FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6771, 118 aa 1>>>pF1KB6771 118 - 118 aa - 118 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.3793+/-0.000232; mu= 8.6516+/- 0.015 mean_var=112.4185+/-21.862, 0's: 0 Z-trim(125.6): 16 B-trim: 0 in 0/59 Lambda= 0.120964 statistics sampled from 49656 (49674) to 49656 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.862), E-opt: 0.2 (0.582), width: 16 Scan time: 4.450 The best scores are: opt bits E(85289) NP_001317054 (OMIM: 185881) vesicle-associated mem ( 118) 765 142.1 2e-34 NP_055047 (OMIM: 185881) vesicle-associated membra ( 116) 743 138.2 2.9e-33 NP_055046 (OMIM: 108600,185880) vesicle-associated ( 118) 608 114.7 3.6e-26 NP_058439 (OMIM: 108600,185880) vesicle-associated ( 116) 586 110.8 5.1e-25 NP_001284367 (OMIM: 108600,185880) vesicle-associa ( 116) 586 110.8 5.1e-25 NP_954740 (OMIM: 108600,185880) vesicle-associated ( 117) 586 110.8 5.1e-25 NP_004772 (OMIM: 603657) vesicle-associated membra ( 100) 461 89.0 1.7e-18 XP_016858330 (OMIM: 603657) PREDICTED: vesicle-ass ( 122) 461 89.0 2e-18 NP_001172056 (OMIM: 606909) vesicle-associated mem ( 140) 269 55.6 2.7e-08 NP_003753 (OMIM: 606909) vesicle-associated membra ( 141) 269 55.6 2.7e-08 NP_003752 (OMIM: 603177) vesicle-associated membra ( 100) 235 49.5 1.3e-06 NP_006625 (OMIM: 607029) vesicle-associated membra ( 116) 201 43.6 8.6e-05 XP_016885552 (OMIM: 300053) PREDICTED: vesicle-ass ( 173) 179 39.9 0.0017 XP_016885249 (OMIM: 300053) PREDICTED: vesicle-ass ( 173) 179 39.9 0.0017 NP_001138621 (OMIM: 300053) vesicle-associated mem ( 179) 179 39.9 0.0017 NP_005629 (OMIM: 300053) vesicle-associated membra ( 220) 179 40.0 0.002 >>NP_001317054 (OMIM: 185881) vesicle-associated membran (118 aa) initn: 765 init1: 765 opt: 765 Z-score: 738.9 bits: 142.1 E(85289): 2e-34 Smith-Waterman score: 765; 100.0% identity (100.0% similar) in 118 aa overlap (1-118:1-118) 10 20 30 40 50 60 pF1KB6 MDRSATAATAPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MDRSATAATAPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQ 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 KLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 KLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFST 70 80 90 100 110 >>NP_055047 (OMIM: 185881) vesicle-associated membrane p (116 aa) initn: 743 init1: 743 opt: 743 Z-score: 718.2 bits: 138.2 E(85289): 2.9e-33 Smith-Waterman score: 743; 100.0% identity (100.0% similar) in 115 aa overlap (4-118:2-116) 10 20 30 40 50 60 pF1KB6 MDRSATAATAPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQ ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 MSATAATAPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQ 10 20 30 40 50 70 80 90 100 110 pF1KB6 KLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFST :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_055 KLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFST 60 70 80 90 100 110 >>NP_055046 (OMIM: 108600,185880) vesicle-associated mem (118 aa) initn: 628 init1: 597 opt: 608 Z-score: 590.8 bits: 114.7 E(85289): 3.6e-26 Smith-Waterman score: 608; 77.8% identity (90.6% similar) in 117 aa overlap (6-118:2-118) 10 20 30 40 50 pF1KB6 MDRSATAATAPPA----APAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVL .: . ::: . : ::::.::::.:::::::::::::.:::::.:::::::: NP_055 MSAPAQPPAEGTEGTAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIIRVNVDKVL 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 ERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYF ::::::::::::::::::::::::.::::::::::::: ::::.::.:::::...:..:: NP_055 ERDQKLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVIYF 60 70 80 90 100 110 pF1KB6 ST : NP_055 FT >>NP_058439 (OMIM: 108600,185880) vesicle-associated mem (116 aa) initn: 606 init1: 575 opt: 586 Z-score: 570.1 bits: 110.8 E(85289): 5.1e-25 Smith-Waterman score: 586; 78.6% identity (91.1% similar) in 112 aa overlap (6-113:2-113) 10 20 30 40 50 pF1KB6 MDRSATAATAPPA----APAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVL .: . ::: . : ::::.::::.:::::::::::::.:::::.:::::::: NP_058 MSAPAQPPAEGTEGTAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIIRVNVDKVL 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 ERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYF ::::::::::::::::::::::::.::::::::::::: ::::.::.:::::...:. NP_058 ERDQKLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVRRD 60 70 80 90 100 110 pF1KB6 ST >>NP_001284367 (OMIM: 108600,185880) vesicle-associated (116 aa) initn: 606 init1: 575 opt: 586 Z-score: 570.1 bits: 110.8 E(85289): 5.1e-25 Smith-Waterman score: 586; 78.6% identity (91.1% similar) in 112 aa overlap (6-113:2-113) 10 20 30 40 50 pF1KB6 MDRSATAATAPPA----APAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVL .: . ::: . : ::::.::::.:::::::::::::.:::::.:::::::: NP_001 MSAPAQPPAEGTEGTAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIIRVNVDKVL 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 ERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYF ::::::::::::::::::::::::.::::::::::::: ::::.::.:::::...:. NP_001 ERDQKLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVRRG 60 70 80 90 100 110 pF1KB6 ST >>NP_954740 (OMIM: 108600,185880) vesicle-associated mem (117 aa) initn: 606 init1: 575 opt: 586 Z-score: 570.1 bits: 110.8 E(85289): 5.1e-25 Smith-Waterman score: 586; 78.6% identity (91.1% similar) in 112 aa overlap (6-113:2-113) 10 20 30 40 50 pF1KB6 MDRSATAATAPPA----APAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVL .: . ::: . : ::::.::::.:::::::::::::.:::::.:::::::: NP_954 MSAPAQPPAEGTEGTAPGGGPPGPPPNMTSNRRLQQTQAQVEEVVDIIRVNVDKVL 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 ERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYF ::::::::::::::::::::::::.::::::::::::: ::::.::.:::::...:. NP_954 ERDQKLSELDDRADALQAGASQFESSAAKLKRKYWWKNCKMMIMLGAICAIIVVVIVSKY 60 70 80 90 100 110 pF1KB6 ST NP_954 R >>NP_004772 (OMIM: 603657) vesicle-associated membrane p (100 aa) initn: 491 init1: 455 opt: 461 Z-score: 453.1 bits: 89.0 E(85289): 1.7e-18 Smith-Waterman score: 461; 81.3% identity (85.7% similar) in 91 aa overlap (24-114:5-94) 10 20 30 40 50 60 pF1KB6 MDRSATAATAPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQ : ::::::::: ::::::::::::::::::::: NP_004 MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQ 10 20 30 40 70 80 90 100 110 pF1KB6 KLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFST :::::::::::::::::::::::::::::::::: :: : :. .:.::::. NP_004 KLSELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAI-GITVLVIFIIIIIVWVVSS 50 60 70 80 90 100 >>XP_016858330 (OMIM: 603657) PREDICTED: vesicle-associa (122 aa) initn: 459 init1: 448 opt: 461 Z-score: 451.9 bits: 89.0 E(85289): 2e-18 Smith-Waterman score: 461; 81.3% identity (85.7% similar) in 91 aa overlap (24-114:5-94) 10 20 30 40 50 60 pF1KB6 MDRSATAATAPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVDIMRVNVDKVLERDQ : ::::::::: ::::::::::::::::::::: XP_016 MSTGPTAATGSNRRLQQTQNQVDEVVDIMRVNVDKVLERDQ 10 20 30 40 70 80 90 100 110 pF1KB6 KLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICAIILIIIIVYFST :::::::::::::::::::::::::::::::::: :: : :. .:.::::. XP_016 KLSELDDRADALQAGASQFETSAAKLKRKYWWKNCKMWAI-GITVLVIFIIIIIGELPFS 50 60 70 80 90 100 XP_016 KLIGKVFSMCSQTIDFVYKNSD 110 120 >>NP_001172056 (OMIM: 606909) vesicle-associated membran (140 aa) initn: 255 init1: 242 opt: 269 Z-score: 270.0 bits: 55.6 E(85289): 2.7e-08 Smith-Waterman score: 269; 36.7% identity (76.5% similar) in 98 aa overlap (17-114:39-132) 10 20 30 40 pF1KB6 MDRSATAATAPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVD : .:: : : .....: :::::.: NP_001 LNDDDVTGSVKSERRNLLEDDSDEEEDFFLGPSGPRFGP----RNDKIKHVQNQVDEVID 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB6 IMRVNVDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICA .:. :. ::.:: ..:.::.:....:. .:. : . . .:.:..::.. :. :.... : NP_001 VMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALVAA 70 80 90 100 110 120 110 pF1KB6 IILIIIIVYFST :.:..::. NP_001 ILLLVIIILIVMKYRT 130 140 >>NP_003753 (OMIM: 606909) vesicle-associated membrane p (141 aa) initn: 255 init1: 242 opt: 269 Z-score: 270.0 bits: 55.6 E(85289): 2.7e-08 Smith-Waterman score: 269; 36.7% identity (76.5% similar) in 98 aa overlap (17-114:40-133) 10 20 30 40 pF1KB6 MDRSATAATAPPAAPAGEGGPPAPPPNLTSNRRLQQTQAQVDEVVD : .:: : : .....: :::::.: NP_003 NDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGP----RNDKIKHVQNQVDEVID 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB6 IMRVNVDKVLERDQKLSELDDRADALQAGASQFETSAAKLKRKYWWKNLKMMIILGVICA .:. :. ::.:: ..:.::.:....:. .:. : . . .:.:..::.. :. :.... : NP_003 VMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIMALVAA 70 80 90 100 110 120 110 pF1KB6 IILIIIIVYFST :.:..::. NP_003 ILLLVIIILIVMKYRT 130 140 118 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 23:56:33 2016 done: Fri Nov 4 23:56:34 2016 Total Scan time: 4.450 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]