FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6654, 389 aa 1>>>pF1KB6654 389 - 389 aa - 389 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.9569+/-0.000407; mu= 13.2207+/- 0.025 mean_var=66.6928+/-13.579, 0's: 0 Z-trim(111.4): 23 B-trim: 674 in 1/54 Lambda= 0.157049 statistics sampled from 19940 (19960) to 19940 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.6), E-opt: 0.2 (0.234), width: 16 Scan time: 6.810 The best scores are: opt bits E(85289) NP_001025 (OMIM: 180390) ribonucleoside-diphosphat ( 389) 2584 594.6 1.4e-169 NP_001159403 (OMIM: 180390) ribonucleoside-diphosp ( 449) 2584 594.6 1.5e-169 NP_056528 (OMIM: 604712,612075,613077) ribonucleos ( 351) 1861 430.7 2.5e-120 NP_001165948 (OMIM: 604712,612075,613077) ribonucl ( 423) 1861 430.8 3e-120 NP_001165949 (OMIM: 604712,612075,613077) ribonucl ( 299) 1662 385.6 8.1e-107 >>NP_001025 (OMIM: 180390) ribonucleoside-diphosphate re (389 aa) initn: 2584 init1: 2584 opt: 2584 Z-score: 3165.8 bits: 594.6 E(85289): 1.4e-169 Smith-Waterman score: 2584; 100.0% identity (100.0% similar) in 389 aa overlap (1-389:1-389) 10 20 30 40 50 60 pF1KB6 MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MLSLRVPLAPITDPQQLQLSPLKGLSLVDKENTPPALSGTRVLASKTARRIFQEPTEPKT 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLI 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIE 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTN 310 320 330 340 350 360 370 380 pF1KB6 FFEKRVGEYQRMGVMSSPTENSFTLDADF ::::::::::::::::::::::::::::: NP_001 FFEKRVGEYQRMGVMSSPTENSFTLDADF 370 380 >>NP_001159403 (OMIM: 180390) ribonucleoside-diphosphate (449 aa) initn: 2584 init1: 2584 opt: 2584 Z-score: 3164.7 bits: 594.6 E(85289): 1.5e-169 Smith-Waterman score: 2584; 100.0% identity (100.0% similar) in 389 aa overlap (1-389:61-449) 10 20 30 pF1KB6 MLSLRVPLAPITDPQQLQLSPLKGLSLVDK :::::::::::::::::::::::::::::: NP_001 FKGCWSEGSPVHPVPAVLSWLLALLRCASTMLSLRVPLAPITDPQQLQLSPLKGLSLVDK 40 50 60 70 80 90 40 50 60 70 80 90 pF1KB6 ENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 ENTPPALSGTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDI 100 110 120 130 140 150 100 110 120 130 140 150 pF1KB6 WQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 WQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFS 160 170 180 190 200 210 160 170 180 190 200 210 pF1KB6 QEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 QEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWA 220 230 240 250 260 270 220 230 240 250 260 270 pF1KB6 LRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHC 280 290 300 310 320 330 280 290 300 310 320 330 pF1KB6 DFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADR 340 350 360 370 380 390 340 350 360 370 380 pF1KB6 LMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF 400 410 420 430 440 >>NP_056528 (OMIM: 604712,612075,613077) ribonucleoside- (351 aa) initn: 1861 init1: 1861 opt: 1861 Z-score: 2281.2 bits: 430.7 E(85289): 2.5e-120 Smith-Waterman score: 1861; 83.8% identity (96.3% similar) in 321 aa overlap (69-389:31-351) 40 50 60 70 80 90 pF1KB6 GTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAE .:::::.. ::::::::.: :::.:::.:. NP_056 MGDPERPEAAGLDQDERSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQ 10 20 30 40 50 60 100 110 120 130 140 150 pF1KB6 ASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEA ::::::::::::::. ::..:: .:.:::::.::::::::::::::::::::::::. :: NP_056 ASFWTAEEVDLSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEA 70 80 90 100 110 120 160 170 180 190 200 210 pF1KB6 RCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKE :::::::: .::.:::::::::::::.:::.:::::::::::: ::::::::::::.:.. NP_056 RCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRK 130 140 150 160 170 180 220 230 240 250 260 270 pF1KB6 ATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFK .:.::::::::::::.:::::::.:::::::::::::::::::::::::::::::::::. NP_056 STFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQ 190 200 210 220 230 240 280 290 300 310 320 330 pF1KB6 HLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFS .::.:::::::::::..::.:::::::::::: :::::: :::::::::::::..::::: NP_056 YLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCILMKQYIEFVADRLLVELGFS 250 260 270 280 290 300 340 350 360 370 380 pF1KB6 KVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF :::..:::::::::::::::::::::::.::::..::. :.: ::::::: NP_056 KVFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF 310 320 330 340 350 >>NP_001165948 (OMIM: 604712,612075,613077) ribonucleosi (423 aa) initn: 1861 init1: 1861 opt: 1861 Z-score: 2279.8 bits: 430.8 E(85289): 3e-120 Smith-Waterman score: 1861; 83.8% identity (96.3% similar) in 321 aa overlap (69-389:103-423) 40 50 60 70 80 90 pF1KB6 GTRVLASKTARRIFQEPTEPKTKAAAPGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAE .:::::.. ::::::::.: :::.:::.:. NP_001 SAPGPAKDDAWRPQAGRSSSDTNESEIKSNEEPLLRKSSRRFVIFPIQYPDIWKMYKQAQ 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB6 ASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEA ::::::::::::::. ::..:: .:.:::::.::::::::::::::::::::::::. :: NP_001 ASFWTAEEVDLSKDLPHWNKLKADEKYFISHILAFFAASDGIVNENLVERFSQEVQVPEA 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB6 RCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKE :::::::: .::.:::::::::::::.:::.:::::::::::: ::::::::::::.:.. NP_001 RCFYGFQILIENVHSEMYSLLIDTYIRDPKKREFLFNAIETMPYVKKKADWALRWIADRK 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB6 ATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFK .:.::::::::::::.:::::::.:::::::::::::::::::::::::::::::::::. NP_001 STFGERVVAFAAVEGVFFSGSFAAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQ 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB6 HLVHKPSEERVREIIINAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFS .::.:::::::::::..::.:::::::::::: :::::: :::::::::::::..::::: NP_001 YLVNKPSEERVREIIVDAVKIEQEFLTEALPVGLIGMNCILMKQYIEFVADRLLVELGFS 320 330 340 350 360 370 340 350 360 370 380 pF1KB6 KVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDADF :::..:::::::::::::::::::::::.::::..::. :.: ::::::: NP_001 KVFQAENPFDFMENISLEGKTNFFEKRVSEYQRFAVMAETTDNVFTLDADF 380 390 400 410 420 >>NP_001165949 (OMIM: 604712,612075,613077) ribonucleosi (299 aa) initn: 1662 init1: 1662 opt: 1662 Z-score: 2038.7 bits: 385.6 E(85289): 8.1e-107 Smith-Waterman score: 1662; 82.4% identity (94.9% similar) in 295 aa overlap (95-389:5-299) 70 80 90 100 110 120 pF1KB6 PGVEDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEER .. ::. .:::::::. ::..:: .:. NP_001 MGDPERPEAAGLDQDEVDLSKDLPHWNKLKADEK 10 20 30 130 140 150 160 170 180 pF1KB6 YFISHVLAFFAASDGIVNENLVERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYI :::::.::::::::::::::::::::::::. :::::::::: .::.::::::::::::: NP_001 YFISHILAFFAASDGIVNENLVERFSQEVQVPEARCFYGFQILIENVHSEMYSLLIDTYI 40 50 60 70 80 90 190 200 210 220 230 240 pF1KB6 KDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIF .:::.:::::::::::: ::::::::::::.:...:.::::::::::::.:::::::.:: NP_001 RDPKKREFLFNAIETMPYVKKKADWALRWIADRKSTFGERVVAFAAVEGVFFSGSFAAIF 100 110 120 130 140 150 250 260 270 280 290 300 pF1KB6 WLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFL :::::::::::::::::::::::::::::::::..::.:::::::::::..::.:::::: NP_001 WLKKRGLMPGLTFSNELISRDEGLHCDFACLMFQYLVNKPSEERVREIIVDAVKIEQEFL 160 170 180 190 200 210 310 320 330 340 350 360 pF1KB6 TEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEK :::::: :::::: :::::::::::::..::::::::..::::::::::::::::::::: NP_001 TEALPVGLIGMNCILMKQYIEFVADRLLVELGFSKVFQAENPFDFMENISLEGKTNFFEK 220 230 240 250 260 270 370 380 pF1KB6 RVGEYQRMGVMSSPTENSFTLDADF ::.::::..::. :.: ::::::: NP_001 RVSEYQRFAVMAETTDNVFTLDADF 280 290 389 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 07:32:38 2016 done: Sat Nov 5 07:32:39 2016 Total Scan time: 6.810 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]