40 50 pF1KB6 MWFLTTLLLWVPVDGQVDTT-KAVITLQPPWVSVFQEETVTLHCEVLHLP-----GSSST :: ::.::: :: .::. : : ...:.:::...:. : :::.:. : : :: NP_001 MWPLTALLLLVPSSGQAATLEKPILSLHPPWTTIFKGERVTLKCDGYH-PLLLELQPIST 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 QWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVF :.:. . ::.. : :. : :::: . ::::.: . ::.::: NP_001 LWYLG----HLLLPSHK-KSIEVQTPGVYRCQTRGAPVSDPIHLSVSNDWLILQVPYAPV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 TEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGK- :::::.:::..: ::.::.. ::..:.: ..:: ..: :.:.. : .: :.::: . NP_001 FEGEPLVLRCRGWYDKVVYKLHYYHDGQAVRYFHSSANYTVLQARASDSGRYQCSGTMRI 120 130 140 150 160 170 180 190 200 210 220 pF1KB6 ----HRYTSAGISVTVKELFPAPVLNASVTSPLLEGNL--VTLSCETKLLLQRPGLQLYF . :: ..:::.::: :::: . . : :.: :.:.: :. : : NP_001 PVESAPMFSAKVAVTVQELFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQF 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB6 SFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPT .:: :...: . ..:: . . :. ::::::: .: :::: :.: NP_001 AFYKYSRAVRRFDWGAEYTVPEPEVEELESYWCEAATATRSVRKRSPWLQLPGPGSPLDP 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB6 PVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHL NP_001 ASTTAPAPWAAALAPGNRPLSFRKPPVSRSVPLVTSVRNTTSTGLQFPASGAPTAGPPAC 300 310 320 330 340 350 >>NP_001307170 (OMIM: 609251) Fc receptor-like B isoform (426 aa) initn: 490 init1: 327 opt: 654 Z-score: 649.9 bits: 129.1 E(85289): 1.8e-29 Smith-Waterman score: 654; 40.5% identity (62.5% similar) in 291 aa overlap (1-278:1-285) 10 20 30 40 50 pF1KB6 MWFLTTLLLWVPVDGQVDTT-KAVITLQPPWVSVFQEETVTLHCEVLHLP-----GSSST :: ::.::: :: .::. : : ...:.:::...:. : :::.:. : : :: NP_001 MWPLTALLLLVPSSGQAATLEKPILSLHPPWTTIFKGERVTLKCDGYH-PLLLELQPIST 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 QWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVF :.:. . ::.. : :. : :::: . ::::.: . ::.::: NP_001 LWYLG----HLLLPSHK-KSIEVQTPGVYRCQTRGAPVSDPIHLSVSNDWLILQVPYAPV 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 TEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGK- :::::.:::..: ::.::.. ::..:.: ..:: ..: :.:.. : .: :.::: . NP_001 FEGEPLVLRCRGWYDKVVYKLHYYHDGQAVRYFHSSANYTVLQARASDSGRYQCSGTMRI 120 130 140 150 160 170 180 190 200 210 220 pF1KB6 ----HRYTSAGISVTVKELFPAPVLNASVTSPLLEGNL--VTLSCETKLLLQRPGLQLYF . :: ..:::.::: :::: . . : :.: :.:.: :. : : NP_001 PVESAPMFSAKVAVTVQELFRAPVLRVMGPREARGAALGGVVLRCDTRLHPQKRDTPLQF 180 190 200 210 220 230 230 240 250 260 270 280 pF1KB6 SFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPT .:: :...: . ..:: . . :. ::::::: .: :::: :.: NP_001 AFYKYSRAVRRFDWGAEYTVPEPEVEELESYWCEAATATRSVRKRSPWLQLPGPGSPLDP 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB6 PVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHL NP_001 ASTTAPAPWAAALAPGNRPLSFRKPPVSRSVPLVTSVRNTTSTGLQFPASGAPTAGPPAC 300 310 320 330 340 350 >>NP_001004340 (OMIM: 601502) high affinity immunoglobul (188 aa) initn: 1218 init1: 618 opt: 640 Z-score: 641.3 bits: 126.3 E(85289): 5.6e-29 Smith-Waterman score: 973; 63.2% identity (64.0% similar) in 272 aa overlap (103-374:11-188) 80 90 100 110 120 130 pF1KB6 TSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLV :::::::::::: ::::::::::::::::: NP_001 MWFLTTLLLWGWLLLQVSSRVFMEGEPLALRCHAWKDKLV 10 20 30 40 140 150 160 170 180 190 pF1KB6 YNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAP :::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 YNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGIS---------- 50 60 70 80 90 200 210 220 230 240 250 pF1KB6 VLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARR NP_001 ------------------------------------------------------------ 260 270 280 290 300 310 pF1KB6 EDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVT . : ::::::::::::::::::::::::::::::: NP_001 ------------------------QYTVKGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVT 100 110 120 320 330 340 350 360 370 pF1KB6 IRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQG :::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IRKELKRKKKWNLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQG 130 140 150 160 170 180 pF1KB6 AT :: NP_001 AT >>XP_016856151 (OMIM: 601502) PREDICTED: high affinity i (195 aa) initn: 1266 init1: 618 opt: 640 Z-score: 641.0 bits: 126.3 E(85289): 5.7e-29 Smith-Waterman score: 975; 61.8% identity (63.9% similar) in 280 aa overlap (95-374:12-195) 70 80 90 100 110 120 pF1KB6 TSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRC :.. .. :::::::::::: ::::::::: XP_016 MWFLTTLLLWVPVDGQV--GWLLLQVSSRVFMEGEPLALRC 10 20 30 130 140 150 160 170 180 pF1KB6 HAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGIS-- 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB6 VKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSE XP_016 ------------------------------------------------------------ 250 260 270 280 290 300 pF1KB6 YQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFL . : ::::::::::::::::::::::: XP_016 --------------------------------QYTVKGLQLPTPVWFHVLFYLAVGIMFL 100 110 120 310 320 330 340 350 360 pF1KB6 VNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEG :::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::: XP_016 VNTVLWVTIRKELKRKKKWNLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEG 130 140 150 160 170 180 370 pF1KB6 VHRKEPQGAT :::::::::: XP_016 VHRKEPQGAT 190 374 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 11:27:53 2016 done: Sat Nov 5 11:27:55 2016 Total Scan time: 7.850 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]