FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6595, 380 aa 1>>>pF1KB6595 380 - 380 aa - 380 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2013+/-0.000961; mu= 17.2010+/- 0.058 mean_var=72.7784+/-14.969, 0's: 0 Z-trim(105.5): 57 B-trim: 17 in 3/48 Lambda= 0.150339 statistics sampled from 8420 (8478) to 8420 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.637), E-opt: 0.2 (0.26), width: 16 Scan time: 1.970 The best scores are: opt bits E(32554) CCDS14565.1 IL13RA2 gene_id:3598|Hs108|chrX ( 380) 2675 589.7 1.5e-168 CCDS2559.1 IL5RA gene_id:3568|Hs108|chr3 ( 420) 369 89.5 5.7e-18 CCDS58813.1 IL5RA gene_id:3568|Hs108|chr3 ( 378) 368 89.3 6.2e-18 CCDS46739.1 IL5RA gene_id:3568|Hs108|chr3 ( 333) 344 84.1 2.1e-16 CCDS2560.1 IL5RA gene_id:3568|Hs108|chr3 ( 335) 344 84.1 2.1e-16 CCDS14573.1 IL13RA1 gene_id:3597|Hs108|chrX ( 427) 328 80.7 2.8e-15 CCDS14406.1 IL2RG gene_id:3561|Hs108|chrX ( 369) 316 78.0 1.5e-14 >>CCDS14565.1 IL13RA2 gene_id:3598|Hs108|chrX (380 aa) initn: 2675 init1: 2675 opt: 2675 Z-score: 3139.7 bits: 589.7 E(32554): 1.5e-168 Smith-Waterman score: 2675; 100.0% identity (100.0% similar) in 380 aa overlap (1-380:1-380) 10 20 30 40 50 60 pF1KB6 MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 HFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 HFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQ 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 SSWAETTYWISPQGIPETKVQDMDCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEGLDH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 SSWAETTYWISPQGIPETKVQDMDCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEGLDH 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 ALQCVDYIKADGQNIGCRFPYLEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 ALQCVDYIKADGQNIGCRFPYLEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLP 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 PVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTATVENETYTLKTTNE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 PVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTATVENETYTLKTTNE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 TRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWLPFGFILILVIFVTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS14 TRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWLPFGFILILVIFVTG 310 320 330 340 350 360 370 380 pF1KB6 LLLRKPNTYPKMIPEFFCDT :::::::::::::::::::: CCDS14 LLLRKPNTYPKMIPEFFCDT 370 380 >>CCDS2559.1 IL5RA gene_id:3568|Hs108|chr3 (420 aa) initn: 196 init1: 146 opt: 369 Z-score: 436.0 bits: 89.5 E(32554): 5.7e-18 Smith-Waterman score: 422; 27.2% identity (56.9% similar) in 364 aa overlap (27-374:25-373) 10 20 30 40 50 60 pF1KB6 MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLD : .:.. :: .: : : :. . :::.: . . CCDS25 MIIVAHVLLILLGATEILQADLLPDEKISLLPPVNFTIKVTG-LAQVLLQWKPNPDQE 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 HFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQ . .. ..::..: . ..: ::.. : :.::. :...:.: .. : . CCDS25 Q-RNVNLEYQVKINAPKEDDYETRITES---KCVTILHKGFSASVRTILQ---NDHSLLA 60 70 80 90 100 110 130 140 150 160 pF1KB6 SSWAETTYWISPQGIPETKVQDMDCV----------YYNWQYLL-CSWKPGIGVLLDTNY :::: .. .: : : :.. .. :. ..: : :.: : . ::.: CCDS25 SSWA-SAELHAPPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQY 120 130 140 150 160 170 180 190 200 210 220 pF1KB6 NLFYWYEGLDHALQCVDYIKAD-GQNIGCRFPYLEA-SDYKDFY-ICVNGSSENKPIRSS :.: : . . .: .: : :.::.: :: : .:. . :::::... :: CCDS25 FLYYRYGSWTE--ECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIRPF 170 180 190 200 210 220 230 240 250 260 270 280 pF1KB6 YFTFQLQNIVKPLPPVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTA : :. : . ::. .: :.. .....: :.. .: .:::::..:.. . . CCDS25 DQLFALHAIDQINPPLNVTAEIEGT-RLSIQWEKPVSAFPIHCFDYEVKIHNTRNGYLQI 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB6 TVENETYTLKTTNETRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWL . .. .. . ::. :. .: . :.::::: . . :.: : :: :. CCDS25 EKLMTNAFISIIDDLSKYDVQVRAAVSSMCREAGLWSEWS-QPIYVGNDEHKP--LREWF 290 300 310 320 330 340 350 360 370 380 pF1KB6 PFGFI--LILVIFVTGLLLRKPNTYPKMIPEFFCDT . .. . ..... .:. . . . :..: CCDS25 VIVIMATICFILLILSLICKICHLWIKLFPPIPAPKSNIKDLFVTTNYEKAGSSETEIEV 350 360 370 380 390 400 >>CCDS58813.1 IL5RA gene_id:3568|Hs108|chr3 (378 aa) initn: 231 init1: 146 opt: 368 Z-score: 435.5 bits: 89.3 E(32554): 6.2e-18 Smith-Waterman score: 421; 28.2% identity (56.1% similar) in 351 aa overlap (27-363:25-356) 10 20 30 40 50 60 pF1KB6 MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLD : .:.. :: .: : : :. . :::.: . . CCDS58 MIIVAHVLLILLGATEILQADLLPDEKISLLPPVNFTIKVTG-LAQVLLQWKPNPDQE 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 HFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQ . .. ..::..: . ..: ::.. : :.::. :...:.: .. : . CCDS58 Q-RNVNLEYQVKINAPKEDDYETRITES---KCVTILHKGFSASVRTILQ---NDHSLLA 60 70 80 90 100 110 130 140 150 160 pF1KB6 SSWAETTYWISPQGIPETKVQDMDCV----------YYNWQYLL-CSWKPGIGVLLDTNY :::: .. .: : : :.. .. :. ..: : :.: : . ::.: CCDS58 SSWA-SAELHAPPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQY 120 130 140 150 160 170 180 190 200 210 220 pF1KB6 NLFYWYEGLDHALQCVDYIKAD-GQNIGCRFPYLEA-SDYKDFY-ICVNGSSENKPIRSS :.: : . . .: .: : :.::.: :: : .:. . :::::... :: CCDS58 FLYYRYGSWTE--ECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIRPF 170 180 190 200 210 220 230 240 250 260 270 280 pF1KB6 YFTFQLQNIVKPLPPVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTA : :. : . ::. .: :.. .....: :.. .: .:::::..:.. . . CCDS58 DQLFALHAIDQINPPLNVTAEIEGT-RLSIQWEKPVSAFPIHCFDYEVKIHNTRNGYLQI 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB6 TVENETYTLKTTNETRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWL . .. .. . ::. :. .: . :.::::: . . :.: : :: : CCDS58 EKLMTNAFISIIDDLSKYDVQVRAAVSSMCREAGLWSEWS-QPIYVGNDEHKP--LREW- 290 300 310 320 330 340 350 360 370 380 pF1KB6 PFGFILILVIFVTGLLLRKPNTYPKMIPEFFCDT :..... . .:: CCDS58 ---FVIVIMATICFILLILSLICKIKLGPVRRKLKSSVI 350 360 370 >>CCDS46739.1 IL5RA gene_id:3568|Hs108|chr3 (333 aa) initn: 231 init1: 146 opt: 344 Z-score: 408.1 bits: 84.1 E(32554): 2.1e-16 Smith-Waterman score: 397; 28.7% identity (56.7% similar) in 314 aa overlap (27-326:25-326) 10 20 30 40 50 60 pF1KB6 MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLD : .:.. :: .: : : :. . :::.: . . CCDS46 MIIVAHVLLILLGATEILQADLLPDEKISLLPPVNFTIKVTG-LAQVLLQWKPNPDQE 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 HFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQ . .. ..::..: . ..: ::.. : :.::. :...:.: .. : . CCDS46 Q-RNVNLEYQVKINAPKEDDYETRITES---KCVTILHKGFSASVRTILQ---NDHSLLA 60 70 80 90 100 110 130 140 150 160 pF1KB6 SSWAETTYWISPQGIPETKVQDMDCV----------YYNWQYLL-CSWKPGIGVLLDTNY :::: .. .: : : :.. .. :. ..: : :.: : . ::.: CCDS46 SSWA-SAELHAPPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQY 120 130 140 150 160 170 180 190 200 210 220 pF1KB6 NLFYWYEGLDHALQCVDYIKAD-GQNIGCRFPYLEA-SDYKDFY-ICVNGSSENKPIRSS :.: : . . .: .: : :.::.: :: : .:. . :::::... :: CCDS46 FLYYRYGSWTE--ECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIRPF 170 180 190 200 210 220 230 240 250 260 270 280 pF1KB6 YFTFQLQNIVKPLPPVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTA : :. : . ::. .: :.. .....: :.. .: .:::::..:.. . . CCDS46 DQLFALHAIDQINPPLNVTAEIEGT-RLSIQWEKPVSAFPIHCFDYEVKIHNTRNGYLQI 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB6 TVENETYTLKTTNETRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWL . .. .. . ::. :. .: . :.::::: CCDS46 EKLMTNAFISIIDDLSKYDVQVRAAVSSMCREAGLWSEWSQPIYVGK 290 300 310 320 330 350 360 370 380 pF1KB6 PFGFILILVIFVTGLLLRKPNTYPKMIPEFFCDT >>CCDS2560.1 IL5RA gene_id:3568|Hs108|chr3 (335 aa) initn: 231 init1: 146 opt: 344 Z-score: 408.1 bits: 84.1 E(32554): 2.1e-16 Smith-Waterman score: 397; 28.7% identity (56.7% similar) in 314 aa overlap (27-326:25-326) 10 20 30 40 50 60 pF1KB6 MAFVCLAIGCLYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLD : .:.. :: .: : : :. . :::.: . . CCDS25 MIIVAHVLLILLGATEILQADLLPDEKISLLPPVNFTIKVTG-LAQVLLQWKPNPDQE 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 HFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQ . .. ..::..: . ..: ::.. : :.::. :...:.: .. : . CCDS25 Q-RNVNLEYQVKINAPKEDDYETRITES---KCVTILHKGFSASVRTILQ---NDHSLLA 60 70 80 90 100 110 130 140 150 160 pF1KB6 SSWAETTYWISPQGIPETKVQDMDCV----------YYNWQYLL-CSWKPGIGVLLDTNY :::: .. .: : : :.. .. :. ..: : :.: : . ::.: CCDS25 SSWA-SAELHAPPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQY 120 130 140 150 160 170 180 190 200 210 220 pF1KB6 NLFYWYEGLDHALQCVDYIKAD-GQNIGCRFPYLEA-SDYKDFY-ICVNGSSENKPIRSS :.: : . . .: .: : :.::.: :: : .:. . :::::... :: CCDS25 FLYYRYGSWTE--ECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIRPF 170 180 190 200 210 220 230 240 250 260 270 280 pF1KB6 YFTFQLQNIVKPLPPVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTA : :. : . ::. .: :.. .....: :.. .: .:::::..:.. . . CCDS25 DQLFALHAIDQINPPLNVTAEIEGT-RLSIQWEKPVSAFPIHCFDYEVKIHNTRNGYLQI 230 240 250 260 270 280 290 300 310 320 330 340 pF1KB6 TVENETYTLKTTNETRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLRFWL . .. .. . ::. :. .: . :.::::: CCDS25 EKLMTNAFISIIDDLSKYDVQVRAAVSSMCREAGLWSEWSQPIYVGFSR 290 300 310 320 330 350 360 370 380 pF1KB6 PFGFILILVIFVTGLLLRKPNTYPKMIPEFFCDT >>CCDS14573.1 IL13RA1 gene_id:3597|Hs108|chrX (427 aa) initn: 326 init1: 202 opt: 328 Z-score: 387.9 bits: 80.7 E(32554): 2.8e-15 Smith-Waterman score: 399; 26.1% identity (55.6% similar) in 403 aa overlap (10-379:8-391) 10 20 30 40 50 pF1KB6 MAFVCLAIGC-LYTFLISTTFGCTSSSDTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSL : :...:. . : ... . ...:: :. : . :.:: . CCDS14 MEWPARLCGLWALLLCAGGGGGGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGA 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 DHFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQC-TNGSE . ..:.. : . ..:.. : : .. . . ::. : .. . :: :: :: CCDS14 S--SNCSLWY---FSHFGDKQDKKIAPETRRSIE-VPLNERICLQVGS----QCSTNESE 60 70 80 90 100 120 130 140 150 160 170 pF1KB6 VQSSWAETTYWISP-QGIPETKVQDMDCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEG : .: ::: .: ::. : ...:...: .:. ::: :: .. ::::.:.::... CCDS14 KPSILVEKC--ISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRS 110 120 130 140 150 160 180 190 200 210 220 230 pF1KB6 LDHALQCVDYIKADGQNIGCRFPYLEASD--YKDFYICVNGSSENKPIRSSYFTFQLQNI :.. :: . .. .:: .:: : ...: ... . . ... :. :. : . CCDS14 LEKIHQCENIFR-EGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSR 170 180 190 200 210 220 240 250 260 270 280 pF1KB6 VKPLPPVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTT------LVTATVE ::: :: ... ... .. ..: : . : .::. ::.:. ...: . : : CCDS14 VKPDPPHIKNLSFHND-DLYVQWENPQNFI-SRCLFYEVEVNNSQTETHNVFYVQEAKCE 230 240 250 260 270 280 290 300 310 320 330 pF1KB6 NETYTLKTTNETRQLCFVV-------------RSKVNIYC-SDDGIWSEWSDKQCWEGED : . .. : . ::.: : :.: : :: .::.::... :. CCDS14 NPEFERNVENTS---CFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSI-GKK 290 300 310 320 330 340 350 360 370 380 pF1KB6 LSKKTLLRFWL--PF---GFILILVIFVTGL--LLRKPNTYP-KMIPEFFCDT .. . . : : : :..:.... : .. : : :.. :.: : CCDS14 RNSTLYITMLLIVPVIVAGAIIVLLLYLKRLKIIIFPPIPDPGKIFKEMFGDQNDDTLHW 340 350 360 370 380 390 CCDS14 KKYDIYEKQTKEETDSVVLIENLKKASQ 400 410 420 >>CCDS14406.1 IL2RG gene_id:3561|Hs108|chrX (369 aa) initn: 189 init1: 97 opt: 316 Z-score: 374.7 bits: 78.0 E(32554): 1.5e-14 Smith-Waterman score: 316; 25.9% identity (56.6% similar) in 251 aa overlap (115-360:31-268) 90 100 110 120 130 140 pF1KB6 ITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSE-VQSSWAETTYWISPQGIPETKVQDM ::.: . ... ::. . .. . .. CCDS14 MLKPSLPFTSLLFLQLPLLGVGLNTTILTPNGNEDTTADFFLTTMPTDSLSVSTLPLPEV 10 20 30 40 50 60 150 160 170 180 190 200 pF1KB6 DCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEGLDH--ALQCVDYIKADGQNIGCRFPY .: .: .:. :.:. . . :: .: :::.. :. . .: :. .. . ::.. CCDS14 QCFVFNVEYMNCTWNSS-SEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGCQLQK 70 80 90 100 110 210 220 230 240 250 260 pF1KB6 LEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLPPVYLTFTRESSCEIKLKWSIP : :. : . .. : : :.. ..:::.: : : ::. . : ...:.:. CCDS14 KEIHLYQTFVVQLQDPRE--PRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWN-- 120 130 140 150 160 170 270 280 290 300 310 pF1KB6 LGPIPARCFDYEIEIRED-DTTLVTATVE-NETYTLKTTNETRQLCFVVRSKVNIYCSDD . . .:... .. : : : . . .:. . ..: ... .. : :::. : :.. CCDS14 -NRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSA 180 190 200 210 220 230 320 330 340 350 360 370 pF1KB6 GIWSEWSDKQCWEGEDLSKKTLLRFWLPFGFILILVIFVTGLLLRKPNTYPKMIPEFFCD ::::: : : . ::.. :: : : :.. .: CCDS14 QHWSEWSHPIHW-GSNTSKEN------PFLFALEAVVISVGSMGLIISLLCVYFWLERTM 240 250 260 270 280 380 pF1KB6 T CCDS14 PRIPTLKNLEDLVTEYHGNFSAWSGVSKGLAESLQPDYSERLCLVSEIPPKGGALGEGPG 290 300 310 320 330 340 380 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:13:10 2016 done: Sat Nov 5 18:13:10 2016 Total Scan time: 1.970 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]