FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6633, 417 aa 1>>>pF1KB6633 417 - 417 aa - 417 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 7.0859+/-0.000775; mu= 10.4147+/- 0.047 mean_var=129.4673+/-26.100, 0's: 0 Z-trim(113.4): 12 B-trim: 487 in 1/53 Lambda= 0.112718 statistics sampled from 13991 (14000) to 13991 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.758), E-opt: 0.2 (0.43), width: 16 Scan time: 2.460 The best scores are: opt bits E(32554) CCDS4129.1 LOX gene_id:4015|Hs108|chr5 ( 417) 2970 493.8 1.3e-139 CCDS10253.1 LOXL1 gene_id:4016|Hs108|chr15 ( 574) 1211 207.8 2.1e-53 CCDS74527.1 LOXL3 gene_id:84695|Hs108|chr2 ( 608) 775 137.0 4.9e-32 CCDS1953.1 LOXL3 gene_id:84695|Hs108|chr2 ( 753) 775 137.0 5.8e-32 CCDS7473.1 LOXL4 gene_id:84171|Hs108|chr10 ( 756) 765 135.4 1.8e-31 CCDS34864.1 LOXL2 gene_id:4017|Hs108|chr8 ( 774) 761 134.7 2.9e-31 >>CCDS4129.1 LOX gene_id:4015|Hs108|chr5 (417 aa) initn: 2970 init1: 2970 opt: 2970 Z-score: 2620.1 bits: 493.8 E(32554): 1.3e-139 Smith-Waterman score: 2970; 100.0% identity (100.0% similar) in 417 aa overlap (1-417:1-417) 10 20 30 40 50 60 pF1KB6 MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 GSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 GSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPT 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 ARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 ARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDD 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 NPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 NPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 EENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 EENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 FSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 FSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADID 310 320 330 340 350 360 370 380 390 400 410 pF1KB6 CQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS41 CQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY 370 380 390 400 410 >>CCDS10253.1 LOXL1 gene_id:4016|Hs108|chr15 (574 aa) initn: 1374 init1: 1168 opt: 1211 Z-score: 1072.2 bits: 207.8 E(32554): 2.1e-53 Smith-Waterman score: 1211; 64.4% identity (80.7% similar) in 270 aa overlap (149-414:308-571) 120 130 140 150 160 170 pF1KB6 PTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDG--MVGDDPYNPYK : : .: :: .. : . . :: : . CCDS10 LYSEGTPGFEQAYPDPGPEAAQAHGGDPRLGWYPPYAN--PPPEAYGPPRALEPPYLPVR 280 290 300 310 320 330 180 190 200 210 220 230 pF1KB6 YSDDNPYYNYYDTYERPR--PGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMY :: : . . .. : :. :::. . :::::: :: :.:::::::. .: CCDS10 SSDTPPPGGERNGAQQGRLSVGSVYRPNQNG----RGLPDLVPDPNYVQASTYVQRAHLY 340 350 360 370 380 390 240 250 260 270 280 290 pF1KB6 NLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQH .:::::::.::::::: .. ::: :::::::::::::::.::::.:::..::::::::: CCDS10 SLRCAAEEKCLASTAYAPEATDYDVRVLLRFPQRVKNQGTADFLPNRPRHTWEWHSCHQH 400 410 420 430 440 450 300 310 320 330 340 350 pF1KB6 YHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDT ::::::::::::::: : ..:::::::::::::..::.: .:.:::.:::::::::::: CCDS10 YHSMDEFSHYDLLDAATGKKVAEGHKASFCLEDSTCDFGNLKRYACTSHTQGLSPGCYDT 460 470 480 490 500 510 360 370 380 390 400 410 pF1KB6 YGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTI :.:::::::::::::.:::::::: :::.:.: :::.:::::::.:.:::... :..: : CCDS10 YNADIDCQWIDITDVQPGNYILKVHVNPKYIVLESDFTNNVVRCNIHYTGRYVSATNCKI 520 530 540 550 560 570 pF1KB6 SPY CCDS10 VQS >>CCDS74527.1 LOXL3 gene_id:84695|Hs108|chr2 (608 aa) initn: 725 init1: 528 opt: 775 Z-score: 688.6 bits: 137.0 E(32554): 4.9e-32 Smith-Waterman score: 775; 49.5% identity (68.9% similar) in 222 aa overlap (194-414:368-584) 170 180 190 200 210 220 pF1KB6 DGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQ : : :. : . ::. .: CCDS74 TEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGV---ICSETASDLLLHSALVQ 340 350 360 370 380 390 230 240 250 260 270 280 pF1KB6 ASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPR ..:.. .. : ::::::::::.: :. : :: :::: ....: : .:: :. : CCDS74 ETAYIEDRPLHMLYCAAEENCLASSARSANW-PYGHRRLLRFSSQIHNLGRADFRPKAGR 400 410 420 430 440 450 290 300 310 320 330 340 pF1KB6 YSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAH .:: :: :: :::::: :.:::.: : . :::::::::::::: :. .:. :. CCDS74 HSWVWHECHGHYHSMDIFTHYDILTPNGTK-VAEGHKASFCLEDTECQEDVSKRYECANF 460 470 480 490 500 510 350 360 370 380 390 400 pF1KB6 -TQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRY ::.. ::.: : :::::::::::::::::::.: .::.. : :::.:::...:. .: CCDS74 GEQGITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKY 520 530 540 550 560 570 410 pF1KB6 TGHHAYASGCTISPY ::. .. .: : CCDS74 DGHRIWVHNCHIGDAFSEEANRRFERYPGQTSNQII 580 590 600 >>CCDS1953.1 LOXL3 gene_id:84695|Hs108|chr2 (753 aa) initn: 725 init1: 528 opt: 775 Z-score: 687.3 bits: 137.0 E(32554): 5.8e-32 Smith-Waterman score: 775; 49.5% identity (68.9% similar) in 222 aa overlap (194-414:513-729) 170 180 190 200 210 220 pF1KB6 DGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQ : : :. : . ::. .: CCDS19 TEVVMSGVRCTGTELSLDQCAHHGTHITCKRTGTRFTAGV---ICSETASDLLLHSALVQ 490 500 510 520 530 230 240 250 260 270 280 pF1KB6 ASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPR ..:.. .. : ::::::::::.: :. : :: :::: ....: : .:: :. : CCDS19 ETAYIEDRPLHMLYCAAEENCLASSARSANW-PYGHRRLLRFSSQIHNLGRADFRPKAGR 540 550 560 570 580 590 290 300 310 320 330 340 pF1KB6 YSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAH .:: :: :: :::::: :.:::.: : . :::::::::::::: :. .:. :. CCDS19 HSWVWHECHGHYHSMDIFTHYDILTPNGTK-VAEGHKASFCLEDTECQEDVSKRYECANF 600 610 620 630 640 650 350 360 370 380 390 400 pF1KB6 -TQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRY ::.. ::.: : :::::::::::::::::::.: .::.. : :::.:::...:. .: CCDS19 GEQGITVGCWDLYRHDIDCQWIDITDVKPGNYILQVVINPNFEVAESDFTNNAMKCNCKY 660 670 680 690 700 710 410 pF1KB6 TGHHAYASGCTISPY ::. .. .: : CCDS19 DGHRIWVHNCHIGDAFSEEANRRFERYPGQTSNQII 720 730 740 750 >>CCDS7473.1 LOXL4 gene_id:84171|Hs108|chr10 (756 aa) initn: 725 init1: 485 opt: 765 Z-score: 678.5 bits: 135.4 E(32554): 1.8e-31 Smith-Waterman score: 765; 49.5% identity (71.6% similar) in 218 aa overlap (196-412:519-731) 170 180 190 200 210 220 pF1KB6 MVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQAS :::. : . . . :::: . .: . CCDS74 EVVMSGVRCSGTELALQQCQRHGPVHCSHGGGRFLAGVSC---MDSAPDLVMNAQLVQET 490 500 510 520 530 540 230 240 250 260 270 280 pF1KB6 TYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYS .:.. . .: :: :::::...: . : : .: :::: .. : : .:: :. : : CCDS74 AYLEDRPLSQLYCAHEENCLSKSADHMDW-PYGYRRLLRFSTQIYNLGRTDFRPKTGRDS 550 560 570 580 590 600 290 300 310 320 330 340 pF1KB6 WEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAH-T : ::.::.::::.. :.::::: : .. ::::::::::::::.: : .::.::. CCDS74 WVWHQCHRHYHSIEVFTHYDLLTLNGSK-VAEGHKASFCLEDTNCPTGLQRRYACANFGE 610 620 630 640 650 660 350 360 370 380 390 400 pF1KB6 QGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTG ::.. ::.::: ::::::.::::: :::::..: ::: : : :::..::...: .: : CCDS74 QGVTVGCWDTYRHDIDCQWVDITDVGPGNYIFQVIVNPHYEVAESDFSNNMLQCRCKYDG 670 680 690 700 710 720 410 pF1KB6 HHAYASGCTISPY :... .: CCDS74 HRVWLHNCHTGNSYPANAELSLEQEQRLRNNLI 730 740 750 >>CCDS34864.1 LOXL2 gene_id:4017|Hs108|chr8 (774 aa) initn: 707 init1: 492 opt: 761 Z-score: 674.8 bits: 134.7 E(32554): 2.9e-31 Smith-Waterman score: 761; 47.1% identity (72.4% similar) in 221 aa overlap (195-414:531-748) 170 180 190 200 210 220 pF1KB6 GMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQA : : . : :.. . . :::: . ..: CCDS34 SNKVVMSGVKCSGTELSLAHCRHDGEDVACPQGGVQYGAGVACSETA-PDLVLNAEMVQQ 510 520 530 540 550 230 240 250 260 270 280 pF1KB6 STYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRY .::.. :. :.:: :::::...: ..: .: :::: ....:.: ::: :. :. CCDS34 TTYLEDRPMFMLQCAMEENCLSASAAQTDPTT-GYRRLLRFSSQIHNNGQSDFRPKNGRH 560 570 580 590 600 610 290 300 310 320 330 340 pF1KB6 SWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAH- .: ::.::.:::::. :.:::::. : . :::::::::::::: :. .. . :. CCDS34 AWIWHDCHRHYHSMEVFTHYDLLNLNGTK-VAEGHKASFCLEDTECEGDIQKNYECANFG 620 630 640 650 660 670 350 360 370 380 390 400 pF1KB6 TQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYT ::.. ::.: : ::::::.::::: ::.:...: .::.. : ::::.::...: :: CCDS34 DQGITMGCWDMYRHDIDCQWVDITDVPPGDYLFQVVINPNFEVAESDYSNNIMKCRSRYD 680 690 700 710 720 730 410 pF1KB6 GHHAYASGCTISPY ::. . .: : CCDS34 GHRIWMYNCHIGGSFSEETEKKFEHFSGLLNNQLSPQ 740 750 760 770 417 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 17:26:44 2016 done: Sat Nov 5 17:26:45 2016 Total Scan time: 2.460 Total Display time: 0.010 Function used was FASTA [36.3.4 Apr, 2011]