FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6571, 375 aa 1>>>pF1KB6571 375 - 375 aa - 375 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2355+/-0.000789; mu= 17.1442+/- 0.047 mean_var=69.1051+/-13.583, 0's: 0 Z-trim(107.8): 38 B-trim: 0 in 0/51 Lambda= 0.154283 statistics sampled from 9742 (9779) to 9742 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.682), E-opt: 0.2 (0.3), width: 16 Scan time: 2.640 The best scores are: opt bits E(32554) CCDS2303.1 MSTN gene_id:2660|Hs108|chr2 ( 375) 2589 585.2 3.1e-167 CCDS8891.1 GDF11 gene_id:10220|Hs108|chr12 ( 407) 1383 316.8 2.1e-86 CCDS4503.1 BMP6 gene_id:654|Hs108|chr6 ( 513) 313 78.7 1.3e-14 CCDS1701.1 GDF7 gene_id:151449|Hs108|chr2 ( 450) 306 77.1 3.4e-14 CCDS34926.1 GDF6 gene_id:392255|Hs108|chr8 ( 455) 301 76.0 7.4e-14 CCDS1521.1 TGFB2 gene_id:7042|Hs108|chr1 ( 414) 298 75.3 1.1e-13 CCDS1890.1 BMP10 gene_id:27302|Hs108|chr2 ( 424) 298 75.3 1.1e-13 CCDS44318.1 TGFB2 gene_id:7042|Hs108|chr1 ( 442) 298 75.3 1.1e-13 CCDS9846.1 TGFB3 gene_id:7043|Hs108|chr14 ( 412) 297 75.1 1.3e-13 CCDS13099.1 BMP2 gene_id:650|Hs108|chr20 ( 396) 295 74.6 1.7e-13 CCDS13254.1 GDF5 gene_id:8200|Hs108|chr20 ( 501) 294 74.5 2.3e-13 CCDS33031.1 TGFB1 gene_id:7040|Hs108|chr19 ( 390) 290 73.5 3.5e-13 CCDS8581.1 GDF3 gene_id:9573|Hs108|chr12 ( 364) 289 73.3 3.9e-13 CCDS13455.1 BMP7 gene_id:655|Hs108|chr20 ( 431) 289 73.3 4.5e-13 CCDS4958.1 BMP5 gene_id:653|Hs108|chr6 ( 454) 282 71.8 1.4e-12 CCDS437.1 BMP8A gene_id:353500|Hs108|chr1 ( 402) 275 70.2 3.7e-12 CCDS9715.1 BMP4 gene_id:652|Hs108|chr14 ( 408) 274 70.0 4.3e-12 CCDS444.1 BMP8B gene_id:656|Hs108|chr1 ( 402) 272 69.5 5.8e-12 CCDS3588.1 BMP3 gene_id:651|Hs108|chr4 ( 472) 269 68.9 1.1e-11 CCDS73117.1 GDF10 gene_id:2662|Hs108|chr10 ( 478) 256 66.0 7.9e-11 >>CCDS2303.1 MSTN gene_id:2660|Hs108|chr2 (375 aa) initn: 2589 init1: 2589 opt: 2589 Z-score: 3115.8 bits: 585.2 E(32554): 3.1e-167 Smith-Waterman score: 2589; 100.0% identity (100.0% similar) in 375 aa overlap (1-375:1-375) 10 20 30 40 50 60 pF1KB6 MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS23 MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIIT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS23 LSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIIT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 MPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS23 MPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPM 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 KDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS23 KDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 FPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS23 FPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 PKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS23 PKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQII 310 320 330 340 350 360 370 pF1KB6 YGKIPAMVVDRCGCS ::::::::::::::: CCDS23 YGKIPAMVVDRCGCS 370 >>CCDS8891.1 GDF11 gene_id:10220|Hs108|chr12 (407 aa) initn: 1349 init1: 1088 opt: 1383 Z-score: 1664.6 bits: 316.8 E(32554): 2.1e-86 Smith-Waterman score: 1645; 65.1% identity (84.9% similar) in 352 aa overlap (34-375:58-407) 10 20 30 40 50 60 pF1KB6 LQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSK : .: : .:.:::... :.:.:: ::::: CCDS88 PAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPDG-CPVCVWRQHSRELRLESIKSQILSK 30 40 50 60 70 80 70 80 90 100 110 120 pF1KB6 LRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDD-SSDGSLEDDDYHATTETIITMP :::. :::::..:..:::::::::....: .: : : . . ::.:.:::::::.:.: CCDS88 LRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMA 90 100 110 120 130 140 130 140 150 160 170 180 pF1KB6 TESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKD :.: .:.::.: :: :.:: :....::.:::::.::::: :.::..::::: ::. CCDS88 QETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRL-KPLTG 150 160 170 180 190 200 190 200 210 220 230 pF1KB6 ---------GTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDEN : :. :::::.... .: ::::: : ::..:..::.:: ::::.:.: . CCDS88 EGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPS 210 220 230 240 250 260 240 250 260 270 280 290 pF1KB6 GHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAF : ::::: ::: .::.::.:..: .. :::::..::::::::.:::::::::::::::: CCDS88 GTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAF 270 280 290 300 310 320 300 310 320 330 340 350 pF1KB6 GWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYF ::::::::::::::::::.::..:.:::::::::.::::::::::::::::::::::::: CCDS88 GWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYF 330 340 350 360 370 380 360 370 pF1KB6 NGKEQIIYGKIPAMVVDRCGCS : :.::::::::.::::::::: CCDS88 NDKQQIIYGKIPGMVVDRCGCS 390 400 >>CCDS4503.1 BMP6 gene_id:654|Hs108|chr6 (513 aa) initn: 279 init1: 168 opt: 313 Z-score: 376.0 bits: 78.7 E(32554): 1.3e-14 Smith-Waterman score: 351; 30.1% identity (53.6% similar) in 276 aa overlap (140-374:238-512) 110 120 130 140 150 160 pF1KB6 DYHATTETIITMPTESDFLMQVDGKPKCCFFKFS-SKIQYNKVVKA-QLWIYLRPVETP- :::. :.: ..:: : .. :: : CCDS45 FLNDADMVMSFVNLVEYDKEFSPRQRHHKEFKFNLSQIPEGEVVTAAEFRIYKDCVMGSF 210 220 230 240 250 260 170 180 190 200 210 220 pF1KB6 --TTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLG : ...: .... . . . .. : : .:. .. . :. :. :.: CCDS45 KNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEG-WLEFDITATSNLWVVTPQHNMG 270 280 290 300 310 320 230 240 250 260 pF1KB6 IEIKALDENG---HDLAVTFPG-PGEDGLNPFL-------EVKVTDT---------PKRS ...... ..: : :. . : : .::. ::.: : .:. CCDS45 LQLSVVTRDGVHVHPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRN 330 340 350 360 370 380 270 280 290 300 310 pF1KB6 RRDFGLDC-------DEHSTESR--CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECE : . : : .:.: . : .. : :.:. .:: ::::::: : ::::.::: CCDS45 RSTQSQDVARVSSASDYNSSELKTACRKHELYVSFQDLGWQDWIIAPKGYAANYCDGECS 390 400 410 420 430 440 320 330 340 350 360 pF1KB6 FVFLQKYPHTH------LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMV : . .. :. ::: ::. :::.:::.. :..:::. . ..: : :: CCDS45 FPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMV 450 460 470 480 490 500 370 pF1KB6 VDRCGCS : ::: CCDS45 VRACGCH 510 >>CCDS1701.1 GDF7 gene_id:151449|Hs108|chr2 (450 aa) initn: 259 init1: 154 opt: 306 Z-score: 368.4 bits: 77.1 E(32554): 3.4e-14 Smith-Waterman score: 308; 29.8% identity (55.3% similar) in 228 aa overlap (166-374:226-449) 140 150 160 170 180 190 pF1KB6 KCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIK-PMKDGTRYTGIRSLKL : .: .:: . :. . ..: : . CCDS17 YSRAAEPLVGQRWEAFDVADAMRRHRREPRPPRAFCLLLRAVAGPVPSPL---ALRRLGF 200 210 220 230 240 250 200 210 220 230 240 250 pF1KB6 DMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDEN-GHDLAVT-FPGPGEDGLNPF : : . :... .. :: : ::.: . : :: .: :: .: CCDS17 GWPGGGGSAAEERAVLVVSSRTQRKES-LFREIRAQARALGAALASEPLPDPGTGTASPR 260 270 280 290 300 310 260 270 280 290 300 pF1KB6 LEV------KVTDTPKRSRRDFGLDCDE-HSTE--SRCCRYPLTVDFEAFGWD-WIIAPK . ... . :. . : . :. . ::: : :: :::. .::: ::::: CCDS17 AVIGGRRRRRTALAGTRTAQGSGGGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIAPL 320 330 340 350 360 370 310 320 330 340 350 pF1KB6 RYKANYCSGECEFVFLQKY-PHTH-----LVHQANPRGSAGPCCTPTKMSPINMLYFNGK :.: .: : :.: . .. : .: :... : .. . ::.:...:::..::... CCDS17 DYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAA 380 390 400 410 420 430 360 370 pF1KB6 EQIIYGKIPAMVVDRCGCS ....: . :::. ::: CCDS17 NNVVYKQYEDMVVEACGCR 440 450 >>CCDS34926.1 GDF6 gene_id:392255|Hs108|chr8 (455 aa) initn: 213 init1: 147 opt: 301 Z-score: 362.3 bits: 76.0 E(32554): 7.4e-14 Smith-Waterman score: 315; 36.2% identity (63.1% similar) in 149 aa overlap (240-374:312-454) 210 220 230 240 250 260 pF1KB6 TVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGP-GEDGLNPFLEVKVTDTPKRSRRDF ..: : : :.: .: : :: CCDS34 TRSQRKNLFAEMREQLGSAEAAGPGAGAEGSWPPPSGAPDARPWLP-----SPGRRRRRT 290 300 310 320 330 270 280 290 300 310 320 pF1KB6 GLDC---DEHSTESR--CCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGECEFVFLQKY- .. .:. .:: : . :: :.:. .::: ::::: .:.: .: : :.: . .. CCDS34 AFASRHGKRHGKKSRLRCSKKPLHVNFKELGWDDWIIAPLEYEAYHCEGVCDFPLRSHLE 340 350 360 370 380 390 330 340 350 360 370 pF1KB6 PHTH-----LVHQANPRGSAGP-CCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS : .: :... .: ::. : ::.:::..::..::... ....: . :::. ::: CCDS34 PTNHAIIQTLMNSMDP-GSTPPSCCVPTKLTPISILYIDAGNNVVYKQYEDMVVESCGCR 400 410 420 430 440 450 >>CCDS1521.1 TGFB2 gene_id:7042|Hs108|chr1 (414 aa) initn: 360 init1: 113 opt: 298 Z-score: 359.3 bits: 75.3 E(32554): 1.1e-13 Smith-Waterman score: 376; 24.9% identity (51.6% similar) in 397 aa overlap (39-375:24-414) 10 20 30 40 50 60 pF1KB6 YIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLET :.. : .. :::::. ::::::.: . CCDS15 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRK-RIEAIRGQILSKLKLTS 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 APNI---SKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPT-- :. ..: ... :.:... .: . . :..:.: : :: CCDS15 PPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFF 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 -ESDFLMQVDGKPKCCFFKFS-SKIQYN--KVVKAQLWIY--LRPVETPTTVFVQILRLI . . . .: . .:. : .. : ..:::.. .. : ... ... CCDS15 PSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQIL 120 130 140 150 160 170 180 190 200 210 220 pF1KB6 KPMKDGT----RYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIK----- : :: : :: . .: . : : :.:: ....::.. . :::..:. CCDS15 KS-KDLTSPTQRYIDSKVVKTRAE---GEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPC 180 190 200 210 220 230 240 250 pF1KB6 ---------ALDENGHDLAVTFPG--------PGED-----------GLNPFL------- . .....: . : : :.. : .: : CCDS15 CTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPS 230 240 250 260 270 280 260 270 280 290 300 310 pF1KB6 -EVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEA-FGWDWIIAPKRYKANYCSG ... .: .:..: . ..... :: :: .::. .:: :: :: :.::.:.: CCDS15 YRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAG 290 300 310 320 330 340 320 330 340 350 360 pF1KB6 ECEFVFLQKYPHTH---LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMV : ... . :.. : . ::..::.:::. . :...::. :: : .. :. CCDS15 ACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIE-QLSNMI 350 360 370 380 390 400 370 pF1KB6 VDRCGCS : : :: CCDS15 VKSCKCS 410 >>CCDS1890.1 BMP10 gene_id:27302|Hs108|chr2 (424 aa) initn: 307 init1: 136 opt: 298 Z-score: 359.1 bits: 75.3 E(32554): 1.1e-13 Smith-Waterman score: 298; 35.4% identity (57.6% similar) in 158 aa overlap (226-374:278-423) 200 210 220 230 240 250 pF1KB6 MNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFP-GPGEDGLNPFLE .. ::. : : .: ::::..: . CCDS18 KHNPLLIVFSDDQSSDKERKEELNEMISHEQLPELDNLGLD---SFSSGPGEEALLQMRS 250 260 270 280 290 300 260 270 280 290 300 310 pF1KB6 VKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWD-WIIAPKRYKANYCSGEC . :. : ::. . . : : :: .::. .::: ::::: :.: : : : CCDS18 NIIYDSTARIRRN--------AKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVC 310 320 330 340 350 320 330 340 350 360 pF1KB6 EFVFLQKY-PHTH-----LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYG-KIPA .. . .. : : ::: : . .. ::.:::. ::..::.. : . : : . CCDS18 NYPLAEHLTPTKHAIIQALVHLKNSQKASKACCVPTKLEPISILYLD-KGVVTYKFKYEG 360 370 380 390 400 410 370 pF1KB6 MVVDRCGCS :.:..::: CCDS18 MAVSECGCR 420 >>CCDS44318.1 TGFB2 gene_id:7042|Hs108|chr1 (442 aa) initn: 360 init1: 113 opt: 298 Z-score: 358.9 bits: 75.3 E(32554): 1.1e-13 Smith-Waterman score: 338; 23.8% identity (49.8% similar) in 412 aa overlap (52-375:36-442) 30 40 50 60 70 pF1KB6 DLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLETAPNI---SKDVIR :::::. ::::::.: . :. ..: CCDS44 LSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPP 10 20 30 40 50 60 80 90 100 110 120 pF1KB6 QLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHAT------------TETI---ITMPT ... :.:... .: . . :..:.: .::. .: :. CCDS44 EVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPS 70 80 90 100 110 120 130 140 150 160 pF1KB6 ---------ESDFLM-QVDGKPKCCFFKFSSKIQYN---------KVVKAQLWIY--LRP .:. : .:. : . . .... ..:::.. .. : CCDS44 GSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNP 130 140 150 160 170 180 170 180 190 200 210 pF1KB6 VETPTTVFVQILRLIKPMKDGT----RYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQ ... ...: :: : :: . .: . : : :.:: ....::.. CCDS44 KARVPEQRIELYQILKS-KDLTSPTQRYIDSKVVKTRAE---GEWLSFDVTDAVHEWLHH 190 200 210 220 230 240 220 230 240 pF1KB6 PESNLGIEIK--------------ALDENGHDLAVTFPG--------PGED--------- . :::..:. . .....: . : : :.. CCDS44 KDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKK 250 260 270 280 290 300 250 260 270 280 290 pF1KB6 --GLNPFL--------EVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEA-FGWD : .: : ... .: .:..: . ..... :: :: .::. .:: CCDS44 NSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWK 310 320 330 340 350 360 300 310 320 330 340 350 pF1KB6 WIIAPKRYKANYCSGECEFVFLQKYPHTH---LVHQANPRGSAGPCCTPTKMSPINMLYF :: :: :.::.:.: : ... . :.. : . ::..::.:::. . :...::. CCDS44 WIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYY 370 380 390 400 410 420 360 370 pF1KB6 NGKEQIIYGKIPAMVVDRCGCS :: : .. :.: : :: CCDS44 IGKTPKIE-QLSNMIVKSCKCS 430 440 >>CCDS9846.1 TGFB3 gene_id:7043|Hs108|chr14 (412 aa) initn: 429 init1: 113 opt: 297 Z-score: 358.1 bits: 75.1 E(32554): 1.3e-13 Smith-Waterman score: 448; 27.9% identity (52.5% similar) in 383 aa overlap (49-375:36-412) 20 30 40 50 60 70 pF1KB6 GPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLETAPN--ISKDV :..:.:::. :::::::: . :. . : CCDS98 QRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPTVMTHV 10 20 30 40 50 60 80 90 100 110 120 130 pF1KB6 IRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATT---ETIITMPTESDFLMQVDG :.: :::.... .:... ...:.: .: .: . : CCDS98 PYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNELAVCPK 70 80 90 100 110 120 140 150 160 170 180 pF1KB6 KPKCCFFKFS-SKIQYNK--VVKAQLWIYLRPVETPTTVF----VQILRLIKPMKD--GT :.:. :... :. . .:.. . :: : .:.. ........: . CCDS98 GITSKVFRFNVSSVEKNRTNLFRAEFRV-LR-VPNPSSKRNEQRIELFQILRPDEHIAKQ 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 RYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKA------------LDE :: : ..: ::. : :.:: ....:: . :::::.::. . : CCDS98 RYIGGKNLPTR---GTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE 190 200 210 220 230 240 240 250 260 pF1KB6 NGHD-LAVTFPG----------------PGEDGLNPFLEVKVT-----DTP----KRSRR : :. . . : : .: :: : . . :.: .:..: CCDS98 NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR 250 260 270 280 290 300 270 280 290 300 310 320 pF1KB6 DFGLDCDEHSTESRCCRYPLTVDF-EAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTH . . .. : :: :: .:: . .:: :. :: : ::.::: : .. :. CCDS98 ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST 310 320 330 340 350 360 330 340 350 360 370 pF1KB6 ---LVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS : . ::..::.:::.: . :...::. :. . .. ::: : :: CCDS98 VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVE-QLSNMVVKSCKCS 370 380 390 400 410 >>CCDS13099.1 BMP2 gene_id:650|Hs108|chr20 (396 aa) initn: 290 init1: 134 opt: 295 Z-score: 356.0 bits: 74.6 E(32554): 1.7e-13 Smith-Waterman score: 380; 26.5% identity (55.5% similar) in 366 aa overlap (41-374:36-395) 20 30 40 50 60 pF1KB6 YLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSR--IEAIKIQILSKLRLET : . : ... : . .....:: . :. CCDS13 RCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 APNISKDVIRQLLPKAPPLRELIDQYDVQRDDSS-DGSLEDDDYHATTETIITMPTESDF :. :.:.. .: : . .: ... : . . : :: .:.: . . CCDS13 RPTPSRDAV---VP--PYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 LMQVDGKP-KCCFFKFSSKIQYNKVVKAQLWIYLRPVETP---TTVF---VQILRLIKPM : ...:: . ::..:: . ...:.: .. . .. .. : ..: ..::: CCDS13 LPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPA 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 KDGTRYTGIRSLKLDM-NPGTGIWQSIDVKTVLQNWLKQPESNLG--IEIKALDE----N .... : : . : ... :.:.:: ... : : ..: : .:. :.: . CCDS13 TANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVS 190 200 210 220 230 240 240 250 260 270 280 pF1KB6 GHDLAVTFPGPGEDG----LNPFL-----EVKVTDTPKRSRRDFGLDCDEHSTESRCCRY . . .. .. . :.: . : :: .:. . ... .: : :. CCDS13 KRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQ-AKHKQRKRLKSSCKRH 250 260 270 280 290 290 300 310 320 330 pF1KB6 PLTVDFEAFGW-DWIIAPKRYKANYCSGECEFVFLQKYPHT-HLVHQA--NPRGSAGP-- :: ::: :: :::.:: :.: :: ::: : . .. : : . :. : .: : CCDS13 PLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKA 300 310 320 330 340 350 340 350 360 370 pF1KB6 CCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS ::.::..: :.:::.. .:... . :::. ::: CCDS13 CCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR 360 370 380 390 375 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 16:58:12 2016 done: Sat Nov 5 16:58:12 2016 Total Scan time: 2.640 Total Display time: 0.050 Function used was FASTA [36.3.4 Apr, 2011]