FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6606, 431 aa 1>>>pF1KB6606 431 - 431 aa - 431 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.0685+/-0.000284; mu= 15.0482+/- 0.018 mean_var=89.7402+/-17.725, 0's: 0 Z-trim(119.7): 4 B-trim: 0 in 0/58 Lambda= 0.135388 statistics sampled from 34008 (34012) to 34008 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.753), E-opt: 0.2 (0.399), width: 16 Scan time: 8.680 The best scores are: opt bits E(85289) NP_057665 (OMIM: 608388) evolutionarily conserved ( 431) 2981 591.8 1.1e-168 NP_001135936 (OMIM: 608388) evolutionarily conserv ( 296) 1834 367.7 2.3e-101 NP_001230133 (OMIM: 608388) evolutionarily conserv ( 296) 1826 366.1 6.8e-101 NP_001135937 (OMIM: 608388) evolutionarily conserv ( 217) 1304 264.1 2.6e-70 >>NP_057665 (OMIM: 608388) evolutionarily conserved sign (431 aa) initn: 2981 init1: 2981 opt: 2981 Z-score: 3149.2 bits: 591.8 E(85289): 1.1e-168 Smith-Waterman score: 2981; 100.0% identity (100.0% similar) in 431 aa overlap (1-431:1-431) 10 20 30 40 50 60 pF1KB6 MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSPPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSPPE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PRQRPTKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 PRQRPTKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 GVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 FLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 FLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 RVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCV 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 YYHILRADLLPPEEREVEETPEEWNLYYPMQLDLEYVRSGWDNYEFDINEVEEGPVFAMC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 YYHILRADLLPPEEREVEETPEEWNLYYPMQLDLEYVRSGWDNYEFDINEVEEGPVFAMC 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 MAGAHDQATMAKWIQGLQETNPTLAQIPVVFRLAGSTRELQTSSAGLEEPPLPEDHQEED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_057 MAGAHDQATMAKWIQGLQETNPTLAQIPVVFRLAGSTRELQTSSAGLEEPPLPEDHQEED 370 380 390 400 410 420 430 pF1KB6 DNLQRQQQGQS ::::::::::: NP_057 DNLQRQQQGQS 430 >>NP_001135936 (OMIM: 608388) evolutionarily conserved s (296 aa) initn: 1855 init1: 1834 opt: 1834 Z-score: 1940.8 bits: 367.7 E(85289): 2.3e-101 Smith-Waterman score: 1834; 100.0% identity (100.0% similar) in 266 aa overlap (1-266:1-266) 10 20 30 40 50 60 pF1KB6 MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSPPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSPPE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PRQRPTKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRQRPTKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 FLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCV :::::::::::::::::::::::::: NP_001 RVTIYQVPLPKDSTGAADPPQPHIVGSGRDAGGVEPLLPDAAGPGVCEEWLGQLRV 250 260 270 280 290 >>NP_001230133 (OMIM: 608388) evolutionarily conserved s (296 aa) initn: 1826 init1: 1826 opt: 1826 Z-score: 1932.4 bits: 366.1 E(85289): 6.8e-101 Smith-Waterman score: 1826; 100.0% identity (100.0% similar) in 265 aa overlap (1-265:1-265) 10 20 30 40 50 60 pF1KB6 MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSPPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSPPE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PRQRPTKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRQRPTKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREY 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 GVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 GVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETE 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 FLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCV ::::::::::::::::::::::::: NP_001 RVTIYQVPLPKDSTGAADPPQPHIVELTCCPRRRGKWKRRRRSGTSTTRCSWTWSM 250 260 270 280 290 >>NP_001135937 (OMIM: 608388) evolutionarily conserved s (217 aa) initn: 1304 init1: 1304 opt: 1304 Z-score: 1383.3 bits: 264.1 E(85289): 2.6e-70 Smith-Waterman score: 1304; 98.9% identity (99.5% similar) in 189 aa overlap (243-431:29-217) 220 230 240 250 260 270 pF1KB6 FPVPRDLPQDPVELAMFGLRHMEPDLSARVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQ .: ::::::::::::::::::::::::::: NP_001 MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPLPKDSTGAADPPQPHIVGIQSPDQ 10 20 30 40 50 280 290 300 310 320 330 pF1KB6 QAALARHNPARPVFVEGPFSLWLRNKCVYYHILRADLLPPEEREVEETPEEWNLYYPMQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QAALARHNPARPVFVEGPFSLWLRNKCVYYHILRADLLPPEEREVEETPEEWNLYYPMQL 60 70 80 90 100 110 340 350 360 370 380 390 pF1KB6 DLEYVRSGWDNYEFDINEVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DLEYVRSGWDNYEFDINEVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFR 120 130 140 150 160 170 400 410 420 430 pF1KB6 LAGSTRELQTSSAGLEEPPLPEDHQEEDDNLQRQQQGQS ::::::::::::::::::::::::::::::::::::::: NP_001 LAGSTRELQTSSAGLEEPPLPEDHQEEDDNLQRQQQGQS 180 190 200 210 431 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 11:33:02 2016 done: Sat Nov 5 11:33:03 2016 Total Scan time: 8.680 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]