FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KB6824, 187 aa 1>>>pF1KB6824 187 - 187 aa - 187 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.0644+/-0.000443; mu= 14.8320+/- 0.028 mean_var=81.8794+/-16.731, 0's: 0 Z-trim(112.4): 159 B-trim: 597 in 1/50 Lambda= 0.141738 statistics sampled from 21144 (21364) to 21144 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.633), E-opt: 0.2 (0.25), width: 16 Scan time: 5.280 The best scores are: opt bits E(85289) NP_006374 (OMIM: 605564,609439,614869) calcium and ( 187) 1243 263.6 1.3e-70 XP_005254183 (OMIM: 605564,609439,614869) PREDICTE ( 210) 1210 256.9 1.5e-68 NP_001288153 (OMIM: 605564,609439,614869) calcium ( 192) 960 205.8 3.4e-53 XP_006720437 (OMIM: 605564,609439,614869) PREDICTE ( 144) 950 203.6 1.2e-52 NP_001258817 (OMIM: 605564,609439,614869) calcium ( 144) 950 203.6 1.2e-52 XP_011519463 (OMIM: 605564,609439,614869) PREDICTE ( 167) 917 196.9 1.4e-50 NP_473454 (OMIM: 610645) calcium and integrin-bind ( 187) 820 177.2 1.4e-44 NP_001258818 (OMIM: 605564,609439,614869) calcium ( 138) 804 173.8 1.1e-43 NP_001287851 (OMIM: 610645) calcium and integrin-b ( 138) 541 120.0 1.7e-27 NP_006375 (OMIM: 602293) calcium and integrin-bind ( 191) 447 100.9 1.3e-21 XP_006720438 (OMIM: 602293) PREDICTED: calcium and ( 264) 429 97.3 2.1e-20 NP_001025052 (OMIM: 610646) calcium and integrin-b ( 185) 415 94.3 1.2e-19 XP_011530816 (OMIM: 610646) PREDICTED: calcium and ( 201) 397 90.7 1.6e-18 NP_001264693 (OMIM: 602293) calcium and integrin-b ( 231) 376 86.4 3.5e-17 XP_016858818 (OMIM: 610646) PREDICTED: calcium and ( 162) 371 85.3 5.5e-17 XP_011530819 (OMIM: 610646) PREDICTED: calcium and ( 187) 338 78.6 6.6e-15 XP_016858819 (OMIM: 610646) PREDICTED: calcium and ( 140) 324 75.6 3.9e-14 NP_000936 (OMIM: 601302) calcineurin subunit B typ ( 170) 263 63.2 2.5e-10 NP_671709 (OMIM: 613821) calcineurin subunit B typ ( 173) 246 59.7 2.9e-09 NP_009167 (OMIM: 606988) calcineurin B homologous ( 195) 200 50.4 2.1e-06 NP_001030086 (OMIM: 604662) calsenilin isoform 2 p ( 230) 197 49.8 3.6e-06 NP_038462 (OMIM: 604662) calsenilin isoform 1 [Hom ( 256) 197 49.9 3.9e-06 NP_001316853 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 180 46.1 2.4e-05 NP_001316854 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 180 46.1 2.4e-05 NP_001316850 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 180 46.1 2.4e-05 NP_001316855 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 180 46.1 2.4e-05 NP_001292555 (OMIM: 114182,616249) calmodulin isof ( 113) 180 46.1 2.4e-05 NP_001316852 (OMIM: 114183) calmodulin isoform 2 [ ( 113) 180 46.1 2.4e-05 NP_001292554 (OMIM: 114182,616249) calmodulin isof ( 113) 180 46.1 2.4e-05 NP_001316851 (OMIM: 114183) calmodulin isoform 1 [ ( 149) 180 46.2 3e-05 NP_005175 (OMIM: 114183) calmodulin isoform 1 [Hom ( 149) 180 46.2 3e-05 NP_001734 (OMIM: 114182,616249) calmodulin isoform ( 149) 180 46.2 3e-05 NP_008819 (OMIM: 114180,614916,616247) calmodulin ( 149) 180 46.2 3e-05 XP_006720321 (OMIM: 114180,614916,616247) PREDICTE ( 150) 180 46.2 3e-05 NP_001292553 (OMIM: 114182,616249) calmodulin isof ( 197) 180 46.3 3.6e-05 NP_005176 (OMIM: 114184) calmodulin-like protein 3 ( 149) 178 45.8 3.9e-05 XP_016859440 (OMIM: 600207) PREDICTED: hippocalcin ( 193) 171 44.5 0.00013 XP_011508648 (OMIM: 600207) PREDICTED: hippocalcin ( 193) 171 44.5 0.00013 XP_005246218 (OMIM: 600207) PREDICTED: hippocalcin ( 193) 171 44.5 0.00013 XP_016859441 (OMIM: 600207) PREDICTED: hippocalcin ( 193) 171 44.5 0.00013 NP_002140 (OMIM: 600207) hippocalcin-like protein ( 193) 171 44.5 0.00013 XP_005246220 (OMIM: 600207) PREDICTED: hippocalcin ( 193) 171 44.5 0.00013 XP_016859439 (OMIM: 600207) PREDICTED: hippocalcin ( 193) 171 44.5 0.00013 NP_001245286 (OMIM: 600207) hippocalcin-like prote ( 193) 171 44.5 0.00013 XP_005246219 (OMIM: 600207) PREDICTED: hippocalcin ( 193) 171 44.5 0.00013 XP_005246217 (OMIM: 600207) PREDICTED: hippocalcin ( 193) 171 44.5 0.00013 NP_001245288 (OMIM: 600207) hippocalcin-like prote ( 193) 171 44.5 0.00013 XP_011508650 (OMIM: 600207) PREDICTED: hippocalcin ( 193) 171 44.5 0.00013 XP_016859442 (OMIM: 600207) PREDICTED: hippocalcin ( 193) 171 44.5 0.00013 NP_001245287 (OMIM: 600207) hippocalcin-like prote ( 193) 171 44.5 0.00013 >>NP_006374 (OMIM: 605564,609439,614869) calcium and int (187 aa) initn: 1243 init1: 1243 opt: 1243 Z-score: 1388.8 bits: 263.6 E(85289): 1.3e-70 Smith-Waterman score: 1243; 100.0% identity (100.0% similar) in 187 aa overlap (1-187:1-187) 10 20 30 40 50 60 pF1KB6 MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QMPELRENPFKERIVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 QMPELRENPFKERIVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 NFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_006 NFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFL 130 140 150 160 170 180 pF1KB6 STFHIRI ::::::: NP_006 STFHIRI >>XP_005254183 (OMIM: 605564,609439,614869) PREDICTED: c (210 aa) initn: 1261 init1: 1210 opt: 1210 Z-score: 1351.7 bits: 256.9 E(85289): 1.5e-68 Smith-Waterman score: 1210; 97.8% identity (97.8% similar) in 186 aa overlap (1-186:1-186) 10 20 30 40 50 60 pF1KB6 MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLII :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLII 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QMPELRENPFKERIVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 QMPELRENPFKERIVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTD 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 NFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 NFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFL 130 140 150 160 170 180 pF1KB6 STFHIRI : : XP_005 RCCHYRGRAWAGQSRAGRDVGAEAPITRYL 190 200 210 >>NP_001288153 (OMIM: 605564,609439,614869) calcium and (192 aa) initn: 988 init1: 801 opt: 960 Z-score: 1075.9 bits: 205.8 E(85289): 3.4e-53 Smith-Waterman score: 960; 80.7% identity (84.4% similar) in 192 aa overlap (1-187:1-192) 10 20 30 40 50 60 pF1KB6 MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLII ::::::::::::::::::::::::::::: .: : . . .. : : NP_001 MGNKQTIFTEEQLDNYQDCTFFNKKDILKWGNRGSEGFGHSSRVTQAVHSLAPGPSCLSC 10 20 30 40 50 60 70 80 90 100 110 pF1KB6 QMPE-----LRENPFKERIVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIY . :.::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 THSDCCVCFLQENPFKERIVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIY 70 80 90 100 110 120 120 130 140 150 160 170 pF1KB6 DFNTDNFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DFNTDNFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAK 130 140 150 160 170 180 180 pF1KB6 APDFLSTFHIRI :::::::::::: NP_001 APDFLSTFHIRI 190 >>XP_006720437 (OMIM: 605564,609439,614869) PREDICTED: c (144 aa) initn: 950 init1: 950 opt: 950 Z-score: 1066.5 bits: 203.6 E(85289): 1.2e-52 Smith-Waterman score: 950; 100.0% identity (100.0% similar) in 144 aa overlap (44-187:1-144) 20 30 40 50 60 70 pF1KB6 DNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLIIQMPELRENPFKER :::::::::::::::::::::::::::::: XP_006 MDYRKSPIVHVPMSLIIQMPELRENPFKER 10 20 30 80 90 100 110 120 130 pF1KB6 IVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 IVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLA 40 50 60 70 80 90 140 150 160 170 180 pF1KB6 RLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI :::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI 100 110 120 130 140 >>NP_001258817 (OMIM: 605564,609439,614869) calcium and (144 aa) initn: 950 init1: 950 opt: 950 Z-score: 1066.5 bits: 203.6 E(85289): 1.2e-52 Smith-Waterman score: 950; 100.0% identity (100.0% similar) in 144 aa overlap (44-187:1-144) 20 30 40 50 60 70 pF1KB6 DNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLIIQMPELRENPFKER :::::::::::::::::::::::::::::: NP_001 MDYRKSPIVHVPMSLIIQMPELRENPFKER 10 20 30 80 90 100 110 120 130 pF1KB6 IVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 IVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLA 40 50 60 70 80 90 140 150 160 170 180 pF1KB6 RLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI :::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 RLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI 100 110 120 130 140 >>XP_011519463 (OMIM: 605564,609439,614869) PREDICTED: c (167 aa) initn: 968 init1: 917 opt: 917 Z-score: 1029.2 bits: 196.9 E(85289): 1.4e-50 Smith-Waterman score: 917; 97.2% identity (97.2% similar) in 143 aa overlap (44-186:1-143) 20 30 40 50 60 70 pF1KB6 DNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLIIQMPELRENPFKER :::::::::::::::::::::::::::::: XP_011 MDYRKSPIVHVPMSLIIQMPELRENPFKER 10 20 30 80 90 100 110 120 130 pF1KB6 IVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_011 IVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLA 40 50 60 70 80 90 140 150 160 170 180 pF1KB6 RLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI ::::::::::::::::::::::::::::::::::::::::::::::: : : XP_011 RLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFLRCCHYRGRAWAGQ 100 110 120 130 140 150 XP_011 SRAGRDVGAEAPITRYL 160 >>NP_473454 (OMIM: 610645) calcium and integrin-binding (187 aa) initn: 820 init1: 820 opt: 820 Z-score: 921.3 bits: 177.2 E(85289): 1.4e-44 Smith-Waterman score: 820; 61.5% identity (87.2% similar) in 187 aa overlap (1-187:1-187) 10 20 30 40 50 60 pF1KB6 MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLII ::::::.::.:::. :::::::..:.:..: :. .:::.:::.:: : :.::. :: NP_473 MGNKQTVFTHEQLEAYQDCTFFTRKEIMRLFYRYQDLAPQLVPLDYTTCPDVKVPYELIG 10 20 30 40 50 60 70 80 90 100 110 120 pF1KB6 QMPELRENPFKERIVAAFSEDGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTD .::::..:::..::. .:::::.:..:...:.:::::. : :::.::: :::::::::.: NP_473 SMPELKDNPFRQRIAQVFSEDGDGHMTLDNFLDMFSVMSEMAPRDLKAYYAFKIYDFNND 70 80 90 100 110 120 130 140 150 160 170 180 pF1KB6 NFICKEDLELTLARLTKSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAKAPDFL ..:: ::: :...::.. :. ::: :::.::..::: : ::.:.. ::..:: .::::: NP_473 DYICAWDLEQTVTKLTRGGLSAEEVSLVCEKVLDEADGDHDGRLSLEDFQNMILRAPDFL 130 140 150 160 170 180 pF1KB6 STFHIRI ::::::: NP_473 STFHIRI >>NP_001258818 (OMIM: 605564,609439,614869) calcium and (138 aa) initn: 804 init1: 804 opt: 804 Z-score: 905.3 bits: 173.8 E(85289): 1.1e-43 Smith-Waterman score: 804; 96.1% identity (98.4% similar) in 127 aa overlap (61-187:12-138) 40 50 60 70 80 90 pF1KB6 HSRFYELAPNLVPMDYRKSPIVHVPMSLIIQMPELRENPFKERIVAAFSEDGEGNLTFND :. . .:::::::::::::::::::::::: NP_001 MGNKQTIFTEEQLDNYQENPFKERIVAAFSEDGEGNLTFND 10 20 30 40 100 110 120 130 140 150 pF1KB6 FVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEEVVLVCD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 FVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEEVVLVCD 50 60 70 80 90 100 160 170 180 pF1KB6 KVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI ::::::::::::::::::::::::::::::::::::: NP_001 KVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI 110 120 130 >>NP_001287851 (OMIM: 610645) calcium and integrin-bindi (138 aa) initn: 541 init1: 541 opt: 541 Z-score: 614.7 bits: 120.0 E(85289): 1.7e-27 Smith-Waterman score: 541; 59.8% identity (86.6% similar) in 127 aa overlap (61-187:12-138) 40 50 60 70 80 90 pF1KB6 HSRFYELAPNLVPMDYRKSPIVHVPMSLIIQMPELRENPFKERIVAAFSEDGEGNLTFND :. ..:::..::. .:::::.:..:... NP_001 MGNKQTVFTHEQLEAYQDNPFRQRIAQVFSEDGDGHMTLDN 10 20 30 40 100 110 120 130 140 150 pF1KB6 FVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEEVVLVCD :.:::::. : :::.::: :::::::::.:..:: ::: :...::.. :. ::: :::. NP_001 FLDMFSVMSEMAPRDLKAYYAFKIYDFNNDDYICAWDLEQTVTKLTRGGLSAEEVSLVCE 50 60 70 80 90 100 160 170 180 pF1KB6 KVIEEADLDGDGKLGFADFEDMIAKAPDFLSTFHIRI ::..::: : ::.:.. ::..:: .:::::::::::: NP_001 KVLDEADGDHDGRLSLEDFQNMILRAPDFLSTFHIRI 110 120 130 >>NP_006375 (OMIM: 602293) calcium and integrin-binding (191 aa) initn: 284 init1: 185 opt: 447 Z-score: 509.0 bits: 100.9 E(85289): 1.3e-21 Smith-Waterman score: 447; 37.9% identity (73.7% similar) in 190 aa overlap (1-185:1-189) 10 20 30 40 50 60 pF1KB6 MGNKQTIFTEEQLDNYQDCTFFNKKDILKLHSRFYELAPNLVPMDYRKSPIVHVPMSLII ::.. . ...: : .::: ::..:..:: : :: :: :. . ..: ..::. :. NP_006 MGGSGSRLSKELLAEYQDLTFLTKQEILLAHRRFCELLPQE-QRSVESSLRAQVPFEQIL 10 20 30 40 50 70 80 90 100 110 pF1KB6 QMPELRENPFKERIVAAFSED-GEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNT ..:::. ::::::: .:: . .. .:.:.::.:..::. ..: ..:..:::.:.::. NP_006 SLPELKANPFKERICRVFSTSPAKDSLSFEDFLDLLSVFSDTATPDIKSHYAFRIFDFDD 60 70 80 90 100 110 120 130 140 150 160 170 pF1KB6 DNFICKEDLELTLARLT----KSELDEEEVVLVCDKVIEEADLDGDGKLGFADFEDMIAK :. . .::: . :: ..:. :. . :...::.:.: :: .....:. .:.. NP_006 DGTLNREDLSRLVNCLTGEGEDTRLSASEMKQLIDNILEESDIDRDGTINLSEFQHVISR 120 130 140 150 160 170 180 pF1KB6 APDFLSTFHIRI .::: :.:.: NP_006 SPDFASSFKIVL 180 190 187 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Fri Nov 4 14:23:39 2016 done: Fri Nov 4 14:23:40 2016 Total Scan time: 5.280 Total Display time: -0.010 Function used was FASTA [36.3.4 Apr, 2011]