FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6820, 186 aa 1>>>pF1KB6820 186 - 186 aa - 186 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 4.7294+/-0.000458; mu= 16.8897+/- 0.029 mean_var=88.8060+/-19.083, 0's: 0 Z-trim(112.6): 296 B-trim: 2018 in 3/46 Lambda= 0.136098 statistics sampled from 21145 (21585) to 21145 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.646), E-opt: 0.2 (0.253), width: 16 Scan time: 5.480 The best scores are: opt bits E(85289) NP_060654 (OMIM: 616596) ADP-ribosylation factor-l ( 186) 1243 253.8 1.2e-67 NP_620150 (OMIM: 616597) ADP-ribosylation factor-l ( 186) 1182 241.8 4.8e-64 NP_001243058 (OMIM: 616597) ADP-ribosylation facto ( 147) 785 163.7 1.2e-40 NP_001654 (OMIM: 600464) ADP-ribosylation factor 6 ( 175) 418 91.8 6.6e-19 NP_001019397 (OMIM: 103180) ADP-ribosylation facto ( 181) 402 88.6 5.9e-18 NP_001019399 (OMIM: 103180) ADP-ribosylation facto ( 181) 402 88.6 5.9e-18 NP_001019398 (OMIM: 103180) ADP-ribosylation facto ( 181) 402 88.6 5.9e-18 NP_001649 (OMIM: 103180) ADP-ribosylation factor 1 ( 181) 402 88.6 5.9e-18 XP_005268913 (OMIM: 103190) PREDICTED: ADP-ribosyl ( 181) 399 88.1 8.9e-18 NP_001168 (OMIM: 603425) ADP-ribosylation factor-l ( 181) 399 88.1 8.9e-18 NP_001650 (OMIM: 103190) ADP-ribosylation factor 3 ( 181) 399 88.1 8.9e-18 NP_001653 (OMIM: 103188) ADP-ribosylation factor 5 ( 180) 387 85.7 4.6e-17 NP_001651 (OMIM: 601177) ADP-ribosylation factor 4 ( 180) 372 82.7 3.5e-16 XP_016871749 (OMIM: 604695) PREDICTED: ADP-ribosyl ( 182) 370 82.4 4.6e-16 NP_004302 (OMIM: 604695) ADP-ribosylation factor-l ( 182) 370 82.4 4.6e-16 NP_001658 (OMIM: 601175) ADP-ribosylation factor-l ( 184) 365 81.4 9.2e-16 NP_001167621 (OMIM: 608922,612291) ADP-ribosylatio ( 428) 358 80.4 4.1e-15 NP_878899 (OMIM: 608922,612291) ADP-ribosylation f ( 428) 358 80.4 4.1e-15 NP_612459 (OMIM: 609351) ADP-ribosylation factor-l ( 196) 345 77.5 1.5e-14 XP_005266310 (OMIM: 609351) PREDICTED: ADP-ribosyl ( 196) 345 77.5 1.5e-14 NP_001265222 (OMIM: 209900,268000,600151,608845,61 ( 186) 329 74.3 1.2e-13 NP_816931 (OMIM: 209900,268000,600151,608845,61357 ( 186) 329 74.3 1.2e-13 XP_016862800 (OMIM: 209900,268000,600151,608845,61 ( 186) 329 74.3 1.2e-13 NP_115522 (OMIM: 209900,268000,600151,608845,61357 ( 186) 329 74.3 1.2e-13 NP_005728 (OMIM: 604787) ADP-ribosylation factor-l ( 192) 328 74.1 1.5e-13 NP_001310442 (OMIM: 209900,268000,600151,608845,61 ( 193) 328 74.1 1.5e-13 NP_001269360 (OMIM: 604787) ADP-ribosylation facto ( 201) 328 74.2 1.5e-13 NP_001182325 (OMIM: 604786) ADP-ribosylation facto ( 200) 325 73.6 2.3e-13 NP_005729 (OMIM: 604786) ADP-ribosylation factor-l ( 200) 325 73.6 2.3e-13 NP_997625 (OMIM: 604786) ADP-ribosylation factor-l ( 200) 325 73.6 2.3e-13 NP_001032241 (OMIM: 604786) ADP-ribosylation facto ( 200) 325 73.6 2.3e-13 XP_016862801 (OMIM: 209900,268000,600151,608845,61 ( 159) 323 73.1 2.6e-13 NP_001310443 (OMIM: 209900,268000,600151,608845,61 ( 159) 323 73.1 2.6e-13 NP_079323 (OMIM: 614439) ADP-ribosylation factor-l ( 192) 323 73.2 2.9e-13 XP_016856722 (OMIM: 103180) PREDICTED: ADP-ribosyl ( 212) 322 73.0 3.5e-13 NP_001652 (OMIM: 600732) ADP-ribosylation factor-l ( 201) 321 72.8 3.9e-13 XP_011523084 (OMIM: 600732) PREDICTED: ADP-ribosyl ( 201) 321 72.8 3.9e-13 NP_001287997 (OMIM: 603425) ADP-ribosylation facto ( 135) 318 72.0 4.5e-13 XP_011510837 (OMIM: 608922,612291) PREDICTED: ADP- ( 403) 323 73.5 4.6e-13 XP_006719454 (OMIM: 103190) PREDICTED: ADP-ribosyl ( 137) 312 70.8 1e-12 XP_005248554 (OMIM: 601747) PREDICTED: E3 ubiquiti ( 398) 315 72.0 1.4e-12 NP_001647 (OMIM: 601747) E3 ubiquitin-protein liga ( 574) 315 72.2 1.7e-12 NP_036229 (OMIM: 608960) ADP-ribosylation factor-l ( 179) 307 70.0 2.4e-12 NP_150231 (OMIM: 601747) E3 ubiquitin-protein liga ( 546) 309 70.9 3.8e-12 NP_150230 (OMIM: 601747) E3 ubiquitin-protein liga ( 569) 305 70.2 6.7e-12 XP_016864933 (OMIM: 601747) PREDICTED: E3 ubiquiti ( 569) 305 70.2 6.7e-12 NP_001254477 (OMIM: 604699) ADP-ribosylation facto ( 201) 299 68.5 7.8e-12 NP_001254476 (OMIM: 604699) ADP-ribosylation facto ( 201) 299 68.5 7.8e-12 XP_016883065 (OMIM: 604699) PREDICTED: ADP-ribosyl ( 201) 299 68.5 7.8e-12 XP_011526784 (OMIM: 604699) PREDICTED: ADP-ribosyl ( 201) 299 68.5 7.8e-12 >>NP_060654 (OMIM: 616596) ADP-ribosylation factor-like (186 aa) initn: 1243 init1: 1243 opt: 1243 Z-score: 1335.6 bits: 253.8 E(85289): 1.2e-67 Smith-Waterman score: 1243; 100.0% identity (100.0% similar) in 186 aa overlap (1-186:1-186) 10 20 30 40 50 60 pF1KB6 MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKV 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 TKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 QGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_060 QGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQH 130 140 150 160 170 180 pF1KB6 SKSRRS :::::: NP_060 SKSRRS >>NP_620150 (OMIM: 616597) ADP-ribosylation factor-like (186 aa) initn: 1182 init1: 1182 opt: 1182 Z-score: 1270.8 bits: 241.8 E(85289): 4.8e-64 Smith-Waterman score: 1182; 91.9% identity (100.0% similar) in 186 aa overlap (1-186:1-186) 10 20 30 40 50 60 pF1KB6 MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKV :.::...:::::..:::::::::::::::::::::::::::::::.:::::::::::::. NP_620 MIALFNKLLDWFKALFWKEEMELTLVGLQYSGKTTFVNVIASGQFNEDMIPTVGFNMRKI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQL ::::::::.::::::::::::::::::::.:::::.::::.::::::.:::::::::::: NP_620 TKGNVTIKLWDIGGQPRFRSMWERYCRGVSAIVYMVDAADQEKIEASKNELHNLLDKPQL 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 QGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQH :::::::::::::::.:::::.:::::::::::::::::::::::::::::::::::::: NP_620 QGIPVLVLGNKRDLPGALDEKELIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQH 130 140 150 160 170 180 pF1KB6 SKSRRS :::::: NP_620 SKSRRS >>NP_001243058 (OMIM: 616597) ADP-ribosylation factor-li (147 aa) initn: 783 init1: 783 opt: 785 Z-score: 850.8 bits: 163.7 E(85289): 1.2e-40 Smith-Waterman score: 785; 85.2% identity (95.6% similar) in 135 aa overlap (1-134:1-135) 10 20 30 40 50 60 pF1KB6 MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKV :.::...:::::..:::::::::::::::::::::::::::::::.:::::::::::::. NP_001 MIALFNKLLDWFKALFWKEEMELTLVGLQYSGKTTFVNVIASGQFNEDMIPTVGFNMRKI 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 TKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQL ::::::::.::::::::::::::::::::.:::::.::::.::::::.:::::::::::: NP_001 TKGNVTIKLWDIGGQPRFRSMWERYCRGVSAIVYMVDAADQEKIEASKNELHNLLDKPQL 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 QGIPVLVLG-NKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQ :::: : . ::: NP_001 QGIPESVCHPGPRDLLLLHLLQRKGQH 130 140 >>NP_001654 (OMIM: 600464) ADP-ribosylation factor 6 [Ho (175 aa) initn: 415 init1: 358 opt: 418 Z-score: 460.4 bits: 91.8 E(85289): 6.6e-19 Smith-Waterman score: 418; 36.5% identity (72.9% similar) in 170 aa overlap (15-183:8-175) 10 20 30 40 50 60 pF1KB6 MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKV .: ..::.. ..::. .::::.. . :: : :::::::.. : NP_001 MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQ-SVTTIPTVGFNVETV 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 TKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQL : :: ...::.::: ..: .:..: :........: :::..:. .:.::: ... .. NP_001 TYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREM 60 70 80 90 100 110 130 140 150 160 170 pF1KB6 QGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEK-DNIDITLQWLIQ . .:...::.:::.:. ... ::..:. :.::. :: . :.. : :: . NP_001 RDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQP-SCATSGDGLYEGLTWLTS 120 130 140 150 160 170 180 pF1KB6 HSKSRRS . :: NP_001 NYKS >>NP_001019397 (OMIM: 103180) ADP-ribosylation factor 1 (181 aa) initn: 401 init1: 325 opt: 402 Z-score: 443.3 bits: 88.6 E(85289): 5.9e-18 Smith-Waterman score: 402; 31.6% identity (72.4% similar) in 174 aa overlap (12-185:9-181) 10 20 30 40 50 60 pF1KB6 MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKV :..:: :.::.. .:::. .::::.. . :.. :::.:::.. : NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTT-IPTIGFNVETV 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 TKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQL :... .::.::: ..: .:..: ..........:. :::... .:.:: .: . .: NP_001 EYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDEL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 QGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQH . .::..::.:::::.. .. .:..: ... :. . :.. :.:: .. NP_001 RDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQ 120 130 140 150 160 170 pF1KB6 SKSRRS .... NP_001 LRNQK 180 >>NP_001019399 (OMIM: 103180) ADP-ribosylation factor 1 (181 aa) initn: 401 init1: 325 opt: 402 Z-score: 443.3 bits: 88.6 E(85289): 5.9e-18 Smith-Waterman score: 402; 31.6% identity (72.4% similar) in 174 aa overlap (12-185:9-181) 10 20 30 40 50 60 pF1KB6 MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKV :..:: :.::.. .:::. .::::.. . :.. :::.:::.. : NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTT-IPTIGFNVETV 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 TKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQL :... .::.::: ..: .:..: ..........:. :::... .:.:: .: . .: NP_001 EYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDEL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 QGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQH . .::..::.:::::.. .. .:..: ... :. . :.. :.:: .. NP_001 RDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQ 120 130 140 150 160 170 pF1KB6 SKSRRS .... NP_001 LRNQK 180 >>NP_001019398 (OMIM: 103180) ADP-ribosylation factor 1 (181 aa) initn: 401 init1: 325 opt: 402 Z-score: 443.3 bits: 88.6 E(85289): 5.9e-18 Smith-Waterman score: 402; 31.6% identity (72.4% similar) in 174 aa overlap (12-185:9-181) 10 20 30 40 50 60 pF1KB6 MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKV :..:: :.::.. .:::. .::::.. . :.. :::.:::.. : NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTT-IPTIGFNVETV 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 TKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQL :... .::.::: ..: .:..: ..........:. :::... .:.:: .: . .: NP_001 EYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDEL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 QGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQH . .::..::.:::::.. .. .:..: ... :. . :.. :.:: .. NP_001 RDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQ 120 130 140 150 160 170 pF1KB6 SKSRRS .... NP_001 LRNQK 180 >>NP_001649 (OMIM: 103180) ADP-ribosylation factor 1 [Ho (181 aa) initn: 401 init1: 325 opt: 402 Z-score: 443.3 bits: 88.6 E(85289): 5.9e-18 Smith-Waterman score: 402; 31.6% identity (72.4% similar) in 174 aa overlap (12-185:9-181) 10 20 30 40 50 60 pF1KB6 MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKV :..:: :.::.. .:::. .::::.. . :.. :::.:::.. : NP_001 MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTT-IPTIGFNVETV 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 TKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQL :... .::.::: ..: .:..: ..........:. :::... .:.:: .: . .: NP_001 EYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDEL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 QGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQH . .::..::.:::::.. .. .:..: ... :. . :.. :.:: .. NP_001 RDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQ 120 130 140 150 160 170 pF1KB6 SKSRRS .... NP_001 LRNQK 180 >>XP_005268913 (OMIM: 103190) PREDICTED: ADP-ribosylatio (181 aa) initn: 401 init1: 335 opt: 399 Z-score: 440.1 bits: 88.1 E(85289): 8.9e-18 Smith-Waterman score: 399; 31.6% identity (72.4% similar) in 174 aa overlap (12-185:9-181) 10 20 30 40 50 60 pF1KB6 MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKV ..::. :.::.. .:::. .::::.. . :.. :::.:::.. : XP_005 MGNIFGNLLKSLIGKKEMRILMVGLDAAGKTTILYKLKLGEIVTT-IPTIGFNVETV 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 TKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQL :... .::.::: ..: .:..: ..........:. :::... .:.:: .: . .: XP_005 EYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDEL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 QGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQH . .::..::.:::::.. .. .:..: ... :. . :.. :.:: .. XP_005 RDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLANQ 120 130 140 150 160 170 pF1KB6 SKSRRS :... XP_005 LKNKK 180 >>NP_001168 (OMIM: 603425) ADP-ribosylation factor-like (181 aa) initn: 391 init1: 338 opt: 399 Z-score: 440.1 bits: 88.1 E(85289): 8.9e-18 Smith-Waterman score: 399; 32.8% identity (71.8% similar) in 174 aa overlap (12-185:9-181) 10 20 30 40 50 60 pF1KB6 MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKV : ::: .::.. ..::. .::::.. . :. :::.:::.. : NP_001 MGGFFSSIFSSLFGTREMRILILGLDGAGKTTILYRLQVGEVVTT-IPTIGFNVETV 10 20 30 40 50 70 80 90 100 110 120 pF1KB6 TKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQL : :. ...::.::: .: .:. : ...:..:..:. ::..: :..:: .:.. .: NP_001 TYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSCDRDRIGISKSELVAMLEEEEL 60 70 80 90 100 110 130 140 150 160 170 180 pF1KB6 QGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQH . ..:..::.:. .:. ... ....: :..::. .. : . ..: ...::.. NP_001 RKAILVVFANKQDMEQAMTSSEMANSLGLPALKDRKWQIFKTSATKGTGLDEAMEWLVET 120 130 140 150 160 170 pF1KB6 SKSRRS :::. NP_001 LKSRQ 180 186 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sat Nov 5 04:04:57 2016 done: Sat Nov 5 04:04:58 2016 Total Scan time: 5.480 Total Display time: -0.030 Function used was FASTA [36.3.4 Apr, 2011]