FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6770, 150 aa 1>>>pF1KB6770 150 - 150 aa - 150 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.2879+/-0.000377; mu= 11.7006+/- 0.023 mean_var=60.6714+/-12.216, 0's: 0 Z-trim(112.6): 6 B-trim: 0 in 0/53 Lambda= 0.164658 statistics sampled from 21598 (21604) to 21598 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.647), E-opt: 0.2 (0.253), width: 16 Scan time: 4.690 The best scores are: opt bits E(85289) NP_002592 (OMIM: 602676,615665) retinal rod rhodop ( 150) 993 244.1 6.4e-65 XP_011509644 (OMIM: 602676,615665) PREDICTED: reti ( 131) 865 213.7 8.1e-56 NP_001277947 (OMIM: 602676,615665) retinal rod rho ( 93) 585 147.1 6.3e-36 NP_001317095 (OMIM: 604011,615518) protein unc-119 ( 145) 134 40.0 0.0017 NP_005139 (OMIM: 604011,615518) protein unc-119 ho ( 240) 134 40.1 0.0026 NP_473376 (OMIM: 604011,615518) protein unc-119 ho ( 220) 127 38.4 0.0076 >>NP_002592 (OMIM: 602676,615665) retinal rod rhodopsin- (150 aa) initn: 993 init1: 993 opt: 993 Z-score: 1286.5 bits: 244.1 E(85289): 6.4e-65 Smith-Waterman score: 993; 100.0% identity (100.0% similar) in 150 aa overlap (1-150:1-150) 10 20 30 40 50 60 pF1KB6 MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 RELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPA 70 80 90 100 110 120 130 140 150 pF1KB6 SVLTGNVIIETKFFDDDLLVSTSRVRLFYV :::::::::::::::::::::::::::::: NP_002 SVLTGNVIIETKFFDDDLLVSTSRVRLFYV 130 140 150 >>XP_011509644 (OMIM: 602676,615665) PREDICTED: retinal (131 aa) initn: 865 init1: 865 opt: 865 Z-score: 1123.1 bits: 213.7 E(85289): 8.1e-56 Smith-Waterman score: 865; 100.0% identity (100.0% similar) in 131 aa overlap (20-150:1-131) 10 20 30 40 50 60 pF1KB6 MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVS ::::::::::::::::::::::::::::::::::::::::: XP_011 MNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVS 10 20 30 40 70 80 90 100 110 120 pF1KB6 RELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 RELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPA 50 60 70 80 90 100 130 140 150 pF1KB6 SVLTGNVIIETKFFDDDLLVSTSRVRLFYV :::::::::::::::::::::::::::::: XP_011 SVLTGNVIIETKFFDDDLLVSTSRVRLFYV 110 120 130 >>NP_001277947 (OMIM: 602676,615665) retinal rod rhodops (93 aa) initn: 585 init1: 585 opt: 585 Z-score: 766.0 bits: 147.1 E(85289): 6.3e-36 Smith-Waterman score: 585; 100.0% identity (100.0% similar) in 88 aa overlap (1-88:1-88) 10 20 30 40 50 60 pF1KB6 MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVS 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 RELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPA :::::::::::::::::::::::::::: NP_001 RELNFSSTEQMEKFRLEQKVYFKGQCLEVGTLS 70 80 90 >>NP_001317095 (OMIM: 604011,615518) protein unc-119 hom (145 aa) initn: 121 init1: 104 opt: 134 Z-score: 183.9 bits: 40.0 E(85289): 0.0017 Smith-Waterman score: 134; 26.3% identity (60.6% similar) in 99 aa overlap (54-149:43-141) 30 40 50 60 70 80 pF1KB6 DAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVSRELNFSSTEQ-MEKFRLEQKVYF :. . :. ..:. .. ...::. .. :: NP_001 PPVSERLPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYF 20 30 40 50 60 70 90 100 110 120 130 140 pF1KB6 KGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETK--FFDDDLLV ..: :. . :.::: ::.: :: . . . : :. . . .. .. .: :: :: NP_001 RNQLLKSFDFHFGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDSFYFVDDRLV 80 90 100 110 120 130 150 pF1KB6 STSRVRLFYV ... : NP_001 MHNKADYSYSGTP 140 >>NP_005139 (OMIM: 604011,615518) protein unc-119 homolo (240 aa) initn: 138 init1: 104 opt: 134 Z-score: 180.5 bits: 40.1 E(85289): 0.0026 Smith-Waterman score: 136; 22.9% identity (57.5% similar) in 153 aa overlap (15-149:84-236) 10 20 30 pF1KB6 MSAKDERAREILRGFKLNWM--NLRDAETGKILWQG-----TED .:.... ..:: ..: .:.. .: NP_005 LQRKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPVSER 60 70 80 90 100 110 40 50 60 70 80 pF1KB6 LSV------PGVEHEARVP--KKILKCKAVSRELNFSSTEQ-MEKFRLEQKVYFKGQCLE : . :.. . .: .:. . :. ..:. .. ...::. .. ::..: :. NP_005 LPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLK 120 130 140 150 160 170 90 100 110 120 130 140 pF1KB6 EWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETK--FFDDDLLVSTSRVR . :.::: ::.: :: . . . : :. . . .. .. .: :: :: ... NP_005 SFDFHFGFCIPSSKNTCEHIYDFPPLSEELISEMIRHPYETQSDSFYFVDDRLVMHNKAD 180 190 200 210 220 230 150 pF1KB6 LFYV : NP_005 YSYSGTP 240 >>NP_473376 (OMIM: 604011,615518) protein unc-119 homolo (220 aa) initn: 121 init1: 104 opt: 127 Z-score: 172.1 bits: 38.4 E(85289): 0.0076 Smith-Waterman score: 129; 24.6% identity (60.7% similar) in 122 aa overlap (15-120:84-205) 10 20 30 pF1KB6 MSAKDERAREILRGFKLNWM--NLRDAETGKILWQG-----TED .:.... ..:: ..: .:.. .: NP_473 LQRKQPIGPEDVLGLQRITGDYLCSPEENIYKIDFVRFKIRDMDSGTVLFEIKKPPVSER 60 70 80 90 100 110 40 50 60 70 80 pF1KB6 LSV------PGVEHEARVP--KKILKCKAVSRELNFSSTEQ-MEKFRLEQKVYFKGQCLE : . :.. . .: .:. . :. ..:. .. ...::. .. ::..: :. NP_473 LPINRRDLDPNAGRFVRYQFTPAFLRLRQVGATVEFTVGDKPVNNFRMIERHYFRNQLLK 120 130 140 150 160 170 90 100 110 120 130 140 pF1KB6 EWFFEFGFVIPNSTNTWQSLIEAAPESQMMPASVLTGNVIIETKFFDDDLLVSTSRVRLF . :.::: ::.: :: . . . : :. . : NP_473 SFDFHFGFCIPSSKNTCEHIYDFPPLSEELSARAGSSGSGEVGASRD 180 190 200 210 220 150 pF1KB6 YV 150 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 23:55:55 2016 done: Fri Nov 4 23:55:55 2016 Total Scan time: 4.690 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]