Result of FASTA (omim) for
pF1KB6610
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6610, 430 aa
1>>>pF1KB6610 430 - 430 aa - 430 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.2249+/-0.00043; mu= -9.2469+/- 0.027
mean_var=357.0086+/-74.703, 0's: 0 Z-trim(121.4): 25 B-trim: 39 in 1/57
Lambda= 0.067879
statistics sampled from 37890 (37917) to 37890 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.769), E-opt: 0.2 (0.445), width: 16
Scan time: 10.770
The best scores are: opt bits E(85289)
NP_001014436 (OMIM: 610106) drebrin-like protein i ( 430) 2896 297.3 4.9e-80
NP_054782 (OMIM: 610106) drebrin-like protein isof ( 431) 2884 296.2 1.1e-79
XP_011513627 (OMIM: 610106) PREDICTED: drebrin-lik ( 438) 2870 294.8 2.9e-79
NP_001271242 (OMIM: 610106) drebrin-like protein i ( 327) 2209 230.0 7.1e-60
NP_001271244 (OMIM: 610106) drebrin-like protein i ( 336) 2161 225.3 1.9e-58
NP_001116428 (OMIM: 610106) drebrin-like protein i ( 439) 1693 179.5 1.4e-44
XP_005265884 (OMIM: 126660) PREDICTED: drebrin iso ( 695) 692 81.7 6.6e-15
NP_004386 (OMIM: 126660) drebrin isoform a [Homo s ( 649) 675 80.0 2e-14
XP_011532749 (OMIM: 126660) PREDICTED: drebrin iso ( 684) 644 77.0 1.7e-13
XP_011532748 (OMIM: 126660) PREDICTED: drebrin iso ( 697) 635 76.1 3.2e-13
XP_016864628 (OMIM: 126660) PREDICTED: drebrin iso ( 697) 635 76.1 3.2e-13
NP_543157 (OMIM: 126660) drebrin isoform b [Homo s ( 651) 618 74.4 9.6e-13
XP_016864629 (OMIM: 126660) PREDICTED: drebrin iso ( 651) 618 74.4 9.6e-13
XP_006714889 (OMIM: 126660) PREDICTED: drebrin iso ( 632) 523 65.1 5.9e-10
NP_001278970 (OMIM: 601306) hematopoietic lineage ( 449) 370 50.0 1.5e-05
NP_005326 (OMIM: 601306) hematopoietic lineage cel ( 486) 363 49.3 2.5e-05
XP_006718510 (OMIM: 164765) PREDICTED: src substra ( 476) 321 45.2 0.00043
NP_612632 (OMIM: 164765) src substrate cortactin i ( 513) 317 44.8 0.0006
NP_005222 (OMIM: 164765) src substrate cortactin i ( 550) 317 44.9 0.00063
>>NP_001014436 (OMIM: 610106) drebrin-like protein isofo (430 aa)
initn: 2896 init1: 2896 opt: 2896 Z-score: 1557.9 bits: 297.3 E(85289): 4.9e-80
Smith-Waterman score: 2896; 100.0% identity (100.0% similar) in 430 aa overlap (1-430:1-430)
10 20 30 40 50 60
pF1KB6 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 QEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGRE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 PAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 DHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGM
370 380 390 400 410 420
430
pF1KB6 FPANYVELIE
::::::::::
NP_001 FPANYVELIE
430
>>NP_054782 (OMIM: 610106) drebrin-like protein isoform (431 aa)
initn: 1574 init1: 1551 opt: 2884 Z-score: 1551.5 bits: 296.2 E(85289): 1.1e-79
Smith-Waterman score: 2884; 99.8% identity (99.8% similar) in 431 aa overlap (1-430:1-431)
10 20 30 40 50 60
pF1KB6 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
130 140 150 160 170 180
190 200 210 220 230
pF1KB6 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQ-RTWEQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
NP_054 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB6 QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 QQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGR
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB6 EPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 EPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEH
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB6 IDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_054 IDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFG
370 380 390 400 410 420
420 430
pF1KB6 MFPANYVELIE
:::::::::::
NP_054 MFPANYVELIE
430
>>XP_011513627 (OMIM: 610106) PREDICTED: drebrin-like pr (438 aa)
initn: 1680 init1: 1657 opt: 2870 Z-score: 1544.0 bits: 294.8 E(85289): 2.9e-79
Smith-Waterman score: 2870; 98.2% identity (98.2% similar) in 438 aa overlap (1-430:1-438)
10 20 30 40 50 60
pF1KB6 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQ
190 200 210 220 230 240
250 260 270 280 290
pF1KB6 QEVVSRNRNEQ--------ESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQ
::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_011 QEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQ
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB6 PETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQ
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB6 QGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGY
370 380 390 400 410 420
420 430
pF1KB6 GPDGHFGMFPANYVELIE
::::::::::::::::::
XP_011 GPDGHFGMFPANYVELIE
430
>>NP_001271242 (OMIM: 610106) drebrin-like protein isofo (327 aa)
initn: 2209 init1: 2209 opt: 2209 Z-score: 1195.9 bits: 230.0 E(85289): 7.1e-60
Smith-Waterman score: 2209; 100.0% identity (100.0% similar) in 327 aa overlap (104-430:1-327)
80 90 100 110 120 130
pF1KB6 SGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVA
::::::::::::::::::::::::::::::
NP_001 MASFLKGAHVTINARAEEDVEPECIMEKVA
10 20 30
140 150 160 170 180 190
pF1KB6 KASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLE
40 50 60 70 80 90
200 210 220 230 240 250
pF1KB6 EKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQES
100 110 120 130 140 150
260 270 280 290 300 310
pF1KB6 AVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLP
160 170 180 190 200 210
320 330 340 350 360 370
pF1KB6 AEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQG
220 230 240 250 260 270
380 390 400 410 420 430
pF1KB6 LCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
280 290 300 310 320
>>NP_001271244 (OMIM: 610106) drebrin-like protein isofo (336 aa)
initn: 1357 init1: 1357 opt: 2161 Z-score: 1170.4 bits: 225.3 E(85289): 1.9e-58
Smith-Waterman score: 2161; 99.7% identity (99.7% similar) in 322 aa overlap (110-430:15-336)
80 90 100 110 120 130
pF1KB6 VLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVAKASGAN
::::::::::::::::::::::::::::::
NP_001 MKATAMTSAWLAQGGAHVTINARAEEDVEPECIMEKVAKASGAN
10 20 30 40
140 150 160 170 180 190
pF1KB6 YSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAE
50 60 70 80 90 100
200 210 220 230 240 250
pF1KB6 EAQRQLEQERRERELREAARREQRYQEQGGEASPQ-RTWEQQQEVVSRNRNEQESAVHPR
::::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::
NP_001 EAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNRNEQESAVHPR
110 120 130 140 150 160
260 270 280 290 300 310
pF1KB6 EIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPA
170 180 190 200 210 220
320 330 340 350 360 370
pF1KB6 PSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARA
230 240 250 260 270 280
380 390 400 410 420 430
pF1KB6 LYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
290 300 310 320 330
>>NP_001116428 (OMIM: 610106) drebrin-like protein isofo (439 aa)
initn: 2944 init1: 1551 opt: 1693 Z-score: 921.1 bits: 179.5 E(85289): 1.4e-44
Smith-Waterman score: 2858; 97.9% identity (97.9% similar) in 439 aa overlap (1-430:1-439)
10 20 30 40 50 60
pF1KB6 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFW
130 140 150 160 170 180
190 200 210 220 230
pF1KB6 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQ-RTWEQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
NP_001 AKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KB6 QQEVVSRNRNEQ--------ESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT
:::::::::::: ::::::::::::::::::::::::::::::::::::::::
NP_001 QQEVVSRNRNEQGSTCASLQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLT
250 260 270 280 290 300
300 310 320 330 340 350
pF1KB6 QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQ
310 320 330 340 350 360
360 370 380 390 400 410
pF1KB6 QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRG
370 380 390 400 410 420
420 430
pF1KB6 YGPDGHFGMFPANYVELIE
:::::::::::::::::::
NP_001 YGPDGHFGMFPANYVELIE
430
>>XP_005265884 (OMIM: 126660) PREDICTED: drebrin isoform (695 aa)
initn: 900 init1: 642 opt: 692 Z-score: 388.6 bits: 81.7 E(85289): 6.6e-15
Smith-Waterman score: 710; 35.4% identity (64.9% similar) in 370 aa overlap (3-324:2-365)
10 20 30 40 50
pF1KB6 MAANLSRNGPALQ--EAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELN
:..: .: :. :: .:. :.: .::::.::: .:.:...:..:::::.:. ...
XP_005 MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFE
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 SGKVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINAR
. ::::.:: ::: ...:::.:::::.:: : :.:: ::::::. .: :..:. : .::
XP_005 NQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNAS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 AEEDVEPECIMEKVAK--ASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGK
. ::.. : ..... : .. .:. :... :::..::::.:. :.::...
XP_005 SVEDIDAGAIGQRLSNGLARLSSPVLHRL--RLREDENAEPVGTTYQKTDAAVEMKRINR
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 DSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRT
..:: .:.:::: :. ::...: . . ..:::: :.: .: .::.::.:. . .:
XP_005 EQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRR
180 190 200 210 220 230
240 250 260
pF1KB6 WEQ------------QQEVVSRNRNEQE--------------SAV------HPREIFKQK
.: .: . . .:.:.: .:. .:::.:::.
XP_005 KQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQ
240 250 260 270 280 290
270 280 290 300 310
pF1KB6 ERAMSTTS----ISSP---QPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPA---
::. :... . :: .::. ::.. . . : . ... : ::. .:
XP_005 ERVASASAGSCDVPSPFNHRPGRPYCPFIKASDSGPSSS----SSSSSSPPRTPFPYITC
300 310 320 330 340 350
320 330 340 350 360 370
pF1KB6 -EEPAPSTP-PCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQ
. : :. ::
XP_005 HRTPNLSSSLPCSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPL
360 370 380 390 400 410
>>NP_004386 (OMIM: 126660) drebrin isoform a [Homo sapie (649 aa)
initn: 805 init1: 642 opt: 675 Z-score: 380.0 bits: 80.0 E(85289): 2e-14
Smith-Waterman score: 726; 34.5% identity (63.5% similar) in 397 aa overlap (3-361:2-385)
10 20 30 40 50
pF1KB6 MAANLSRNGPALQ--EAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELN
:..: .: :. :: .:. :.: .::::.::: .:.:...:..:::::.:. ...
NP_004 MAGVSFSGHRLELLAAYEEVIREESAADWALYTYEDGSDDLKLAASGEGGLQELSGHFE
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 SGKVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINAR
. ::::.:: ::: ...:::.:::::.:: : :.:: ::::::. .: :..:. : .::
NP_004 NQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNAS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 AEEDVEPECIMEKVAK--ASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGK
. ::.. : ..... : .. .:. :... :::..::::.:. :.::...
NP_004 SVEDIDAGAIGQRLSNGLARLSSPVLHRL--RLREDENAEPVGTTYQKTDAAVEMKRINR
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 DSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRT
..:: .:.:::: :. ::...: . . ..:::: :.: .: .::.::.:. . .:
NP_004 EQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRR
180 190 200 210 220 230
240 250 260
pF1KB6 WEQ------------QQEVVSRNRNEQE--------------SAV------HPREIFKQK
.: .: . . .:.:.: .:. .:::.:::.
NP_004 KQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQ
240 250 260 270 280 290
270 280 290 300 310 320
pF1KB6 ERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPC
::. :... : : ::: .. .. ..: :. .: :.. . :::
NP_004 ERVASASAGSCDVP----SPFNHRPGSHLDSHRRMAPTPIPTRS----PSDSSTASTPVA
300 310 320 330 340
330 340 350 360 370 380
pF1KB6 --LVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDY
. .: .:.. .:: . :: .:. : .:
NP_004 EQIERALDEVTSSQPPP---LPPPPPPAQETQEPSPILDSEETRAAAPQAWAGPMEEPPQ
350 360 370 380 390 400
390 400 410 420 430
pF1KB6 QAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
NP_004 AQAPPRGPGSPAEDLMFMESAEQAVLAAPVEPATADATEIHDAADTIETDTATADTTVAN
410 420 430 440 450 460
>>XP_011532749 (OMIM: 126660) PREDICTED: drebrin isoform (684 aa)
initn: 848 init1: 590 opt: 644 Z-score: 363.3 bits: 77.0 E(85289): 1.7e-13
Smith-Waterman score: 662; 34.6% identity (63.7% similar) in 358 aa overlap (18-324:4-354)
10 20 30 40 50
pF1KB6 MAANLSRNGPALQEAYVRVVTEKSPTDW-----ALFTYEGNSNDIRVAGTGEGGLEEMVE
: . .::. : ::.::: .:.:...:..:::::.:.
XP_011 MSTRQIRPRSPS-WHFTTRALYTYEDGSDDLKLAASGEGGLQELSG
10 20 30 40
60 70 80 90 100 110
pF1KB6 ELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTI
.... ::::.:: ::: ...:::.:::::.:: : :.:: ::::::. .: :..:. : .
XP_011 HFENQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIV
50 60 70 80 90 100
120 130 140 150 160 170
pF1KB6 NARAEEDVEPECIMEKVAK--ASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKR
:: . ::.. : ..... : .. .:. :... :::..::::.:. :.::
XP_011 NASSVEDIDAGAIGQRLSNGLARLSSPVLHRL--RLREDENAEPVGTTYQKTDAAVEMKR
110 120 130 140 150 160
180 190 200 210 220 230
pF1KB6 VGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASP
.....:: .:.:::: :. ::...: . . ..:::: :.: .: .::.::.:. .
XP_011 INREQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEE
170 180 190 200 210 220
240 250 260
pF1KB6 QRTWEQ------------QQEVVSRNRNEQE--------------SAV------HPREIF
.: .: .: . . .:.:.: .:. .:::.:
XP_011 HRRKQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFF
230 240 250 260 270 280
270 280 290 300 310
pF1KB6 KQKERAMSTTS----ISSP---QPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPA
::.::. :... . :: .::. ::.. . . : . ... : ::. .:
XP_011 KQQERVASASAGSCDVPSPFNHRPGRPYCPFIKASDSGPSS----SSSSSSSPPRTPFPY
290 300 310 320 330
320 330 340 350 360
pF1KB6 ----EEPAPSTP-PCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGL
. : :. ::
XP_011 ITCHRTPNLSSSLPCSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQP
340 350 360 370 380 390
>>XP_011532748 (OMIM: 126660) PREDICTED: drebrin isoform (697 aa)
initn: 848 init1: 590 opt: 635 Z-score: 358.4 bits: 76.1 E(85289): 3.2e-13
Smith-Waterman score: 653; 35.4% identity (64.9% similar) in 342 aa overlap (29-324:32-367)
10 20 30 40 50
pF1KB6 MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELN
::.::: .:.:...:..:::::.:. ...
XP_011 AGHPWHGTAALASSQAWRDGRERQALVSCRALYTYEDGSDDLKLAASGEGGLQELSGHFE
10 20 30 40 50 60
60 70 80 90 100 110
pF1KB6 SGKVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINAR
. ::::.:: ::: ...:::.:::::.:: : :.:: ::::::. .: :..:. : .::
XP_011 NQKVMYGFCSVKDSQAALPKYVLINWVGEDVPDARKCACASHVAKVAEFFQGVDVIVNAS
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB6 AEEDVEPECIMEKVAK--ASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGK
. ::.. : ..... : .. .:. : .: . . :::..::::.:. :.::...
XP_011 SVEDIDAGAIGQRLSNGLARLSSPVLHRLRLR-EDENAE-PVGTTYQKTDAAVEMKRINR
130 140 150 160 170
180 190 200 210 220 230
pF1KB6 DSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRT
..:: .:.:::: :. ::...: . . ..:::: :.: .: .::.::.:. . .:
XP_011 EQFWEQAKKEEELRKEEERKKALDERLRFEQERMEQERQEQEERERRYREREQQIEEHRR
180 190 200 210 220 230
240 250 260
pF1KB6 WEQ------------QQEVVSRNRNEQE--------------SAV------HPREIFKQK
.: .: . . .:.:.: .:. .:::.:::.
XP_011 KQQTLEAEEAKRRLKEQSIFGDHRDEEEETHMKKSESEVEEAAAIIAQRPDNPREFFKQQ
240 250 260 270 280 290
270 280 290 300 310
pF1KB6 ERAMSTTS----ISSP---QPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPA---
::. :... . :: .::. ::.. . . : . ... : ::. .:
XP_011 ERVASASAGSCDVPSPFNHRPGRPYCPFIKASDSGPSSS----SSSSSSPPRTPFPYITC
300 310 320 330 340 350
320 330 340 350 360 370
pF1KB6 -EEPAPSTP-PCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQ
. : :. ::
XP_011 HRTPNLSSSLPCSHLDSHRRMAPTPIPTRSPSDSSTASTPVAEQIERALDEVTSSQPPPL
360 370 380 390 400 410
430 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 11:34:19 2016 done: Sat Nov 5 11:34:20 2016
Total Scan time: 10.770 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]