FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6593, 377 aa 1>>>pF1KB6593 377 - 377 aa - 377 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1227+/-0.000336; mu= 13.8436+/- 0.021 mean_var=92.9539+/-18.911, 0's: 0 Z-trim(116.9): 10 B-trim: 362 in 1/52 Lambda= 0.133027 statistics sampled from 28430 (28440) to 28430 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.696), E-opt: 0.2 (0.333), width: 16 Scan time: 7.620 The best scores are: opt bits E(85289) NP_002801 (OMIM: 601648) 26S proteasome non-ATPase ( 377) 2416 473.6 3.3e-133 NP_001317621 (OMIM: 601648) 26S proteasome non-ATP ( 380) 2400 470.5 2.8e-132 XP_016857345 (OMIM: 601648) PREDICTED: 26S proteas ( 330) 2054 404.1 2.4e-112 XP_006711527 (OMIM: 601648) PREDICTED: 26S proteas ( 333) 2038 401.0 2.1e-111 >>NP_002801 (OMIM: 601648) 26S proteasome non-ATPase reg (377 aa) initn: 2416 init1: 2416 opt: 2416 Z-score: 2512.4 bits: 473.6 E(85289): 3.3e-133 Smith-Waterman score: 2416; 100.0% identity (100.0% similar) in 377 aa overlap (1-377:1-377) 10 20 30 40 50 60 pF1KB6 MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 LTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 EKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 ASAAEAGIATTGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ASAAEAGIATTGTEDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEF 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 GQAESADIDASSAMDTSEPAKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GQAESADIDASSAMDTSEPAKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLA 310 320 330 340 350 360 370 pF1KB6 SQATKDGKKDKKEEDKK ::::::::::::::::: NP_002 SQATKDGKKDKKEEDKK 370 >>NP_001317621 (OMIM: 601648) 26S proteasome non-ATPase (380 aa) initn: 1633 init1: 1633 opt: 2400 Z-score: 2495.8 bits: 470.5 E(85289): 2.8e-132 Smith-Waterman score: 2400; 99.2% identity (99.2% similar) in 380 aa overlap (1-377:1-380) 10 20 30 40 50 60 pF1KB6 MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MVLESTMVCVDNSEYMRNGDFLPTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 LTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LTTLTPDTGRILSKLHTVQPKGKITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDN 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKDLVKLAKRLKKEKVNVDIINFGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLA 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DALISSPILAGEGGAMLGLGASDFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAA 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 ASAAEAGIATTGTE---DSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQG :::::::::::::: ::::::::::::::::::::::::::::::::::::::::::: NP_001 ASAAEAGIATTGTEGERDSDDALLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQG 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB6 AEFGQAESADIDASSAMDTSEPAKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AEFGQAESADIDASSAMDTSEPAKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMG 310 320 330 340 350 360 360 370 pF1KB6 SLASQATKDGKKDKKEEDKK :::::::::::::::::::: NP_001 SLASQATKDGKKDKKEEDKK 370 380 >>XP_016857345 (OMIM: 601648) PREDICTED: 26S proteasome (330 aa) initn: 2054 init1: 2054 opt: 2054 Z-score: 2137.8 bits: 404.1 E(85289): 2.4e-112 Smith-Waterman score: 2054; 99.1% identity (99.7% similar) in 325 aa overlap (53-377:6-330) 30 40 50 60 70 80 pF1KB6 PTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKG :.. :::::::::::::::::::::::::: XP_016 MVLESTMVCDCEVLTTLTPDTGRILSKLHTVQPKG 10 20 30 90 100 110 120 130 140 pF1KB6 KITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIIN 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB6 FGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGAS 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB6 DFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATTGTEDSDDALLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATTGTEDSDDALLK 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB6 MTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADIDASSAMDTSEPAKE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADIDASSAMDTSEPAKE 220 230 240 250 260 270 330 340 350 360 370 pF1KB6 EDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDGKKDKKEEDKK ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 EDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDGKKDKKEEDKK 280 290 300 310 320 330 >>XP_006711527 (OMIM: 601648) PREDICTED: 26S proteasome (333 aa) initn: 1271 init1: 1271 opt: 2038 Z-score: 2121.2 bits: 401.0 E(85289): 2.1e-111 Smith-Waterman score: 2038; 98.2% identity (98.8% similar) in 328 aa overlap (53-377:6-333) 30 40 50 60 70 80 pF1KB6 PTRLQAQQDAVNIVCHSKTRSNPENNVGLITLANDCEVLTTLTPDTGRILSKLHTVQPKG :.. :::::::::::::::::::::::::: XP_006 MVLESTMVCDCEVLTTLTPDTGRILSKLHTVQPKG 10 20 30 90 100 110 120 130 140 pF1KB6 KITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIIN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 KITFCTGIRVAHLALKHRQGKNHKMRIIAFVGSPVEDNEKDLVKLAKRLKKEKVNVDIIN 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB6 FGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGAS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 FGEEEVNTEKLTAFVNTLNGKDGTGSHLVTVPPGPSLADALISSPILAGEGGAMLGLGAS 100 110 120 130 140 150 210 220 230 240 250 pF1KB6 DFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATTGTE---DSDDA :::::::::::::::::::::::::::::::::::::::::::::::::::: ::::: XP_006 DFEFGVDPSADPELALALRVSMEEQRQRQEEEARRAAAASAAEAGIATTGTEGERDSDDA 160 170 180 190 200 210 260 270 280 290 300 310 pF1KB6 LLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADIDASSAMDTSEP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 LLKMTISQQEFGRTGLPDLSSMTEEEQIAYAMQMSLQGAEFGQAESADIDASSAMDTSEP 220 230 240 250 260 270 320 330 340 350 360 370 pF1KB6 AKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDGKKDKKEEDKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 AKEEDDYDVMQDPEFLQSVLENLPGVDPNNEAIRNAMGSLASQATKDGKKDKKEEDKK 280 290 300 310 320 330 377 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 11:03:04 2016 done: Sat Nov 5 11:03:05 2016 Total Scan time: 7.620 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]