FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6727, 92 aa 1>>>pF1KB6727 92 - 92 aa - 92 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.2491+/-0.000294; mu= 14.4018+/- 0.018 mean_var=53.7073+/-10.867, 0's: 0 Z-trim(118.0): 42 B-trim: 740 in 1/48 Lambda= 0.175008 statistics sampled from 30367 (30430) to 30367 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.762), E-opt: 0.2 (0.357), width: 16 Scan time: 3.650 The best scores are: opt bits E(85289) XP_016882363 (OMIM: 602359) PREDICTED: phospholemm ( 92) 608 160.4 3.8e-40 NP_068702 (OMIM: 602359) phospholemman precursor [ ( 92) 608 160.4 3.8e-40 NP_005022 (OMIM: 602359) phospholemman precursor [ ( 92) 608 160.4 3.8e-40 NP_001265646 (OMIM: 602359) phospholemman precurso ( 92) 608 160.4 3.8e-40 NP_001265647 (OMIM: 602359) phospholemman precurso ( 92) 608 160.4 3.8e-40 XP_016882364 (OMIM: 602359) PREDICTED: phospholemm ( 110) 608 160.5 4.3e-40 XP_016882365 (OMIM: 602359) PREDICTED: phospholemm ( 110) 608 160.5 4.3e-40 NP_001158303 (OMIM: 606683) FXYD domain-containing ( 95) 258 72.0 1.5e-13 NP_071286 (OMIM: 606683) FXYD domain-containing io ( 95) 258 72.0 1.5e-13 NP_001158304 (OMIM: 606683) FXYD domain-containing ( 95) 258 72.0 1.5e-13 NP_001158308 (OMIM: 606683) FXYD domain-containing ( 95) 258 72.0 1.5e-13 NP_001158309 (OMIM: 606683) FXYD domain-containing ( 95) 258 72.0 1.5e-13 NP_005962 (OMIM: 604996) FXYD domain-containing io ( 87) 211 60.1 5.4e-10 XP_016882366 (OMIM: 604996) PREDICTED: FXYD domain ( 87) 211 60.1 5.4e-10 XP_016882367 (OMIM: 604996) PREDICTED: FXYD domain ( 87) 211 60.1 5.4e-10 NP_001129483 (OMIM: 604996) FXYD domain-containing ( 87) 211 60.1 5.4e-10 NP_001129479 (OMIM: 604996) FXYD domain-containing ( 144) 211 60.3 7.9e-10 NP_001671 (OMIM: 154020,601814) sodium/potassium-t ( 66) 201 57.5 2.5e-09 NP_067614 (OMIM: 154020,601814) sodium/potassium-t ( 64) 194 55.7 8.4e-09 NP_775183 (OMIM: 616926) FXYD domain-containing io ( 89) 183 53.1 7.4e-08 NP_001171892 (OMIM: 616926) FXYD domain-containing ( 89) 183 53.1 7.4e-08 NP_071289 (OMIM: 606684) FXYD domain-containing io ( 80) 176 51.3 2.3e-07 NP_001129480 (OMIM: 604996) FXYD domain-containing ( 96) 159 47.0 5.2e-06 XP_005259053 (OMIM: 604996) PREDICTED: FXYD domain ( 113) 159 47.1 5.9e-06 NP_001129484 (OMIM: 604996) FXYD domain-containing ( 113) 159 47.1 5.9e-06 NP_068710 (OMIM: 604996) FXYD domain-containing io ( 113) 159 47.1 5.9e-06 XP_011525334 (OMIM: 604996) PREDICTED: FXYD domain ( 170) 159 47.3 8e-06 NP_001307842 (OMIM: 606669) FXYD domain-containing ( 147) 135 41.1 0.00048 NP_659003 (OMIM: 606669) FXYD domain-containing io ( 178) 135 41.2 0.00055 NP_001158077 (OMIM: 606669) FXYD domain-containing ( 178) 135 41.2 0.00055 NP_054883 (OMIM: 606669) FXYD domain-containing io ( 178) 135 41.2 0.00055 >>XP_016882363 (OMIM: 602359) PREDICTED: phospholemman i (92 aa) initn: 608 init1: 608 opt: 608 Z-score: 841.8 bits: 160.4 E(85289): 3.8e-40 Smith-Waterman score: 608; 100.0% identity (100.0% similar) in 92 aa overlap (1-92:1-92) 10 20 30 40 50 60 pF1KB6 MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRC 10 20 30 40 50 60 70 80 90 pF1KB6 RCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR :::::::::::::::::::::::::::::::: XP_016 RCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR 70 80 90 >>NP_068702 (OMIM: 602359) phospholemman precursor [Homo (92 aa) initn: 608 init1: 608 opt: 608 Z-score: 841.8 bits: 160.4 E(85289): 3.8e-40 Smith-Waterman score: 608; 100.0% identity (100.0% similar) in 92 aa overlap (1-92:1-92) 10 20 30 40 50 60 pF1KB6 MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_068 MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRC 10 20 30 40 50 60 70 80 90 pF1KB6 RCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR :::::::::::::::::::::::::::::::: NP_068 RCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR 70 80 90 >>NP_005022 (OMIM: 602359) phospholemman precursor [Homo (92 aa) initn: 608 init1: 608 opt: 608 Z-score: 841.8 bits: 160.4 E(85289): 3.8e-40 Smith-Waterman score: 608; 100.0% identity (100.0% similar) in 92 aa overlap (1-92:1-92) 10 20 30 40 50 60 pF1KB6 MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_005 MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRC 10 20 30 40 50 60 70 80 90 pF1KB6 RCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR :::::::::::::::::::::::::::::::: NP_005 RCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR 70 80 90 >>NP_001265646 (OMIM: 602359) phospholemman precursor [H (92 aa) initn: 608 init1: 608 opt: 608 Z-score: 841.8 bits: 160.4 E(85289): 3.8e-40 Smith-Waterman score: 608; 100.0% identity (100.0% similar) in 92 aa overlap (1-92:1-92) 10 20 30 40 50 60 pF1KB6 MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRC 10 20 30 40 50 60 70 80 90 pF1KB6 RCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR :::::::::::::::::::::::::::::::: NP_001 RCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR 70 80 90 >>NP_001265647 (OMIM: 602359) phospholemman precursor [H (92 aa) initn: 608 init1: 608 opt: 608 Z-score: 841.8 bits: 160.4 E(85289): 3.8e-40 Smith-Waterman score: 608; 100.0% identity (100.0% similar) in 92 aa overlap (1-92:1-92) 10 20 30 40 50 60 pF1KB6 MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRC 10 20 30 40 50 60 70 80 90 pF1KB6 RCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR :::::::::::::::::::::::::::::::: NP_001 RCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR 70 80 90 >>XP_016882364 (OMIM: 602359) PREDICTED: phospholemman i (110 aa) initn: 608 init1: 608 opt: 608 Z-score: 840.8 bits: 160.5 E(85289): 4.3e-40 Smith-Waterman score: 608; 100.0% identity (100.0% similar) in 92 aa overlap (1-92:19-110) 10 20 30 40 pF1KB6 MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLV :::::::::::::::::::::::::::::::::::::::::: XP_016 MWESKGTHCLIRGVPPRTMASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLV 10 20 30 40 50 60 50 60 70 80 90 pF1KB6 IAGILFILGILIVLSRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IAGILFILGILIVLSRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR 70 80 90 100 110 >>XP_016882365 (OMIM: 602359) PREDICTED: phospholemman i (110 aa) initn: 608 init1: 608 opt: 608 Z-score: 840.8 bits: 160.5 E(85289): 4.3e-40 Smith-Waterman score: 608; 100.0% identity (100.0% similar) in 92 aa overlap (1-92:19-110) 10 20 30 40 pF1KB6 MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLV :::::::::::::::::::::::::::::::::::::::::: XP_016 MWESKGTHCLIRGVPPRTMASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLV 10 20 30 40 50 60 50 60 70 80 90 pF1KB6 IAGILFILGILIVLSRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR :::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 IAGILFILGILIVLSRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR 70 80 90 100 110 >>NP_001158303 (OMIM: 606683) FXYD domain-containing ion (95 aa) initn: 305 init1: 238 opt: 258 Z-score: 364.0 bits: 72.0 E(85289): 1.5e-13 Smith-Waterman score: 258; 51.2% identity (75.6% similar) in 82 aa overlap (7-84:4-83) 10 20 30 40 50 pF1KB6 MASLGHILVFCVGLLT----MAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVL .::: .::. . ::. :: ::: ::::.:.:::::.: .:: .:::..: NP_001 MELVLVFLCSLLAPMVLASAAEKEKEMDPFHYDYQTLRIGGLVFAVVLFSVGILLIL 10 20 30 40 50 60 70 80 90 pF1KB6 SRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR ::::.:.:::. :. : .::. .. : NP_001 SRRCKCSFNQKPRA--PGDEEAQVENLITANATEPQKAEN 60 70 80 90 >>NP_071286 (OMIM: 606683) FXYD domain-containing ion tr (95 aa) initn: 305 init1: 238 opt: 258 Z-score: 364.0 bits: 72.0 E(85289): 1.5e-13 Smith-Waterman score: 258; 51.2% identity (75.6% similar) in 82 aa overlap (7-84:4-83) 10 20 30 40 50 pF1KB6 MASLGHILVFCVGLLT----MAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVL .::: .::. . ::. :: ::: ::::.:.:::::.: .:: .:::..: NP_071 MELVLVFLCSLLAPMVLASAAEKEKEMDPFHYDYQTLRIGGLVFAVVLFSVGILLIL 10 20 30 40 50 60 70 80 90 pF1KB6 SRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR ::::.:.:::. :. : .::. .. : NP_071 SRRCKCSFNQKPRA--PGDEEAQVENLITANATEPQKAEN 60 70 80 90 >>NP_001158304 (OMIM: 606683) FXYD domain-containing ion (95 aa) initn: 305 init1: 238 opt: 258 Z-score: 364.0 bits: 72.0 E(85289): 1.5e-13 Smith-Waterman score: 258; 51.2% identity (75.6% similar) in 82 aa overlap (7-84:4-83) 10 20 30 40 50 pF1KB6 MASLGHILVFCVGLLT----MAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVL .::: .::. . ::. :: ::: ::::.:.:::::.: .:: .:::..: NP_001 MELVLVFLCSLLAPMVLASAAEKEKEMDPFHYDYQTLRIGGLVFAVVLFSVGILLIL 10 20 30 40 50 60 70 80 90 pF1KB6 SRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR ::::.:.:::. :. : .::. .. : NP_001 SRRCKCSFNQKPRA--PGDEEAQVENLITANATEPQKAEN 60 70 80 90 92 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 23:38:43 2016 done: Fri Nov 4 23:38:43 2016 Total Scan time: 3.650 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]