FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6810, 185 aa 1>>>pF1KB6810 185 - 185 aa - 185 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 6.4726+/-0.000293; mu= 8.4197+/- 0.018 mean_var=106.3971+/-20.912, 0's: 0 Z-trim(120.0): 43 B-trim: 670 in 2/54 Lambda= 0.124340 statistics sampled from 34566 (34610) to 34566 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.759), E-opt: 0.2 (0.406), width: 16 Scan time: 6.210 The best scores are: opt bits E(85289) NP_001120700 (OMIM: 604511) chromobox protein homo ( 185) 1238 231.7 5.2e-61 NP_006798 (OMIM: 604511) chromobox protein homolog ( 185) 1238 231.7 5.2e-61 NP_057671 (OMIM: 604477) chromobox protein homolog ( 183) 848 161.7 5.9e-40 XP_005249668 (OMIM: 604477) PREDICTED: chromobox p ( 183) 848 161.7 5.9e-40 NP_009207 (OMIM: 604477) chromobox protein homolog ( 183) 848 161.7 5.9e-40 NP_036249 (OMIM: 604478) chromobox protein homolog ( 191) 781 149.7 2.5e-36 NP_001120793 (OMIM: 604478) chromobox protein homo ( 191) 781 149.7 2.5e-36 NP_001120794 (OMIM: 604478) chromobox protein homo ( 191) 781 149.7 2.5e-36 NP_116036 (OMIM: 602770,613080) chromobox protein ( 211) 205 46.4 3.5e-05 NP_005180 (OMIM: 602770,613080) chromobox protein ( 532) 208 47.2 5.1e-05 XP_011523684 (OMIM: 602770,613080) PREDICTED: chro ( 586) 208 47.3 5.5e-05 NP_059990 (OMIM: 611626) M-phase phosphoprotein 8 ( 860) 207 47.2 8.5e-05 XP_011533426 (OMIM: 611626) PREDICTED: M-phase pho ( 879) 207 47.2 8.6e-05 XP_011513299 (OMIM: 603778) PREDICTED: chromodomai ( 522) 202 46.2 0.00011 NP_004815 (OMIM: 603778) chromodomain Y-like prote ( 544) 202 46.2 0.00011 XP_006724240 (OMIM: 608457) PREDICTED: chromobox p ( 192) 195 44.6 0.00011 XP_006724239 (OMIM: 608457) PREDICTED: chromobox p ( 200) 191 43.9 0.00019 XP_005261470 (OMIM: 608457) PREDICTED: chromobox p ( 158) 185 42.8 0.00033 XP_016884168 (OMIM: 608457) PREDICTED: chromobox p ( 250) 185 42.9 0.00048 NP_783640 (OMIM: 608457) chromobox protein homolog ( 251) 185 42.9 0.00048 XP_011528327 (OMIM: 608457) PREDICTED: chromobox p ( 165) 181 42.1 0.00057 XP_006724241 (OMIM: 608457) PREDICTED: chromobox p ( 166) 181 42.1 0.00057 XP_006724238 (OMIM: 608457) PREDICTED: chromobox p ( 258) 181 42.2 0.00081 XP_006724237 (OMIM: 608457) PREDICTED: chromobox p ( 259) 181 42.2 0.00082 NP_003646 (OMIM: 603079) E3 SUMO-protein ligase CB ( 560) 185 43.1 0.00092 NP_001180355 (OMIM: 606503) histone-lysine N-methy ( 230) 176 41.3 0.0014 NP_001180353 (OMIM: 606503) histone-lysine N-methy ( 410) 176 41.4 0.0022 XP_011529814 (OMIM: 400016,415000) PREDICTED: test ( 470) 165 39.5 0.0096 >>NP_001120700 (OMIM: 604511) chromobox protein homolog (185 aa) initn: 1238 init1: 1238 opt: 1238 Z-score: 1216.3 bits: 231.7 E(85289): 5.2e-61 Smith-Waterman score: 1238; 100.0% identity (100.0% similar) in 185 aa overlap (1-185:1-185) 10 20 30 40 50 60 pF1KB6 MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEDDDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEDDDK 130 140 150 160 170 180 pF1KB6 KDDKN ::::: NP_001 KDDKN >>NP_006798 (OMIM: 604511) chromobox protein homolog 1 [ (185 aa) initn: 1238 init1: 1238 opt: 1238 Z-score: 1216.3 bits: 231.7 E(85289): 5.2e-61 Smith-Waterman score: 1238; 100.0% identity (100.0% similar) in 185 aa overlap (1-185:1-185) 10 20 30 40 50 60 pF1KB6 MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDC 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPE 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 RIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEDDDK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 RIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEDDDK 130 140 150 160 170 180 pF1KB6 KDDKN ::::: NP_006 KDDKN >>NP_057671 (OMIM: 604477) chromobox protein homolog 3 [ (183 aa) initn: 848 init1: 449 opt: 848 Z-score: 838.3 bits: 161.7 E(85289): 5.9e-40 Smith-Waterman score: 848; 73.6% identity (88.2% similar) in 178 aa overlap (1-178:11-181) 10 20 30 40 50 pF1KB6 MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDN :::::: :. ..: : : ::.:::::::::::.:::::.::::::.: :: NP_057 MASNKTTLQKMGKKQNGKS-KKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADN 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 TWEPEENLDCPDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKP :::::::::::.:: ::.:::...: : : :::. :::: ...:: :::.. ..:: NP_057 TWEPEENLDCPELIEAFLNSQKAGKEKD---GTKRKSLSDSE--SDDSKSKKKRDAADKP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 RGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTW :::::::.:::::::::::::::::::::.::::::: :::::.::::.::.:::::::: NP_057 RGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEERLTW 120 130 140 150 160 170 180 pF1KB6 HSYPSEDDDKKDDKN :: : ::. NP_057 HSCP-EDEAQ 180 >>XP_005249668 (OMIM: 604477) PREDICTED: chromobox prote (183 aa) initn: 848 init1: 449 opt: 848 Z-score: 838.3 bits: 161.7 E(85289): 5.9e-40 Smith-Waterman score: 848; 73.6% identity (88.2% similar) in 178 aa overlap (1-178:11-181) 10 20 30 40 50 pF1KB6 MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDN :::::: :. ..: : : ::.:::::::::::.:::::.::::::.: :: XP_005 MASNKTTLQKMGKKQNGKS-KKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADN 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 TWEPEENLDCPDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKP :::::::::::.:: ::.:::...: : : :::. :::: ...:: :::.. ..:: XP_005 TWEPEENLDCPELIEAFLNSQKAGKEKD---GTKRKSLSDSE--SDDSKSKKKRDAADKP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 RGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTW :::::::.:::::::::::::::::::::.::::::: :::::.::::.::.:::::::: XP_005 RGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEERLTW 120 130 140 150 160 170 180 pF1KB6 HSYPSEDDDKKDDKN :: : ::. XP_005 HSCP-EDEAQ 180 >>NP_009207 (OMIM: 604477) chromobox protein homolog 3 [ (183 aa) initn: 848 init1: 449 opt: 848 Z-score: 838.3 bits: 161.7 E(85289): 5.9e-40 Smith-Waterman score: 848; 73.6% identity (88.2% similar) in 178 aa overlap (1-178:11-181) 10 20 30 40 50 pF1KB6 MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDN :::::: :. ..: : : ::.:::::::::::.:::::.::::::.: :: NP_009 MASNKTTLQKMGKKQNGKS-KKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADN 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 TWEPEENLDCPDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKP :::::::::::.:: ::.:::...: : : :::. :::: ...:: :::.. ..:: NP_009 TWEPEENLDCPELIEAFLNSQKAGKEKD---GTKRKSLSDSE--SDDSKSKKKRDAADKP 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 RGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTW :::::::.:::::::::::::::::::::.::::::: :::::.::::.::.:::::::: NP_009 RGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEERLTW 120 130 140 150 160 170 180 pF1KB6 HSYPSEDDDKKDDKN :: : ::. NP_009 HSCP-EDEAQ 180 >>NP_036249 (OMIM: 604478) chromobox protein homolog 5 [ (191 aa) initn: 817 init1: 414 opt: 781 Z-score: 773.1 bits: 149.7 E(85289): 2.5e-36 Smith-Waterman score: 781; 63.9% identity (82.7% similar) in 191 aa overlap (1-183:1-187) 10 20 30 40 50 60 pF1KB6 MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDC :::: .:. .. :.:::::::::::::::::.:::::::::::.: ::::::.:::: NP_036 MGKK-TKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDC 10 20 30 40 50 70 80 90 100 110 pF1KB6 PDLIAEFLQSQKTAHE------TDKSEGGKRKAD-SDSEDKGEESKPKKKKEESEK-PRG :.::.::... : .: .:::..:::.. :.: : . : :::.:.:. :: NP_036 PELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSAD---DIKSKKKREQSNDIARG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 FARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHS : ::::::.::::::: :.::::::::..:::::: ::::::::::.::.:::::::::. NP_036 FERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHA 120 130 140 150 160 170 180 pF1KB6 YPSEDDDKKDDKN :: . ..:. . NP_036 YPEDAENKEKETAKS 180 190 >>NP_001120793 (OMIM: 604478) chromobox protein homolog (191 aa) initn: 817 init1: 414 opt: 781 Z-score: 773.1 bits: 149.7 E(85289): 2.5e-36 Smith-Waterman score: 781; 63.9% identity (82.7% similar) in 191 aa overlap (1-183:1-187) 10 20 30 40 50 60 pF1KB6 MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDC :::: .:. .. :.:::::::::::::::::.:::::::::::.: ::::::.:::: NP_001 MGKK-TKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDC 10 20 30 40 50 70 80 90 100 110 pF1KB6 PDLIAEFLQSQKTAHE------TDKSEGGKRKAD-SDSEDKGEESKPKKKKEESEK-PRG :.::.::... : .: .:::..:::.. :.: : . : :::.:.:. :: NP_001 PELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSAD---DIKSKKKREQSNDIARG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 FARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHS : ::::::.::::::: :.::::::::..:::::: ::::::::::.::.:::::::::. NP_001 FERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHA 120 130 140 150 160 170 180 pF1KB6 YPSEDDDKKDDKN :: . ..:. . NP_001 YPEDAENKEKETAKS 180 190 >>NP_001120794 (OMIM: 604478) chromobox protein homolog (191 aa) initn: 817 init1: 414 opt: 781 Z-score: 773.1 bits: 149.7 E(85289): 2.5e-36 Smith-Waterman score: 781; 63.9% identity (82.7% similar) in 191 aa overlap (1-183:1-187) 10 20 30 40 50 60 pF1KB6 MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDC :::: .:. .. :.:::::::::::::::::.:::::::::::.: ::::::.:::: NP_001 MGKK-TKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDC 10 20 30 40 50 70 80 90 100 110 pF1KB6 PDLIAEFLQSQKTAHE------TDKSEGGKRKAD-SDSEDKGEESKPKKKKEESEK-PRG :.::.::... : .: .:::..:::.. :.: : . : :::.:.:. :: NP_001 PELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSAD---DIKSKKKREQSNDIARG 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 FARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHS : ::::::.::::::: :.::::::::..:::::: ::::::::::.::.:::::::::. NP_001 FERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHA 120 130 140 150 160 170 180 pF1KB6 YPSEDDDKKDDKN :: . ..:. . NP_001 YPEDAENKEKETAKS 180 190 >>NP_116036 (OMIM: 602770,613080) chromobox protein homo (211 aa) initn: 229 init1: 172 opt: 205 Z-score: 214.0 bits: 46.4 E(85289): 3.5e-05 Smith-Waterman score: 205; 33.3% identity (65.7% similar) in 105 aa overlap (10-114:1-104) 10 20 30 40 50 60 pF1KB6 MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDC .::. :. ...: .:..:. :::.:::.::.:.:.. :.::::::. NP_116 MEELSSVGEQVFAAECILSKRLRKGKLEYLVKWRGWSSKHNSWEPEENILD 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 PDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPE : :. : :... .:... . ::: . . : ...: . :.: NP_116 PRLLLAF-QKKEHEKEVQNRKRGKRPRGRPRKLTAMSSCSRRSKLKVGGCAGYADPTSQH 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 RIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEDDDK NP_116 PLGVGGRQREGLGPSGRGWHFCQQSVPLLGKQEPPFFLSLSFCCQGPQPAESSSPPLPGA 120 130 140 150 160 170 >>NP_005180 (OMIM: 602770,613080) chromobox protein homo (532 aa) initn: 199 init1: 199 opt: 208 Z-score: 211.1 bits: 47.2 E(85289): 5.1e-05 Smith-Waterman score: 208; 34.3% identity (67.6% similar) in 102 aa overlap (10-110:1-101) 10 20 30 40 50 60 pF1KB6 MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDC .::. :. ...: .:..:. :::.:::.::.:.:.. :.::::::. NP_005 MEELSSVGEQVFAAECILSKRLRKGKLEYLVKWRGWSSKHNSWEPEENILD 10 20 30 40 50 70 80 90 100 110 pF1KB6 PDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKK-EESEKPRGFARGLEP : :. : :... .:... . ::: . . : ...: .: . : NP_005 PRLLLAF-QKKEHEKEVQNRKRGKRPRGRPRKLTAMSSCSRRSKLKEPDAPSKSKSSSSS 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 ERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEDDD NP_005 SSSTSSSSSSDEEDDSDLDAKRGPRGRETHPVPQKKAQILVAKPELKDPIRKKRGRKPLP 120 130 140 150 160 170 185 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 20:09:30 2016 done: Sat Nov 5 20:09:30 2016 Total Scan time: 6.210 Total Display time: -0.020 Function used was FASTA [36.3.4 Apr, 2011]