FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6605, 393 aa 1>>>pF1KB6605 393 - 393 aa - 393 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.6335+/-0.000322; mu= 14.2781+/- 0.020 mean_var=174.1313+/-35.354, 0's: 0 Z-trim(121.1): 22 B-trim: 150 in 1/52 Lambda= 0.097193 statistics sampled from 37307 (37332) to 37307 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.769), E-opt: 0.2 (0.438), width: 16 Scan time: 7.010 The best scores are: opt bits E(85289) NP_001018079 (OMIM: 607378) plasminogen activator ( 393) 2706 391.1 2.4e-108 NP_056455 (OMIM: 607378) plasminogen activator inh ( 387) 2643 382.3 1.1e-105 NP_001018077 (OMIM: 607378) plasminogen activator ( 408) 1636 241.1 3.6e-63 NP_001018078 (OMIM: 607378) plasminogen activator ( 402) 1616 238.3 2.5e-62 >>NP_001018079 (OMIM: 607378) plasminogen activator inhi (393 aa) initn: 2706 init1: 2706 opt: 2706 Z-score: 2066.2 bits: 391.1 E(85289): 2.4e-108 Smith-Waterman score: 2706; 100.0% identity (100.0% similar) in 393 aa overlap (1-393:1-393) 10 20 30 40 50 60 pF1KB6 MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTDLDQSNVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTDLDQSNVT 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 EETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGA 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 DGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGG 310 320 330 340 350 360 370 380 390 pF1KB6 RGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA ::::::::::::::::::::::::::::::::: NP_001 RGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA 370 380 390 >>NP_056455 (OMIM: 607378) plasminogen activator inhibit (387 aa) initn: 1678 init1: 1402 opt: 2643 Z-score: 2018.6 bits: 382.3 E(85289): 1.1e-105 Smith-Waterman score: 2643; 98.5% identity (98.5% similar) in 393 aa overlap (1-393:1-387) 10 20 30 40 50 60 pF1KB6 MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 TNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 GKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMG 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 RGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTDLDQSNVT :::::::::::::::::::::: :::::::::::::::::::::::::::::::: NP_056 RGDGFDSRGKREFDRHSGSDRS------GLKHEDKRGGSGSHNWGTVKDELTDLDQSNVT 190 200 210 220 230 250 260 270 280 290 300 pF1KB6 EETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 EETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGA 240 250 260 270 280 290 310 320 330 340 350 360 pF1KB6 DGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_056 DGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGG 300 310 320 330 340 350 370 380 390 pF1KB6 RGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA ::::::::::::::::::::::::::::::::: NP_056 RGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA 360 370 380 >>NP_001018077 (OMIM: 607378) plasminogen activator inhi (408 aa) initn: 1952 init1: 1604 opt: 1636 Z-score: 1255.2 bits: 241.1 E(85289): 3.6e-63 Smith-Waterman score: 2666; 96.3% identity (96.3% similar) in 408 aa overlap (1-393:1-408) 10 20 30 40 50 60 pF1KB6 MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMG 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 RGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELT-------- :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQK 190 200 210 220 230 240 240 250 260 270 280 pF1KB6 -------DLDQSNVTEETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKD ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QISYNYSDLDQSNVTEETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKD 250 260 270 280 290 300 290 300 310 320 330 340 pF1KB6 RAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFG 310 320 330 340 350 360 350 360 370 380 390 pF1KB6 DLGRPGRGGRGGRGGRGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLGRPGRGGRGGRGGRGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA 370 380 390 400 >>NP_001018078 (OMIM: 607378) plasminogen activator inhi (402 aa) initn: 1750 init1: 1402 opt: 1616 Z-score: 1240.1 bits: 238.3 E(85289): 2.5e-62 Smith-Waterman score: 2603; 94.9% identity (94.9% similar) in 408 aa overlap (1-393:1-402) 10 20 30 40 50 60 pF1KB6 MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQ 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 TNSNAAGKQLRKESQKDRKNPLPPSVGVVDKKEETQPPVALKKEGIRRVGRRPDQQLQGE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIDRPIRGRGGLGRGRGGRGRGMG 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 RGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELT-------- :::::::::::::::::::::: :::::::::::::::::::::::: NP_001 RGDGFDSRGKREFDRHSGSDRS------GLKHEDKRGGSGSHNWGTVKDELTESPKYIQK 190 200 210 220 230 240 250 260 270 280 pF1KB6 -------DLDQSNVTEETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKD ::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QISYNYSDLDQSNVTEETPEGEEHHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKD 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB6 RAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFG 300 310 320 330 340 350 350 360 370 380 390 pF1KB6 DLGRPGRGGRGGRGGRGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA :::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLGRPGRGGRGGRGGRGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA 360 370 380 390 400 393 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 11:32:29 2016 done: Sat Nov 5 11:32:30 2016 Total Scan time: 7.010 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]