FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6813, 160 aa 1>>>pF1KB6813 160 - 160 aa - 160 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.5376+/-0.00029; mu= 11.3459+/- 0.018 mean_var=80.3723+/-15.803, 0's: 0 Z-trim(117.9): 17 B-trim: 245 in 1/57 Lambda= 0.143061 statistics sampled from 30398 (30415) to 30398 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.743), E-opt: 0.2 (0.357), width: 16 Scan time: 4.680 The best scores are: opt bits E(85289) NP_006592 (OMIM: 607061) prostaglandin E synthase ( 160) 1146 245.3 3e-65 XP_005268633 (OMIM: 607061) PREDICTED: prostagland ( 164) 1139 243.9 8.4e-65 NP_001269533 (OMIM: 607061) prostaglandin E syntha ( 164) 1139 243.9 8.4e-65 XP_011536075 (OMIM: 607061) PREDICTED: prostagland ( 161) 1050 225.5 2.8e-59 XP_016874205 (OMIM: 607061) PREDICTED: prostagland ( 165) 1043 224.1 7.8e-59 NP_001269530 (OMIM: 607061) prostaglandin E syntha ( 139) 906 195.8 2.2e-50 XP_011536076 (OMIM: 607061) PREDICTED: prostagland ( 143) 899 194.3 6.2e-50 NP_001269531 (OMIM: 607061) prostaglandin E syntha ( 130) 687 150.6 8.5e-37 XP_006719262 (OMIM: 607061) PREDICTED: prostagland ( 134) 680 149.1 2.4e-36 NP_001269534 (OMIM: 607061) prostaglandin E syntha ( 109) 675 148.0 4.1e-36 NP_001269532 (OMIM: 607061) prostaglandin E syntha ( 127) 472 106.2 1.9e-23 >>NP_006592 (OMIM: 607061) prostaglandin E synthase 3 is (160 aa) initn: 1146 init1: 1146 opt: 1146 Z-score: 1292.3 bits: 245.3 E(85289): 3e-65 Smith-Waterman score: 1146; 100.0% identity (100.0% similar) in 160 aa overlap (1-160:1-160) 10 20 30 40 50 60 pF1KB6 MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCID 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 PNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNF 70 80 90 100 110 120 130 140 150 160 pF1KB6 DRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE :::::::::::::::::::::::::::::::::::::::: NP_006 DRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE 130 140 150 160 >>XP_005268633 (OMIM: 607061) PREDICTED: prostaglandin E (164 aa) initn: 1139 init1: 1139 opt: 1139 Z-score: 1284.4 bits: 243.9 E(85289): 8.4e-65 Smith-Waterman score: 1139; 100.0% identity (100.0% similar) in 159 aa overlap (2-160:6-164) 10 20 30 40 50 pF1KB6 MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLF ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MFYLRQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 HCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 HCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDED 70 80 90 100 110 120 120 130 140 150 160 pF1KB6 MSNFDRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE :::::::::::::::::::::::::::::::::::::::::::: XP_005 MSNFDRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE 130 140 150 160 >>NP_001269533 (OMIM: 607061) prostaglandin E synthase 3 (164 aa) initn: 1139 init1: 1139 opt: 1139 Z-score: 1284.4 bits: 243.9 E(85289): 8.4e-65 Smith-Waterman score: 1139; 100.0% identity (100.0% similar) in 159 aa overlap (2-160:6-164) 10 20 30 40 50 pF1KB6 MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLF ::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MSLEKQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 HCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 HCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDED 70 80 90 100 110 120 120 130 140 150 160 pF1KB6 MSNFDRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE :::::::::::::::::::::::::::::::::::::::::::: NP_001 MSNFDRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE 130 140 150 160 >>XP_011536075 (OMIM: 607061) PREDICTED: prostaglandin E (161 aa) initn: 1077 init1: 1050 opt: 1050 Z-score: 1185.2 bits: 225.5 E(85289): 2.8e-59 Smith-Waterman score: 1050; 99.3% identity (99.3% similar) in 148 aa overlap (1-148:1-148) 10 20 30 40 50 60 pF1KB6 MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCID 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 PNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNF 70 80 90 100 110 120 130 140 150 160 pF1KB6 DRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE :::::::::::::::::::::::::: : XP_011 DRFSEMMNNMGGDEDVDLPEVDGADDVSLKILFSVYFHTIK 130 140 150 160 >>XP_016874205 (OMIM: 607061) PREDICTED: prostaglandin E (165 aa) initn: 1070 init1: 1043 opt: 1043 Z-score: 1177.3 bits: 224.1 E(85289): 7.8e-59 Smith-Waterman score: 1043; 99.3% identity (99.3% similar) in 147 aa overlap (2-148:6-152) 10 20 30 40 50 pF1KB6 MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLF ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MFYLRQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 HCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 HCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDED 70 80 90 100 110 120 120 130 140 150 160 pF1KB6 MSNFDRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE :::::::::::::::::::::::::::::: : XP_016 MSNFDRFSEMMNNMGGDEDVDLPEVDGADDVSLKILFSVYFHTIK 130 140 150 160 >>NP_001269530 (OMIM: 607061) prostaglandin E synthase 3 (139 aa) initn: 901 init1: 901 opt: 906 Z-score: 1025.5 bits: 195.8 E(85289): 2.2e-50 Smith-Waterman score: 945; 86.9% identity (86.9% similar) in 160 aa overlap (1-160:1-139) 10 20 30 40 50 60 pF1KB6 MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCID 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 PNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNF 70 80 90 100 110 120 130 140 150 160 pF1KB6 DRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE ::::: :::::::::::::: NP_001 DRFSE---------------------DSQDSDDEKMPDLE 130 >>XP_011536076 (OMIM: 607061) PREDICTED: prostaglandin E (143 aa) initn: 894 init1: 894 opt: 899 Z-score: 1017.5 bits: 194.3 E(85289): 6.2e-50 Smith-Waterman score: 938; 86.8% identity (86.8% similar) in 159 aa overlap (2-160:6-143) 10 20 30 40 50 pF1KB6 MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLF ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 MFYLRQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 HCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDED :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 HCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDED 70 80 90 100 110 120 120 130 140 150 160 pF1KB6 MSNFDRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE ::::::::: :::::::::::::: XP_011 MSNFDRFSE---------------------DSQDSDDEKMPDLE 130 140 >>NP_001269531 (OMIM: 607061) prostaglandin E synthase 3 (130 aa) initn: 692 init1: 677 opt: 687 Z-score: 781.6 bits: 150.6 E(85289): 8.5e-37 Smith-Waterman score: 850; 81.2% identity (81.2% similar) in 160 aa overlap (1-160:1-130) 10 20 30 40 50 60 pF1KB6 MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCID 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNF ::::::::::::::::::::::::::::::::::: NP_001 PNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAK------------------------- 70 80 90 130 140 150 160 pF1KB6 DRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE ::::::::::::::::::::::::::::::::::: NP_001 -----MMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE 100 110 120 130 >>XP_006719262 (OMIM: 607061) PREDICTED: prostaglandin E (134 aa) initn: 685 init1: 670 opt: 680 Z-score: 773.6 bits: 149.1 E(85289): 2.4e-36 Smith-Waterman score: 843; 81.1% identity (81.1% similar) in 159 aa overlap (2-160:6-134) 10 20 30 40 50 pF1KB6 MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLF ::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MFYLRQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLF 10 20 30 40 50 60 60 70 80 90 100 110 pF1KB6 HCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDED ::::::::::::::::::::::::::::::::::::::: XP_006 HCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAK--------------------- 70 80 90 120 130 140 150 160 pF1KB6 MSNFDRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE ::::::::::::::::::::::::::::::::::: XP_006 ---------MMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE 100 110 120 130 >>NP_001269534 (OMIM: 607061) prostaglandin E synthase 3 (109 aa) initn: 757 init1: 674 opt: 675 Z-score: 769.3 bits: 148.0 E(85289): 4.1e-36 Smith-Waterman score: 678; 82.6% identity (87.6% similar) in 121 aa overlap (1-121:1-109) 10 20 30 40 50 60 pF1KB6 MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCID :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCID 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 PNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNF ::::::::::::::::::::::::::::::::::: : .:..:: : .. NP_001 PNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAK------------DSQDSDDEKMPDL 70 80 90 100 130 140 150 160 pF1KB6 DRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE . NP_001 E 160 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 00:02:48 2016 done: Sat Nov 5 00:02:48 2016 Total Scan time: 4.680 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]