Result of FASTA (omim) for
pF1KB6608
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6608, 431 aa
1>>>pF1KB6608 431 - 431 aa - 431 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.8628+/-0.000431; mu= 14.7808+/- 0.027
mean_var=106.0983+/-20.084, 0's: 0 Z-trim(114.2): 341 B-trim: 129 in 2/51
Lambda= 0.124515
statistics sampled from 23511 (23898) to 23511 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.28), width: 16
Scan time: 8.040
The best scores are: opt bits E(85289)
NP_002649 (OMIM: 104300,191840,601709) urokinase-t ( 431) 3080 564.4 2e-160
XP_011538168 (OMIM: 104300,191840,601709) PREDICTE ( 431) 3066 561.9 1.1e-159
NP_001138503 (OMIM: 104300,191840,601709) urokinas ( 414) 2900 532.1 1e-150
NP_001306120 (OMIM: 104300,191840,601709) urokinas ( 345) 2456 452.2 9.3e-127
NP_001519 (OMIM: 604552) hepatocyte growth factor ( 655) 982 187.7 7.6e-47
XP_011532764 (OMIM: 234000,610618,610619) PREDICTE ( 503) 676 132.6 2.2e-30
NP_000496 (OMIM: 234000,610618,610619) coagulation ( 615) 676 132.7 2.6e-30
NP_001284368 (OMIM: 604552) hepatocyte growth fact ( 662) 659 129.7 2.2e-29
NP_003610 (OMIM: 249500,606709) neurotrypsin precu ( 875) 623 123.3 2.4e-27
NP_001306118 (OMIM: 173370,612348) tissue-type pla ( 473) 619 122.4 2.6e-27
XP_011520753 (OMIM: 613797) PREDICTED: serine prot ( 280) 599 118.6 2.1e-26
NP_690851 (OMIM: 613797) serine protease 33 precur ( 280) 599 118.6 2.1e-26
XP_011520754 (OMIM: 613797) PREDICTED: serine prot ( 280) 599 118.6 2.1e-26
NP_892018 (OMIM: 610477) transmembrane protease se (1059) 550 110.3 2.5e-23
XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 550 110.3 2.5e-23
NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 541 108.2 3.3e-23
XP_016882220 (OMIM: 142440) PREDICTED: serine prot ( 417) 534 107.0 9.2e-23
XP_005258895 (OMIM: 142440) PREDICTED: serine prot ( 417) 534 107.0 9.2e-23
NP_892028 (OMIM: 142440) serine protease hepsin pr ( 417) 534 107.0 9.2e-23
XP_006723244 (OMIM: 142440) PREDICTED: serine prot ( 417) 534 107.0 9.2e-23
NP_002142 (OMIM: 142440) serine protease hepsin pr ( 417) 534 107.0 9.2e-23
XP_016882221 (OMIM: 142440) PREDICTED: serine prot ( 393) 533 106.8 1e-22
XP_016878460 (OMIM: 610560) PREDICTED: polyserase- ( 621) 520 104.7 7e-22
XP_016878459 (OMIM: 610560) PREDICTED: polyserase- ( 634) 520 104.7 7.1e-22
XP_016878458 (OMIM: 610560) PREDICTED: polyserase- ( 637) 520 104.7 7.2e-22
NP_001245220 (OMIM: 610560) polyserase-2 isoform 3 ( 752) 520 104.8 8.1e-22
XP_016878457 (OMIM: 610560) PREDICTED: polyserase- ( 761) 520 104.8 8.1e-22
NP_001245219 (OMIM: 610560) polyserase-2 isoform 2 ( 850) 520 104.8 8.8e-22
NP_775773 (OMIM: 610560) polyserase-2 isoform 1 pr ( 855) 520 104.8 8.9e-22
XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 515 103.6 1e-21
NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 515 103.6 1e-21
NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 515 103.8 1.3e-21
XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 515 103.8 1.4e-21
XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 515 103.8 1.4e-21
NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 498 100.7 9.7e-21
NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 498 100.7 1e-20
NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 498 100.7 1e-20
NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 493 99.6 1.3e-20
NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 491 99.3 1.9e-20
NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 491 99.3 2e-20
NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 491 99.4 2.1e-20
XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 487 98.5 2.8e-20
XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 487 98.5 2.8e-20
NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 486 98.7 6.1e-20
NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 477 96.6 8.2e-20
NP_077078 (OMIM: 191081) tryptase beta-2 prepropro ( 275) 476 96.5 9.3e-20
NP_071402 (OMIM: 609343) brain-specific serine pro ( 317) 476 96.5 1e-19
XP_005255530 (OMIM: 609343) PREDICTED: brain-speci ( 317) 476 96.5 1e-19
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 475 96.3 1.2e-19
XP_016859995 (OMIM: 176860,612283,612304) PREDICTE ( 495) 477 96.9 1.3e-19
>>NP_002649 (OMIM: 104300,191840,601709) urokinase-type (431 aa)
initn: 3080 init1: 3080 opt: 3080 Z-score: 3001.2 bits: 564.4 E(85289): 2e-160
Smith-Waterman score: 3080; 100.0% identity (100.0% similar) in 431 aa overlap (1-431:1-431)
10 20 30 40 50 60
pF1KB6 MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
370 380 390 400 410 420
430
pF1KB6 SHTKEENGLAL
:::::::::::
NP_002 SHTKEENGLAL
430
>>XP_011538168 (OMIM: 104300,191840,601709) PREDICTED: u (431 aa)
initn: 3066 init1: 3066 opt: 3066 Z-score: 2987.6 bits: 561.9 E(85289): 1.1e-159
Smith-Waterman score: 3066; 99.8% identity (99.8% similar) in 431 aa overlap (1-431:1-431)
10 20 30 40 50 60
pF1KB6 MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
XP_011 YCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
370 380 390 400 410 420
430
pF1KB6 SHTKEENGLAL
:::::::::::
XP_011 SHTKEENGLAL
430
>>NP_001138503 (OMIM: 104300,191840,601709) urokinase-ty (414 aa)
initn: 2900 init1: 2900 opt: 2900 Z-score: 2826.7 bits: 532.1 E(85289): 1e-150
Smith-Waterman score: 2900; 99.8% identity (100.0% similar) in 403 aa overlap (29-431:12-414)
10 20 30 40 50 60
pF1KB6 MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
.:::::::::::::::::::::::::::::::
NP_001 MVFHLRTRYEQANCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
10 20 30 40
70 80 90 100 110 120
pF1KB6 HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
50 60 70 80 90 100
130 140 150 160 170 180
pF1KB6 YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
110 120 130 140 150 160
190 200 210 220 230 240
pF1KB6 GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
170 180 190 200 210 220
250 260 270 280 290 300
pF1KB6 RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
230 240 250 260 270 280
310 320 330 340 350 360
pF1KB6 PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
290 300 310 320 330 340
370 380 390 400 410 420
pF1KB6 CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
350 360 370 380 390 400
430
pF1KB6 SHTKEENGLAL
:::::::::::
NP_001 SHTKEENGLAL
410
>>NP_001306120 (OMIM: 104300,191840,601709) urokinase-ty (345 aa)
initn: 2456 init1: 2456 opt: 2456 Z-score: 2396.7 bits: 452.2 E(85289): 9.3e-127
Smith-Waterman score: 2456; 100.0% identity (100.0% similar) in 345 aa overlap (87-431:1-345)
60 70 80 90 100 110
pF1KB6 FGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGL
::::::::::::::::::::::::::::::
NP_001 MGRPCLPWNSATVLQQTYHAHRSDALQLGL
10 20 30
120 130 140 150 160 170
pF1KB6 GKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPR
40 50 60 70 80 90
180 190 200 210 220 230
pF1KB6 FKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYI
100 110 120 130 140 150
240 250 260 270 280 290
pF1KB6 VYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQ
160 170 180 190 200 210
300 310 320 330 340 350
pF1KB6 TICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVT
220 230 240 250 260 270
360 370 380 390 400 410
pF1KB6 TKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFL
280 290 300 310 320 330
420 430
pF1KB6 PWIRSHTKEENGLAL
:::::::::::::::
NP_001 PWIRSHTKEENGLAL
340
>>NP_001519 (OMIM: 604552) hepatocyte growth factor acti (655 aa)
initn: 988 init1: 416 opt: 982 Z-score: 962.0 bits: 187.7 E(85289): 7.6e-47
Smith-Waterman score: 986; 38.7% identity (61.8% similar) in 419 aa overlap (25-424:242-646)
10 20 30 40 50
pF1KB6 MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCP
: . . ::::::: .. : ::
NP_001 EGGDRWARVRQGHVEQCECFGGRTWCEGTRHTACLSSPCLNGGTC-HLIVATGTTVCACP
220 230 240 250 260 270
60 70 80 90 100 110
pF1KB6 KKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQL
:.:. :.:. .. :. ::: ::: :::.. : :: ::: . :. . . : :
NP_001 PGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALL
280 290 300 310 320 330
120 130 140 150 160
pF1KB6 GLGKHNYCRNPDNRRRPWCYVQVGLKPLVQE-CMVHDC-------------ADGKKPSSP
::: : ::::::: .:::::: : . : : : .. : : .:.::
NP_001 GLGPHAYCRNPDNDERPWCYV-VKDSALSWEYCRLEACESLTRVQLSPDLLATLPEPASP
340 350 360 370 380
170 180 190 200 210
pF1KB6 PEELKFQCGQKT-----LRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLIS
.. ::.. :::: :::: . ..::.:::: : : :.:::.
NP_001 GRQ---ACGRRHKKRTFLRPR--IIGGSSSLPGSHPWLAAIYI---GDSF---CAGSLVH
390 400 410 420 430
220 230 240 250 260 270
pF1KB6 PCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHND
:::.::.::: : ... : ::. .: .:. . : .:. : . ::. . . : :
NP_001 TCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDH-D
440 450 460 470 480 490
280 290 300 310 320 330
pF1KB6 IALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMT
..:.....: ::: :. .: :::: . : .:.:.:.:. . . : .:. .
NP_001 LVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSLREA
500 510 520 530 540 550
340 350 360 370 380 390
pF1KB6 VVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVS
.: :.. ..:..:. ::.... .::::. . :.:.:::::::::.: .: : ::.:
NP_001 LVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYGIIS
560 570 580 590 600 610
400 410 420 430
pF1KB6 WGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
:: ::. ::::::::.... :: .. .
NP_001 WGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS
620 630 640 650
>>XP_011532764 (OMIM: 234000,610618,610619) PREDICTED: c (503 aa)
initn: 929 init1: 260 opt: 676 Z-score: 666.4 bits: 132.6 E(85289): 2.2e-30
Smith-Waterman score: 896; 35.2% identity (54.7% similar) in 446 aa overlap (33-423:71-501)
10 20 30 40 50 60
pF1KB6 ALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHC
::.:: :. . . :.:: . : :
XP_011 TEQAAVARCQCKGPDAHCQRLASQACRTNPCLHGGRCLE---VEGHRLCHCPVGYTGAFC
50 60 70 80 90
70 80 90 100 110 120
pF1KB6 EIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSD-ALQLGLGKHNY
..: . .::.: : ::: : : : :: :: : . ::. .. : . ::: : .
XP_011 DVDTKASCYDGRGLSYRGLARTTLSGAPCQPWAS----EATYRNVTAEQARNWGLGGHAF
100 110 120 130 140 150
130 140 150 160
pF1KB6 CRNPDNRRRPWCYVQVGLKPLVQECMVHDC-----ADGKKPSSP----------PEELKF
:::::: ::::.: . . : . .: : : :: : :
XP_011 CRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQAAPPTPVSPRLHVPLMPAQPAPPKP
160 170 180 190 200 210
170 180 190
pF1KB6 Q--------------------------------CGQ---KTLRPRFKIIGGEFTTIENQP
: ::: :.: ...:: . .:
XP_011 QPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHP
220 230 240 250 260 270
200 210 220 230 240 250
pF1KB6 WFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGE
..::.: : :.::::.::::..:.::. : : :: : ::. : : . .
XP_011 YIAALYWGHS------FCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPC
280 290 300 310 320
260 270 280 290 300 310
pF1KB6 MKFEVENLILHKDYSADTLAHHNDIALLKIR-SKEGRCAQPSRTIQTICLPSMYNDPQFG
. . :.. ::. .: .....:.:::... . .: :: : .: .:::: :.
XP_011 QTLAVRSYRLHEAFSP--VSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSET
330 340 350 360 370 380
320 330 340 350 360 370
pF1KB6 TSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTD
: :...:.:.. : :. . : ..: ..:. : .:: . ::::. . ::
XP_011 TLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGTD
390 400 410 420 430 440
380 390 400 410 420
pF1KB6 SCQGDSGGPLVCSLQG---RMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEEN
.::::::::::: :. :.:: ::.::: ::. ..:::::: :...: ::: ::
XP_011 ACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHTVS
450 460 470 480 490 500
430
pF1KB6 GLAL
>>NP_000496 (OMIM: 234000,610618,610619) coagulation fac (615 aa)
initn: 955 init1: 260 opt: 676 Z-score: 665.3 bits: 132.7 E(85289): 2.6e-30
Smith-Waterman score: 896; 35.2% identity (54.7% similar) in 446 aa overlap (33-423:183-613)
10 20 30 40 50 60
pF1KB6 ALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHC
::.:: :. . . :.:: . : :
NP_000 TEQAAVARCQCKGPDAHCQRLASQACRTNPCLHGGRCLE---VEGHRLCHCPVGYTGAFC
160 170 180 190 200
70 80 90 100 110 120
pF1KB6 EIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSD-ALQLGLGKHNY
..: . .::.: : ::: : : : :: :: : . ::. .. : . ::: : .
NP_000 DVDTKASCYDGRGLSYRGLARTTLSGAPCQPWAS----EATYRNVTAEQARNWGLGGHAF
210 220 230 240 250 260
130 140 150 160
pF1KB6 CRNPDNRRRPWCYVQVGLKPLVQECMVHDC-----ADGKKPSSP----------PEELKF
:::::: ::::.: . . : . .: : : :: : :
NP_000 CRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQAAPPTPVSPRLHVPLMPAQPAPPKP
270 280 290 300 310 320
170 180 190
pF1KB6 Q--------------------------------CGQ---KTLRPRFKIIGGEFTTIENQP
: ::: :.: ...:: . .:
NP_000 QPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCGQRLRKSLSSMTRVVGGLVALRGAHP
330 340 350 360 370 380
200 210 220 230 240 250
pF1KB6 WFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGE
..::.: : :.::::.::::..:.::. : : :: : ::. : : . .
NP_000 YIAALYWGHS------FCAGSLIAPCWVLTAAHCLQDRPAPEDLTVVLGQERRNHSCEPC
390 400 410 420 430
260 270 280 290 300 310
pF1KB6 MKFEVENLILHKDYSADTLAHHNDIALLKIR-SKEGRCAQPSRTIQTICLPSMYNDPQFG
. . :.. ::. .: .....:.:::... . .: :: : .: .:::: :.
NP_000 QTLAVRSYRLHEAFSP--VSYQHDLALLRLQEDADGSCALLSPYVQPVCLPSGAARPSET
440 450 460 470 480 490
320 330 340 350 360 370
pF1KB6 TSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTD
: :...:.:.. : :. . : ..: ..:. : .:: . ::::. . ::
NP_000 TLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGSSILPGMLCAGFLEGGTD
500 510 520 530 540 550
380 390 400 410 420
pF1KB6 SCQGDSGGPLVCSLQG---RMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEEN
.::::::::::: :. :.:: ::.::: ::. ..:::::: :...: ::: ::
NP_000 ACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYTDVAYYLAWIREHTVS
560 570 580 590 600 610
430
pF1KB6 GLAL
>>NP_001284368 (OMIM: 604552) hepatocyte growth factor a (662 aa)
initn: 988 init1: 416 opt: 659 Z-score: 648.4 bits: 129.7 E(85289): 2.2e-29
Smith-Waterman score: 976; 38.0% identity (61.5% similar) in 426 aa overlap (25-424:242-653)
10 20 30 40 50
pF1KB6 MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCP
: . . ::::::: .. : ::
NP_001 EGGDRWARVRQGHVEQCECFGGRTWCEGTRHTACLSSPCLNGGTC-HLIVATGTTVCACP
220 230 240 250 260 270
60 70 80 90 100 110
pF1KB6 KKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQL
:.:. :.:. .. :. ::: ::: :::.. : :: ::: . :. . . : :
NP_001 PGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALL
280 290 300 310 320 330
120 130 140 150
pF1KB6 GLGKHNYCRNPDNRRRPWCYVQVGLKPLVQE-CMVHDC---ADGKK--------------
::: : ::::::: .:::::: : . : : : .. : ..:..
NP_001 GLGPHAYCRNPDNDERPWCYV-VKDSALSWEYCRLEACDLETEGRESLTRVQLSPDLLAT
340 350 360 370 380
160 170 180 190 200
pF1KB6 ---PSSPPEELKFQCGQKT-----LRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYV
:.:: .. ::.. :::: :::: . ..::.:::: : :
NP_001 LPEPASPGRQ---ACGRRHKKRTFLRPR--IIGGSSSLPGSHPWLAAIYI---GDSF---
390 400 410 420 430
210 220 230 240 250 260
pF1KB6 CGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSAD
:.:::. :::.::.::: : ... : ::. .: .:. . : .:. : . ::.
NP_001 CAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVF
440 450 460 470 480 490
270 280 290 300 310 320
pF1KB6 TLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLY
. . : :..:.....: ::: :. .: :::: . : .:.:.:.:. . . :
NP_001 NPSDH-DLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGY
500 510 520 530 540 550
330 340 350 360 370 380
pF1KB6 PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRM
.:. ..: :.. ..:..:. ::.... .::::. . :.:.:::::::::.: .:
NP_001 SSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVA
560 570 580 590 600 610
390 400 410 420 430
pF1KB6 TLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
: ::.::: ::. ::::::::.... :: .. .
NP_001 YLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS
620 630 640 650 660
>>NP_003610 (OMIM: 249500,606709) neurotrypsin precursor (875 aa)
initn: 568 init1: 176 opt: 623 Z-score: 611.8 bits: 123.3 E(85289): 2.4e-27
Smith-Waterman score: 628; 33.5% identity (60.1% similar) in 358 aa overlap (78-424:543-874)
50 60 70 80 90 100
pF1KB6 IHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTM---GRPCLPWNSATVLQQTY
:.: : . :: :. : . .:
NP_003 VEVFINGQWGTICDDGWTDKDAAVICRQLGYKGPARARTMAYFGEGKGPIHVDNVKCTGN
520 530 540 550 560 570
110 120 130 140 150 160
pF1KB6 HAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPS--SPPE
. .: .. .:.:: ::. .. .:. : ::: : : :
NP_003 ERSLADCIKQDIGRHN-CRHSED---------AGVI-----CDYF----GKKASGNSNKE
580 590 600 610
170 180 190 200 210 220
pF1KB6 ELKFQCGQKTLRPRFK-IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVIS
:. :: . :. : : ::::. . . :: ... . :. .::..:.: :::..
NP_003 SLSSVCGLRLLHRRQKRIIGGKNSLRGGWPWQVSLRLKSSHGDGRLLCGATLLSSCWVLT
620 630 640 650 660 670
230 240 250 260 270 280
pF1KB6 ATHCFIDYPKK-EDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLK
:.::: : .. ..: : .: . . : .. :.....:..: : . ::::..
NP_003 AAHCFKRYGNSTRSYAVRVGDYHTLVPEEFEEEIGVQQIVIHREYRPDRSDY--DIALVR
680 690 700 710 720 730
290 300 310 320 330
pF1KB6 IRSKEGRCAQPSRTIQTICLPSMYNDPQ-FGTSCEITGFGKENSTDYLYPEQLKMTVVKL
... : .::. : . ::: . :: ...: :::.: .: : . :..... :
NP_003 LQGPEEQCARFSSHVLPACLPLWRERPQKTASNCYITGWG---DTGRAYSRTLQQAAIPL
740 750 760 770 780
340 350 360 370 380 390
pF1KB6 ISHRECQQPHYYGSEVTTKMLCAAD--PQWKTDSCQGDSGGPLVCSLQGR-MTLTGIVSW
. .: :.. : .. : .::::.. . ..:::::::::::.: :. .. :..::
NP_003 LPKRFCEE--RYKGRFTGRMLCAGNLHEHKRVDSCQGDSGGPLMCERPGESWVVYGVTSW
790 800 810 820 830 840
400 410 420 430
pF1KB6 GRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
: ::..::.:::::.:: :.:::.: ::
NP_003 GYGCGVKDSPGVYTKVSAFVPWIKSVTKL
850 860 870
>>NP_001306118 (OMIM: 173370,612348) tissue-type plasmin (473 aa)
initn: 1153 init1: 276 opt: 619 Z-score: 611.5 bits: 122.4 E(85289): 2.6e-27
Smith-Waterman score: 1178; 43.3% identity (66.4% similar) in 420 aa overlap (18-424:72-472)
10 20 30 40
pF1KB6 MRALLARLLLCVLVVSDSKGSNELHQVP-SNCD---CLNGGTCVSNK
..: . :.:: ..:. :.::::: .
NP_001 RDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQAL
50 60 70 80 90 100
50 60 70 80 90 100
pF1KB6 YFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQT
:::.. :.::. :.:. ::: .: :: ::: ::: : : :::::: .. ..
NP_001 YFSDF-VCQCPEGFAGKCCEIGNSD-CYFGNGSAYRGTHSLTESGASCLPWNSMILIGKV
110 120 130 140 150
110 120 130 140 150 160
pF1KB6 YHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEE
: :. .: :::::::::::::. .:::.: . . . : : .:.
NP_001 YTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCST----------
160 170 180 190 200
170 180 190 200 210 220
pF1KB6 LKFQCGQKTL-RPRFKIIGGEFTTIENQPWFAAIYRRHR-GGSVTYVCGGSLISPCWVIS
:: . .:.:.: :: :. : ..:: :::. .:: . . ..::: ::: ::..:
NP_001 ----CGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILS
210 220 230 240 250 260
230 240 250 260 270 280
pF1KB6 ATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKI
:.::: . . : :::. . :.:::::. :.::... :: . ::::::..
NP_001 AAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDT--YDNDIALLQL
270 280 290 300 310 320
290 300 310 320 330 340
pF1KB6 RSKEGRCAQPSRTIQTICLPSM-YNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLI
.: .:::: : ...:.::: . :.. : ::..:.::... . .: :.:: . :.:
NP_001 KSDSSRCAQESSVVRTVCLPPADLQLPDW-TECELSGYGKHEALSPFYSERLKEAHVRLY
330 340 350 360 370 380
350 360 370 380 390
pF1KB6 SHRECQQPHYYGSEVTTKMLCAAD-----PQWKT-DSCQGDSGGPLVCSLQGRMTLTGIV
.: . : . :: .::::.: :: . :.::::::::::: .:::::.::.
NP_001 PSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGII
390 400 410 420 430 440
400 410 420 430
pF1KB6 SWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
::: ::. :: :::::.:...: :::.. .
NP_001 SWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
450 460 470
431 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 11:33:42 2016 done: Sat Nov 5 11:33:44 2016
Total Scan time: 8.040 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]