FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6804, 184 aa 1>>>pF1KB6804 184 - 184 aa - 184 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1718+/-0.000978; mu= 13.6689+/- 0.059 mean_var=73.2393+/-14.730, 0's: 0 Z-trim(106.4): 193 B-trim: 609 in 2/49 Lambda= 0.149866 statistics sampled from 8767 (8985) to 8767 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.659), E-opt: 0.2 (0.276), width: 16 Scan time: 1.910 The best scores are: opt bits E(32554) CCDS840.1 RAP1A gene_id:5906|Hs108|chr1 ( 184) 1209 270.3 4.6e-73 CCDS8984.1 RAP1B gene_id:5908|Hs108|chr12 ( 184) 1128 252.8 8.5e-68 CCDS58253.1 RAP1B gene_id:5908|Hs108|chr12 ( 165) 750 171.1 3.1e-43 CCDS9485.1 RAP2A gene_id:5911|Hs108|chr13 ( 183) 750 171.1 3.4e-43 CCDS58254.1 RAP1B gene_id:5908|Hs108|chr12 ( 142) 744 169.7 6.9e-43 CCDS14632.1 RAP2C gene_id:57826|Hs108|chrX ( 183) 744 169.8 8.4e-43 CCDS3170.1 RAP2B gene_id:5912|Hs108|chr3 ( 183) 737 168.3 2.4e-42 CCDS8702.1 KRAS gene_id:3845|Hs108|chr12 ( 188) 677 155.3 2e-38 CCDS8703.1 KRAS gene_id:3845|Hs108|chr12 ( 189) 670 153.8 5.6e-38 CCDS7698.1 HRAS gene_id:3265|Hs108|chr11 ( 189) 653 150.1 7.2e-37 CCDS877.1 NRAS gene_id:4893|Hs108|chr1 ( 189) 633 145.8 1.4e-35 CCDS7814.1 RRAS2 gene_id:22800|Hs108|chr11 ( 204) 607 140.2 7.5e-34 CCDS3100.1 MRAS gene_id:22808|Hs108|chr3 ( 208) 606 140.0 8.9e-34 CCDS7699.1 HRAS gene_id:3265|Hs108|chr11 ( 170) 599 138.4 2.2e-33 CCDS5460.1 RALA gene_id:5898|Hs108|chr7 ( 206) 595 137.6 4.6e-33 CCDS1123.1 RIT1 gene_id:6016|Hs108|chr1 ( 219) 581 134.6 3.9e-32 CCDS58037.1 RIT1 gene_id:6016|Hs108|chr1 ( 236) 581 134.6 4.1e-32 CCDS11921.1 RIT2 gene_id:6014|Hs108|chr18 ( 217) 567 131.6 3.2e-31 CCDS2131.1 RALB gene_id:5899|Hs108|chr2 ( 206) 561 130.3 7.5e-31 CCDS12774.1 RRAS gene_id:6237|Hs108|chr19 ( 218) 551 128.1 3.5e-30 CCDS6687.1 DIRAS2 gene_id:54769|Hs108|chr9 ( 199) 523 122.1 2.2e-28 CCDS12092.1 DIRAS1 gene_id:148252|Hs108|chr19 ( 198) 497 116.4 1.1e-26 CCDS53603.1 RRAS2 gene_id:22800|Hs108|chr11 ( 169) 487 114.2 4.2e-26 CCDS58036.1 RIT1 gene_id:6016|Hs108|chr1 ( 183) 484 113.6 7e-26 CCDS8673.1 RERG gene_id:85004|Hs108|chr12 ( 199) 467 109.9 9.5e-25 CCDS58252.1 RAP1B gene_id:5908|Hs108|chr12 ( 137) 463 109.0 1.3e-24 CCDS62431.1 RIT2 gene_id:6014|Hs108|chr18 ( 153) 446 105.3 1.8e-23 CCDS5927.1 RHEB gene_id:6009|Hs108|chr7 ( 184) 426 101.1 4.2e-22 CCDS76024.1 RAP2C gene_id:57826|Hs108|chrX ( 117) 406 96.6 5.9e-21 CCDS35246.1 ERAS gene_id:3266|Hs108|chrX ( 233) 396 94.6 4.5e-20 CCDS8778.1 RHEBL1 gene_id:121268|Hs108|chr12 ( 183) 387 92.6 1.4e-19 CCDS42410.1 RAB12 gene_id:201475|Hs108|chr18 ( 244) 375 90.1 1.1e-18 CCDS641.1 DIRAS3 gene_id:9077|Hs108|chr1 ( 229) 367 88.4 3.4e-18 CCDS1720.1 RAB10 gene_id:10890|Hs108|chr2 ( 200) 363 87.5 5.6e-18 CCDS1058.1 RAB13 gene_id:5872|Hs108|chr1 ( 203) 363 87.5 5.7e-18 CCDS10183.1 RAB8B gene_id:51762|Hs108|chr15 ( 207) 363 87.5 5.8e-18 CCDS3976.1 RAB3C gene_id:115827|Hs108|chr5 ( 227) 359 86.6 1.1e-17 CCDS12339.1 RAB8A gene_id:4218|Hs108|chr19 ( 207) 353 85.3 2.6e-17 CCDS53753.1 RERG gene_id:85004|Hs108|chr12 ( 180) 346 83.8 6.6e-17 CCDS9570.1 RAB2B gene_id:84932|Hs108|chr14 ( 216) 346 83.8 7.6e-17 CCDS11703.1 RAB37 gene_id:326624|Hs108|chr17 ( 216) 345 83.6 8.9e-17 CCDS560.1 RAB3B gene_id:5865|Hs108|chr1 ( 219) 345 83.6 9e-17 CCDS12372.1 RAB3A gene_id:5864|Hs108|chr19 ( 220) 345 83.6 9e-17 CCDS44544.1 RRAS2 gene_id:22800|Hs108|chr11 ( 127) 339 82.1 1.4e-16 CCDS12257.1 RAB3D gene_id:9545|Hs108|chr19 ( 219) 340 82.5 1.9e-16 CCDS4962.1 RAB23 gene_id:51715|Hs108|chr6 ( 237) 339 82.3 2.3e-16 CCDS46306.1 RAB1A gene_id:5861|Hs108|chr2 ( 205) 338 82.1 2.4e-16 CCDS6175.1 RAB2A gene_id:5862|Hs108|chr8 ( 212) 338 82.1 2.5e-16 CCDS82198.1 RAB37 gene_id:326624|Hs108|chr17 ( 196) 333 81.0 5e-16 CCDS3052.1 RAB7A gene_id:7879|Hs108|chr3 ( 207) 333 81.0 5.2e-16 >>CCDS840.1 RAP1A gene_id:5906|Hs108|chr1 (184 aa) initn: 1209 init1: 1209 opt: 1209 Z-score: 1425.3 bits: 270.3 E(32554): 4.6e-73 Smith-Waterman score: 1209; 100.0% identity (100.0% similar) in 184 aa overlap (1-184:1-184) 10 20 30 40 50 60 pF1KB6 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS84 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS84 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS84 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS 130 140 150 160 170 180 pF1KB6 CLLL :::: CCDS84 CLLL >>CCDS8984.1 RAP1B gene_id:5908|Hs108|chr12 (184 aa) initn: 1128 init1: 1128 opt: 1128 Z-score: 1330.6 bits: 252.8 E(32554): 8.5e-68 Smith-Waterman score: 1128; 95.1% identity (96.2% similar) in 184 aa overlap (1-184:1-184) 10 20 30 40 50 60 pF1KB6 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG ::::::::::::::::::::::::::::::::::::::::::::::: :::::::::::: CCDS89 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL ::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: CCDS89 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS :::::::::::::::::: :::::::::::::::::::::::::::::::: : ::.: CCDS89 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS 130 140 150 160 170 180 pF1KB6 CLLL : :: CCDS89 CQLL >>CCDS58253.1 RAP1B gene_id:5908|Hs108|chr12 (165 aa) initn: 1000 init1: 744 opt: 750 Z-score: 889.6 bits: 171.1 E(32554): 3.1e-43 Smith-Waterman score: 964; 85.3% identity (86.4% similar) in 184 aa overlap (1-184:1-165) 10 20 30 40 50 60 pF1KB6 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG :::::::::::::::::::::::::::::::::::::::::: CCDS58 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRK------------------ 10 20 30 40 70 80 90 100 110 120 pF1KB6 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL :::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: CCDS58 -EQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 50 60 70 80 90 100 130 140 150 160 170 180 pF1KB6 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS :::::::::::::::::: :::::::::::::::::::::::::::::::: : ::.: CCDS58 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS 110 120 130 140 150 160 pF1KB6 CLLL : :: CCDS58 CQLL >>CCDS9485.1 RAP2A gene_id:5911|Hs108|chr13 (183 aa) initn: 699 init1: 636 opt: 750 Z-score: 889.0 bits: 171.1 E(32554): 3.4e-43 Smith-Waterman score: 750; 62.4% identity (84.0% similar) in 181 aa overlap (1-181:1-180) 10 20 30 40 50 60 pF1KB6 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: CCDS94 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::.:::::: :: CCDS94 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS :.:: :.. .:. ::..: .: :.:.::::: :.:.: ..:::.: . .: : .. CCDS94 ESEREVSSSEGRALAEEW-GCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSA 130 140 150 160 170 pF1KB6 CLLL : CCDS94 CNIQ 180 >>CCDS58254.1 RAP1B gene_id:5908|Hs108|chr12 (142 aa) initn: 847 init1: 744 opt: 744 Z-score: 883.5 bits: 169.7 E(32554): 6.9e-43 Smith-Waterman score: 767; 72.8% identity (73.9% similar) in 184 aa overlap (1-184:1-142) 10 20 30 40 50 60 pF1KB6 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG ::::::::::::::::::: CCDS58 MREYKLVVLGSGGVGKSAL----------------------------------------- 10 70 80 90 100 110 120 pF1KB6 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL :::::::::::::::::::::::::::::::::::::::::::::.::::::::::::: CCDS58 -EQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDL 20 30 40 50 60 70 130 140 150 160 170 180 pF1KB6 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS :::::::::::::::::: :::::::::::::::::::::::::::::::: : ::.: CCDS58 EDERVVGKEQGQNLARQWNNCAFLESSAKSKINVNEIFYDLVRQINRKTPVPGKARKKSS 80 90 100 110 120 130 pF1KB6 CLLL : :: CCDS58 CQLL 140 >>CCDS14632.1 RAP2C gene_id:57826|Hs108|chrX (183 aa) initn: 703 init1: 634 opt: 744 Z-score: 881.9 bits: 169.8 E(32554): 8.4e-43 Smith-Waterman score: 744; 61.7% identity (83.1% similar) in 183 aa overlap (1-183:1-182) 10 20 30 40 50 60 pF1KB6 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: CCDS14 MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::.:::::: :: CCDS14 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIVRVKRYEKVPLILVGNKVDL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS : :: : . .:. ::..: .: :.:.::::: :.:.: ..:::.: .. ::. . CCDS14 EPEREVMSSEGRALAQEW-GCPFMETSAKSKSMVDELFAEIVRQMNYSSLPEKQDQCCTT 130 140 150 160 170 pF1KB6 CLLL :.. CCDS14 CVVQ 180 >>CCDS3170.1 RAP2B gene_id:5912|Hs108|chr3 (183 aa) initn: 697 init1: 635 opt: 737 Z-score: 873.8 bits: 168.3 E(32554): 2.4e-42 Smith-Waterman score: 737; 60.9% identity (83.2% similar) in 184 aa overlap (1-184:1-183) 10 20 30 40 50 60 pF1KB6 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG :::::.:::::::::::::::::: : :.::::::::: :::..::: . .:::::::: CCDS31 MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL ::::..:::::.:::::: ::::.. :..:.:.. .:.::.::: : ::::::::: :: CCDS31 TEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS : :: :. .:. ::..: .: :.:.:::.: .:.:.: ..:::.: . . . .. CCDS31 EGEREVSYGEGKALAEEW-SCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSA 130 140 150 160 170 pF1KB6 CLLL :..: CCDS31 CVIL 180 >>CCDS8702.1 KRAS gene_id:3845|Hs108|chr12 (188 aa) initn: 642 init1: 557 opt: 677 Z-score: 803.5 bits: 155.3 E(32554): 2e-38 Smith-Waterman score: 677; 55.3% identity (81.1% similar) in 190 aa overlap (1-184:1-188) 10 20 30 40 50 60 pF1KB6 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG : ::::::.:.:::::::::.:..:. ::..::::::::::::: .: . :.:.:::::: CCDS87 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL :...:::: ::..:.:: :..:. ..:.:.. :::: ::::.:::::.:::::::: CCDS87 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINR---KTPVEKKKPK . :.: .:.:.:::.. . :.:.:::.. .:.. :: :::.: . : . :: : CCDS87 PS-RTVDTKQAQDLARSY-GIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKK 130 140 150 160 170 180 pF1KB6 KKS---CLLL ::: :... CCDS87 KKSKTKCVIM 180 >>CCDS8703.1 KRAS gene_id:3845|Hs108|chr12 (189 aa) initn: 597 init1: 549 opt: 670 Z-score: 795.3 bits: 153.8 E(32554): 5.6e-38 Smith-Waterman score: 670; 54.5% identity (80.1% similar) in 191 aa overlap (1-184:1-189) 10 20 30 40 50 60 pF1KB6 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG : ::::::.:.:::::::::.:..:. ::..::::::::::::: .: . :.:.:::::: CCDS87 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL :...:::: ::..:.:: :..:. ..:.:.. :::: ::::.:::::.:::::::: CCDS87 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQIN----RKTPVEKKKP . :.: .:.:.:::.. . :.:.:::.. :.. :: :::.: .: :.: : CCDS87 PS-RTVDTKQAQDLARSY-GIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTP 130 140 150 160 170 180 pF1KB6 ---KKKSCLLL : :.:... CCDS87 GCVKIKKCIIM 180 >>CCDS7698.1 HRAS gene_id:3265|Hs108|chr11 (189 aa) initn: 595 init1: 546 opt: 653 Z-score: 775.4 bits: 150.1 E(32554): 7.2e-37 Smith-Waterman score: 653; 55.0% identity (83.9% similar) in 180 aa overlap (1-180:1-177) 10 20 30 40 50 60 pF1KB6 MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAG : ::::::.:.:::::::::.:..:. ::..::::::::::::: .: . :.:.:::::: CCDS76 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDL :...:::: ::..:.:: :..:. ..:.:... :::: ::::..::::.:::::::: CCDS76 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 EDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKS :.: ..:.:.:::.. . ..:.:::.. .:.. :: :::.: :. ..: .: .: CCDS76 A-ARTVESRQAQDLARSY-GIPYIETSAKTRQGVEDAFYTLVREI-RQHKLRKLNPPDES 130 140 150 160 170 pF1KB6 CLLL CCDS76 GPGCMSCKCVLS 180 184 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 00:09:52 2016 done: Sat Nov 5 00:09:53 2016 Total Scan time: 1.910 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]