FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6613, 412 aa 1>>>pF1KB6613 412 - 412 aa - 412 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2409+/-0.00043; mu= 17.6432+/- 0.027 mean_var=73.3028+/-14.377, 0's: 0 Z-trim(110.5): 56 B-trim: 32 in 1/53 Lambda= 0.149801 statistics sampled from 18800 (18855) to 18800 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.589), E-opt: 0.2 (0.221), width: 16 Scan time: 7.660 The best scores are: opt bits E(85289) NP_005530 (OMIM: 600106) type I inositol 1,4,5-tri ( 412) 2808 616.6 3.5e-176 NP_001307971 (OMIM: 600106) type I inositol 1,4,5- ( 348) 2124 468.7 9.7e-132 XP_016871693 (OMIM: 600106) PREDICTED: type I inos ( 354) 2122 468.3 1.3e-131 XP_016871694 (OMIM: 600106) PREDICTED: type I inos ( 307) 2022 446.6 3.8e-125 >>NP_005530 (OMIM: 600106) type I inositol 1,4,5-trispho (412 aa) initn: 2808 init1: 2808 opt: 2808 Z-score: 3284.0 bits: 616.6 E(85289): 3.5e-176 Smith-Waterman score: 2808; 100.0% identity (100.0% similar) in 412 aa overlap (1-412:1-412) 10 20 30 40 50 60 pF1KB6 MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 YEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 YEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 DFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 VNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 SVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 ALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKEL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 ALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKEL 310 320 330 340 350 360 370 380 390 400 410 pF1KB6 VLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ :::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 VLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ 370 380 390 400 410 >>NP_001307971 (OMIM: 600106) type I inositol 1,4,5-tris (348 aa) initn: 2122 init1: 2122 opt: 2124 Z-score: 2486.2 bits: 468.7 E(85289): 9.7e-132 Smith-Waterman score: 2124; 92.6% identity (95.9% similar) in 340 aa overlap (73-412:10-348) 50 60 70 80 90 100 pF1KB6 THKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFT ::.:.: . : .. .. . . .. NP_001 MEYDPTVKRKEILASTTTWWRNLEDIMPSQACHRNTNM- 10 20 30 110 120 130 140 150 160 pF1KB6 ALGSFYFLHESLKNIYQFDFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ALGSFYFLHESLKNIYQFDFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWS 40 50 60 70 80 90 170 180 190 200 210 220 pF1KB6 RKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRF 100 110 120 130 140 150 230 240 250 260 270 280 pF1KB6 EKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLE 160 170 180 190 200 210 290 300 310 320 330 340 pF1KB6 KKLFDYFNQEVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KKLFDYFNQEVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNT 220 230 240 250 260 270 350 360 370 380 390 400 pF1KB6 RCPAWCDRILMSPSAKELVLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RCPAWCDRILMSPSAKELVLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPH 280 290 300 310 320 330 410 pF1KB6 AHVHKCCVVQ :::::::::: NP_001 AHVHKCCVVQ 340 >>XP_016871693 (OMIM: 600106) PREDICTED: type I inositol (354 aa) initn: 2122 init1: 2122 opt: 2122 Z-score: 2483.7 bits: 468.3 E(85289): 1.3e-131 Smith-Waterman score: 2122; 100.0% identity (100.0% similar) in 310 aa overlap (103-412:45-354) 80 90 100 110 120 130 pF1KB6 KELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYRKVAG :::::::::::::::::::::::::::::: XP_016 RRGRCSRIFRVLGGNVSIGSYPAKHLLRLKALGSFYFLHESLKNIYQFDFKAKKYRKVAG 20 30 40 50 60 70 140 150 160 170 180 190 pF1KB6 KEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNL 80 90 100 110 120 130 200 210 220 230 240 250 pF1KB6 VAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATM 140 150 160 170 180 190 260 270 280 290 300 310 pF1KB6 QTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGTALLEFDKELSVF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 QTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGTALLEFDKELSVF 200 210 220 230 240 250 320 330 340 350 360 370 pF1KB6 KDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKELVLRSESEEKVVT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKELVLRSESEEKVVT 260 270 280 290 300 310 380 390 400 410 pF1KB6 YDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ :::::::::::::::::::::::::::::::::::::::: XP_016 YDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ 320 330 340 350 >>XP_016871694 (OMIM: 600106) PREDICTED: type I inositol (307 aa) initn: 2022 init1: 2022 opt: 2022 Z-score: 2367.8 bits: 446.6 E(85289): 3.8e-125 Smith-Waterman score: 2022; 99.7% identity (100.0% similar) in 302 aa overlap (1-302:1-302) 10 20 30 40 50 60 pF1KB6 MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 YEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQF 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 DFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 VNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 SVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGT 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 ALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKEL :. XP_016 AVGRPVG 412 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 11:06:17 2016 done: Sat Nov 5 11:06:18 2016 Total Scan time: 7.660 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]