FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6691, 428 aa 1>>>pF1KB6691 428 - 428 aa - 428 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.1431+/-0.000966; mu= 13.5035+/- 0.058 mean_var=95.3711+/-18.623, 0's: 0 Z-trim(107.0): 56 B-trim: 5 in 1/50 Lambda= 0.131331 statistics sampled from 9283 (9325) to 9283 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.668), E-opt: 0.2 (0.286), width: 16 Scan time: 2.570 The best scores are: opt bits E(32554) CCDS53486.1 SMYD3 gene_id:64754|Hs108|chr1 ( 428) 2940 567.6 8.4e-162 CCDS31083.1 SMYD3 gene_id:64754|Hs108|chr1 ( 369) 2548 493.2 1.7e-139 CCDS31022.1 SMYD2 gene_id:56950|Hs108|chr1 ( 433) 671 137.6 2.2e-32 CCDS82480.1 SMYD1 gene_id:150572|Hs108|chr2 ( 477) 654 134.5 2.2e-31 CCDS33240.1 SMYD1 gene_id:150572|Hs108|chr2 ( 490) 455 96.8 5.1e-20 >>CCDS53486.1 SMYD3 gene_id:64754|Hs108|chr1 (428 aa) initn: 2940 init1: 2940 opt: 2940 Z-score: 3018.3 bits: 567.6 E(32554): 8.4e-162 Smith-Waterman score: 2940; 99.8% identity (100.0% similar) in 428 aa overlap (1-428:1-428) 10 20 30 40 50 60 pF1KB6 MEPLKVEKFATANRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLM ::::::::::::.::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 MEPLKVEKFATAKRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 RCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSES :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 RCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAPSES 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 EKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFAKVIC 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 NSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEELTICYL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 DMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHW :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 DMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTGDEQVWKEVQESLKKIEELKAHW 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 KWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 KWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLLEEALFYGTRTMEPYRI 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 FFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS53 FFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVTHGREHSLIEDLILLLEE 370 380 390 400 410 420 pF1KB6 CDANIRAS :::::::: CCDS53 CDANIRAS >>CCDS31083.1 SMYD3 gene_id:64754|Hs108|chr1 (369 aa) initn: 2548 init1: 2548 opt: 2548 Z-score: 2617.8 bits: 493.2 E(32554): 1.7e-139 Smith-Waterman score: 2548; 100.0% identity (100.0% similar) in 369 aa overlap (60-428:1-369) 30 40 50 60 70 80 pF1KB6 LFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRVAKYCSAKCQKKAWPDHKRECKC :::::::::::::::::::::::::::::: CCDS31 MRCSQCRVAKYCSAKCQKKAWPDHKRECKC 10 20 30 90 100 110 120 130 140 pF1KB6 LKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 LKSCKPRYPPDSVRLLGRVVFKLMDGAPSESEKLYSFYDLESNINKLTEDKKEGLRQLVM 40 50 60 70 80 90 150 160 170 180 190 200 pF1KB6 TFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 TFQHFMREEIQDASQLPPAFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSISLLNHSCD 100 110 120 130 140 150 210 220 230 240 250 260 pF1KB6 PNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 PNCSIVFNGPHLLLRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQ 160 170 180 190 200 210 270 280 290 300 310 320 pF1KB6 DKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 DKDADMLTGDEQVWKEVQESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLK 220 230 240 250 260 270 330 340 350 360 370 380 pF1KB6 VLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS31 VLDCAMDACINLGLLEEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQA 280 290 300 310 320 330 390 400 410 420 pF1KB6 MKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS ::::::::::::::::::::::::::::::::::::::: CCDS31 MKNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS 340 350 360 >>CCDS31022.1 SMYD2 gene_id:56950|Hs108|chr1 (433 aa) initn: 811 init1: 329 opt: 671 Z-score: 694.8 bits: 137.6 E(32554): 2.2e-32 Smith-Waterman score: 822; 32.8% identity (63.4% similar) in 424 aa overlap (6-414:9-426) 10 20 30 40 50 pF1KB6 MEPLKVEKFATANRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKE .:.: . ..: ::::. :.. :.::: ::.. . :: :. :. :: CCDS31 MRAEGLGGLERFCSPGKGRGLRALQPFQVGDLLFSCPAYAYVLTVNERGNHCEYCFTRKE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 KLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRY-PPDSVRLLGRVVFKL-MDG : .:..:. : ::...:::. :: :: ::. . . : ..::: .:.. : . CCDS31 GLSKCGRCKQAFYCNVECQKEDWPMHKLECSPMVVFGENWNPSETVRLTARILAKQKIHP 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 APSESEKLYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAF . :::: . ..::...:: ..::. ... . ...::. ... .: .: : CCDS31 ERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYSKHLG----FPDNDSLVVLF 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 AKVICNSFTICNAEMQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEEL :.: ::.::: . :....: ...:...:.:::: :: ....: .:::..:. :::. CCDS31 AQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEV 180 190 200 210 220 230 240 250 260 270 280 pF1KB6 TICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLT----GD----EQVWKEVQ :.:.:. .:.: .:::.: : :.: .: :.::: . .: : . :. CCDS31 FTSYIDLLYPTEDRNDRLRDSYFFTCECQECTTKDKDKAKVEIRKLSDPPKAEAIRDMVR 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB6 ESLKKIEELK--AHWKWE-QVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLL . . :::.. :.: ..: .:. . : . : :.:.:... :: .:. . CCDS31 YARNVIEEFRRAKHYKSPSELLEICELSQEKMSSVFEDSNVYMLHMMYQAMGVCLYMQDW 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB6 EEALFYGTRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAM--KNLRLAFDIMRV : :: :: . ..:: .: . . .:.:.: . :. .: : :. :. ::.: CCDS31 EGALQYGQKIIKPYSKHYPLYSLNVASMWLKLGRLYM--GLEHKAAGEKALKKAIAIMEV 360 370 380 390 400 410 410 420 pF1KB6 THGREHSLIEDLILLLEECDANIRAS .::..: : .. CCDS31 AHGKDHPYISEIKQEIESH 420 430 >>CCDS82480.1 SMYD1 gene_id:150572|Hs108|chr2 (477 aa) initn: 721 init1: 325 opt: 654 Z-score: 676.8 bits: 134.5 E(32554): 2.2e-31 Smith-Waterman score: 817; 31.5% identity (64.6% similar) in 435 aa overlap (6-426:9-436) 10 20 30 40 50 pF1KB6 MEPLKVEKFATANRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKE :: :.. ..: ::.:. . ....: . .: . . :: :. .: CCDS82 MTIGRMENVEVFTAEGKGRGLKATKEFWAADIIFAERAYSAVVFDSLVNFVCHTCFKRQE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 KLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAP :: ::.::. :.::. ::: :: .:: ::. .: . : ...:: .:..... . CCDS82 KLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKR-YGKVPNENIRLAARIMWRVEREGT 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 SESEK-LYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFA . .: : : ::....... :.... :: : :: .. . :. :. . . :. CCDS82 GLTEGCLVSVDDLQNHVEHFGEEEQKDLRVDVDTFLQYWPPQSQQFSMQY----ISHIFG 120 130 140 150 160 170 180 190 200 210 220 230 pF1KB6 KVICNSFTICNAE-MQEVGVGLYPSISLLNHSCDPNCSIVFNGPHLLLRAVRDIEVGEEL . ::.::. . . .: ::::..:...:.::.: :::...::. .. :::. : :::: CCDS82 VINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGKIELRALGKISEGEEL 180 190 200 210 220 230 240 250 260 270 280 pF1KB6 TICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTG-------DEQVWKEV-- :. :.:.: .::::..::. :: :.: : .:: . :: :.. : ...: ::. CCDS82 TVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQKKLKD-DLFLGVKDNPKPSQEVVKEMIQ 240 250 260 270 280 290 290 300 310 320 330 340 pF1KB6 --QESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVLDCAMDACINLGLL ...:.::.. ... ...:. .:. . .. . : :::.:..:. . .. : . CCDS82 FSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNIYMLRMLSIVSEVLSYLQAF 300 310 320 330 340 350 350 360 370 380 390 400 pF1KB6 EEALFYGTRTMEPY-RIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMRVT ::: ::. : .. : ... :.. . :. ::..: . : : . . . :. :. :: CCDS82 EEASFYARRMVDGYMKLYHPNNAQL-GMAVMRAGLTNWHAGNIEVGHGMICKAYAILLVT 360 370 380 390 400 410 410 420 pF1KB6 HGREHSLIEDLILLLEECDANIRAS :: : . .:: . . . ..: CCDS82 HGPSHPITKDLEAMRVQTEMELRMFRQNEFMYYKMREAALNNQPMQVMAEPSNEPSPALF 420 430 440 450 460 470 >>CCDS33240.1 SMYD1 gene_id:150572|Hs108|chr2 (490 aa) initn: 710 init1: 241 opt: 455 Z-score: 472.9 bits: 96.8 E(32554): 5.1e-20 Smith-Waterman score: 789; 31.0% identity (62.7% similar) in 448 aa overlap (6-426:9-449) 10 20 30 40 50 pF1KB6 MEPLKVEKFATANRGNGLRAVTPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKE :: :.. ..: ::.:. . ....: . .: . . :: :. .: CCDS33 MTIGRMENVEVFTAEGKGRGLKATKEFWAADIIFAERAYSAVVFDSLVNFVCHTCFKRQE 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 KLMRCSQCRVAKYCSAKCQKKAWPDHKRECKCLKSCKPRYPPDSVRLLGRVVFKLMDGAP :: ::.::. :.::. ::: :: .:: ::. .: . : ...:: .:..... . CCDS33 KLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKR-YGKVPNENIRLAARIMWRVEREGT 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 SESEK-LYSFYDLESNINKLTEDKKEGLRQLVMTFQHFMREEIQDASQLPPAFDLFEAFA . .: : : ::....... :.... :: : :: .. . :. :. . . :. CCDS33 GLTEGCLVSVDDLQNHVEHFGEEEQKDLRVDVDTFLQYWPPQSQQFSMQY----ISHIFG 120 130 140 150 160 170 180 190 200 210 220 pF1KB6 KVICNSFTICNAE-MQEVGVGLYPSISLLNHSCDPNCSIVFN-GPH------------LL . ::.::. . . .: ::::..:...:.::.: :::...:: : : . CCDS33 VINCNGFTLSDQRGLQAVGVGIFPNLGLVNHDCWPNCTVIFNNGNHEAVKSMFHTQMRIE 180 190 200 210 220 230 230 240 250 260 270 pF1KB6 LRAVRDIEVGEELTICYLDMLMTSEERRKQLRDQYCFECDCFRCQTQDKDADMLTG---- :::. : :::::. :.:.: .::::..::. :: :.: : .:: . :: :.. : CCDS33 LRALGKISEGEELTVSYIDFLNVSEERKRQLKKQYYFDCTCEHCQKKLKD-DLFLGVKDN 240 250 260 270 280 290 280 290 300 310 320 330 pF1KB6 ---DEQVWKEV----QESLKKIEELKAHWKWEQVLAMCQAIISSNSERLPDINIYQLKVL ...: ::. ...:.::.. ... ...:. .:. . .. . : :::.:..: CCDS33 PKPSQEVVKEMIQFSKDTLEKIDKARSEGLYHEVVKLCRECLEKQEPVFADTNIYMLRML 300 310 320 330 340 350 340 350 360 370 380 390 pF1KB6 DCAMDACINLGLLEEALFYGTRTMEPY-RIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAM . . .. : .::: ::. : .. : ... :.. . :. ::..: . : : . . CCDS33 SIVSEVLSYLQAFEEASFYARRMVDGYMKLYHPNNAQL-GMAVMRAGLTNWHAGNIEVGH 360 370 380 390 400 410 400 410 420 pF1KB6 KNLRLAFDIMRVTHGREHSLIEDLILLLEECDANIRAS . :. :. :::: : . .:: . . . ..: CCDS33 GMICKAYAILLVTHGPSHPITKDLEAMRVQTEMELRMFRQNEFMYYKMREAALNNQPMQV 420 430 440 450 460 470 CCDS33 MAEPSNEPSPALFHKKQ 480 490 428 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 11:23:54 2016 done: Sat Nov 5 11:23:54 2016 Total Scan time: 2.570 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]