FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6698, 445 aa 1>>>pF1KB6698 445 - 445 aa - 445 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.3677+/-0.000381; mu= 17.6619+/- 0.024 mean_var=70.2920+/-13.659, 0's: 0 Z-trim(112.4): 68 B-trim: 147 in 1/52 Lambda= 0.152975 statistics sampled from 21301 (21369) to 21301 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.618), E-opt: 0.2 (0.251), width: 16 Scan time: 7.410 The best scores are: opt bits E(85289) NP_001060 (OMIM: 615101,615763) tubulin beta-2A ch ( 445) 2994 670.1 3.3e-192 NP_821080 (OMIM: 610031,612850) tubulin beta-2B ch ( 445) 2983 667.6 1.8e-191 NP_006079 (OMIM: 602660) tubulin beta-4B chain [Ho ( 445) 2910 651.5 1.3e-186 NP_006078 (OMIM: 602662) tubulin beta-4A chain iso ( 444) 2866 641.8 1e-183 NP_821133 (OMIM: 156610,191130,615771) tubulin bet ( 444) 2866 641.8 1e-183 NP_001276058 (OMIM: 602662) tubulin beta-4A chain ( 444) 2866 641.8 1e-183 NP_001276056 (OMIM: 602662) tubulin beta-4A chain ( 489) 2866 641.8 1.1e-183 NP_001276052 (OMIM: 602662) tubulin beta-4A chain ( 495) 2866 641.8 1.1e-183 NP_006077 (OMIM: 600638,602661,614039) tubulin bet ( 450) 2793 625.7 7.5e-179 NP_115914 (OMIM: 615103) tubulin beta-6 chain isof ( 446) 2745 615.1 1.1e-175 NP_001290453 (OMIM: 615103) tubulin beta-6 chain i ( 446) 2745 615.1 1.1e-175 NP_001280141 (OMIM: 156610,191130,615771) tubulin ( 464) 2741 614.2 2.2e-175 NP_817124 (OMIM: 616768,616780) tubulin beta-8 cha ( 444) 2711 607.6 2.1e-173 NP_001280143 (OMIM: 156610,191130,615771) tubulin ( 400) 2496 560.1 3.7e-159 NP_110400 (OMIM: 612901,613112) tubulin beta-1 cha ( 451) 2416 542.5 8.4e-154 NP_001276060 (OMIM: 602662) tubulin beta-4A chain ( 372) 2397 538.3 1.3e-152 NP_001280144 (OMIM: 156610,191130,615771) tubulin ( 372) 2397 538.3 1.3e-152 NP_001280145 (OMIM: 156610,191130,615771) tubulin ( 372) 2397 538.3 1.3e-152 NP_001276059 (OMIM: 602662) tubulin beta-4A chain ( 372) 2397 538.3 1.3e-152 NP_001297244 (OMIM: 615101,615763) tubulin beta-2A ( 360) 2356 529.2 6.7e-150 NP_001184110 (OMIM: 600638,602661,614039) tubulin ( 378) 2344 526.6 4.4e-149 NP_001290456 (OMIM: 615103) tubulin beta-6 chain i ( 374) 2319 521.1 2e-147 XP_011517761 (OMIM: 616768,616780) PREDICTED: tubu ( 372) 2293 515.3 1.1e-145 XP_016883574 (OMIM: 612901,613112) PREDICTED: tubu ( 429) 2262 508.5 1.4e-143 NP_001290457 (OMIM: 615103) tubulin beta-6 chain i ( 381) 2180 490.4 3.5e-138 NP_001290455 (OMIM: 615103) tubulin beta-6 chain i ( 409) 2171 488.4 1.5e-137 XP_016871681 (OMIM: 616768,616780) PREDICTED: tubu ( 332) 2015 453.9 2.8e-127 XP_016871682 (OMIM: 616768,616780) PREDICTED: tubu ( 332) 2015 453.9 2.8e-127 NP_001290458 (OMIM: 615103) tubulin beta-6 chain i ( 300) 1826 412.2 9.4e-115 NP_001290459 (OMIM: 615103) tubulin beta-6 chain i ( 300) 1826 412.2 9.4e-115 XP_011517762 (OMIM: 616768,616780) PREDICTED: tubu ( 291) 1637 370.5 3.3e-102 NP_006073 (OMIM: 602530) tubulin alpha-1B chain [H ( 451) 1277 291.1 3.9e-78 NP_006000 (OMIM: 602529,611603) tubulin alpha-1A c ( 451) 1269 289.4 1.3e-77 NP_001257328 (OMIM: 602529,611603) tubulin alpha-1 ( 451) 1269 289.4 1.3e-77 NP_005991 (OMIM: 191110,616208) tubulin alpha-4A c ( 448) 1267 288.9 1.8e-77 NP_005992 (OMIM: 602528) tubulin alpha-3C/D chain ( 450) 1258 286.9 7.1e-77 NP_061816 (OMIM: 605742,613180) tubulin alpha-8 ch ( 449) 1240 283.0 1.1e-75 NP_001265481 (OMIM: 191110,616208) tubulin alpha-4 ( 433) 1215 277.4 5e-74 NP_001257329 (OMIM: 602529,611603) tubulin alpha-1 ( 416) 1162 265.7 1.6e-70 NP_001180343 (OMIM: 605742,613180) tubulin alpha-8 ( 383) 1082 248.1 3.1e-65 NP_001061 (OMIM: 191135,615412) tubulin gamma-1 ch ( 451) 1006 231.3 4e-60 NP_057521 (OMIM: 605785) tubulin gamma-2 chain iso ( 451) 996 229.1 1.8e-59 NP_001280142 (OMIM: 156610,191130,615771) tubulin ( 242) 820 190.1 5.4e-48 XP_016860313 (OMIM: 191110,616208) PREDICTED: tubu ( 295) 767 178.5 2.1e-44 NP_001307438 (OMIM: 605785) tubulin gamma-2 chain ( 460) 625 147.2 8.2e-35 NP_001290454 (OMIM: 615103) tubulin beta-6 chain i ( 104) 568 134.3 1.5e-31 XP_011522916 (OMIM: 605785) PREDICTED: tubulin gam ( 298) 520 124.0 5.5e-28 XP_016879942 (OMIM: 605785) PREDICTED: tubulin gam ( 298) 520 124.0 5.5e-28 NP_057346 (OMIM: 607345) tubulin epsilon chain [Ho ( 475) 517 123.4 1.3e-27 XP_016879945 (OMIM: 605785) PREDICTED: tubulin gam ( 274) 480 115.1 2.3e-25 >>NP_001060 (OMIM: 615101,615763) tubulin beta-2A chain (445 aa) initn: 2994 init1: 2994 opt: 2994 Z-score: 3571.8 bits: 670.1 E(85289): 3.3e-192 Smith-Waterman score: 2994; 100.0% identity (100.0% similar) in 445 aa overlap (1-445:1-445) 10 20 30 40 50 60 pF1KB6 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 430 440 pF1KB6 EYQQYQDATADEQGEFEEEEGEDEA ::::::::::::::::::::::::: NP_001 EYQQYQDATADEQGEFEEEEGEDEA 430 440 >>NP_821080 (OMIM: 610031,612850) tubulin beta-2B chain (445 aa) initn: 2983 init1: 2983 opt: 2983 Z-score: 3558.6 bits: 667.6 E(85289): 1.8e-191 Smith-Waterman score: 2983; 99.6% identity (99.8% similar) in 445 aa overlap (1-445:1-445) 10 20 30 40 50 60 pF1KB6 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV ::::::::::::::::::::::::::::::::::::::::::::::::::::::.::::: NP_821 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_821 PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_821 RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_821 EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_821 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_821 AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_821 LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 430 440 pF1KB6 EYQQYQDATADEQGEFEEEEGEDEA ::::::::::::::::::::::::: NP_821 EYQQYQDATADEQGEFEEEEGEDEA 430 440 >>NP_006079 (OMIM: 602660) tubulin beta-4B chain [Homo s (445 aa) initn: 2910 init1: 2910 opt: 2910 Z-score: 3471.6 bits: 651.5 E(85289): 1.3e-186 Smith-Waterman score: 2910; 96.4% identity (99.1% similar) in 445 aa overlap (1-445:1-445) 10 20 30 40 50 60 pF1KB6 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV ::::::.:::::::::::::::::::::::::::.:::::::::::::::::::.:.::: NP_006 MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV :::.:::::::::::::::::::::::::::::::::::::::::::::.:::::::::: NP_006 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_006 EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: NP_006 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: NP_006 AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 430 440 pF1KB6 EYQQYQDATADEQGEFEEEEGEDEA ::::::::::.:.:::::: :. : NP_006 EYQQYQDATAEEEGEFEEEAEEEVA 430 440 >>NP_006078 (OMIM: 602662) tubulin beta-4A chain isoform (444 aa) initn: 2873 init1: 2841 opt: 2866 Z-score: 3419.1 bits: 641.8 E(85289): 1e-183 Smith-Waterman score: 2866; 95.1% identity (98.9% similar) in 445 aa overlap (1-445:1-444) 10 20 30 40 50 60 pF1KB6 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV ::::::.:::::::::::::::::::::::::::.:::::::::::::::::::.:..:: NP_006 MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV :::.::::::::::::::::::::::::::::::::::::::::::::::::::.::::: NP_006 PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV :::.::::::::::::::::::::::::::::::::::.::::::::::.:::::::::: NP_006 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_006 EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: NP_006 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG :::::::::::::::.:::::::::::::::.::.::::::::::::::::::::::::: NP_006 AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 430 440 pF1KB6 EYQQYQDATADEQGEFEEEEGEDEA :::::::::: :.:::::: :. : NP_006 EYQQYQDATA-EEGEFEEEAEEEVA 430 440 >>NP_821133 (OMIM: 156610,191130,615771) tubulin beta ch (444 aa) initn: 2863 init1: 2863 opt: 2866 Z-score: 3419.1 bits: 641.8 E(85289): 1e-183 Smith-Waterman score: 2866; 95.3% identity (99.1% similar) in 445 aa overlap (1-445:1-444) 10 20 30 40 50 60 pF1KB6 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV ::::::::::::::::::::::::::::::::::.:::::::::.::.::::::.:.::: NP_821 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_821 PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV :::.:::::::::::::::::::::::::::::::::::::::::::::.:::::::::: NP_821 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_821 EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM ::::::::::::::::::::::::::::::::::::::::::::::::::::.::.:::: NP_821 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG :::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::: NP_821 AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS :::..::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_821 LKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 430 440 pF1KB6 EYQQYQDATADEQGEFEEEEGEDEA ::::::::::.:. .: :: .:.:: NP_821 EYQQYQDATAEEEEDFGEE-AEEEA 430 440 >>NP_001276058 (OMIM: 602662) tubulin beta-4A chain isof (444 aa) initn: 2873 init1: 2841 opt: 2866 Z-score: 3419.1 bits: 641.8 E(85289): 1e-183 Smith-Waterman score: 2866; 95.1% identity (98.9% similar) in 445 aa overlap (1-445:1-444) 10 20 30 40 50 60 pF1KB6 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV ::::::.:::::::::::::::::::::::::::.:::::::::::::::::::.:..:: NP_001 MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV :::.::::::::::::::::::::::::::::::::::::::::::::::::::.::::: NP_001 PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV :::.::::::::::::::::::::::::::::::::::.::::::::::.:::::::::: NP_001 RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::::: NP_001 EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::: NP_001 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG :::::::::::::::.:::::::::::::::.::.::::::::::::::::::::::::: NP_001 AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS :::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 LKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 430 440 pF1KB6 EYQQYQDATADEQGEFEEEEGEDEA :::::::::: :.:::::: :. : NP_001 EYQQYQDATA-EEGEFEEEAEEEVA 430 440 >>NP_001276056 (OMIM: 602662) tubulin beta-4A chain isof (489 aa) initn: 2873 init1: 2841 opt: 2866 Z-score: 3418.5 bits: 641.8 E(85289): 1.1e-183 Smith-Waterman score: 2866; 95.1% identity (98.9% similar) in 445 aa overlap (1-445:46-489) 10 20 30 pF1KB6 MREIVHIQAGQCGNQIGAKFWEVISDEHGI ::::::.::::::::::::::::::::::: NP_001 AVSAASSTLAAAAAPRARATAAASTLSATAMREIVHLQAGQCGNQIGAKFWEVISDEHGI 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB6 DPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNF ::::.:::::::::::::::::::.:..:::::.:::::::::::::::::::::::::: NP_001 DPTGTYHGDSDLQLERINVYYNEATGGNYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNF 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB6 VFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTL ::::::::::::::::::::::::.::::::::.:::::::::::::::::::::::::: NP_001 VFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTL 140 150 160 170 180 190 160 170 180 190 200 210 pF1KB6 LISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEALYDI ::::::::.::::::::::.:::::::::::::::::::::::::::::: ::::::::: NP_001 LISKIREEFPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDI 200 210 220 230 240 250 220 230 240 250 260 270 pF1KB6 CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGF 260 270 280 290 300 310 280 290 300 310 320 330 pF1KB6 APLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQM :::::::::::::::::::::::::.:::::::::::::::::::.:::::::::::::: NP_001 APLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQM 320 330 340 350 360 370 340 350 360 370 380 390 pF1KB6 LNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFR :.::.::::::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_001 LSVQSKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQFTAMFR 380 390 400 410 420 430 400 410 420 430 440 pF1KB6 RKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA :::::::::::::::::::::::::::::::::::::::: :.:::::: :. : NP_001 RKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATA-EEGEFEEEAEEEVA 440 450 460 470 480 >>NP_001276052 (OMIM: 602662) tubulin beta-4A chain isof (495 aa) initn: 2873 init1: 2841 opt: 2866 Z-score: 3418.4 bits: 641.8 E(85289): 1.1e-183 Smith-Waterman score: 2866; 95.1% identity (98.9% similar) in 445 aa overlap (1-445:52-495) 10 20 30 pF1KB6 MREIVHIQAGQCGNQIGAKFWEVISDEHGI ::::::.::::::::::::::::::::::: NP_001 AVSAASSTLAAAAAPRARATAAASTLSATAMREIVHLQAGQCGNQIGAKFWEVISDEHGI 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB6 DPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNF ::::.:::::::::::::::::::.:..:::::.:::::::::::::::::::::::::: NP_001 DPTGTYHGDSDLQLERINVYYNEATGGNYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNF 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB6 VFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTL ::::::::::::::::::::::::.::::::::.:::::::::::::::::::::::::: NP_001 VFGQSGAGNNWAKGHYTEGAELVDAVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTL 150 160 170 180 190 200 160 170 180 190 200 210 pF1KB6 LISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEALYDI ::::::::.::::::::::.:::::::::::::::::::::::::::::: ::::::::: NP_001 LISKIREEFPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDI 210 220 230 240 250 260 220 230 240 250 260 270 pF1KB6 CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGF 270 280 290 300 310 320 280 290 300 310 320 330 pF1KB6 APLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQM :::::::::::::::::::::::::.:::::::::::::::::::.:::::::::::::: NP_001 APLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQM 330 340 350 360 370 380 340 350 360 370 380 390 pF1KB6 LNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFR :.::.::::::::::::::::::::::::::::.:::::::::::::::::::::::::: NP_001 LSVQSKNSSYFVEWIPNNVKTAVCDIPPRGLKMAATFIGNSTAIQELFKRISEQFTAMFR 390 400 410 420 430 440 400 410 420 430 440 pF1KB6 RKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA :::::::::::::::::::::::::::::::::::::::: :.:::::: :. : NP_001 RKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATA-EEGEFEEEAEEEVA 450 460 470 480 490 >>NP_006077 (OMIM: 600638,602661,614039) tubulin beta-3 (450 aa) initn: 2784 init1: 2784 opt: 2793 Z-score: 3331.9 bits: 625.7 E(85289): 7.5e-179 Smith-Waterman score: 2793; 91.9% identity (98.2% similar) in 446 aa overlap (1-445:1-446) 10 20 30 40 50 60 pF1KB6 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV ::::::::::::::::::::::::::::::::.:.: ::::::::::.::::::...::: NP_006 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV ::::::::::::::::::: ::..::::::.::::::::::::::::::::::::::::: NP_006 PRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV ::: :.::::::::::::::::::::::::::::.::::::::::::::.:::::::::: NP_006 RKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL ::::::::.::::::::::: ::::::::::::::::.:::::::::::::::::::: : NP_006 EPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM ::::::::::::::::::::::::::::::::::.::::::::::::::::::::.:::: NP_006 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG ::::::::::::::..::::::::::::::: .:.:::::::::::::::.::::::::: NP_006 AACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS ::::.::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 LKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 430 440 pF1KB6 EYQQYQDATADEQGE-FEEEEGEDEA ::::::::::.:.:: .:..: :.:: NP_006 EYQQYQDATAEEEGEMYEDDEEESEAQGPK 430 440 450 >>NP_115914 (OMIM: 615103) tubulin beta-6 chain isoform (446 aa) initn: 2725 init1: 2725 opt: 2745 Z-score: 3274.8 bits: 615.1 E(85289): 1.1e-175 Smith-Waterman score: 2745; 91.2% identity (97.1% similar) in 443 aa overlap (1-442:1-443) 10 20 30 40 50 60 pF1KB6 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV :::::::::::::::::.::::::::::::::.:.: ::: ::::::::::::....::: NP_115 MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV ::: :::::::::::::::::::.::::::.:::.:::::::::::::::::::.::::: NP_115 PRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDAVLDVV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV ::: : ::::::::::::::::::::::::::::::::.::::::::::::::::::::: NP_115 RKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVMPSPKVSDTVV 130 140 150 160 170 180 190 200 210 220 230 240 pF1KB6 EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL :::::::::::::::::::: ::::::::::::::::::::::::::::::::::::: : NP_115 EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSL 190 200 210 220 230 240 250 260 270 280 290 300 pF1KB6 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM :::::::::::::::::::::::::::::::::::::::::::::::::::::::..::: NP_115 RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDARNMM 250 260 270 280 290 300 310 320 330 340 350 360 pF1KB6 AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG ::::::::::::::..::: ::::::::::: .:.:::::::::::::::.::::::::: NP_115 AACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG 310 320 330 340 350 360 370 380 390 400 410 420 pF1KB6 LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS :::..::::::::::::::::::::.:::::::::::.:::::::::::::::::::::: NP_115 LKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVS 370 380 390 400 410 420 430 440 pF1KB6 EYQQYQDATADEQGE-FEEEEGEDEA ::::::::::.. : ::.:: : NP_115 EYQQYQDATANDGEEAFEDEEEEIDG 430 440 445 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 02:02:43 2016 done: Sat Nov 5 02:02:45 2016 Total Scan time: 7.410 Total Display time: 0.060 Function used was FASTA [36.3.4 Apr, 2011]