Result of FASTA (omim) for
pF1KB6656
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB6656, 450 aa
1>>>pF1KB6656 450 - 450 aa - 450 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 14.3206+/-0.000815; mu= -27.7401+/- 0.048
mean_var=974.9698+/-221.896, 0's: 0 Z-trim(113.2): 1245 B-trim: 1185 in 1/56
Lambda= 0.041075
statistics sampled from 21120 (22505) to 21120 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.616), E-opt: 0.2 (0.264), width: 16
Scan time: 9.070
The best scores are: opt bits E(85289)
NP_001120662 (OMIM: 124095) tyrosine-protein kinas ( 450) 3029 196.3 1.4e-49
XP_016877414 (OMIM: 124095) PREDICTED: tyrosine-pr ( 450) 3029 196.3 1.4e-49
XP_005254222 (OMIM: 124095) PREDICTED: tyrosine-pr ( 450) 3029 196.3 1.4e-49
NP_004374 (OMIM: 124095) tyrosine-protein kinase C ( 450) 3029 196.3 1.4e-49
NP_647611 (OMIM: 600038) megakaryocyte-associated ( 466) 1621 112.9 1.8e-24
XP_011526320 (OMIM: 600038) PREDICTED: megakaryocy ( 507) 1621 113.0 1.9e-24
NP_647612 (OMIM: 600038) megakaryocyte-associated ( 507) 1621 113.0 1.9e-24
NP_002369 (OMIM: 600038) megakaryocyte-associated ( 508) 1621 113.0 1.9e-24
NP_001129473 (OMIM: 164690) Abelson tyrosine-prote ( 542) 1094 81.8 5e-15
NP_001161711 (OMIM: 164690) Abelson tyrosine-prote (1043) 1094 82.2 7.4e-15
NP_001161710 (OMIM: 164690) Abelson tyrosine-prote (1058) 1094 82.2 7.4e-15
NP_001129472 (OMIM: 164690) Abelson tyrosine-prote (1064) 1094 82.2 7.4e-15
NP_001161709 (OMIM: 164690) Abelson tyrosine-prote (1079) 1094 82.2 7.5e-15
XP_005245145 (OMIM: 164690) PREDICTED: Abelson tyr (1146) 1094 82.2 7.8e-15
NP_001161708 (OMIM: 164690) Abelson tyrosine-prote (1161) 1094 82.2 7.8e-15
NP_005149 (OMIM: 164690) Abelson tyrosine-protein (1167) 1094 82.2 7.9e-15
XP_016856524 (OMIM: 164690) PREDICTED: Abelson tyr (1182) 1094 82.2 7.9e-15
NP_009298 (OMIM: 164690) Abelson tyrosine-protein (1182) 1094 82.2 7.9e-15
NP_005148 (OMIM: 189980) tyrosine-protein kinase A (1130) 1080 81.4 1.4e-14
NP_009297 (OMIM: 189980) tyrosine-protein kinase A (1149) 1080 81.4 1.4e-14
NP_001706 (OMIM: 191305,613375) tyrosine-protein k ( 505) 1013 76.9 1.3e-13
NP_001317394 (OMIM: 191305,613375) tyrosine-protei ( 434) 997 75.9 2.4e-13
NP_001036236 (OMIM: 153390,615758) tyrosine-protei ( 509) 981 75.0 5e-13
NP_005347 (OMIM: 153390,615758) tyrosine-protein k ( 509) 981 75.0 5e-13
NP_001165602 (OMIM: 142370) tyrosine-protein kinas ( 504) 960 73.8 1.2e-12
NP_001165604 (OMIM: 142370) tyrosine-protein kinas ( 505) 960 73.8 1.2e-12
NP_001165600 (OMIM: 142370) tyrosine-protein kinas ( 505) 960 73.8 1.2e-12
NP_001165603 (OMIM: 142370) tyrosine-protein kinas ( 506) 960 73.8 1.2e-12
NP_001165601 (OMIM: 142370) tyrosine-protein kinas ( 525) 960 73.8 1.2e-12
NP_002101 (OMIM: 142370) tyrosine-protein kinase H ( 526) 960 73.8 1.2e-12
NP_001104567 (OMIM: 165120) tyrosine-protein kinas ( 491) 935 72.3 3.2e-12
XP_016868905 (OMIM: 165120) PREDICTED: tyrosine-pr ( 491) 935 72.3 3.2e-12
NP_002341 (OMIM: 165120) tyrosine-protein kinase L ( 512) 935 72.3 3.3e-12
XP_011515831 (OMIM: 165120) PREDICTED: tyrosine-pr ( 682) 935 72.5 3.9e-12
XP_011527315 (OMIM: 114500,190090,616937) PREDICTE ( 536) 928 71.9 4.5e-12
NP_938033 (OMIM: 114500,190090,616937) proto-oncog ( 536) 928 71.9 4.5e-12
NP_005408 (OMIM: 114500,190090,616937) proto-oncog ( 536) 928 71.9 4.5e-12
NP_005424 (OMIM: 164880) tyrosine-protein kinase Y ( 543) 927 71.9 4.8e-12
XP_016881449 (OMIM: 164880) PREDICTED: tyrosine-pr ( 543) 927 71.9 4.8e-12
XP_005266947 (OMIM: 137025) PREDICTED: tyrosine-pr ( 534) 925 71.8 5.1e-12
NP_694592 (OMIM: 137025) tyrosine-protein kinase F ( 534) 925 71.8 5.1e-12
NP_001036194 (OMIM: 164940) tyrosine-protein kinas ( 529) 920 71.5 6.3e-12
NP_005239 (OMIM: 164940) tyrosine-protein kinase F ( 529) 920 71.5 6.3e-12
XP_011539312 (OMIM: 164940) PREDICTED: tyrosine-pr ( 529) 920 71.5 6.3e-12
NP_001036212 (OMIM: 164940) tyrosine-protein kinas ( 529) 920 71.5 6.3e-12
XP_006710515 (OMIM: 164940) PREDICTED: tyrosine-pr ( 529) 920 71.5 6.3e-12
NP_005966 (OMIM: 602004) protein-tyrosine kinase 6 ( 451) 909 70.7 9e-12
XP_016866140 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 891 69.7 2.1e-11
NP_002028 (OMIM: 137025) tyrosine-protein kinase F ( 537) 891 69.7 2.1e-11
XP_016866141 (OMIM: 137025) PREDICTED: tyrosine-pr ( 537) 891 69.7 2.1e-11
>>NP_001120662 (OMIM: 124095) tyrosine-protein kinase CS (450 aa)
initn: 3029 init1: 3029 opt: 3029 Z-score: 1011.3 bits: 196.3 E(85289): 1.4e-49
Smith-Waterman score: 3029; 100.0% identity (100.0% similar) in 450 aa overlap (1-450:1-450)
10 20 30 40 50 60
pF1KB6 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
370 380 390 400 410 420
430 440 450
pF1KB6 NCWHLDAAMRPSFLQLREQLEHIKTHELHL
::::::::::::::::::::::::::::::
NP_001 NCWHLDAAMRPSFLQLREQLEHIKTHELHL
430 440 450
>>XP_016877414 (OMIM: 124095) PREDICTED: tyrosine-protei (450 aa)
initn: 3029 init1: 3029 opt: 3029 Z-score: 1011.3 bits: 196.3 E(85289): 1.4e-49
Smith-Waterman score: 3029; 100.0% identity (100.0% similar) in 450 aa overlap (1-450:1-450)
10 20 30 40 50 60
pF1KB6 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
370 380 390 400 410 420
430 440 450
pF1KB6 NCWHLDAAMRPSFLQLREQLEHIKTHELHL
::::::::::::::::::::::::::::::
XP_016 NCWHLDAAMRPSFLQLREQLEHIKTHELHL
430 440 450
>>XP_005254222 (OMIM: 124095) PREDICTED: tyrosine-protei (450 aa)
initn: 3029 init1: 3029 opt: 3029 Z-score: 1011.3 bits: 196.3 E(85289): 1.4e-49
Smith-Waterman score: 3029; 100.0% identity (100.0% similar) in 450 aa overlap (1-450:1-450)
10 20 30 40 50 60
pF1KB6 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
370 380 390 400 410 420
430 440 450
pF1KB6 NCWHLDAAMRPSFLQLREQLEHIKTHELHL
::::::::::::::::::::::::::::::
XP_005 NCWHLDAAMRPSFLQLREQLEHIKTHELHL
430 440 450
>>NP_004374 (OMIM: 124095) tyrosine-protein kinase CSK [ (450 aa)
initn: 3029 init1: 3029 opt: 3029 Z-score: 1011.3 bits: 196.3 E(85289): 1.4e-49
Smith-Waterman score: 3029; 100.0% identity (100.0% similar) in 450 aa overlap (1-450:1-450)
10 20 30 40 50 60
pF1KB6 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB6 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB6 SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB6 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB6 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB6 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB6 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
370 380 390 400 410 420
430 440 450
pF1KB6 NCWHLDAAMRPSFLQLREQLEHIKTHELHL
::::::::::::::::::::::::::::::
NP_004 NCWHLDAAMRPSFLQLREQLEHIKTHELHL
430 440 450
>>NP_647611 (OMIM: 600038) megakaryocyte-associated tyro (466 aa)
initn: 1597 init1: 764 opt: 1621 Z-score: 560.2 bits: 112.9 E(85289): 1.8e-24
Smith-Waterman score: 1621; 54.1% identity (81.3% similar) in 434 aa overlap (8-440:6-437)
10 20 30 40 50
pF1KB6 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGI
: ::.::.: . .: : ::::.::. . .. .::..:... :.::.
NP_647 MPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGL
10 20 30 40 50
60 70 80 90 100 110
pF1KB6 IPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLC
. :. ...::...: ::::::::::::. ..: . : ::: ::::::::. .::::.::
NP_647 LAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB6 VSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAA
:: : :::.... ..:.::: :.: :::..::::..: ..::.:..:: .:: .:
NP_647 VSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KB6 QDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASV
..:. :.:: ::...: : ::.:::: :. :.: :.::::: :: :.:::::: :..:
NP_647 EEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAV
180 190 200 210 220 230
240 250 260 270 280 290
pF1KB6 MTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVC
::...: :::.:::::... ::::: :...::.::..::.:::.... ::.::: :
NP_647 MTKMQHENLVRLLGVILHQ--GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KB6 EAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALR
:.:::::....:::::::::.::::: :::::::::.: . :...:::::::::::.
NP_647 EGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALK
300 310 320 330 340 350
360 370 380 390 400 410
pF1KB6 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM
. ::..::::::::.::::..:.::.:::.. ::.: :::::.:. :.::: :. .:
NP_647 HGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLM
360 370 380 390 400 410
420 430 440 450
pF1KB6 KNCWHLDAAMRPSFLQLREQLEHIKTHELHL
..::. . : :: : .: :.:
NP_647 SSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQEP
420 430 440 450 460
>>XP_011526320 (OMIM: 600038) PREDICTED: megakaryocyte-a (507 aa)
initn: 1597 init1: 764 opt: 1621 Z-score: 559.8 bits: 113.0 E(85289): 1.9e-24
Smith-Waterman score: 1621; 54.1% identity (81.3% similar) in 434 aa overlap (8-440:47-478)
10 20 30
pF1KB6 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLT
: ::.::.: . .: : ::::.:
XP_011 DSAEELPRVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVT
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB6 IVAVTKDPNWYKAKNKV-GREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLL
:. . .. .::..:... :.::.. :. ...::...: ::::::::::::. ..: . :
XP_011 ILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KB6 YPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHY
::: ::::::::. .::::.:::: : :::.... ..:.::: :.: :::..::::
XP_011 QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHY
140 150 160 170 180 190
160 170 180 190 200 210
pF1KB6 TSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG
..: ..::.:..:: .:: .:..:. :.:: ::...: : ::.:::: :. :.: :
XP_011 SKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KB6 NKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVD
.::::: :: :.:::::: :..:::...: :::.:::::... ::::: :...::.::.
XP_011 QKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQ--GLYIVMEHVSKGNLVN
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB6 YLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT
.::.:::.... ::.::: : :.:::::....:::::::::.::::: :::::::::.
XP_011 FLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLA
320 330 340 350 360 370
340 350 360 370 380 390
pF1KB6 KEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV
: . :...:::::::::::.. ::..::::::::.::::..:.::.:::.. ::.:
XP_011 KAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVS
380 390 400 410 420 430
400 410 420 430 440 450
pF1KB6 PRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
:::::.:. :.::: :. .:..::. . : :: : .: :.:
XP_011 EAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQ
440 450 460 470 480 490
XP_011 DADGSTSPRSQEP
500
>>NP_647612 (OMIM: 600038) megakaryocyte-associated tyro (507 aa)
initn: 1597 init1: 764 opt: 1621 Z-score: 559.8 bits: 113.0 E(85289): 1.9e-24
Smith-Waterman score: 1621; 54.1% identity (81.3% similar) in 434 aa overlap (8-440:47-478)
10 20 30
pF1KB6 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLT
: ::.::.: . .: : ::::.:
NP_647 DSAEELPRVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVT
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB6 IVAVTKDPNWYKAKNKV-GREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLL
:. . .. .::..:... :.::.. :. ...::...: ::::::::::::. ..: . :
NP_647 ILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KB6 YPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHY
::: ::::::::. .::::.:::: : :::.... ..:.::: :.: :::..::::
NP_647 QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHY
140 150 160 170 180 190
160 170 180 190 200 210
pF1KB6 TSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG
..: ..::.:..:: .:: .:..:. :.:: ::...: : ::.:::: :. :.: :
NP_647 SKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KB6 NKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVD
.::::: :: :.:::::: :..:::...: :::.:::::... ::::: :...::.::.
NP_647 QKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQ--GLYIVMEHVSKGNLVN
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB6 YLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT
.::.:::.... ::.::: : :.:::::....:::::::::.::::: :::::::::.
NP_647 FLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLA
320 330 340 350 360 370
340 350 360 370 380 390
pF1KB6 KEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV
: . :...:::::::::::.. ::..::::::::.::::..:.::.:::.. ::.:
NP_647 KAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVS
380 390 400 410 420 430
400 410 420 430 440 450
pF1KB6 PRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
:::::.:. :.::: :. .:..::. . : :: : .: :.:
NP_647 EAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQ
440 450 460 470 480 490
NP_647 DADGSTSPRSQEP
500
>>NP_002369 (OMIM: 600038) megakaryocyte-associated tyro (508 aa)
initn: 1597 init1: 764 opt: 1621 Z-score: 559.8 bits: 113.0 E(85289): 1.9e-24
Smith-Waterman score: 1621; 54.1% identity (81.3% similar) in 434 aa overlap (8-440:48-479)
10 20 30
pF1KB6 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLT
: ::.::.: . .: : ::::.:
NP_002 TRGQQQLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVT
20 30 40 50 60 70
40 50 60 70 80 90
pF1KB6 IVAVTKDPNWYKAKNKV-GREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLL
:. . .. .::..:... :.::.. :. ...::...: ::::::::::::. ..: . :
NP_002 ILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KB6 YPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHY
::: ::::::::. .::::.:::: : :::.... ..:.::: :.: :::..::::
NP_002 QPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHY
140 150 160 170 180 190
160 170 180 190 200 210
pF1KB6 TSDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRG
..: ..::.:..:: .:: .:..:. :.:: ::...: : ::.:::: :. :.: :
NP_002 SKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLG
200 210 220 230 240 250
220 230 240 250 260 270
pF1KB6 NKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVD
.::::: :: :.:::::: :..:::...: :::.:::::... ::::: :...::.::.
NP_002 QKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQ--GLYIVMEHVSKGNLVN
260 270 280 290 300 310
280 290 300 310 320 330
pF1KB6 YLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLT
.::.:::.... ::.::: : :.:::::....:::::::::.::::: :::::::::.
NP_002 FLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLA
320 330 340 350 360 370
340 350 360 370 380 390
pF1KB6 KEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVV
: . :...:::::::::::.. ::..::::::::.::::..:.::.:::.. ::.:
NP_002 KAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVS
380 390 400 410 420 430
400 410 420 430 440 450
pF1KB6 PRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
:::::.:. :.::: :. .:..::. . : :: : .: :.:
NP_002 EAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQ
440 450 460 470 480 490
NP_002 DADGSTSPRSQEP
500
>>NP_001129473 (OMIM: 164690) Abelson tyrosine-protein k (542 aa)
initn: 907 init1: 382 opt: 1094 Z-score: 390.8 bits: 81.8 E(85289): 5e-15
Smith-Waterman score: 1094; 41.6% identity (69.3% similar) in 437 aa overlap (15-441:92-519)
10 20 30 40
pF1KB6 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKD
.: :.: ..... : . ::. : ... ...
NP_001 DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQN
70 80 90 100 110 120
50 60 70 80 90 100
pF1KB6 PNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLF
.: ....: : .: .:.::. :.. : : :.:: ..: :: :: .: :
NP_001 GEWSEVRSKNG-QGWVPSNYITP---VNSLEKHS---WYHGPVSRSAAEYLLSSLINGSF
130 140 150 160 170
110 120 130 140 150 160
pF1KB6 LVRESTNYPGDYTLCVSCDGKVEHYRIMYHAS-KLSIDEEVYFENLMQLVEHYTSDADGL
::::: . ::. .. . .:.: :::: :. :. . : : .: .::.:... ::::
NP_001 LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL
180 190 200 210 220 230
170 180 190 200 210
pF1KB6 CTRL--IKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK--V
: : :: . :: . . .. . : .. .. . . .: :..:.:..: .. . :
NP_001 VTTLHYPAPKCNKPTVYGVSPIHDK-WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTV
240 250 260 270 280 290
220 230 240 250 260 270
pF1KB6 AVKCIKNDAT-AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYL
::: .:.:. .. :: ::.:: ...: :::::::: . : .::::::: :.:.:::
NP_001 AVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPP-FYIVTEYMPYGNLLDYL
300 310 320 330 340 350
280 290 300 310 320 330
pF1KB6 RSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE
: .: . . :: .. .. :::::: .::.:::::::: ::.:..:.::.::::..
NP_001 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL
360 370 380 390 400 410
340 350 360 370 380 390
pF1KB6 ASS---TQDTG-KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD
.. : .: :.:.::::::.: . :: :::::.::.::::: ..: ::: : :..
NP_001 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ
420 430 440 450 460 470
400 410 420 430 440 450
pF1KB6 VVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
: .::::.:. :.:::: :::.:. ::. . : :::: . .. .:
NP_001 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEVLL
480 490 500 510 520 530
NP_001 HCANQTCITL
540
>>NP_001161711 (OMIM: 164690) Abelson tyrosine-protein k (1043 aa)
initn: 907 init1: 382 opt: 1094 Z-score: 387.8 bits: 82.2 E(85289): 7.4e-15
Smith-Waterman score: 1094; 41.6% identity (69.3% similar) in 437 aa overlap (15-441:77-504)
10 20 30 40
pF1KB6 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKD
.: :.: ..... : . ::. : ... ...
NP_001 DVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQN
50 60 70 80 90 100
50 60 70 80 90 100
pF1KB6 PNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLF
.: ....: : .: .:.::. :.. : : :.:: ..: :: :: .: :
NP_001 GEWSEVRSKNG-QGWVPSNYITP---VNSLEKHS---WYHGPVSRSAAEYLLSSLINGSF
110 120 130 140 150
110 120 130 140 150 160
pF1KB6 LVRESTNYPGDYTLCVSCDGKVEHYRIMYHAS-KLSIDEEVYFENLMQLVEHYTSDADGL
::::: . ::. .. . .:.: :::: :. :. . : : .: .::.:... ::::
NP_001 LVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGL
160 170 180 190 200 210
170 180 190 200 210
pF1KB6 CTRL--IKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNK--V
: : :: . :: . . .. . : .. .. . . .: :..:.:..: .. . :
NP_001 VTTLHYPAPKCNKPTVYGVSPIHDK-WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTV
220 230 240 250 260 270
220 230 240 250 260 270
pF1KB6 AVKCIKNDAT-AQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYL
::: .:.:. .. :: ::.:: ...: :::::::: . : .::::::: :.:.:::
NP_001 AVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTLEPP-FYIVTEYMPYGNLLDYL
280 290 300 310 320 330
280 290 300 310 320 330
pF1KB6 RSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKE
: .: . . :: .. .. :::::: .::.:::::::: ::.:..:.::.::::..
NP_001 RECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRL
340 350 360 370 380 390
340 350 360 370 380 390
pF1KB6 ASS---TQDTG-KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKD
.. : .: :.:.::::::.: . :: :::::.::.::::: ..: ::: : :..
NP_001 MTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQ
400 410 420 430 440 450
400 410 420 430 440 450
pF1KB6 VVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHIKTHELHL
: .::::.:. :.:::: :::.:. ::. . : :::: . .. .:
NP_001 VYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVA
460 470 480 490 500 510
NP_001 EELGRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRG
520 530 540 550 560 570
450 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 11:16:34 2016 done: Sat Nov 5 11:16:35 2016
Total Scan time: 9.070 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]