FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6745, 101 aa 1>>>pF1KB6745 101 - 101 aa - 101 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7337+/-0.000264; mu= 11.8371+/- 0.016 mean_var=51.0644+/-10.035, 0's: 0 Z-trim(119.7): 27 B-trim: 190 in 1/53 Lambda= 0.179480 statistics sampled from 33963 (33990) to 33963 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.782), E-opt: 0.2 (0.399), width: 16 Scan time: 4.360 The best scores are: opt bits E(85289) NP_002610 (OMIM: 173460) platelet factor 4 precurs ( 101) 657 176.9 5e-45 NP_002611 (OMIM: 173461) platelet factor 4 variant ( 104) 531 144.3 3.4e-35 XP_005265753 (OMIM: 173460) PREDICTED: platelet fa ( 110) 467 127.7 3.4e-30 NP_001502 (OMIM: 155730) growth-regulated alpha pr ( 107) 265 75.4 1.9e-14 NP_002985 (OMIM: 600324) C-X-C motif chemokine 5 p ( 114) 260 74.1 4.8e-14 NP_002695 (OMIM: 121010) platelet basic protein pr ( 128) 255 72.8 1.3e-13 NP_002984 (OMIM: 138965) C-X-C motif chemokine 6 p ( 114) 245 70.2 7.1e-13 NP_002080 (OMIM: 139110) C-X-C motif chemokine 2 p ( 107) 242 69.4 1.2e-12 NP_002081 (OMIM: 139111) C-X-C motif chemokine 3 p ( 107) 233 67.1 5.8e-12 NP_000575 (OMIM: 146930) interleukin-8 precursor [ ( 99) 190 55.9 1.2e-08 NP_001556 (OMIM: 147310) C-X-C motif chemokine 10 ( 98) 150 45.6 1.6e-05 NP_002407 (OMIM: 601704) C-X-C motif chemokine 9 p ( 125) 141 43.3 9.9e-05 NP_006410 (OMIM: 605149) C-X-C motif chemokine 13 ( 109) 130 40.4 0.00063 XP_006714126 (OMIM: 605149) PREDICTED: C-X-C motif ( 109) 130 40.4 0.00063 NP_002979 (OMIM: 603757) C-C motif chemokine 18 pr ( 89) 114 36.2 0.0094 >>NP_002610 (OMIM: 173460) platelet factor 4 precursor [ (101 aa) initn: 657 init1: 657 opt: 657 Z-score: 929.4 bits: 176.9 E(85289): 5e-45 Smith-Waterman score: 657; 100.0% identity (100.0% similar) in 101 aa overlap (1-101:1-101) 10 20 30 40 50 60 pF1KB6 MSSAAGFCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQVRPRHITSLEV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MSSAAGFCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQVRPRHITSLEV 10 20 30 40 50 60 70 80 90 100 pF1KB6 IKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES ::::::::::::::::::::::::::::::::::::::::: NP_002 IKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES 70 80 90 100 >>NP_002611 (OMIM: 173461) platelet factor 4 variant pre (104 aa) initn: 542 init1: 529 opt: 531 Z-score: 752.9 bits: 144.3 E(85289): 3.4e-35 Smith-Waterman score: 531; 84.6% identity (89.4% similar) in 104 aa overlap (1-101:1-104) 10 20 30 40 50 pF1KB6 MSSAAG---FCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQVRPRHITS ::::: :.: .:::.:::::.::::: ::::::::::::::::::::::::::: NP_002 MSSAARSRLTRATRQEMLFLALLLLPVVVAFARAEAEEDGDLQCLCVKTTSQVRPRHITS 10 20 30 40 50 60 60 70 80 90 100 pF1KB6 LEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES ::::::::::::::::::::::::::::::: :::::::. ::: NP_002 LEVIKAGPHCPTAQLIATLKNGRKICLDLQALLYKKIIKEHLES 70 80 90 100 >>XP_005265753 (OMIM: 173460) PREDICTED: platelet factor (110 aa) initn: 467 init1: 467 opt: 467 Z-score: 663.0 bits: 127.7 E(85289): 3.4e-30 Smith-Waterman score: 467; 100.0% identity (100.0% similar) in 71 aa overlap (31-101:40-110) 10 20 30 40 50 60 pF1KB6 MSSAAGFCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQVRPRHITSLEV :::::::::::::::::::::::::::::: XP_005 PAECLATVPGAAPAPPTWLEQLLSGGGVIYAEAEEDGDLQCLCVKTTSQVRPRHITSLEV 10 20 30 40 50 60 70 80 90 100 pF1KB6 IKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES ::::::::::::::::::::::::::::::::::::::::: XP_005 IKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES 70 80 90 100 110 >>NP_001502 (OMIM: 155730) growth-regulated alpha protei (107 aa) initn: 189 init1: 164 opt: 265 Z-score: 380.5 bits: 75.4 E(85289): 1.9e-14 Smith-Waterman score: 265; 46.6% identity (71.8% similar) in 103 aa overlap (1-101:1-103) 10 20 30 40 50 pF1KB6 MSSAAGFCA-SRPGLLFLGLLLLPLVVA-FASAEAEEDGDLQCLCVKTTSQVRPRHITSL :. :: : : : :: ..:::: ::.: .: : .:.: :..: . ..:..: :. NP_001 MARAALSAAPSNPRLLRVALLLLLLVAAGRRAAGASVATELRCQCLQTLQGIHPKNIQSV 10 20 30 40 50 60 60 70 80 90 100 pF1KB6 EVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES .: . :::: ...::::::::: ::. .:. ::::.:.:.: NP_001 NVKSPGPHCAQTEVIATLKNGRKACLNPASPIVKKIIEKMLNSDKSN 70 80 90 100 >>NP_002985 (OMIM: 600324) C-X-C motif chemokine 5 precu (114 aa) initn: 240 init1: 199 opt: 260 Z-score: 373.1 bits: 74.1 E(85289): 4.8e-14 Smith-Waterman score: 260; 40.2% identity (75.3% similar) in 97 aa overlap (4-100:15-108) 10 20 30 40 pF1KB6 MSSAAGFCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQ ....:: :..: :: : .: :. : .:.:.:..::. NP_002 MSLLSSRAARVPGPSSSLCAL---LVLLLLLTQPGPIASAGPAAAVLRELRCVCLQTTQG 10 20 30 40 50 50 60 70 80 90 100 pF1KB6 VRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES :.:. :..:.:. ::.: ....:.::::..:::: .::. ::.:.:.:. NP_002 VHPKMISNLQVFAIGPQCSKVEVVASLKNGKEICLDPEAPFLKKVIQKILDGGNKEN 60 70 80 90 100 110 >>NP_002695 (OMIM: 121010) platelet basic protein prepro (128 aa) initn: 245 init1: 212 opt: 255 Z-score: 365.3 bits: 72.8 E(85289): 1.3e-13 Smith-Waterman score: 255; 52.9% identity (80.0% similar) in 70 aa overlap (30-99:52-121) 10 20 30 40 50 pF1KB6 MSSAAGFCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQVRPRHITSLE : ... ..:.:.:.:::: ..:..: ::: NP_002 VLLLLSLLLTALASSTKGQTKRNLAKGKEESLDSDLYAELRCMCIKTTSGIHPKNIQSLE 30 40 50 60 70 80 60 70 80 90 100 pF1KB6 VIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES :: : :: ...:::::.::::::: .:: :::..: : NP_002 VIGKGTHCNQVEVIATLKDGRKICLDPDAPRIKKIVQKKLAGDESAD 90 100 110 120 >>NP_002984 (OMIM: 138965) C-X-C motif chemokine 6 precu (114 aa) initn: 238 init1: 166 opt: 245 Z-score: 352.1 bits: 70.2 E(85289): 7.1e-13 Smith-Waterman score: 245; 40.4% identity (72.7% similar) in 99 aa overlap (4-101:15-109) 10 20 30 40 pF1KB6 MSSAAGFCASRPGLLFLGLLLLPL-VVAFASAEAEEDGDLQCLCVKTTS ....:: :: : ::: : .: :. . .:.: :...: NP_002 MSLPSSRAARVPGPSGSLCA----LLALLLLLTPPGPLASAGPVSAVLTELRCTCLRVTL 10 20 30 40 50 50 60 70 80 90 100 pF1KB6 QVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES .: :. : .:.:. :::.: ....:.::::...::: .::. ::.:.:.:.: NP_002 RVNPKTIGKLQVFPAGPQCSKVEVVASLKNGKQVCLDPEAPFLKKVIQKILDSGNKKN 60 70 80 90 100 110 >>NP_002080 (OMIM: 139110) C-X-C motif chemokine 2 precu (107 aa) initn: 181 init1: 156 opt: 242 Z-score: 348.3 bits: 69.4 E(85289): 1.2e-12 Smith-Waterman score: 242; 44.1% identity (72.0% similar) in 93 aa overlap (10-101:11-103) 10 20 30 40 50 pF1KB6 MSSAAGFCASRPGLLFLGLLLLPLVVAFASAE-AEEDGDLQCLCVKTTSQVRPRHITSL : : :: ..:::: ::.: : : .:.: :..: . .. ..: :. NP_002 MARATLSAAPSNPRLLRVALLLLLLVAASRRAAGAPLATELRCQCLQTLQGIHLKNIQSV 10 20 30 40 50 60 60 70 80 90 100 pF1KB6 EVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES .: . :::: ...:::::::.: ::. .:. ::::.:.:.. NP_002 KVKSPGPHCAQTEVIATLKNGQKACLNPASPMVKKIIEKMLKNGKSN 70 80 90 100 >>NP_002081 (OMIM: 139111) C-X-C motif chemokine 3 precu (107 aa) initn: 176 init1: 151 opt: 233 Z-score: 335.7 bits: 67.1 E(85289): 5.8e-12 Smith-Waterman score: 233; 44.0% identity (71.4% similar) in 91 aa overlap (10-99:11-101) 10 20 30 40 50 pF1KB6 MSSAAGFCASRPGLLFLGLLLLPLVVAFASAE-AEEDGDLQCLCVKTTSQVRPRHITSL : : :: ..:::: ::.: : : .:.: :..: . .. ..: :. NP_002 MAHATLSAAPSNPRLLRVALLLLLLVAASRRAAGASVVTELRCQCLQTLQGIHLKNIQSV 10 20 30 40 50 60 60 70 80 90 100 pF1KB6 EVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES .: . :::: ...:::::::.: ::. .:. .:::.:.: NP_002 NVRSPGPHCAQTEVIATLKNGKKACLNPASPMVQKIIEKILNKGSTN 70 80 90 100 >>NP_000575 (OMIM: 146930) interleukin-8 precursor [Homo (99 aa) initn: 139 init1: 131 opt: 190 Z-score: 276.1 bits: 55.9 E(85289): 1.2e-08 Smith-Waterman score: 190; 29.3% identity (71.7% similar) in 92 aa overlap (10-100:3-94) 10 20 30 40 50 pF1KB6 MSSAAGFCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQ-VRPRHITSLE :. .. .:. .:. .. ... . .:.: :.:: :. .:. : :. NP_000 MTSKLAVALLAAFLISAALCEGAVLPRSAKELRCQCIKTYSKPFHPKFIKELR 10 20 30 40 50 60 70 80 90 100 pF1KB6 VIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES ::..:::: ....:. :..::..::: . .....:.:. NP_000 VIESGPHCANTEIIVKLSDGRELCLDPKENWVQRVVEKFLKRAENS 60 70 80 90 101 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 18:17:03 2016 done: Sat Nov 5 18:17:03 2016 Total Scan time: 4.360 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]