FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6645, 419 aa 1>>>pF1KB6645 419 - 419 aa - 419 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9052+/-0.000403; mu= 15.1125+/- 0.025 mean_var=120.4388+/-24.185, 0's: 0 Z-trim(115.7): 417 B-trim: 301 in 1/54 Lambda= 0.116867 statistics sampled from 25710 (26262) to 25710 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.675), E-opt: 0.2 (0.308), width: 16 Scan time: 5.660 The best scores are: opt bits E(85289) NP_796376 (OMIM: 600104,616040) synaptotagmin-2 [H ( 419) 2803 484.0 3e-136 XP_016855802 (OMIM: 600104,616040) PREDICTED: syna ( 419) 2803 484.0 3e-136 NP_001129976 (OMIM: 600104,616040) synaptotagmin-2 ( 419) 2803 484.0 3e-136 XP_016855799 (OMIM: 600104,616040) PREDICTED: syna ( 476) 2803 484.0 3.3e-136 XP_011507494 (OMIM: 600104,616040) PREDICTED: syna ( 422) 2787 481.3 2e-135 XP_016855800 (OMIM: 600104,616040) PREDICTED: syna ( 422) 2787 481.3 2e-135 XP_016855801 (OMIM: 600104,616040) PREDICTED: syna ( 422) 2787 481.3 2e-135 XP_016855798 (OMIM: 600104,616040) PREDICTED: syna ( 479) 2787 481.4 2.1e-135 XP_005269170 (OMIM: 185605) PREDICTED: synaptotagm ( 419) 2142 372.5 1.1e-102 XP_006719639 (OMIM: 185605) PREDICTED: synaptotagm ( 419) 2142 372.5 1.1e-102 NP_001278830 (OMIM: 185605) synaptotagmin-1 isofor ( 419) 2142 372.5 1.1e-102 NP_005630 (OMIM: 185605) synaptotagmin-1 isoform 1 ( 422) 2135 371.4 2.4e-102 NP_001129277 (OMIM: 185605) synaptotagmin-1 isofor ( 422) 2135 371.4 2.4e-102 XP_016875398 (OMIM: 185605) PREDICTED: synaptotagm ( 422) 2135 371.4 2.4e-102 NP_001129278 (OMIM: 185605) synaptotagmin-1 isofor ( 422) 2135 371.4 2.4e-102 XP_011537012 (OMIM: 185605) PREDICTED: synaptotagm ( 422) 2135 371.4 2.4e-102 XP_016882664 (OMIM: 600782) PREDICTED: synaptotagm ( 386) 1614 283.5 6.4e-76 XP_016882665 (OMIM: 600782) PREDICTED: synaptotagm ( 386) 1614 283.5 6.4e-76 NP_003171 (OMIM: 600782) synaptotagmin-5 isoform 1 ( 386) 1614 283.5 6.4e-76 XP_006723402 (OMIM: 600782) PREDICTED: synaptotagm ( 386) 1614 283.5 6.4e-76 XP_006723403 (OMIM: 600782) PREDICTED: synaptotagm ( 385) 1603 281.6 2.3e-75 XP_006723404 (OMIM: 600782) PREDICTED: synaptotagm ( 383) 1455 256.7 7.4e-68 NP_001284703 (OMIM: 600782) synaptotagmin-5 isofor ( 382) 1444 254.8 2.7e-67 XP_006718799 (OMIM: 604146) PREDICTED: synaptotagm ( 293) 980 176.5 7.9e-44 NP_004191 (OMIM: 604146) synaptotagmin-7 isoform 2 ( 403) 980 176.6 9.9e-44 XP_011543645 (OMIM: 604146) PREDICTED: synaptotagm ( 409) 980 176.6 1e-43 NP_001287702 (OMIM: 604146) synaptotagmin-7 isofor ( 447) 980 176.7 1.1e-43 XP_005274444 (OMIM: 604146) PREDICTED: synaptotagm ( 449) 980 176.7 1.1e-43 XP_011543643 (OMIM: 604146) PREDICTED: synaptotagm ( 453) 980 176.7 1.1e-43 NP_001238994 (OMIM: 604146) synaptotagmin-7 isofor ( 478) 980 176.7 1.1e-43 XP_011543642 (OMIM: 604146) PREDICTED: synaptotagm ( 484) 980 176.7 1.1e-43 NP_001257734 (OMIM: 607718) synaptotagmin-6 [Homo ( 425) 979 176.5 1.2e-43 NP_995320 (OMIM: 607718) synaptotagmin-6 [Homo sap ( 425) 979 176.5 1.2e-43 XP_016855860 (OMIM: 607718) PREDICTED: synaptotagm ( 443) 979 176.5 1.2e-43 XP_011543641 (OMIM: 604146) PREDICTED: synaptotagm ( 528) 980 176.7 1.2e-43 XP_005274442 (OMIM: 604146) PREDICTED: synaptotagm ( 611) 980 176.8 1.3e-43 XP_011543640 (OMIM: 604146) PREDICTED: synaptotagm ( 617) 980 176.8 1.3e-43 XP_005274441 (OMIM: 604146) PREDICTED: synaptotagm ( 642) 980 176.8 1.4e-43 XP_011543639 (OMIM: 604146) PREDICTED: synaptotagm ( 648) 980 176.8 1.4e-43 XP_011543638 (OMIM: 604146) PREDICTED: synaptotagm ( 651) 980 176.8 1.4e-43 XP_005274440 (OMIM: 604146) PREDICTED: synaptotagm ( 686) 980 176.8 1.4e-43 XP_011543637 (OMIM: 604146) PREDICTED: synaptotagm ( 692) 980 176.8 1.4e-43 NP_001153801 (OMIM: 600327) synaptotagmin-3 [Homo ( 590) 954 172.4 2.7e-42 NP_001153800 (OMIM: 600327) synaptotagmin-3 [Homo ( 590) 954 172.4 2.7e-42 NP_115674 (OMIM: 600327) synaptotagmin-3 [Homo sap ( 590) 954 172.4 2.7e-42 XP_011525692 (OMIM: 600327) PREDICTED: synaptotagm ( 590) 954 172.4 2.7e-42 XP_011525693 (OMIM: 600327) PREDICTED: synaptotagm ( 590) 954 172.4 2.7e-42 NP_783860 (OMIM: 613528) synaptotagmin-9 [Homo sap ( 491) 934 168.9 2.4e-41 XP_011518206 (OMIM: 613528) PREDICTED: synaptotagm ( 492) 934 168.9 2.4e-41 XP_011518204 (OMIM: 613528) PREDICTED: synaptotagm ( 535) 934 169.0 2.6e-41 >>NP_796376 (OMIM: 600104,616040) synaptotagmin-2 [Homo (419 aa) initn: 2803 init1: 2803 opt: 2803 Z-score: 2567.0 bits: 484.0 E(85289): 3e-136 Smith-Waterman score: 2803; 100.0% identity (100.0% similar) in 419 aa overlap (1-419:1-419) 10 20 30 40 50 60 pF1KB6 MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_796 MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_796 PPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 ETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_796 ETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 VFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_796 VFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 VKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_796 VKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 DVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_796 DVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVL 310 320 330 340 350 360 370 380 390 400 410 pF1KB6 DYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_796 DYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK 370 380 390 400 410 >>XP_016855802 (OMIM: 600104,616040) PREDICTED: synaptot (419 aa) initn: 2803 init1: 2803 opt: 2803 Z-score: 2567.0 bits: 484.0 E(85289): 3e-136 Smith-Waterman score: 2803; 100.0% identity (100.0% similar) in 419 aa overlap (1-419:1-419) 10 20 30 40 50 60 pF1KB6 MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 ETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 VFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 VKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 DVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVL 310 320 330 340 350 360 370 380 390 400 410 pF1KB6 DYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK 370 380 390 400 410 >>NP_001129976 (OMIM: 600104,616040) synaptotagmin-2 [Ho (419 aa) initn: 2803 init1: 2803 opt: 2803 Z-score: 2567.0 bits: 484.0 E(85289): 3e-136 Smith-Waterman score: 2803; 100.0% identity (100.0% similar) in 419 aa overlap (1-419:1-419) 10 20 30 40 50 60 pF1KB6 MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQDDDDA 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 ETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDPYVK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 VFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGE 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 VKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNLKKM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 DVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVL 310 320 330 340 350 360 370 380 390 400 410 pF1KB6 DYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGKNK 370 380 390 400 410 >>XP_016855799 (OMIM: 600104,616040) PREDICTED: synaptot (476 aa) initn: 2803 init1: 2803 opt: 2803 Z-score: 2566.4 bits: 484.0 E(85289): 3.3e-136 Smith-Waterman score: 2803; 100.0% identity (100.0% similar) in 419 aa overlap (1-419:58-476) 10 20 30 pF1KB6 MRNIFKRNQEPIVAPATTTATMPIGPVDNS :::::::::::::::::::::::::::::: XP_016 LWAGLSQGKTTSGCSPCPLHLSSPAVSSATMRNIFKRNQEPIVAPATTTATMPIGPVDNS 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB6 TESGGAGESQEDMFAKLKEKLFNEINKIPLPPWALIAIAVVAGLLLLTCCFCICKKCCCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TESGGAGESQEDMFAKLKEKLFNEINKIPLPPWALIAIAVVAGLLLLTCCFCICKKCCCK 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB6 KKKNKKEKGKGMKNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKKNKKEKGKGMKNAMNMKDMKGGQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYD 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB6 FQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTF 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB6 KVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEK 270 280 290 300 310 320 280 290 300 310 320 330 pF1KB6 LGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 LGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKK 330 340 350 360 370 380 340 350 360 370 380 390 pF1KB6 KTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSD 390 400 410 420 430 440 400 410 pF1KB6 MLANPRRPIAQWHSLKPEEEVDALLGKNK ::::::::::::::::::::::::::::: XP_016 MLANPRRPIAQWHSLKPEEEVDALLGKNK 450 460 470 >>XP_011507494 (OMIM: 600104,616040) PREDICTED: synaptot (422 aa) initn: 2053 init1: 2053 opt: 2787 Z-score: 2552.4 bits: 481.3 E(85289): 2e-135 Smith-Waterman score: 2787; 99.3% identity (99.3% similar) in 422 aa overlap (1-419:1-422) 10 20 30 40 50 60 pF1KB6 MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPL 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 PPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQ---DD ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_011 PPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQLPQDD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 DDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 DDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB6 YVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 YVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDI 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB6 IGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB6 KKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 KKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVV 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB6 TVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 TVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGK 370 380 390 400 410 420 pF1KB6 NK :: XP_011 NK >>XP_016855800 (OMIM: 600104,616040) PREDICTED: synaptot (422 aa) initn: 2053 init1: 2053 opt: 2787 Z-score: 2552.4 bits: 481.3 E(85289): 2e-135 Smith-Waterman score: 2787; 99.3% identity (99.3% similar) in 422 aa overlap (1-419:1-422) 10 20 30 40 50 60 pF1KB6 MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPL 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 PPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQ---DD ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_016 PPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQLPQDD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 DDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB6 YVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDI 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB6 IGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB6 KKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVV 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB6 TVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGK 370 380 390 400 410 420 pF1KB6 NK :: XP_016 NK >>XP_016855801 (OMIM: 600104,616040) PREDICTED: synaptot (422 aa) initn: 2053 init1: 2053 opt: 2787 Z-score: 2552.4 bits: 481.3 E(85289): 2e-135 Smith-Waterman score: 2787; 99.3% identity (99.3% similar) in 422 aa overlap (1-419:1-422) 10 20 30 40 50 60 pF1KB6 MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPL 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 PPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQ---DD ::::::::::::::::::::::::::::::::::::::::::::::::::::::: :: XP_016 PPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKGGQLPQDD 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 DDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDP :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTSDP 130 140 150 160 170 180 180 190 200 210 220 230 pF1KB6 YVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKHDI 190 200 210 220 230 240 240 250 260 270 280 290 pF1KB6 IGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAKNL 250 260 270 280 290 300 300 310 320 330 340 350 pF1KB6 KKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 KKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQVVV 310 320 330 340 350 360 360 370 380 390 400 410 pF1KB6 TVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALLGK 370 380 390 400 410 420 pF1KB6 NK :: XP_016 NK >>XP_016855798 (OMIM: 600104,616040) PREDICTED: synaptot (479 aa) initn: 2053 init1: 2053 opt: 2787 Z-score: 2551.7 bits: 481.4 E(85289): 2.1e-135 Smith-Waterman score: 2787; 99.3% identity (99.3% similar) in 422 aa overlap (1-419:58-479) 10 20 30 pF1KB6 MRNIFKRNQEPIVAPATTTATMPIGPVDNS :::::::::::::::::::::::::::::: XP_016 LWAGLSQGKTTSGCSPCPLHLSSPAVSSATMRNIFKRNQEPIVAPATTTATMPIGPVDNS 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB6 TESGGAGESQEDMFAKLKEKLFNEINKIPLPPWALIAIAVVAGLLLLTCCFCICKKCCCK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 TESGGAGESQEDMFAKLKEKLFNEINKIPLPPWALIAIAVVAGLLLLTCCFCICKKCCCK 90 100 110 120 130 140 100 110 120 130 140 pF1KB6 KKKNKKEKGKGMKNAMNMKDMKGGQ---DDDDAETGLTEGEGEGEEEKEPENLGKLQFSL ::::::::::::::::::::::::: :::::::::::::::::::::::::::::::: XP_016 KKKNKKEKGKGMKNAMNMKDMKGGQLPQDDDDAETGLTEGEGEGEEEKEPENLGKLQFSL 150 160 170 180 190 200 150 160 170 180 190 200 pF1KB6 DYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNET :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DYDFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNET 210 220 230 240 250 260 210 220 230 240 250 260 pF1KB6 FTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 FTFKVPYQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEE 270 280 290 300 310 320 270 280 290 300 310 320 pF1KB6 PEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PEKLGDICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTT 330 340 350 360 370 380 330 340 350 360 370 380 pF1KB6 VKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VKKKTLNPYFNESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRH 390 400 410 420 430 440 390 400 410 pF1KB6 WSDMLANPRRPIAQWHSLKPEEEVDALLGKNK :::::::::::::::::::::::::::::::: XP_016 WSDMLANPRRPIAQWHSLKPEEEVDALLGKNK 450 460 470 >>XP_005269170 (OMIM: 185605) PREDICTED: synaptotagmin-1 (419 aa) initn: 2395 init1: 1685 opt: 2142 Z-score: 1964.7 bits: 372.5 E(85289): 1.1e-102 Smith-Waterman score: 2142; 77.4% identity (90.7% similar) in 421 aa overlap (4-419:2-419) 10 20 30 40 50 60 pF1KB6 MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPL . . ..: ..:: .::.. . : .:.:: .. ::..:: :.:::::..::..:::: XP_005 MVSESHHEALAAPPVTTVAT-VLP-SNATEPASPGEGKEDAFSKLKEKFMNELHKIPL 10 20 30 40 50 70 80 90 100 110 pF1KB6 PPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKG-GQ---- :::::::::.:: ::.::::::::::: :::..:: : :: :::.::::.: :. XP_005 PPWALIAIAIVAVLLVLTCCFCICKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKD 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 DDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTS .:::::::::.:: : :: :: :.:::::.::::::: ::: ::..:::::::::::::: XP_005 QDDDAETGLTDGE-EKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 DPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKH :::::::::::::::.:::::::::::.::: :::::::.::::::::::.::::::::: XP_005 DPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKH 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 DIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAK ::::: ::::::::.:. :::::::..:::: ::::::: ::::::::::::: ::::: XP_005 DIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAK 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 NLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQV ::::::::::::::::::::::::::::::::.::.:::::.:::::::.:::::::::: XP_005 NLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQV 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB6 VVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALL :::::::::.:::.::::.::: :.::.::::::::::::::::::::.:. ::::::.: XP_005 VVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAML 360 370 380 390 400 410 pF1KB6 GKNK . .: XP_005 AVKK >>XP_006719639 (OMIM: 185605) PREDICTED: synaptotagmin-1 (419 aa) initn: 2395 init1: 1685 opt: 2142 Z-score: 1964.7 bits: 372.5 E(85289): 1.1e-102 Smith-Waterman score: 2142; 77.4% identity (90.7% similar) in 421 aa overlap (4-419:2-419) 10 20 30 40 50 60 pF1KB6 MRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQEDMFAKLKEKLFNEINKIPL . . ..: ..:: .::.. . : .:.:: .. ::..:: :.:::::..::..:::: XP_006 MVSESHHEALAAPPVTTVAT-VLP-SNATEPASPGEGKEDAFSKLKEKFMNELHKIPL 10 20 30 40 50 70 80 90 100 110 pF1KB6 PPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNKKEKGKGMKNAMNMKDMKG-GQ---- :::::::::.:: ::.::::::::::: :::..:: : :: :::.::::.: :. XP_006 PPWALIAIAIVAVLLVLTCCFCICKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKD 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 DDDDAETGLTEGEGEGEEEKEPENLGKLQFSLDYDFQANQLTVGVLQAAELPALDMGGTS .:::::::::.:: : :: :: :.:::::.::::::: ::: ::..:::::::::::::: XP_006 QDDDAETGLTDGE-EKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTS 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 DPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFKVPYQELGGKTLVMAIYDFDRFSKH :::::::::::::::.:::::::::::.::: :::::::.::::::::::.::::::::: XP_006 DPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKH 180 190 200 210 220 230 240 250 260 270 280 290 pF1KB6 DIIGEVKVPMNTVDLGQPIEEWRDLQGGEKEEPEKLGDICTSLRYVPTAGKLTVCILEAK ::::: ::::::::.:. :::::::..:::: ::::::: ::::::::::::: ::::: XP_006 DIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAK 240 250 260 270 280 290 300 310 320 330 340 350 pF1KB6 NLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFNESFSFEIPFEQIQKVQV ::::::::::::::::::::::::::::::::.::.:::::.:::::::.:::::::::: XP_006 NLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQV 300 310 320 330 340 350 360 370 380 390 400 410 pF1KB6 VVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWHSLKPEEEVDALL :::::::::.:::.::::.::: :.::.::::::::::::::::::::.:. ::::::.: XP_006 VVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAML 360 370 380 390 400 410 pF1KB6 GKNK . .: XP_006 AVKK 419 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 11:14:10 2016 done: Sat Nov 5 11:14:11 2016 Total Scan time: 5.660 Total Display time: 0.030 Function used was FASTA [36.3.4 Apr, 2011]