FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6740, 142 aa 1>>>pF1KB6740 142 - 142 aa - 142 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7822+/-0.000377; mu= 13.1388+/- 0.023 mean_var=50.8275+/-10.180, 0's: 0 Z-trim(112.1): 17 B-trim: 539 in 1/52 Lambda= 0.179897 statistics sampled from 20919 (20932) to 20919 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.631), E-opt: 0.2 (0.245), width: 16 Scan time: 4.500 The best scores are: opt bits E(85289) NP_006692 (OMIM: 608572,611595) thioredoxin-like p ( 142) 976 260.9 5e-70 NP_001292486 (OMIM: 608572,611595) thioredoxin-lik ( 134) 905 242.5 1.7e-64 NP_001290400 (OMIM: 608572,611595) thioredoxin-lik ( 103) 614 166.9 7.2e-42 NP_001292492 (OMIM: 608572,611595) thioredoxin-lik ( 71) 487 133.9 4.4e-32 NP_001292493 (OMIM: 608572,611595) thioredoxin-lik ( 71) 487 133.9 4.4e-32 NP_003320 (OMIM: 187700) thioredoxin isoform 1 [Ho ( 105) 115 37.4 0.0071 NP_006532 (OMIM: 612754) glutaredoxin-3 isoform 1 ( 335) 120 38.9 0.0078 NP_001186797 (OMIM: 612754) glutaredoxin-3 isoform ( 335) 120 38.9 0.0078 >>NP_006692 (OMIM: 608572,611595) thioredoxin-like prote (142 aa) initn: 976 init1: 976 opt: 976 Z-score: 1378.3 bits: 260.9 E(85289): 5e-70 Smith-Waterman score: 976; 100.0% identity (100.0% similar) in 142 aa overlap (1-142:1-142) 10 20 30 40 50 60 pF1KB6 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYL 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 VDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 VDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVY 70 80 90 100 110 120 130 140 pF1KB6 RGARKGRGLVVSPKDYSTKYRY :::::::::::::::::::::: NP_006 RGARKGRGLVVSPKDYSTKYRY 130 140 >>NP_001292486 (OMIM: 608572,611595) thioredoxin-like pr (134 aa) initn: 617 init1: 617 opt: 905 Z-score: 1279.1 bits: 242.5 E(85289): 1.7e-64 Smith-Waterman score: 905; 94.4% identity (94.4% similar) in 142 aa overlap (1-142:1-134) 10 20 30 40 50 60 pF1KB6 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYL :::::::::::::::::::::::::::::::::::::::::::: :::::::: NP_001 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEV--------KNFAVIYL 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 VDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 VDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVY 60 70 80 90 100 110 130 140 pF1KB6 RGARKGRGLVVSPKDYSTKYRY :::::::::::::::::::::: NP_001 RGARKGRGLVVSPKDYSTKYRY 120 130 >>NP_001290400 (OMIM: 608572,611595) thioredoxin-like pr (103 aa) initn: 614 init1: 614 opt: 614 Z-score: 872.7 bits: 166.9 E(85289): 7.2e-42 Smith-Waterman score: 614; 100.0% identity (100.0% similar) in 91 aa overlap (52-142:13-103) 30 40 50 60 70 80 pF1KB6 EDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTV :::::::::::::::::::::::::::::: NP_001 MLLARKQILCVNVKNFAVIYLVDITEVPDFNKMYELYDPCTV 10 20 30 40 90 100 110 120 130 140 pF1KB6 MFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYR 50 60 70 80 90 100 pF1KB6 Y : NP_001 Y >>NP_001292492 (OMIM: 608572,611595) thioredoxin-like pr (71 aa) initn: 487 init1: 487 opt: 487 Z-score: 697.0 bits: 133.9 E(85289): 4.4e-32 Smith-Waterman score: 487; 100.0% identity (100.0% similar) in 71 aa overlap (72-142:1-71) 50 60 70 80 90 100 pF1KB6 DEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNK :::::::::::::::::::::::::::::: NP_001 MYELYDPCTVMFFFRNKHIMIDLGTGNNNK 10 20 30 110 120 130 140 pF1KB6 INWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY ::::::::::::::::::::::::::::::::::::::::: NP_001 INWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY 40 50 60 70 >>NP_001292493 (OMIM: 608572,611595) thioredoxin-like pr (71 aa) initn: 487 init1: 487 opt: 487 Z-score: 697.0 bits: 133.9 E(85289): 4.4e-32 Smith-Waterman score: 487; 100.0% identity (100.0% similar) in 71 aa overlap (72-142:1-71) 50 60 70 80 90 100 pF1KB6 DEVLYSIAEKVKNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNK :::::::::::::::::::::::::::::: NP_001 MYELYDPCTVMFFFRNKHIMIDLGTGNNNK 10 20 30 110 120 130 140 pF1KB6 INWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY ::::::::::::::::::::::::::::::::::::::::: NP_001 INWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKYRY 40 50 60 70 >>NP_003320 (OMIM: 187700) thioredoxin isoform 1 [Homo s (105 aa) initn: 47 init1: 36 opt: 115 Z-score: 172.6 bits: 37.4 E(85289): 0.0071 Smith-Waterman score: 115; 23.4% identity (60.7% similar) in 107 aa overlap (4-108:1-103) 10 20 30 40 50 60 pF1KB6 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYL :. .... ..:. . :..::. :. : : . ..:..:: .: ::.: NP_003 MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSN--VIFL 10 20 30 40 50 70 80 90 100 110 pF1KB6 -VDITEVPDFNKMYELYDPCTVMF-FFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIET ::. . : . :. : : ::.. . . ... .:..:.. .... NP_003 EVDVDDCQDVASECEV--KCMPTFQFFKKGQKVGEFSGANKEKLEATINELV 60 70 80 90 100 120 130 140 pF1KB6 VYRGARKGRGLVVSPKDYSTKYRY >>NP_006532 (OMIM: 612754) glutaredoxin-3 isoform 1 [Hom (335 aa) initn: 46 init1: 46 opt: 120 Z-score: 171.8 bits: 38.9 E(85289): 0.0078 Smith-Waterman score: 120; 24.4% identity (60.3% similar) in 78 aa overlap (13-90:21-97) 10 20 30 40 50 pF1KB6 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKV : .. . . ..:..: : : : .:.::. .:... NP_006 MAAGAAEAAVAAVEEVGSAGQFEELLRLKAKSLLVVHFWAPWAPQCAQMNEVMAELAKEL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 KNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEM . . . : . ::. .. ::. . : .:: ...: NP_006 PQVSFVKL-EAEGVPEVSEKYEISSVPTFLFFKNSQKIDRLDGAHAPELTKKVQRHASSG 70 80 90 100 110 120 130 140 pF1KB6 VDIIETVYRGARKGRGLVVSPKDYSTKYRY NP_006 SFLPSANEHLKEDLNLRLKKLTHAAPCMLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSF 120 130 140 150 160 170 >>NP_001186797 (OMIM: 612754) glutaredoxin-3 isoform 1 [ (335 aa) initn: 46 init1: 46 opt: 120 Z-score: 171.8 bits: 38.9 E(85289): 0.0078 Smith-Waterman score: 120; 24.4% identity (60.3% similar) in 78 aa overlap (13-90:21-97) 10 20 30 40 50 pF1KB6 MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKV : .. . . ..:..: : : : .:.::. .:... NP_001 MAAGAAEAAVAAVEEVGSAGQFEELLRLKAKSLLVVHFWAPWAPQCAQMNEVMAELAKEL 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 KNFAVIYLVDITEVPDFNKMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEM . . . : . ::. .. ::. . : .:: ...: NP_001 PQVSFVKL-EAEGVPEVSEKYEISSVPTFLFFKNSQKIDRLDGAHAPELTKKVQRHASSG 70 80 90 100 110 120 130 140 pF1KB6 VDIIETVYRGARKGRGLVVSPKDYSTKYRY NP_001 SFLPSANEHLKEDLNLRLKKLTHAAPCMLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSF 120 130 140 150 160 170 142 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 15:31:43 2016 done: Fri Nov 4 15:31:44 2016 Total Scan time: 4.500 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]