FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6793, 127 aa 1>>>pF1KB6793 127 - 127 aa - 127 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8440+/-0.000323; mu= 8.8061+/- 0.020 mean_var=71.2826+/-13.837, 0's: 0 Z-trim(115.9): 27 B-trim: 786 in 1/54 Lambda= 0.151909 statistics sampled from 26581 (26608) to 26581 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.685), E-opt: 0.2 (0.312), width: 16 Scan time: 4.330 The best scores are: opt bits E(85289) NP_003078 (OMIM: 602998) gamma-synuclein isoform 1 ( 127) 756 174.0 5.6e-44 XP_011530506 (OMIM: 127750,163890,168601,605543) P ( 170) 396 95.2 4.1e-20 XP_011530507 (OMIM: 127750,163890,168601,605543) P ( 170) 396 95.2 4.1e-20 XP_011530509 (OMIM: 127750,163890,168601,605543) P ( 170) 396 95.2 4.1e-20 XP_011530508 (OMIM: 127750,163890,168601,605543) P ( 170) 396 95.2 4.1e-20 XP_011530505 (OMIM: 127750,163890,168601,605543) P ( 170) 396 95.2 4.1e-20 NP_000336 (OMIM: 127750,163890,168601,605543) alph ( 140) 388 93.4 1.2e-19 NP_001139526 (OMIM: 127750,163890,168601,605543) a ( 140) 388 93.4 1.2e-19 XP_016864051 (OMIM: 127750,163890,168601,605543) P ( 140) 388 93.4 1.2e-19 XP_011530510 (OMIM: 127750,163890,168601,605543) P ( 140) 388 93.4 1.2e-19 XP_016864052 (OMIM: 127750,163890,168601,605543) P ( 140) 388 93.4 1.2e-19 NP_001139527 (OMIM: 127750,163890,168601,605543) a ( 140) 388 93.4 1.2e-19 NP_009292 (OMIM: 127750,163890,168601,605543) alph ( 112) 383 92.3 2e-19 NP_001304964 (OMIM: 127750,602569) beta-synuclein ( 104) 341 83.1 1.1e-16 NP_001304966 (OMIM: 127750,602569) beta-synuclein ( 104) 341 83.1 1.1e-16 NP_003076 (OMIM: 127750,602569) beta-synuclein iso ( 134) 342 83.3 1.2e-16 XP_006714979 (OMIM: 127750,602569) PREDICTED: beta ( 134) 342 83.3 1.2e-16 NP_001001502 (OMIM: 127750,602569) beta-synuclein ( 134) 342 83.3 1.2e-16 XP_006714977 (OMIM: 127750,602569) PREDICTED: beta ( 152) 342 83.3 1.3e-16 XP_011532942 (OMIM: 127750,602569) PREDICTED: beta ( 152) 342 83.3 1.3e-16 XP_006714978 (OMIM: 127750,602569) PREDICTED: beta ( 152) 342 83.3 1.3e-16 NP_001317049 (OMIM: 602998) gamma-synuclein isofor ( 126) 325 79.6 1.5e-15 NP_001304963 (OMIM: 127750,602569) beta-synuclein ( 120) 222 57.0 9e-09 NP_001304965 (OMIM: 127750,602569) beta-synuclein ( 120) 222 57.0 9e-09 >>NP_003078 (OMIM: 602998) gamma-synuclein isoform 1 [Ho (127 aa) initn: 756 init1: 756 opt: 756 Z-score: 910.5 bits: 174.0 E(85289): 5.6e-44 Smith-Waterman score: 756; 100.0% identity (100.0% similar) in 127 aa overlap (1-127:1-127) 10 20 30 40 50 60 pF1KB6 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 EQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_003 EQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAE 70 80 90 100 110 120 pF1KB6 EAQSGGD ::::::: NP_003 EAQSGGD >>XP_011530506 (OMIM: 127750,163890,168601,605543) PREDI (170 aa) initn: 569 init1: 381 opt: 396 Z-score: 482.1 bits: 95.2 E(85289): 4.1e-20 Smith-Waterman score: 396; 60.2% identity (86.4% similar) in 118 aa overlap (1-118:1-116) 10 20 30 40 50 60 pF1KB6 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTK :::: ::.: ::::::.:.:::::::.::: ::::::.:::.::::.::..:..:::::: XP_011 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 EQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAE ::.. :. :::..:..:: :::: : .::...: :.:..: . :. . ::..:.: XP_011 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKKHPKYK--PSKRQENVVM 70 80 90 100 110 pF1KB6 EAQSGGD XP_011 FLVQVKKICFPQVGKPFSFLRFFSSFFFQVKAFWRSQYPSLKVARSHVYICN 120 130 140 150 160 170 >>XP_011530507 (OMIM: 127750,163890,168601,605543) PREDI (170 aa) initn: 569 init1: 381 opt: 396 Z-score: 482.1 bits: 95.2 E(85289): 4.1e-20 Smith-Waterman score: 396; 60.2% identity (86.4% similar) in 118 aa overlap (1-118:1-116) 10 20 30 40 50 60 pF1KB6 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTK :::: ::.: ::::::.:.:::::::.::: ::::::.:::.::::.::..:..:::::: XP_011 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 EQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAE ::.. :. :::..:..:: :::: : .::...: :.:..: . :. . ::..:.: XP_011 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKKHPKYK--PSKRQENVVM 70 80 90 100 110 pF1KB6 EAQSGGD XP_011 FLVQVKKICFPQVGKPFSFLRFFSSFFFQVKAFWRSQYPSLKVARSHVYICN 120 130 140 150 160 170 >>XP_011530509 (OMIM: 127750,163890,168601,605543) PREDI (170 aa) initn: 569 init1: 381 opt: 396 Z-score: 482.1 bits: 95.2 E(85289): 4.1e-20 Smith-Waterman score: 396; 60.2% identity (86.4% similar) in 118 aa overlap (1-118:1-116) 10 20 30 40 50 60 pF1KB6 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTK :::: ::.: ::::::.:.:::::::.::: ::::::.:::.::::.::..:..:::::: XP_011 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 EQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAE ::.. :. :::..:..:: :::: : .::...: :.:..: . :. . ::..:.: XP_011 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKKHPKYK--PSKRQENVVM 70 80 90 100 110 pF1KB6 EAQSGGD XP_011 FLVQVKKICFPQVGKPFSFLRFFSSFFFQVKAFWRSQYPSLKVARSHVYICN 120 130 140 150 160 170 >>XP_011530508 (OMIM: 127750,163890,168601,605543) PREDI (170 aa) initn: 569 init1: 381 opt: 396 Z-score: 482.1 bits: 95.2 E(85289): 4.1e-20 Smith-Waterman score: 396; 60.2% identity (86.4% similar) in 118 aa overlap (1-118:1-116) 10 20 30 40 50 60 pF1KB6 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTK :::: ::.: ::::::.:.:::::::.::: ::::::.:::.::::.::..:..:::::: XP_011 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 EQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAE ::.. :. :::..:..:: :::: : .::...: :.:..: . :. . ::..:.: XP_011 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKKHPKYK--PSKRQENVVM 70 80 90 100 110 pF1KB6 EAQSGGD XP_011 FLVQVKKICFPQVGKPFSFLRFFSSFFFQVKAFWRSQYPSLKVARSHVYICN 120 130 140 150 160 170 >>XP_011530505 (OMIM: 127750,163890,168601,605543) PREDI (170 aa) initn: 569 init1: 381 opt: 396 Z-score: 482.1 bits: 95.2 E(85289): 4.1e-20 Smith-Waterman score: 396; 60.2% identity (86.4% similar) in 118 aa overlap (1-118:1-116) 10 20 30 40 50 60 pF1KB6 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTK :::: ::.: ::::::.:.:::::::.::: ::::::.:::.::::.::..:..:::::: XP_011 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 EQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAE ::.. :. :::..:..:: :::: : .::...: :.:..: . :. . ::..:.: XP_011 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKKHPKYK--PSKRQENVVM 70 80 90 100 110 pF1KB6 EAQSGGD XP_011 FLVQVKKICFPQVGKPFSFLRFFSSFFFQVKAFWRSQYPSLKVARSHVYICN 120 130 140 150 160 170 >>NP_000336 (OMIM: 127750,163890,168601,605543) alpha-sy (140 aa) initn: 569 init1: 381 opt: 388 Z-score: 474.0 bits: 93.4 E(85289): 1.2e-19 Smith-Waterman score: 388; 62.7% identity (88.2% similar) in 110 aa overlap (1-107:1-110) 10 20 30 40 50 60 pF1KB6 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTK :::: ::.: ::::::.:.:::::::.::: ::::::.:::.::::.::..:..:::::: NP_000 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 EQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDL---RPSAPQQEGEASKEKEE ::.. :. :::..:..:: :::: : .::...: :.:..: . .:::. NP_000 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP 70 80 90 100 110 120 120 pF1KB6 VAEEAQSGGD NP_000 DNEAYEMPSEEGYQDYEPEA 130 140 >>NP_001139526 (OMIM: 127750,163890,168601,605543) alpha (140 aa) initn: 569 init1: 381 opt: 388 Z-score: 474.0 bits: 93.4 E(85289): 1.2e-19 Smith-Waterman score: 388; 62.7% identity (88.2% similar) in 110 aa overlap (1-107:1-110) 10 20 30 40 50 60 pF1KB6 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTK :::: ::.: ::::::.:.:::::::.::: ::::::.:::.::::.::..:..:::::: NP_001 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 EQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDL---RPSAPQQEGEASKEKEE ::.. :. :::..:..:: :::: : .::...: :.:..: . .:::. NP_001 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP 70 80 90 100 110 120 120 pF1KB6 VAEEAQSGGD NP_001 DNEAYEMPSEEGYQDYEPEA 130 140 >>XP_016864051 (OMIM: 127750,163890,168601,605543) PREDI (140 aa) initn: 569 init1: 381 opt: 388 Z-score: 474.0 bits: 93.4 E(85289): 1.2e-19 Smith-Waterman score: 388; 62.7% identity (88.2% similar) in 110 aa overlap (1-107:1-110) 10 20 30 40 50 60 pF1KB6 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTK :::: ::.: ::::::.:.:::::::.::: ::::::.:::.::::.::..:..:::::: XP_016 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 EQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDL---RPSAPQQEGEASKEKEE ::.. :. :::..:..:: :::: : .::...: :.:..: . .:::. XP_016 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP 70 80 90 100 110 120 120 pF1KB6 VAEEAQSGGD XP_016 DNEAYEMPSEEGYQDYEPEA 130 140 >>XP_011530510 (OMIM: 127750,163890,168601,605543) PREDI (140 aa) initn: 569 init1: 381 opt: 388 Z-score: 474.0 bits: 93.4 E(85289): 1.2e-19 Smith-Waterman score: 388; 62.7% identity (88.2% similar) in 110 aa overlap (1-107:1-110) 10 20 30 40 50 60 pF1KB6 MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTK :::: ::.: ::::::.:.:::::::.::: ::::::.:::.::::.::..:..:::::: XP_011 MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 EQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDL---RPSAPQQEGEASKEKEE ::.. :. :::..:..:: :::: : .::...: :.:..: . .:::. XP_011 EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP 70 80 90 100 110 120 120 pF1KB6 VAEEAQSGGD XP_011 DNEAYEMPSEEGYQDYEPEA 130 140 127 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 00:01:34 2016 done: Sat Nov 5 00:01:34 2016 Total Scan time: 4.330 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]