FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6709, 79 aa 1>>>pF1KB6709 79 - 79 aa - 79 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9337+/-0.000283; mu= 9.1421+/- 0.018 mean_var=55.0524+/-11.089, 0's: 0 Z-trim(118.4): 90 B-trim: 267 in 2/48 Lambda= 0.172857 statistics sampled from 31155 (31253) to 31155 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.767), E-opt: 0.2 (0.366), width: 16 Scan time: 3.960 The best scores are: opt bits E(85289) NP_003113 (OMIM: 167790,167800,608189) serine prot ( 79) 539 141.6 1.2e-34 NP_066937 (OMIM: 605753) serine protease inhibitor ( 84) 180 52.1 1.1e-07 NP_001258649 (OMIM: 605753) serine protease inhibi ( 119) 174 50.7 4.3e-07 NP_001258647 (OMIM: 605753) serine protease inhibi ( 134) 174 50.7 4.8e-07 NP_995313 (OMIM: 615868) serine protease inhibitor ( 80) 170 49.6 6.2e-07 NP_001182219 (OMIM: 615868) serine protease inhibi ( 80) 170 49.6 6.2e-07 NP_001035523 (OMIM: 613511) serine protease inhibi ( 86) 167 48.9 1.1e-06 XP_011532707 (OMIM: 605753) PREDICTED: serine prot ( 186) 169 49.6 1.5e-06 NP_006837 (OMIM: 147050,256500,605010) serine prot (1064) 162 48.2 2.2e-05 XP_011535853 (OMIM: 147050,256500,605010) PREDICTE (1066) 162 48.2 2.2e-05 NP_001121170 (OMIM: 147050,256500,605010) serine p (1094) 162 48.2 2.3e-05 NP_055286 (OMIM: 613929) serine protease inhibitor ( 86) 147 43.9 3.5e-05 XP_016865198 (OMIM: 613511) PREDICTED: serine prot ( 107) 145 43.5 6e-05 NP_001121171 (OMIM: 147050,256500,605010) serine p ( 916) 155 46.4 6.6e-05 XP_011539731 (OMIM: 103320,615120) PREDICTED: agri (2004) 153 46.1 0.00018 NP_940978 (OMIM: 103320,615120) agrin isoform 2 pr (2045) 153 46.1 0.00019 XP_005244806 (OMIM: 103320,615120) PREDICTED: agri (2049) 153 46.1 0.00019 NP_001292204 (OMIM: 103320,615120) agrin isoform 1 (2068) 153 46.1 0.00019 NP_001035218 (OMIM: 615205) serine protease inhibi ( 94) 136 41.2 0.00025 NP_003683 (OMIM: 603421) tomoregulin-1 precursor [ ( 380) 142 43.0 0.0003 NP_001292074 (OMIM: 605734) tomoregulin-2 isoform ( 175) 138 41.8 0.0003 XP_016859229 (OMIM: 605734) PREDICTED: tomoregulin ( 266) 138 41.9 0.00044 XP_016859228 (OMIM: 605734) PREDICTED: tomoregulin ( 337) 138 42.0 0.00053 NP_001292063 (OMIM: 605734) tomoregulin-2 isoform ( 346) 138 42.0 0.00054 XP_011509192 (OMIM: 605734) PREDICTED: tomoregulin ( 365) 138 42.0 0.00057 NP_057276 (OMIM: 605734) tomoregulin-2 isoform 1 p ( 374) 138 42.0 0.00058 >>NP_003113 (OMIM: 167790,167800,608189) serine protease (79 aa) initn: 539 init1: 539 opt: 539 Z-score: 742.9 bits: 141.6 E(85289): 1.2e-34 Smith-Waterman score: 539; 100.0% identity (100.0% similar) in 79 aa overlap (1-79:1-79) 10 20 30 40 50 60 pF1KB6 MKVTGIFLLSALALLSLSGNTGADSLGREAKCYNELNGCTKIYDPVCGTDGNTYPNECVL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MKVTGIFLLSALALLSLSGNTGADSLGREAKCYNELNGCTKIYDPVCGTDGNTYPNECVL 10 20 30 40 50 60 70 pF1KB6 CFENRKRQTSILIQKSGPC ::::::::::::::::::: NP_003 CFENRKRQTSILIQKSGPC 70 >>NP_066937 (OMIM: 605753) serine protease inhibitor Kaz (84 aa) initn: 184 init1: 167 opt: 180 Z-score: 258.6 bits: 52.1 E(85289): 1.1e-07 Smith-Waterman score: 180; 38.7% identity (65.3% similar) in 75 aa overlap (6-79:10-84) 10 20 30 40 50 pF1KB6 MKVTGIFLLSALALLSLSGNTGADSLGREAKCYN-ELNGCTKIYDPVCGTDGNTYP ..::.. :: . : : : .: . .: :: . ..::::.: .:: NP_066 MALSVLRLALLLLAVTFAASLIPQFGLFSKYRTPNCSQYRLPGCPRHFNPVCGSDMSTYA 10 20 30 40 50 60 60 70 pF1KB6 NECVLCFENRKRQTSILIQKSGPC :::.::.. :. .: : ..::: NP_066 NECTLCMKIREGGHNIKIIRNGPC 70 80 >>NP_001258649 (OMIM: 605753) serine protease inhibitor (119 aa) initn: 184 init1: 167 opt: 174 Z-score: 248.2 bits: 50.7 E(85289): 4.3e-07 Smith-Waterman score: 174; 41.5% identity (66.2% similar) in 65 aa overlap (16-79:55-119) 10 20 30 40 pF1KB6 MKVTGIFLLSALALLSLSGNTGADSLGREAKCYN-ELNGCTKIYD :: . : : : .: . .: :: . .. NP_001 PGERGPPEKSGFGSQTGGGPCPAPGGLGDASLIPQFGLFSKYRTPNCSQYRLPGCPRHFN 30 40 50 60 70 80 50 60 70 pF1KB6 PVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC ::::.: .:: :::.::.. :. .: : ..::: NP_001 PVCGSDMSTYANECTLCMKIREGGHNIKIIRNGPC 90 100 110 >>NP_001258647 (OMIM: 605753) serine protease inhibitor (134 aa) initn: 184 init1: 167 opt: 174 Z-score: 247.4 bits: 50.7 E(85289): 4.8e-07 Smith-Waterman score: 174; 41.5% identity (66.2% similar) in 65 aa overlap (16-79:70-134) 10 20 30 40 pF1KB6 MKVTGIFLLSALALLSLSGNTGADSLGREAKCYN-ELNGCTKIYD :: . : : : .: . .: :: . .. NP_001 TGGGPCPAPGGLGDGTRAPVTGGSPEDLPASLIPQFGLFSKYRTPNCSQYRLPGCPRHFN 40 50 60 70 80 90 50 60 70 pF1KB6 PVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC ::::.: .:: :::.::.. :. .: : ..::: NP_001 PVCGSDMSTYANECTLCMKIREGGHNIKIIRNGPC 100 110 120 130 >>NP_995313 (OMIM: 615868) serine protease inhibitor Kaz (80 aa) initn: 166 init1: 108 opt: 170 Z-score: 245.5 bits: 49.6 E(85289): 6.2e-07 Smith-Waterman score: 170; 37.3% identity (65.1% similar) in 83 aa overlap (1-79:1-80) 10 20 30 40 50 pF1KB6 MKVTGIFLLSALALLSLSGNTGADSLGREAKCYNELNG----CTKIYDPVCGTDGNTYPN ::..:.::: .:::. . ::. : : .. : .:.. ::. .: ::.::.:: : NP_995 MKLSGMFLLLSLALFCFL--TGVFSQGGQVDC-GEFQDPKVYCTRESNPHCGSDGQTYGN 10 20 30 40 50 60 70 pF1KB6 ECVLCFENRKRQTSILIQKSGPC .:..: : .: ... : : NP_995 KCAFCKAIVKSGGKISLKHPGKC 60 70 80 >>NP_001182219 (OMIM: 615868) serine protease inhibitor (80 aa) initn: 166 init1: 108 opt: 170 Z-score: 245.5 bits: 49.6 E(85289): 6.2e-07 Smith-Waterman score: 170; 37.3% identity (65.1% similar) in 83 aa overlap (1-79:1-80) 10 20 30 40 50 pF1KB6 MKVTGIFLLSALALLSLSGNTGADSLGREAKCYNELNG----CTKIYDPVCGTDGNTYPN ::..:.::: .:::. . ::. : : .. : .:.. ::. .: ::.::.:: : NP_001 MKLSGMFLLLSLALFCFL--TGVFSQGGQVDC-GEFQDPKVYCTRESNPHCGSDGQTYGN 10 20 30 40 50 60 70 pF1KB6 ECVLCFENRKRQTSILIQKSGPC .:..: : .: ... : : NP_001 KCAFCKAIVKSGGKISLKHPGKC 60 70 80 >>NP_001035523 (OMIM: 613511) serine protease inhibitor (86 aa) initn: 127 init1: 116 opt: 167 Z-score: 241.0 bits: 48.9 E(85289): 1.1e-06 Smith-Waterman score: 167; 32.6% identity (62.8% similar) in 86 aa overlap (1-79:1-86) 10 20 30 40 50 pF1KB6 MKVTGIFLLSALALLSLSGNTGADSLGREAKC--YNELNG-----CTKIYDPVCGTDGNT :..:.: :: ::.: .. . : . . . : :..: : ..:::.::.::.: NP_001 MRATAIVLLLALTLATMFSIECAKQTKQMVDCSHYKKLPPGQQRFCHHMYDPICGSDGKT 10 20 30 40 50 60 60 70 pF1KB6 YPNECVLCFENRKRQTSILIQKSGPC : :.: .: . .: . .. . . : : NP_001 YKNDCFFCSKVKKTDGTLKFVHFGKC 70 80 >>XP_011532707 (OMIM: 605753) PREDICTED: serine protease (186 aa) initn: 167 init1: 167 opt: 169 Z-score: 238.5 bits: 49.6 E(85289): 1.5e-06 Smith-Waterman score: 169; 41.8% identity (70.9% similar) in 55 aa overlap (26-79:132-186) 10 20 30 40 50 pF1KB6 MKVTGIFLLSALALLSLSGNTGADSLGREAKCYN-ELNGCTKIYDPVCGTDGNTY : . .: . .: :: . ..::::.: .:: XP_011 AQVTDRRGKTAGAGGGWRCRCCAWRCCSWQLPSQPNCSQYRLPGCPRHFNPVCGSDMSTY 110 120 130 140 150 160 60 70 pF1KB6 PNECVLCFENRKRQTSILIQKSGPC :::.::.. :. .: : ..::: XP_011 ANECTLCMKIREGGHNIKIIRNGPC 170 180 >>NP_006837 (OMIM: 147050,256500,605010) serine protease (1064 aa) initn: 367 init1: 150 opt: 162 Z-score: 217.5 bits: 48.2 E(85289): 2.2e-05 Smith-Waterman score: 162; 53.7% identity (68.3% similar) in 41 aa overlap (39-79:1006-1046) 10 20 30 40 50 60 pF1KB6 LSALALLSLSGNTGADSLGREAKCYNELNGCTKIYDPVCGTDGNTYPNECVLCFENRKRQ : : :::: ::.:: : :.:: :: :: NP_006 SQEEDSPDSFSSLDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQ 980 990 1000 1010 1020 1030 70 pF1KB6 TSILIQKSGPC :. :...: : NP_006 TNTHIRSTGKCEESSTPGTTAASMPPSDE 1040 1050 1060 >-- initn: 231 init1: 136 opt: 155 Z-score: 208.1 bits: 46.4 E(85289): 7.5e-05 Smith-Waterman score: 155; 48.8% identity (70.7% similar) in 41 aa overlap (39-79:111-151) 10 20 30 40 50 60 pF1KB6 LSALALLSLSGNTGADSLGREAKCYNELNGCTKIYDPVCGTDGNTYPNECVLCFENRKRQ : :. ::::::.:: :.:.:: :: : NP_006 RHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTG 90 100 110 120 130 140 70 pF1KB6 TSILIQKSGPC ..: ... : : NP_006 SQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAEL 150 160 170 180 190 200 >>XP_011535853 (OMIM: 147050,256500,605010) PREDICTED: s (1066 aa) initn: 367 init1: 150 opt: 162 Z-score: 217.5 bits: 48.2 E(85289): 2.2e-05 Smith-Waterman score: 162; 53.7% identity (68.3% similar) in 41 aa overlap (39-79:1008-1048) 10 20 30 40 50 60 pF1KB6 LSALALLSLSGNTGADSLGREAKCYNELNGCTKIYDPVCGTDGNTYPNECVLCFENRKRQ : : :::: ::.:: : :.:: :: :: XP_011 SQEEDSPDSFSSLDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQ 980 990 1000 1010 1020 1030 70 pF1KB6 TSILIQKSGPC :. :...: : XP_011 TNTHIRSTGKCEESSTPGTTAASMPPSDE 1040 1050 1060 >-- initn: 231 init1: 136 opt: 155 Z-score: 208.1 bits: 46.4 E(85289): 7.5e-05 Smith-Waterman score: 155; 48.8% identity (70.7% similar) in 41 aa overlap (39-79:83-123) 10 20 30 40 50 60 pF1KB6 LSALALLSLSGNTGADSLGREAKCYNELNGCTKIYDPVCGTDGNTYPNECVLCFENRKRQ : :. ::::::.:: :.:.:: :: : XP_011 RHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTG 60 70 80 90 100 110 70 pF1KB6 TSILIQKSGPC ..: ... : : XP_011 SQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAEL 120 130 140 150 160 170 79 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 23:30:03 2016 done: Fri Nov 4 23:30:04 2016 Total Scan time: 3.960 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]