FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6774, 151 aa 1>>>pF1KB6774 151 - 151 aa - 151 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.9607+/-0.000298; mu= 13.6859+/- 0.019 mean_var=63.7652+/-12.600, 0's: 0 Z-trim(117.0): 14 B-trim: 0 in 0/57 Lambda= 0.160614 statistics sampled from 28689 (28703) to 28689 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.741), E-opt: 0.2 (0.337), width: 16 Scan time: 5.150 The best scores are: opt bits E(85289) NP_067080 (OMIM: 605304) neuroglobin [Homo sapiens ( 151) 1005 240.8 6.2e-64 NP_005321 (OMIM: 142100) hemoglobin subunit epsilo ( 147) 159 44.8 6.3e-05 NP_599030 (OMIM: 608759) cytoglobin [Homo sapiens] ( 190) 147 42.1 0.00053 XP_005257062 (OMIM: 608759) PREDICTED: cytoglobin ( 202) 147 42.1 0.00056 NP_000550 (OMIM: 141749,142200) hemoglobin subunit ( 147) 139 40.1 0.0016 NP_000175 (OMIM: 141749,142250,613977) hemoglobin ( 147) 138 39.9 0.0018 NP_000510 (OMIM: 142000) hemoglobin subunit delta ( 147) 130 38.1 0.0066 NP_000509 (OMIM: 140700,141749,141900,603902,60390 ( 147) 129 37.8 0.0078 >>NP_067080 (OMIM: 605304) neuroglobin [Homo sapiens] (151 aa) initn: 1005 init1: 1005 opt: 1005 Z-score: 1268.7 bits: 240.8 E(85289): 6.2e-64 Smith-Waterman score: 1005; 100.0% identity (100.0% similar) in 151 aa overlap (1-151:1-151) 10 20 30 40 50 60 pF1KB6 MERPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLFQYNCRQFSSPEDCLSSPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 MERPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLFQYNCRQFSSPEDCLSSPE 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 FLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHRAVGVKLSSFSTVGESLLYMLEKC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_067 FLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHRAVGVKLSSFSTVGESLLYMLEKC 70 80 90 100 110 120 130 140 150 pF1KB6 LGPAFTPATRAAWSQLYGAVVQAMSRGWDGE ::::::::::::::::::::::::::::::: NP_067 LGPAFTPATRAAWSQLYGAVVQAMSRGWDGE 130 140 150 >>NP_005321 (OMIM: 142100) hemoglobin subunit epsilon [H (147 aa) initn: 122 init1: 70 opt: 159 Z-score: 209.5 bits: 44.8 E(85289): 6.3e-05 Smith-Waterman score: 159; 28.0% identity (61.6% similar) in 125 aa overlap (22-145:23-143) 10 20 30 40 50 pF1KB6 MERPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLFQYNCRQFSSPEDCLSSP : : ..::... : .:. . ..::: :..: NP_005 MVHFTAEEKAAVTSLWSKMNVEEAGGEALGRLLVVYPWTQRFFD-SFGNLSSPSAILGNP 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 EFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKH-RAVGVKLSSFSTVGESLLYMLE . : .::. . :. :...: . .:.:.. : . : .:. .:. .. .: NP_005 KVKAHGKKVLTSFGDAIKNMDNL---KPAFAKLSELHCDKLHVDPENFKLLGNVMVIILA 60 70 80 90 100 110 120 130 140 150 pF1KB6 KCLGPAFTPATRAAWSQLYGAVVQAMSRGWDGE .: ::: ..:::..: .::. :.. NP_005 THFGKEFTPEVQAAWQKLVSAVAIALAHKYH 120 130 140 >>NP_599030 (OMIM: 608759) cytoglobin [Homo sapiens] (190 aa) initn: 76 init1: 76 opt: 147 Z-score: 192.8 bits: 42.1 E(85289): 0.00053 Smith-Waterman score: 147; 22.6% identity (57.4% similar) in 155 aa overlap (1-148:19-171) 10 20 30 40 pF1KB6 MERPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLF . . : . .. : . . . :.....:.:. :. : NP_599 MEKVPGEMEIERRERSEELSEAERKAVQAMWARLYANCEDVGVAILVRFFVNFPSAKQYF 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB6 QYNCRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHRAVGVK . . ... .: . ::.. : .:: .....: :..: ... :: .:. : :. : NP_599 S-QFKHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAH-ALKHK 70 80 90 100 110 110 120 130 140 150 pF1KB6 LSS--FSTVGESLLYMLEKCLGPAFTPATRAAWSQLYGAV---VQAMSR--GWDGE . :. .. .: .. . .. : : :. ::..: : . : : . :: NP_599 VEPVYFKILSGVILEVVAEEFASDFPPETQRAWAKLRGLIYSHVTAAYKEVGWVQQVPNA 120 130 140 150 160 170 NP_599 TTPPATLPSSGP 180 190 >>XP_005257062 (OMIM: 608759) PREDICTED: cytoglobin isof (202 aa) initn: 76 init1: 76 opt: 147 Z-score: 192.5 bits: 42.1 E(85289): 0.00056 Smith-Waterman score: 147; 22.6% identity (57.4% similar) in 155 aa overlap (1-148:19-171) 10 20 30 40 pF1KB6 MERPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLF . . : . .. : . . . :.....:.:. :. : XP_005 MEKVPGEMEIERRERSEELSEAERKAVQAMWARLYANCEDVGVAILVRFFVNFPSAKQYF 10 20 30 40 50 60 50 60 70 80 90 100 pF1KB6 QYNCRQFSSPEDCLSSPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHRAVGVK . . ... .: . ::.. : .:: .....: :..: ... :: .:. : :. : XP_005 S-QFKHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAH-ALKHK 70 80 90 100 110 110 120 130 140 150 pF1KB6 LSS--FSTVGESLLYMLEKCLGPAFTPATRAAWSQLYGAV---VQAMSR--GWDGE . :. .. .: .. . .. : : :. ::..: : . : : . :: XP_005 VEPVYFKILSGVILEVVAEEFASDFPPETQRAWAKLRGLIYSHVTAAYKEVGWVQQVPNA 120 130 140 150 160 170 XP_005 TTHSSWRRSPEGSWGRQASCPSCC 180 190 200 >>NP_000550 (OMIM: 141749,142200) hemoglobin subunit gam (147 aa) initn: 109 init1: 69 opt: 139 Z-score: 184.4 bits: 40.1 E(85289): 0.0016 Smith-Waterman score: 139; 26.0% identity (61.8% similar) in 123 aa overlap (24-145:25-143) 10 20 30 40 50 pF1KB6 MERPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLFQYNCRQFSSPEDCLSSP : ..::... : .:. . ..:: ...: NP_000 MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFD-SFGNLSSASAIMGNP 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 EFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKH-RAVGVKLSSFSTVGESLLYMLE . : .::. . :. ...::.. .:.:.. : . : .:. .:. :. .: NP_000 KVKAHGKKVLTSLGDATKHLDDLKGT---FAQLSELHCDKLHVDPENFKLLGNVLVTVLA 60 70 80 90 100 110 120 130 140 150 pF1KB6 KCLGPAFTPATRAAWSQLYGAVVQAMSRGWDGE .: ::: ..:.:... ::..:.: NP_000 IHFGKEFTPEVQASWQKMVTAVASALSSRYH 120 130 140 >>NP_000175 (OMIM: 141749,142250,613977) hemoglobin subu (147 aa) initn: 108 init1: 64 opt: 138 Z-score: 183.2 bits: 39.9 E(85289): 0.0018 Smith-Waterman score: 138; 25.2% identity (61.8% similar) in 123 aa overlap (24-145:25-143) 10 20 30 40 50 pF1KB6 MERPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLFQYNCRQFSSPEDCLSSP : ..::... : .:. . ..:: ...: NP_000 MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFD-SFGNLSSASAIMGNP 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 EFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKH-RAVGVKLSSFSTVGESLLYMLE . : .::. . :. ...::.. .:.:.. : . : .:. .:. :. .: NP_000 KVKAHGKKVLTSLGDAIKHLDDLKGT---FAQLSELHCDKLHVDPENFKLLGNVLVTVLA 60 70 80 90 100 110 120 130 140 150 pF1KB6 KCLGPAFTPATRAAWSQLYGAVVQAMSRGWDGE .: ::: ..:.:... .:..:.: NP_000 IHFGKEFTPEVQASWQKMVTGVASALSSRYH 120 130 140 >>NP_000510 (OMIM: 142000) hemoglobin subunit delta [Hom (147 aa) initn: 100 init1: 51 opt: 130 Z-score: 173.1 bits: 38.1 E(85289): 0.0066 Smith-Waterman score: 130; 22.4% identity (60.8% similar) in 143 aa overlap (4-145:6-143) 10 20 30 40 50 pF1KB6 MERPEPEL-IRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLFQYNCRQFSSPEDCLS :: . . : :. . . : ..::... : .:. . ..:::. .. NP_000 MVHLTPEEKTAVNALWGKVNVDAV--GGEALGRLLVVYPWTQRFFE-SFGDLSSPDAVMG 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 SPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHRAVGVKLSSFSTVGESLLYML .:. : .::. ... .......:.. :. : . . : .: .:. :. .: NP_000 NPKVKAHGKKVLGAFSDGLAHLDNLKGTFSQLSEL--HCDKLHVDPENFRLLGNVLVCVL 60 70 80 90 100 110 120 130 140 150 pF1KB6 EKCLGPAFTPATRAAWSQLYGAVVQAMSRGWDGE . .: ::: .::.... ..:..:.. NP_000 ARNFGKEFTPQMQAAYQKVVAGVANALAHKYH 120 130 140 >>NP_000509 (OMIM: 140700,141749,141900,603902,603903,60 (147 aa) initn: 51 init1: 51 opt: 129 Z-score: 171.9 bits: 37.8 E(85289): 0.0078 Smith-Waterman score: 129; 22.5% identity (62.7% similar) in 142 aa overlap (5-145:8-143) 10 20 30 40 50 pF1KB6 MERPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLFQYNCRQFSSPEDCLS : . : :. . : : ..::... : .:. . ..:.:. .. NP_000 MVHLTPEEKSAVTALWGKVNVD--EVGGEALGRLLVVYPWTQRFFE-SFGDLSTPDAVMG 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 SPEFLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKH-RAVGVKLSSFSTVGESLLYM .:. : .::. ... .......:.. .:.:.. : . : .: .:. :. . NP_000 NPKVKAHGKKVLGAFSDGLAHLDNLKGT---FATLSELHCDKLHVDPENFRLLGNVLVCV 60 70 80 90 100 110 120 130 140 150 pF1KB6 LEKCLGPAFTPATRAAWSQLYGAVVQAMSRGWDGE : . .: ::: ..::.... ..:..:.. NP_000 LAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH 120 130 140 151 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 23:57:05 2016 done: Fri Nov 4 23:57:06 2016 Total Scan time: 5.150 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]