FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6772, 151 aa 1>>>pF1KB6772 151 - 151 aa - 151 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9497+/-0.000353; mu= 14.1505+/- 0.022 mean_var=76.8560+/-15.586, 0's: 0 Z-trim(113.8): 98 B-trim: 10 in 1/56 Lambda= 0.146297 statistics sampled from 23128 (23256) to 23128 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.667), E-opt: 0.2 (0.273), width: 16 Scan time: 4.950 The best scores are: opt bits E(85289) NP_066299 (OMIM: 609931) myosin light polypeptide ( 151) 1003 220.7 7.3e-58 NP_524147 (OMIM: 609931) myosin light polypeptide ( 151) 974 214.5 5.1e-56 NP_001186558 (OMIM: 609930) myosin light chain 6B ( 208) 829 184.1 1.1e-46 NP_002466 (OMIM: 609930) myosin light chain 6B [Ho ( 208) 829 184.1 1.1e-46 NP_001002841 (OMIM: 160770) myosin light chain 4 [ ( 197) 790 175.8 3e-44 XP_005257448 (OMIM: 160770) PREDICTED: myosin ligh ( 197) 790 175.8 3e-44 NP_002467 (OMIM: 160770) myosin light chain 4 [Hom ( 197) 790 175.8 3e-44 NP_524146 (OMIM: 160780) myosin light chain 1/3, s ( 150) 763 170.0 1.3e-42 XP_016880172 (OMIM: 160770) PREDICTED: myosin ligh ( 228) 757 168.9 4.2e-42 XP_011523141 (OMIM: 160770) PREDICTED: myosin ligh ( 228) 757 168.9 4.2e-42 XP_016880173 (OMIM: 160770) PREDICTED: myosin ligh ( 228) 757 168.9 4.2e-42 NP_524144 (OMIM: 160780) myosin light chain 1/3, s ( 194) 754 168.2 5.8e-42 NP_000249 (OMIM: 160790,608751) myosin light chain ( 195) 752 167.8 7.8e-42 NP_005176 (OMIM: 114184) calmodulin-like protein 3 ( 149) 430 99.7 1.9e-21 NP_001316851 (OMIM: 114183) calmodulin isoform 1 [ ( 149) 428 99.3 2.5e-21 NP_008819 (OMIM: 114180,614916,616247) calmodulin ( 149) 428 99.3 2.5e-21 NP_005175 (OMIM: 114183) calmodulin isoform 1 [Hom ( 149) 428 99.3 2.5e-21 NP_001734 (OMIM: 114182,616249) calmodulin isoform ( 149) 428 99.3 2.5e-21 XP_006720321 (OMIM: 114180,614916,616247) PREDICTE ( 150) 426 98.9 3.3e-21 NP_001292553 (OMIM: 114182,616249) calmodulin isof ( 197) 426 99.0 4.1e-21 NP_001316850 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 302 72.6 2.1e-13 NP_001316853 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 302 72.6 2.1e-13 NP_001316852 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 302 72.6 2.1e-13 NP_001292554 (OMIM: 114182,616249) calmodulin isof ( 113) 302 72.6 2.1e-13 NP_001316854 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 302 72.6 2.1e-13 NP_001316855 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 302 72.6 2.1e-13 NP_001292555 (OMIM: 114182,616249) calmodulin isof ( 113) 302 72.6 2.1e-13 NP_003270 (OMIM: 191039) troponin C, skeletal musc ( 160) 300 72.3 3.5e-13 XP_011527333 (OMIM: 191039) PREDICTED: troponin C, ( 145) 290 70.1 1.4e-12 NP_003271 (OMIM: 191040,611879,613243) troponin C, ( 161) 276 67.2 1.2e-11 NP_004057 (OMIM: 603187) centrin-1 [Homo sapiens] ( 172) 260 63.9 1.3e-10 NP_059118 (OMIM: 605183) calmodulin-like protein 5 ( 146) 245 60.7 1e-09 NP_004335 (OMIM: 300006) centrin-2 [Homo sapiens] ( 172) 245 60.7 1.2e-09 NP_004356 (OMIM: 602907) centrin-3 isoform 2 [Homo ( 167) 243 60.3 1.5e-09 NP_057450 (OMIM: 607314,614899) calcium-binding pr ( 220) 238 59.3 3.9e-09 NP_001305425 (OMIM: 607314,614899) calcium-binding ( 226) 238 59.3 4e-09 NP_001317242 (OMIM: 610171) calmodulin-like protei ( 164) 235 58.6 4.9e-09 NP_619650 (OMIM: 610171) calmodulin-like protein 6 ( 181) 235 58.6 5.2e-09 XP_005244786 (OMIM: 610171) PREDICTED: calmodulin- ( 203) 235 58.7 5.7e-09 NP_001138417 (OMIM: 609211) myosin regulatory ligh ( 172) 225 56.5 2.2e-08 NP_001138416 (OMIM: 609211) myosin regulatory ligh ( 172) 225 56.5 2.2e-08 NP_291024 (OMIM: 609211) myosin regulatory light c ( 172) 225 56.5 2.2e-08 NP_062829 (OMIM: 607315) calcium-binding protein 5 ( 173) 220 55.4 4.5e-08 NP_006088 (OMIM: 609905) myosin regulatory light p ( 172) 218 55.0 6.1e-08 XP_016882481 (OMIM: 607315) PREDICTED: calcium-bin ( 284) 220 55.6 6.5e-08 NP_004267 (OMIM: 605563) calcium-binding protein 1 ( 167) 216 54.6 8e-08 NP_001284694 (OMIM: 602907) centrin-3 isoform 1 [H ( 191) 216 54.6 8.8e-08 NP_112482 (OMIM: 605563) calcium-binding protein 1 ( 227) 216 54.7 9.9e-08 NP_000423 (OMIM: 160781,608758) myosin regulatory ( 166) 214 54.2 1.1e-07 NP_001028849 (OMIM: 605563) calcium-binding protei ( 370) 216 54.9 1.4e-07 >>NP_066299 (OMIM: 609931) myosin light polypeptide 6 is (151 aa) initn: 1003 init1: 1003 opt: 1003 Z-score: 1159.8 bits: 220.7 E(85289): 7.3e-58 Smith-Waterman score: 1003; 100.0% identity (100.0% similar) in 151 aa overlap (1-151:1-151) 10 20 30 40 50 60 pF1KB6 MCDFTEDQTAEFKEAFQLFDRTGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 MCDFTEDQTAEFKEAFQLFDRTGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDEM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 NVKVLDFEHFLPMLQTVAKNKDQGTYEDYVEGLRVFDKEGNGTVMGAEIRHVLVTLGEKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_066 NVKVLDFEHFLPMLQTVAKNKDQGTYEDYVEGLRVFDKEGNGTVMGAEIRHVLVTLGEKM 70 80 90 100 110 120 130 140 150 pF1KB6 TEEEVEMLVAGHEDSNGCINYEAFVRHILSG ::::::::::::::::::::::::::::::: NP_066 TEEEVEMLVAGHEDSNGCINYEAFVRHILSG 130 140 150 >>NP_524147 (OMIM: 609931) myosin light polypeptide 6 is (151 aa) initn: 1052 init1: 974 opt: 974 Z-score: 1126.7 bits: 214.5 E(85289): 5.1e-56 Smith-Waterman score: 974; 96.7% identity (98.7% similar) in 151 aa overlap (1-151:1-151) 10 20 30 40 50 60 pF1KB6 MCDFTEDQTAEFKEAFQLFDRTGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDEM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_524 MCDFTEDQTAEFKEAFQLFDRTGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDEM 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 NVKVLDFEHFLPMLQTVAKNKDQGTYEDYVEGLRVFDKEGNGTVMGAEIRHVLVTLGEKM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_524 NVKVLDFEHFLPMLQTVAKNKDQGTYEDYVEGLRVFDKEGNGTVMGAEIRHVLVTLGEKM 70 80 90 100 110 120 130 140 150 pF1KB6 TEEEVEMLVAGHEDSNGCINYEAFVRHILSG :::::::::::::::::::::: .:: .:.: NP_524 TEEEVEMLVAGHEDSNGCINYEELVRMVLNG 130 140 150 >>NP_001186558 (OMIM: 609930) myosin light chain 6B [Hom (208 aa) initn: 829 init1: 829 opt: 829 Z-score: 959.5 bits: 184.1 E(85289): 1.1e-46 Smith-Waterman score: 829; 81.8% identity (94.6% similar) in 148 aa overlap (3-150:60-207) 10 20 30 pF1KB6 MCDFTEDQTAEFKEAFQLFDRTGDGKILYSQC .:..:: ::::::.::::.:::::::::: NP_001 PPAKTKAEPAVPQAPQKTQEPPVDLSKVVIEFNKDQLEEFKEAFELFDRVGDGKILYSQC 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB6 GDVMRALGQNPTNAEVLKVLGNPKSDEMNVKVLDFEHFLPMLQTVAKNKDQGTYEDYVEG :::::::::::::::::::::::::::.. . .::: ::::::.::::. :::::::.:: NP_001 GDVMRALGQNPTNAEVLKVLGNPKSDELKSRRVDFETFLPMLQAVAKNRGQGTYEDYLEG 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB6 LRVFDKEGNGTVMGAEIRHVLVTLGEKMTEEEVEMLVAGHEDSNGCINYEAFVRHILSG .::::::::: :::::.::::.:::::::::::: ..:::::::::::::::..:::: NP_001 FRVFDKEGNGKVMGAELRHVLTTLGEKMTEEEVETVLAGHEDSNGCINYEAFLKHILSV 150 160 170 180 190 200 >>NP_002466 (OMIM: 609930) myosin light chain 6B [Homo s (208 aa) initn: 829 init1: 829 opt: 829 Z-score: 959.5 bits: 184.1 E(85289): 1.1e-46 Smith-Waterman score: 829; 81.8% identity (94.6% similar) in 148 aa overlap (3-150:60-207) 10 20 30 pF1KB6 MCDFTEDQTAEFKEAFQLFDRTGDGKILYSQC .:..:: ::::::.::::.:::::::::: NP_002 PPAKTKAEPAVPQAPQKTQEPPVDLSKVVIEFNKDQLEEFKEAFELFDRVGDGKILYSQC 30 40 50 60 70 80 40 50 60 70 80 90 pF1KB6 GDVMRALGQNPTNAEVLKVLGNPKSDEMNVKVLDFEHFLPMLQTVAKNKDQGTYEDYVEG :::::::::::::::::::::::::::.. . .::: ::::::.::::. :::::::.:: NP_002 GDVMRALGQNPTNAEVLKVLGNPKSDELKSRRVDFETFLPMLQAVAKNRGQGTYEDYLEG 90 100 110 120 130 140 100 110 120 130 140 150 pF1KB6 LRVFDKEGNGTVMGAEIRHVLVTLGEKMTEEEVEMLVAGHEDSNGCINYEAFVRHILSG .::::::::: :::::.::::.:::::::::::: ..:::::::::::::::..:::: NP_002 FRVFDKEGNGKVMGAELRHVLTTLGEKMTEEEVETVLAGHEDSNGCINYEAFLKHILSV 150 160 170 180 190 200 >>NP_001002841 (OMIM: 160770) myosin light chain 4 [Homo (197 aa) initn: 704 init1: 704 opt: 790 Z-score: 915.3 bits: 175.8 E(85289): 3e-44 Smith-Waterman score: 790; 77.5% identity (92.7% similar) in 151 aa overlap (3-151:47-197) 10 20 30 pF1KB6 MCDFTEDQTAEFKEAFQLFDRT--GDGKILYS ::: :: ::::::.::::: :. :: :. NP_001 PAPAPAPAPAPAPAPEAPKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGEMKITYG 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB6 QCGDVMRALGQNPTNAEVLKVLGNPKSDEMNVKVLDFEHFLPMLQTVAKNKDQGTYEDYV :::::.:::::::::::::.:::.:: .:::::.:::: :::.:: ...::.::::::.: NP_001 QCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFV 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB6 EGLRVFDKEGNGTVMGAEIRHVLVTLGEKMTEEEVEMLVAGHEDSNGCINYEAFVRHILS :::::::::.::::::::.::::.:::::::: :::.:.::.::.::::::::::.::.: NP_001 EGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQEDANGCINYEAFVKHIMS 140 150 160 170 180 190 pF1KB6 G : NP_001 G >>XP_005257448 (OMIM: 160770) PREDICTED: myosin light ch (197 aa) initn: 704 init1: 704 opt: 790 Z-score: 915.3 bits: 175.8 E(85289): 3e-44 Smith-Waterman score: 790; 77.5% identity (92.7% similar) in 151 aa overlap (3-151:47-197) 10 20 30 pF1KB6 MCDFTEDQTAEFKEAFQLFDRT--GDGKILYS ::: :: ::::::.::::: :. :: :. XP_005 PAPAPAPAPAPAPAPEAPKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGEMKITYG 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB6 QCGDVMRALGQNPTNAEVLKVLGNPKSDEMNVKVLDFEHFLPMLQTVAKNKDQGTYEDYV :::::.:::::::::::::.:::.:: .:::::.:::: :::.:: ...::.::::::.: XP_005 QCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFV 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB6 EGLRVFDKEGNGTVMGAEIRHVLVTLGEKMTEEEVEMLVAGHEDSNGCINYEAFVRHILS :::::::::.::::::::.::::.:::::::: :::.:.::.::.::::::::::.::.: XP_005 EGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQEDANGCINYEAFVKHIMS 140 150 160 170 180 190 pF1KB6 G : XP_005 G >>NP_002467 (OMIM: 160770) myosin light chain 4 [Homo sa (197 aa) initn: 704 init1: 704 opt: 790 Z-score: 915.3 bits: 175.8 E(85289): 3e-44 Smith-Waterman score: 790; 77.5% identity (92.7% similar) in 151 aa overlap (3-151:47-197) 10 20 30 pF1KB6 MCDFTEDQTAEFKEAFQLFDRT--GDGKILYS ::: :: ::::::.::::: :. :: :. NP_002 PAPAPAPAPAPAPAPEAPKEPAFDPKSVKIDFTADQIEEFKEAFSLFDRTPTGEMKITYG 20 30 40 50 60 70 40 50 60 70 80 90 pF1KB6 QCGDVMRALGQNPTNAEVLKVLGNPKSDEMNVKVLDFEHFLPMLQTVAKNKDQGTYEDYV :::::.:::::::::::::.:::.:: .:::::.:::: :::.:: ...::.::::::.: NP_002 QCGDVLRALGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFV 80 90 100 110 120 130 100 110 120 130 140 150 pF1KB6 EGLRVFDKEGNGTVMGAEIRHVLVTLGEKMTEEEVEMLVAGHEDSNGCINYEAFVRHILS :::::::::.::::::::.::::.:::::::: :::.:.::.::.::::::::::.::.: NP_002 EGLRVFDKESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQEDANGCINYEAFVKHIMS 140 150 160 170 180 190 pF1KB6 G : NP_002 G >>NP_524146 (OMIM: 160780) myosin light chain 1/3, skele (150 aa) initn: 836 init1: 754 opt: 763 Z-score: 886.0 bits: 170.0 E(85289): 1.3e-42 Smith-Waterman score: 763; 76.2% identity (92.5% similar) in 147 aa overlap (4-150:3-149) 10 20 30 40 50 60 pF1KB6 MCDFTEDQTAEFKEAFQLFDRTGDGKILYSQCGDVMRALGQNPTNAEVLKVLGNPKSDEM :. :: ::::::: :::::::.:: :: :::.:::: ::::::: ::::::...:. NP_524 MSFSADQIAEFKEAFLLFDRTGDSKITLSQVGDVLRALGTNPTNAEVRKVLGNPSNEEL 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 NVKVLDFEHFLPMLQTVAKNKDQGTYEDYVEGLRVFDKEGNGTVMGAEIRHVLVTLGEKM :.: ..::.::::.:....::::.::::.:::::::::::::::::::.::::.:::::: NP_524 NAKKIEFEQFLPMMQAISNNKDQATYEDFVEGLRVFDKEGNGTVMGAELRHVLATLGEKM 60 70 80 90 100 110 130 140 150 pF1KB6 TEEEVEMLVAGHEDSNGCINYEAFVRHILSG ::::: :.::.:::::::::::::.::.: NP_524 KEEEVEALMAGQEDSNGCINYEAFVKHIMSI 120 130 140 150 >>XP_016880172 (OMIM: 160770) PREDICTED: myosin light ch (228 aa) initn: 725 init1: 704 opt: 757 Z-score: 876.8 bits: 168.9 E(85289): 4.2e-42 Smith-Waterman score: 757; 78.3% identity (94.4% similar) in 143 aa overlap (11-151:86-228) 10 20 30 pF1KB6 MCDFTEDQTAEFKEAFQLFDRT--GDGKILYSQCGDVMRA ::::::.::::: :. :: :.:::::.:: XP_016 EYGQPHLSVSIALSWRRRRRRKKRRSSCPHEFKEAFSLFDRTPTGEMKITYGQCGDVLRA 60 70 80 90 100 110 40 50 60 70 80 90 pF1KB6 LGQNPTNAEVLKVLGNPKSDEMNVKVLDFEHFLPMLQTVAKNKDQGTYEDYVEGLRVFDK :::::::::::.:::.:: .:::::.:::: :::.:: ...::.::::::.::::::::: XP_016 LGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDK 120 130 140 150 160 170 100 110 120 130 140 150 pF1KB6 EGNGTVMGAEIRHVLVTLGEKMTEEEVEMLVAGHEDSNGCINYEAFVRHILSG :.::::::::.::::.:::::::: :::.:.::.::.::::::::::.::.:: XP_016 ESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQEDANGCINYEAFVKHIMSG 180 190 200 210 220 >>XP_011523141 (OMIM: 160770) PREDICTED: myosin light ch (228 aa) initn: 725 init1: 704 opt: 757 Z-score: 876.8 bits: 168.9 E(85289): 4.2e-42 Smith-Waterman score: 757; 78.3% identity (94.4% similar) in 143 aa overlap (11-151:86-228) 10 20 30 pF1KB6 MCDFTEDQTAEFKEAFQLFDRT--GDGKILYSQCGDVMRA ::::::.::::: :. :: :.:::::.:: XP_011 EYGQPHLSVSIALSWRRRRRRKKRRSSCPHEFKEAFSLFDRTPTGEMKITYGQCGDVLRA 60 70 80 90 100 110 40 50 60 70 80 90 pF1KB6 LGQNPTNAEVLKVLGNPKSDEMNVKVLDFEHFLPMLQTVAKNKDQGTYEDYVEGLRVFDK :::::::::::.:::.:: .:::::.:::: :::.:: ...::.::::::.::::::::: XP_011 LGQNPTNAEVLRVLGKPKPEEMNVKMLDFETFLPILQHISRNKEQGTYEDFVEGLRVFDK 120 130 140 150 160 170 100 110 120 130 140 150 pF1KB6 EGNGTVMGAEIRHVLVTLGEKMTEEEVEMLVAGHEDSNGCINYEAFVRHILSG :.::::::::.::::.:::::::: :::.:.::.::.::::::::::.::.:: XP_011 ESNGTVMGAELRHVLATLGEKMTEAEVEQLLAGQEDANGCINYEAFVKHIMSG 180 190 200 210 220 151 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 13:57:49 2016 done: Sat Nov 5 13:57:49 2016 Total Scan time: 4.950 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]